Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 110634068

GI number: 110634068

Start: 1840050

End: 1841393

Strand: Direct

Name: accC [H]

Synonym: Meso_1716

Alternate gene names: 110634068

Gene position: 1840050-1841393 (Clockwise)

Preceding gene: 110634067

Following gene: 110634069

Centisome position: 41.7

GC content: 59.67

Gene sequence:

>1344_bases
ATGTTCCAGAAGATCCTCATCGCCAATCGCGGCGAGATCGCGCTCCGGGTGCTGCGCGCCTGTAAGGAATTGGGAATTCA
GACCGTGGCGGTCCATTCCACGGCTGATGCGGATGCCATGCATGTCCGCCTTGCGGACGAAAGCGTTTGTATCGGTCCTC
CCGCCTCACGCGAAAGCTATCTTAATATTCATCAGATTCTTGCCGCGTGCGAGATCACCGGGGCGGATGCGGTTCACCCG
GGCTACGGTTTTCTCTCCGAAAACGCGAAATTTGCCGAAATCCTGGCCGCGCACAACGTGACCTTCATCGGCCCCTCGGC
CGAACATATCCGTACTATGGGCGACAAGATCGAAGCCAAGCGTACGGCCAAGCGATTGGGCATTCCTGTCGTGCCGGGAT
CGGAAGGCGCGGTGCGCGACGAGCGCGAGGCGAAGCGAATCGCCGCCGAAGTTGGCTATCCCGTGCTCATCAAGGCTTCG
GCCGGCGGCGGAGGGCGCGGGATGAAGGTTGCCCGCAACGAAGCCGGGCTGGCGGAGGCGCTTGCGACTGCTCGCACCGA
GGCCGGCGCAGCTTTTGGCGACGACGCCGTCTATATCGAAAAATATCTGGAAAAGCCGCGCCACATCGAGGTTCAGGTGG
TGGGGGACGGCGCCCACAATGCTGTCCATCTCGGCGAGCGCGATTGCTCCCTGCAGCGCCGCCACCAGAAGGTATGGGAG
GAGGCAAACTCGCCCGCGCTCAACGTGGAACAGCGCATGAAAATCGGCGAGACGGTCGCAAATGCGATGGCCGAGCTCGG
CTATTCCGGCGCGGGGACCATAGAATTCCTCTATGAGAACGGCGAATTCTACTTCATCGAGATGAACACGCGTCTTCAGG
TGGAGCATCCGGTGACGGAGGCGATCACCGGGATCGACCTGGTGCATGAGCAGATCCGGGTAGCATCGGGCGCTGGCCTT
TCCGTCCGTCAGGAAGAAGTGCGGTTTCATGGTCATGCCATTGAATGCCGGATCAACGCGGAGGACCCACGCACTTTCGT
CCCCTCGCCCGGCACGATCACCCATTTTCATACGCCGGGCGGCCTTGGCGTGCGGGTCGATTCGGGGGTCTATTCCGGCT
ATCGCATTCCTCCTTATTACGACAGCCTCATTGGCAAACTCATTGTTCATGGCCGCAACCGCGTAGAATGCATGATGCGC
CTTCGCCGTGCCCTTGACGAATTCGTCGTGGACGGCATCAATTCAACATTGCCGCTCTTTCGTGAGCTTGTGGGCAATGT
TGATGTGGCAAACGGCGATTATGACATCCATTGGCTGGAGAACCATCTCGCAGCCAATGAATAA

Upstream 100 bases:

>100_bases
CCTCGCCCCGCGCCGGCGTGGTCAAGTCCATCTTGGTTGAAGATGGACAGCCGGTCGAATATGGCGAGCCTCTGGTCGTG
ATCGAGTAGCGGGATCCCTG

Downstream 100 bases:

>100_bases
TCTTCAGGCGCCGTTATGACGCGCCCCCTCGCCCCCGGTTTCCATATCCCTCCGGATTTGCTTCTGCGCGCCTATGCGAC
CGGCGTCTTTCCGATGGCCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFQKILIANRGEIALRVLRACKELGIQTVAVHSTADADAMHVRLADESVCIGPPASRESYLNIHQILAACEITGADAVHP
GYGFLSENAKFAEILAAHNVTFIGPSAEHIRTMGDKIEAKRTAKRLGIPVVPGSEGAVRDEREAKRIAAEVGYPVLIKAS
AGGGGRGMKVARNEAGLAEALATARTEAGAAFGDDAVYIEKYLEKPRHIEVQVVGDGAHNAVHLGERDCSLQRRHQKVWE
EANSPALNVEQRMKIGETVANAMAELGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVASGAGL
SVRQEEVRFHGHAIECRINAEDPRTFVPSPGTITHFHTPGGLGVRVDSGVYSGYRIPPYYDSLIGKLIVHGRNRVECMMR
LRRALDEFVVDGINSTLPLFRELVGNVDVANGDYDIHWLENHLAANE

Sequences:

>Translated_447_residues
MFQKILIANRGEIALRVLRACKELGIQTVAVHSTADADAMHVRLADESVCIGPPASRESYLNIHQILAACEITGADAVHP
GYGFLSENAKFAEILAAHNVTFIGPSAEHIRTMGDKIEAKRTAKRLGIPVVPGSEGAVRDEREAKRIAAEVGYPVLIKAS
AGGGGRGMKVARNEAGLAEALATARTEAGAAFGDDAVYIEKYLEKPRHIEVQVVGDGAHNAVHLGERDCSLQRRHQKVWE
EANSPALNVEQRMKIGETVANAMAELGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVASGAGL
SVRQEEVRFHGHAIECRINAEDPRTFVPSPGTITHFHTPGGLGVRVDSGVYSGYRIPPYYDSLIGKLIVHGRNRVECMMR
LRRALDEFVVDGINSTLPLFRELVGNVDVANGDYDIHWLENHLAANE
>Mature_447_residues
MFQKILIANRGEIALRVLRACKELGIQTVAVHSTADADAMHVRLADESVCIGPPASRESYLNIHQILAACEITGADAVHP
GYGFLSENAKFAEILAAHNVTFIGPSAEHIRTMGDKIEAKRTAKRLGIPVVPGSEGAVRDEREAKRIAAEVGYPVLIKAS
AGGGGRGMKVARNEAGLAEALATARTEAGAAFGDDAVYIEKYLEKPRHIEVQVVGDGAHNAVHLGERDCSLQRRHQKVWE
EANSPALNVEQRMKIGETVANAMAELGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTEAITGIDLVHEQIRVASGAGL
SVRQEEVRFHGHAIECRINAEDPRTFVPSPGTITHFHTPGGLGVRVDSGVYSGYRIPPYYDSLIGKLIVHGRNRVECMMR
LRRALDEFVVDGINSTLPLFRELVGNVDVANGDYDIHWLENHLAANE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=51.3513513513513, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=51.3513513513513, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=51.3513513513513, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=45.9276018099548, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=45.6375838926174, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=45.6375838926174, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=45.6375838926174, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=30.1158301158301, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=30.1158301158301, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=30.1158301158301, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=30.1158301158301, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=30.1158301158301, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=29.3774319066148, Blast_Score=212, Evalue=5e-55,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=60.2678571428571, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1786216, Length=246, Percent_Identity=26.0162601626016, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=48.1900452488688, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=443, Percent_Identity=47.4040632054176, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=42.8888888888889, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=494, Percent_Identity=28.5425101214575, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=26.8101761252446, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=26.8101761252446, Blast_Score=185, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319685, Length=427, Percent_Identity=41.92037470726, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=42.2818791946309, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=42.5055928411633, Blast_Score=318, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6323863, Length=483, Percent_Identity=31.2629399585921, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=29.8651252408478, Blast_Score=203, Evalue=6e-53,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=47.4387527839644, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651757, Length=424, Percent_Identity=45.7547169811321, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=388, Percent_Identity=44.5876288659794, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=27.8884462151394, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=27.8884462151394, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=28.5714285714286, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=28.5714285714286, Blast_Score=191, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48750; Mature: 48750

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIALRVLRACKELGIQTVAVHSTADADAMHVRLADESVCIGPPASRESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LNIHQILAACEITGADAVHPGYGFLSENAKFAEILAAHNVTFIGPSAEHIRTMGDKIEAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
RTAKRLGIPVVPGSEGAVRDEREAKRIAAEVGYPVLIKASAGGGGRGMKVARNEAGLAEA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCHHHHH
LATARTEAGAAFGDDAVYIEKYLEKPRHIEVQVVGDGAHNAVHLGERDCSLQRRHQKVWE
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHH
EANSPALNVEQRMKIGETVANAMAELGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVASGAGLSVRQEEVRFHGHAIECRINAEDPRTFVPSPGTITHFHTPG
HHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCEEEEEEECCCCCCEECCCCCCEEEEECCC
GLGVRVDSGVYSGYRIPPYYDSLIGKLIVHGRNRVECMMRLRRALDEFVVDGINSTLPLF
CCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RELVGNVDVANGDYDIHWLENHLAANE
HHHHCCCEECCCCEEEEEEHHHCCCCC
>Mature Secondary Structure
MFQKILIANRGEIALRVLRACKELGIQTVAVHSTADADAMHVRLADESVCIGPPASRESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LNIHQILAACEITGADAVHPGYGFLSENAKFAEILAAHNVTFIGPSAEHIRTMGDKIEAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
RTAKRLGIPVVPGSEGAVRDEREAKRIAAEVGYPVLIKASAGGGGRGMKVARNEAGLAEA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCHHHHH
LATARTEAGAAFGDDAVYIEKYLEKPRHIEVQVVGDGAHNAVHLGERDCSLQRRHQKVWE
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHH
EANSPALNVEQRMKIGETVANAMAELGYSGAGTIEFLYENGEFYFIEMNTRLQVEHPVTE
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVHEQIRVASGAGLSVRQEEVRFHGHAIECRINAEDPRTFVPSPGTITHFHTPG
HHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCEEEEEEECCCCCCEECCCCCCEEEEECCC
GLGVRVDSGVYSGYRIPPYYDSLIGKLIVHGRNRVECMMRLRRALDEFVVDGINSTLPLF
CCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RELVGNVDVANGDYDIHWLENHLAANE
HHHHCCCEECCCCEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]