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The map label for this gene is pncB

Identifier: 110634090

GI number: 110634090

Start: 1857464

End: 1858768

Strand: Direct

Name: pncB

Synonym: Meso_1739

Alternate gene names: 110634090

Gene position: 1857464-1858768 (Clockwise)

Preceding gene: 110634088

Following gene: 110634092

Centisome position: 42.1

GC content: 58.62

Gene sequence:

>1305_bases
ATGACCGTTACCGATATCGCACGCCGGGTTTACAATCACACCTGGAAGCTTGATCCCATCTGCCGCAGCTTGCTCGACAC
GGATTTTTACAAGCTTCTGATGCTCCAAATGATTTGGGGCCTCTACCAGGATGTGGACGCCACTTTTTCGCTGACCAACC
GGAACCATCGCGTCCGCCTTGCCGACGAAATAGACGAGGCCGAGTTGCGTGCGCAGCTAGACCACGCCCGCACGATCCGC
TTTTCAAAAAAGGAGATGATCTGGCTCGCCGGCAATTCCTTCTACGGTCGCAAGCAGATCTTCAGCCCCGAGTTCCTCGC
TTGGCTCGCCGATTTCCAACTGCCTGAATATGAGCTGAGGCGACGCGACGGTCAGTTTGAACTTCACTTTTACGGCCGCT
GGATGGAAACCACCATGTGGGAAATTCCGGCTCTGGCCATAATCAACGAATTGCGCTCACGCGCGGCCATGCGCACCCTT
GGCCGCTTTGCCCTGGACGTGCTCTACGCTCGCGCCAAGGCGAAGGTCTGGGAAAAGGTCGAACGCCTGAAGAAGTACCC
GGACATTCGCATCTCCGACTTCGGAACGCGACGCCGCCATTCCTTTTTATGGCAACGCTGGTGCGTGGAGGCCTTGAAGG
AAGGAATCGGCGAATCCTTCACCGGCACGTCCAATGTGCTGCTGGCCATGGATACGGACCTGGAAGCGCTGGGAACGAAT
GCCCACGAGCTTCCGATGGTTCTTGCGGCGCTAAGCAGCTCCGACGAGGAACTGAAAGCCTCGCCCTATCAGGTCCTCAA
GGATTGGCAGAGCTATTACGGCGGCAATCTCTTGATCGTGCTGCCGGATACGTTCGGAACCGAATCGTTCCTTGAGGACG
CACCGGGATGGGTCGCGGATTGGACCGGCTTCCGCCCCGATAGCGCGCCCCCCATCGAAGGCGGCGAGCGCATCATCTCC
TGGTGGGAGCAACATGGCCGGGACCCGCGGGAAAAGCTGCTGATCTTTTCCGACGCCCTCGACGTCGATACAATCGAGCA
GACATATCGGCACTTCAAGGGCCGTTCCCGCCTGAGCTTCGGCTGGGGAACCAATCTTACAAACGACTTCGACGGCTGCG
CCCCCGAAAAGATCGACAGGCTGAAAGCGATATCGCTTGTTTGCAAGGTAAGCAGTGCCAACGGCCGTCCCGCCGTGAAG
CTCTCCGACAATCCGGAAAAGGCAACCGGCAGGCCTGAGGAGATCCAGCGTTATCTGCGCGTTTTCGGCAGCCGCAACCG
CGTGCACCAGCCGGTAGAGGTGTAG

Upstream 100 bases:

>100_bases
TCCAGATTGACATTTGCGCCATGGAGGTGTGGGTTGCGCTCAATATGGACGTCAGGATCTGCTCCTGCCGGTCCGGAATT
GGCCAAGCGCGAAGGGCGTC

Downstream 100 bases:

>100_bases
GGATAACGCCTACGCGTCCTGCTCAAGCATCTCTTTAACAGTAGTCGCCAACTGCTTGAGGGAGAACGGCTTCGGAAGGA
ACCCGAAAATGGCGTCCTCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTVTDIARRVYNHTWKLDPICRSLLDTDFYKLLMLQMIWGLYQDVDATFSLTNRNHRVRLADEIDEAELRAQLDHARTIR
FSKKEMIWLAGNSFYGRKQIFSPEFLAWLADFQLPEYELRRRDGQFELHFYGRWMETTMWEIPALAIINELRSRAAMRTL
GRFALDVLYARAKAKVWEKVERLKKYPDIRISDFGTRRRHSFLWQRWCVEALKEGIGESFTGTSNVLLAMDTDLEALGTN
AHELPMVLAALSSSDEELKASPYQVLKDWQSYYGGNLLIVLPDTFGTESFLEDAPGWVADWTGFRPDSAPPIEGGERIIS
WWEQHGRDPREKLLIFSDALDVDTIEQTYRHFKGRSRLSFGWGTNLTNDFDGCAPEKIDRLKAISLVCKVSSANGRPAVK
LSDNPEKATGRPEEIQRYLRVFGSRNRVHQPVEV

Sequences:

>Translated_434_residues
MTVTDIARRVYNHTWKLDPICRSLLDTDFYKLLMLQMIWGLYQDVDATFSLTNRNHRVRLADEIDEAELRAQLDHARTIR
FSKKEMIWLAGNSFYGRKQIFSPEFLAWLADFQLPEYELRRRDGQFELHFYGRWMETTMWEIPALAIINELRSRAAMRTL
GRFALDVLYARAKAKVWEKVERLKKYPDIRISDFGTRRRHSFLWQRWCVEALKEGIGESFTGTSNVLLAMDTDLEALGTN
AHELPMVLAALSSSDEELKASPYQVLKDWQSYYGGNLLIVLPDTFGTESFLEDAPGWVADWTGFRPDSAPPIEGGERIIS
WWEQHGRDPREKLLIFSDALDVDTIEQTYRHFKGRSRLSFGWGTNLTNDFDGCAPEKIDRLKAISLVCKVSSANGRPAVK
LSDNPEKATGRPEEIQRYLRVFGSRNRVHQPVEV
>Mature_433_residues
TVTDIARRVYNHTWKLDPICRSLLDTDFYKLLMLQMIWGLYQDVDATFSLTNRNHRVRLADEIDEAELRAQLDHARTIRF
SKKEMIWLAGNSFYGRKQIFSPEFLAWLADFQLPEYELRRRDGQFELHFYGRWMETTMWEIPALAIINELRSRAAMRTLG
RFALDVLYARAKAKVWEKVERLKKYPDIRISDFGTRRRHSFLWQRWCVEALKEGIGESFTGTSNVLLAMDTDLEALGTNA
HELPMVLAALSSSDEELKASPYQVLKDWQSYYGGNLLIVLPDTFGTESFLEDAPGWVADWTGFRPDSAPPIEGGERIISW
WEQHGRDPREKLLIFSDALDVDTIEQTYRHFKGRSRLSFGWGTNLTNDFDGCAPEKIDRLKAISLVCKVSSANGRPAVKL
SDNPEKATGRPEEIQRYLRVFGSRNRVHQPVEV

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=410, Percent_Identity=34.1463414634146, Blast_Score=183, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324783, Length=434, Percent_Identity=27.4193548387097, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_MESSB (Q11HJ2)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674298.1
- ProteinModelPortal:   Q11HJ2
- SMR:   Q11HJ2
- STRING:   Q11HJ2
- GeneID:   4182502
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1739
- NMPDR:   fig|266779.1.peg.3821
- eggNOG:   COG1488
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- PhylomeDB:   Q11HJ2
- ProtClustDB:   PRK05321
- BioCyc:   MSP266779:MESO_1739-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 50296; Mature: 50165

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTDIARRVYNHTWKLDPICRSLLDTDFYKLLMLQMIWGLYQDVDATFSLTNRNHRVRL
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEE
ADEIDEAELRAQLDHARTIRFSKKEMIWLAGNSFYGRKQIFSPEFLAWLADFQLPEYELR
HHHCCHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCHHCCCHHHHHHHHHCCCCHHHHH
RRDGQFELHFYGRWMETTMWEIPALAIINELRSRAAMRTLGRFALDVLYARAKAKVWEKV
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLKKYPDIRISDFGTRRRHSFLWQRWCVEALKEGIGESFTGTSNVLLAMDTDLEALGTN
HHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHCCC
AHELPMVLAALSSSDEELKASPYQVLKDWQSYYGGNLLIVLPDTFGTESFLEDAPGWVAD
HHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEC
WTGFRPDSAPPIEGGERIISWWEQHGRDPREKLLIFSDALDVDTIEQTYRHFKGRSRLSF
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCHHHHHHHHHHHCCCCCEEE
GWGTNLTNDFDGCAPEKIDRLKAISLVCKVSSANGRPAVKLSDNPEKATGRPEEIQRYLR
CCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHH
VFGSRNRVHQPVEV
HHCCCCCCCCCCCC
>Mature Secondary Structure 
TVTDIARRVYNHTWKLDPICRSLLDTDFYKLLMLQMIWGLYQDVDATFSLTNRNHRVRL
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEE
ADEIDEAELRAQLDHARTIRFSKKEMIWLAGNSFYGRKQIFSPEFLAWLADFQLPEYELR
HHHCCHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCHHCCCHHHHHHHHHCCCCHHHHH
RRDGQFELHFYGRWMETTMWEIPALAIINELRSRAAMRTLGRFALDVLYARAKAKVWEKV
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLKKYPDIRISDFGTRRRHSFLWQRWCVEALKEGIGESFTGTSNVLLAMDTDLEALGTN
HHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHCCC
AHELPMVLAALSSSDEELKASPYQVLKDWQSYYGGNLLIVLPDTFGTESFLEDAPGWVAD
HHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEC
WTGFRPDSAPPIEGGERIISWWEQHGRDPREKLLIFSDALDVDTIEQTYRHFKGRSRLSF
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCHHHHHHHHHHHCCCCCEEE
GWGTNLTNDFDGCAPEKIDRLKAISLVCKVSSANGRPAVKLSDNPEKATGRPEEIQRYLR
CCCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHH
VFGSRNRVHQPVEV
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA