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The map label for this gene is adk

Identifier: 110634009

GI number: 110634009

Start: 1784919

End: 1785503

Strand: Reverse

Name: adk

Synonym: Meso_1657

Alternate gene names: 110634009

Gene position: 1785503-1784919 (Counterclockwise)

Preceding gene: 110634010

Following gene: 110634008

Centisome position: 40.47

GC content: 61.88

Gene sequence:

>585_bases
ATGAGGCTTATACTTCTCGGGCCGCCGGGGGCGGGCAAGGGAACCCAAGCGCAGATCCTGGTTGAAAAGCTGCACATTCC
GCAACTCTCCACGGGAGATATGCTGCGCGCTGCGGTGAAGGCCGAGACCGAGATCGGCAAGAAGGCCAAGGCGGTGATGG
ATGCGGGCGAGCTCGTGTCCGACGCCATCGTCAACGCCATCGTGGCGGAACGGATTGATCAGCCCGACTGCGCGAATGGT
TTCATTCTAGACGGCTATCCACGTACGCTGGCGCAGGCCGATGCGGTCGAAGCGATGCTCGGCGAGCGCGGCCTGAAGCT
TGACGCGGTCATCGAACTCGTGGTCGACGATAAGGCGTTGGTTGGCCGGATCATGAAGCGGGCGGAAGACGCACAAGCCG
CGGGCCAGCCGGTGCGCCGTGATGACAATCCGGAGGTCTTCGAGGAGCGCCTGCGCGAATATTACAAAAAGACGGCGCCG
CTGGTCGGGTATTATTATGCAAAGGGCCTGCTGAAGGGCGTCGACGGCATGGCCTCGATCGATGAGGTGACGCGGCAGAT
CGAAGGGATCCTGGCAAAGGCGTAA

Upstream 100 bases:

>100_bases
TCACGCTCGATACGGTGGCGCAGGTTCAGGGGCACTTGATCGCTCACCAGTATGAAGGTCTGATCAAGAAATCGAAACTC
CGGGGGGGCAAGAGGGGACG

Downstream 100 bases:

>100_bases
TCCCTTGCAGGGTCAGGGCAGCGGAACGCGAGCCCTGCCGGGCAATCGCGGTTGACGCTGGTCCTTTTATCGACTATAGC
GGCGCATCTCCTAACGAGAC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRLILLGPPGAGKGTQAQILVEKLHIPQLSTGDMLRAAVKAETEIGKKAKAVMDAGELVSDAIVNAIVAERIDQPDCANG
FILDGYPRTLAQADAVEAMLGERGLKLDAVIELVVDDKALVGRIMKRAEDAQAAGQPVRRDDNPEVFEERLREYYKKTAP
LVGYYYAKGLLKGVDGMASIDEVTRQIEGILAKA

Sequences:

>Translated_194_residues
MRLILLGPPGAGKGTQAQILVEKLHIPQLSTGDMLRAAVKAETEIGKKAKAVMDAGELVSDAIVNAIVAERIDQPDCANG
FILDGYPRTLAQADAVEAMLGERGLKLDAVIELVVDDKALVGRIMKRAEDAQAAGQPVRRDDNPEVFEERLREYYKKTAP
LVGYYYAKGLLKGVDGMASIDEVTRQIEGILAKA
>Mature_194_residues
MRLILLGPPGAGKGTQAQILVEKLHIPQLSTGDMLRAAVKAETEIGKKAKAVMDAGELVSDAIVNAIVAERIDQPDCANG
FILDGYPRTLAQADAVEAMLGERGLKLDAVIELVVDDKALVGRIMKRAEDAQAAGQPVRRDDNPEVFEERLREYYKKTAP
LVGYYYAKGLLKGVDGMASIDEVTRQIEGILAKA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=40, Blast_Score=160, Evalue=8e-40,
Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=40, Blast_Score=160, Evalue=9e-40,
Organism=Homo sapiens, GI4502011, Length=192, Percent_Identity=33.8541666666667, Blast_Score=113, Evalue=8e-26,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=30.5, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=29, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=29, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=29, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=29, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI28144899, Length=190, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI28144897, Length=190, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI7706497, Length=198, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI22749187, Length=130, Percent_Identity=31.5384615384615, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786680, Length=222, Percent_Identity=46.8468468468468, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=38.785046728972, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17567503, Length=194, Percent_Identity=35.0515463917526, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=193, Percent_Identity=27.4611398963731, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17533833, Length=193, Percent_Identity=26.9430051813472, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=33.8541666666667, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=43.1472081218274, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=33.1683168316832, Blast_Score=105, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=189, Percent_Identity=28.042328042328, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=42.654028436019, Blast_Score=169, Evalue=7e-43,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=33.502538071066, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=33.502538071066, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17647141, Length=196, Percent_Identity=33.1632653061224, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24663208, Length=196, Percent_Identity=33.1632653061224, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221459597, Length=192, Percent_Identity=26.5625, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356893, Length=192, Percent_Identity=26.5625, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MESSB (Q11HS3)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674217.1
- ProteinModelPortal:   Q11HS3
- SMR:   Q11HS3
- STRING:   Q11HS3
- GeneID:   4180174
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1657
- NMPDR:   fig|266779.1.peg.403
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- PhylomeDB:   Q11HS3
- ProtClustDB:   PRK00279
- BioCyc:   MSP266779:MESO_1657-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20930; Mature: 20930

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAQILVEKLHIPQLSTGDMLRAAVKAETEIGKKAKAVMDAGELVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAIVNAIVAERIDQPDCANGFILDGYPRTLAQADAVEAMLGERGLKLDAVIELVVDDKAL
HHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
VGRIMKRAEDAQAAGQPVRRDDNPEVFEERLREYYKKTAPLVGYYYAKGLLKGVDGMASI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
DEVTRQIEGILAKA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAQILVEKLHIPQLSTGDMLRAAVKAETEIGKKAKAVMDAGELVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAIVNAIVAERIDQPDCANGFILDGYPRTLAQADAVEAMLGERGLKLDAVIELVVDDKAL
HHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
VGRIMKRAEDAQAAGQPVRRDDNPEVFEERLREYYKKTAPLVGYYYAKGLLKGVDGMASI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHH
DEVTRQIEGILAKA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA