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The map label for this gene is gltA [H]

Identifier: 110633998

GI number: 110633998

Start: 1774922

End: 1776211

Strand: Direct

Name: gltA [H]

Synonym: Meso_1646

Alternate gene names: 110633998

Gene position: 1774922-1776211 (Clockwise)

Preceding gene: 110633997

Following gene: 110634004

Centisome position: 40.23

GC content: 58.91

Gene sequence:

>1290_bases
ATGGCGAATTCGACGGTGACACTTGAACTTGGTGGGAATAGCAGCGAATACCCAGTGCGCCAGGCATCGATCGGACCCGG
TGTTTTCGACATTTCGTCCCTCTACAAGCAGACCGGGATGTTTACTTACGATCCCGGCTTTACCTCCACGGCAAGCTGCG
AGTCCAAGATCACCTATATCGATGGCGACGAAGGCCTGTTGCTTCACCGCGGCTATCCGATCGACCAGCTCGCCGAGCAA
GGCGATTTTCTCGAGGTTTGCTATCTGCTCCTCTACGGGGAACTGCCGACAAAGGCGCAGAAGGAAGACTTCGACCTACG
CGTGACCAGGCACACGATGATTCACGAGCAGATGTCGCGCTTCTTCACCGGCTTCCGCCGTGATGCGCACCCGATGGCCG
TCATGTGCGGCGTAGTGGGCGCCCTCTCCGCCTTCTACCATGACTCGACGGATATCTCCGACCCGCACCAGCGCATGGTT
GCCTCCATCCGCATGATCGCAAAGATGCCGACCATTGCGGCCATGGCTTACAAATACCATATCGGCCAGCCATTCATGTA
CCCGCGCAACGAGCTCTCCTACGCGGCTAACTTTCTGCACATGTGCTTCGCTGTTCCCTGCGAGGAATATAAGGTCAATC
CGGTCCTCGCACGGGCGATGGACCGCATTTTCATCCTGCATGCCGATCACGAGCAGAACGCGTCGACCTCGACGGTGCGG
CTTGCAGGCTCCTCGGGCGCCAATCCGTTCGCCTGCATTGCAGCCGGAATTGCTTGCCTATGGGGTCCCGCCCATGGCGG
CGCCAATGAGGCCGCGCTCAATATGCTCGCGGAAATCGGCAGTGTGGACCGTATCCCGGAATATATCGCCCGCGCCAAGG
ACAAGAACGATCCCTTCCGCCTCATGGGCTTCGGTCATCGGGTCTATAAAAACTATGACCCGCGCGCGAAGATCATGCAG
AAAACCTGTCATGAAGTGTTGTCGGAGCTTGGCATCAAGGACGACCCGCAGCTCGACATCGCCATGGAGCTCGAGCGCAT
CGCCCTCACCGACGAATACTTCATCGAGAAGAAGCTCTATCCGAATATCGACTTCTACTCCGGCATCACGCTGAAGGCGC
TCGGCTTCCCGACGACCATGTTCACCGTGCTCTTCGCCGTCGCCCGCACGGTTGGCTGGATCGCGCAGTGGAAGGAGATG
ATCGAGGATCCGCAGCAGAAGATCGGACGTCCGCGCCAGCTCTACACCGGTGCGCCGCAGCGCGATTACGTGCCGATCGC
AAAGCGGTGA

Upstream 100 bases:

>100_bases
CGCTAGCTAGAGGCACCTTAAAGCCGTGCTGGCGGTTGCCTGCCGCTTGTCGCGGCGACGACATTCCTGCCCAAGTTTCA
AGACAGAGAGGTGATGTGCG

Downstream 100 bases:

>100_bases
CCCGATTCGCGCTCTGAGATGACAACCTCCTCCGTTCACATTCGAGCGGAGGAGGTTTTTCTTTACAAGCGGTTGAACCG
CGACCTTTTTAAGATAGAGC

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MANSTVTLELGGNSSEYPVRQASIGPGVFDISSLYKQTGMFTYDPGFTSTASCESKITYIDGDEGLLLHRGYPIDQLAEQ
GDFLEVCYLLLYGELPTKAQKEDFDLRVTRHTMIHEQMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPHQRMV
ASIRMIAKMPTIAAMAYKYHIGQPFMYPRNELSYAANFLHMCFAVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLAEIGSVDRIPEYIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQ
KTCHEVLSELGIKDDPQLDIAMELERIALTDEYFIEKKLYPNIDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEM
IEDPQQKIGRPRQLYTGAPQRDYVPIAKR

Sequences:

>Translated_429_residues
MANSTVTLELGGNSSEYPVRQASIGPGVFDISSLYKQTGMFTYDPGFTSTASCESKITYIDGDEGLLLHRGYPIDQLAEQ
GDFLEVCYLLLYGELPTKAQKEDFDLRVTRHTMIHEQMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPHQRMV
ASIRMIAKMPTIAAMAYKYHIGQPFMYPRNELSYAANFLHMCFAVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
LAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLAEIGSVDRIPEYIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQ
KTCHEVLSELGIKDDPQLDIAMELERIALTDEYFIEKKLYPNIDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEM
IEDPQQKIGRPRQLYTGAPQRDYVPIAKR
>Mature_428_residues
ANSTVTLELGGNSSEYPVRQASIGPGVFDISSLYKQTGMFTYDPGFTSTASCESKITYIDGDEGLLLHRGYPIDQLAEQG
DFLEVCYLLLYGELPTKAQKEDFDLRVTRHTMIHEQMSRFFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPHQRMVA
SIRMIAKMPTIAAMAYKYHIGQPFMYPRNELSYAANFLHMCFAVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGIACLWGPAHGGANEAALNMLAEIGSVDRIPEYIARAKDKNDPFRLMGFGHRVYKNYDPRAKIMQK
TCHEVLSELGIKDDPQLDIAMELERIALTDEYFIEKKLYPNIDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEMI
EDPQQKIGRPRQLYTGAPQRDYVPIAKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=356, Percent_Identity=25.8426966292135, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786939, Length=430, Percent_Identity=69.0697674418605, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=30, Blast_Score=155, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17555174, Length=387, Percent_Identity=25.8397932816537, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=335, Percent_Identity=25.3731343283582, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=339, Percent_Identity=26.2536873156342, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=450, Percent_Identity=24, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24640126, Length=406, Percent_Identity=26.8472906403941, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24640124, Length=406, Percent_Identity=26.8472906403941, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356863, Length=357, Percent_Identity=26.3305322128852, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48113; Mature: 47982

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSTVTLELGGNSSEYPVRQASIGPGVFDISSLYKQTGMFTYDPGFTSTASCESKITYI
CCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEE
DGDEGLLLHRGYPIDQLAEQGDFLEVCYLLLYGELPTKAQKEDFDLRVTRHTMIHEQMSR
ECCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHH
FFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPHQRMVASIRMIAKMPTIAAMAYKYH
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHC
IGQPFMYPRNELSYAANFLHMCFAVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLAEIGSVDRIPEYIARAKDKNDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
LMGFGHRVYKNYDPRAKIMQKTCHEVLSELGIKDDPQLDIAMELERIALTDEYFIEKKLY
EEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PNIDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEMIEDPQQKIGRPRQLYTGAPQ
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEECCCCCC
RDYVPIAKR
CCCCCCCCC
>Mature Secondary Structure 
ANSTVTLELGGNSSEYPVRQASIGPGVFDISSLYKQTGMFTYDPGFTSTASCESKITYI
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEE
DGDEGLLLHRGYPIDQLAEQGDFLEVCYLLLYGELPTKAQKEDFDLRVTRHTMIHEQMSR
ECCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHH
FFTGFRRDAHPMAVMCGVVGALSAFYHDSTDISDPHQRMVASIRMIAKMPTIAAMAYKYH
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHC
IGQPFMYPRNELSYAANFLHMCFAVPCEEYKVNPVLARAMDRIFILHADHEQNASTSTVR
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHCEEEEEECCCCCCCCCCEEE
LAGSSGANPFACIAAGIACLWGPAHGGANEAALNMLAEIGSVDRIPEYIARAKDKNDPFR
EECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEE
LMGFGHRVYKNYDPRAKIMQKTCHEVLSELGIKDDPQLDIAMELERIALTDEYFIEKKLY
EEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PNIDFYSGITLKALGFPTTMFTVLFAVARTVGWIAQWKEMIEDPQQKIGRPRQLYTGAPQ
CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEECCCCCC
RDYVPIAKR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8526514 [H]