Click here to switch to the map view.

The map label for this gene is pdhA [H]

Identifier: 110633982

GI number: 110633982

Start: 1755848

End: 1756930

Strand: Reverse

Name: pdhA [H]

Synonym: Meso_1630

Alternate gene names: 110633982

Gene position: 1756930-1755848 (Counterclockwise)

Preceding gene: 110633983

Following gene: 110633981

Centisome position: 39.82

GC content: 59.65

Gene sequence:

>1083_bases
ATGGCGAGAGCCGCCACCAAGACCTCTGCCAAACCGGCGCCTGCAAGGGCGGGAACCAGACCCGCCAAGAAAACCATCCC
GATGCTGAACGACACTCCGGTTCTCGATATACCGAAGCCGGAAGAATTCACGAAGGAGCAGGAACTTTCCTCGTTCCGCG
AGATGCTGCTCATCCGGCGCTTCGAGGAGAAGGCCGGTCAACTCTACGGAATGGGCTTTATCGGTGGCTTCTGTCACCTC
TATATCGGTCAGGAAGCGGTCGTCATCGGCATGCAGATGGCGATGAAGGAAGGCGACCAGGTGATCACCGGCTACCGTGA
TCACGGGCATATGCTTGCCACCGGCATGGACCCGCGCGGCGTGATGGCCGAGCTAACCGGCCGGCGAAGCGGTTATTCCA
GGGGCAAGGGCGGCTCGATGCACATGTTCTCCAAGGAGAAAAATTTCTTCGGAGGCCATGGCATCGTCGGCGCGCAGGTC
CCGCTTGGAACGGGTATAGCGCTTGCCAACCGCTATCGCGGCAATGACAGCGTTTCGCTCACCTATTTCGGCGATGGCGC
GGCCAATCAGGGGCAGGTCTATGAGAGCTTCAATATGGCCTCGCTCTGGAAGCTGCCGGTCATCTACATCATTGAAAACA
ACCGCTACGCCATGGGGACGGCTGTATCCCGCTCTTCCGCGGAAACCAACTTCGCGCATCGCGGCCTGTCTTTCAAAATA
CCCGGCGTCCAGGTGGACGGAATGGATGTGCGCGCGGTGAAGGCCGCCGGCGATATGGCCGTCGAATGGTGCCGTTCGGG
CAAGGGGCCGATCATCCTGGAAATGCAGACCTATCGTTATCGCGGACATTCGATGTCCGACCCGGCCAAGTACCGCTCGA
AGGACGAAGTGCAGAAGATGCGCTCGGAGCATGATCCCATCGAGCAGGTGCGCAAGCGCCTTCTGGACAAGAAGTGGGCA
AGCGAAGACGACTTGAAGGCCGTGGACAAGGAGGTGCGCGACATCGTCGCCGATGCGGCCGATTTCGCGCAATCCGATCC
CGAGCCGGATCCGTCCGAGCTCTATACCGATATCCTGATCTAA

Upstream 100 bases:

>100_bases
CAGCGCTGCACTCCCGCCATGGACTACATGGATGTCCTGCGGCAATATGTCGAACCCGAGCGGGCGGCGTGTTGTCAAGA
CGATCTAGGGAGCGAAACAG

Downstream 100 bases:

>100_bases
GGGGGGAGTGTACCTATGCCCACGCAGATACTCATGCCCGCTCTCTCTCCGACCATGGAAGAGGGCAACCTCTCAAAATG
GGTGAAGAAGGAAGGCGATA

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MARAATKTSAKPAPARAGTRPAKKTIPMLNDTPVLDIPKPEEFTKEQELSSFREMLLIRRFEEKAGQLYGMGFIGGFCHL
YIGQEAVVIGMQMAMKEGDQVITGYRDHGHMLATGMDPRGVMAELTGRRSGYSRGKGGSMHMFSKEKNFFGGHGIVGAQV
PLGTGIALANRYRGNDSVSLTYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTAVSRSSAETNFAHRGLSFKI
PGVQVDGMDVRAVKAAGDMAVEWCRSGKGPIILEMQTYRYRGHSMSDPAKYRSKDEVQKMRSEHDPIEQVRKRLLDKKWA
SEDDLKAVDKEVRDIVADAADFAQSDPEPDPSELYTDILI

Sequences:

>Translated_360_residues
MARAATKTSAKPAPARAGTRPAKKTIPMLNDTPVLDIPKPEEFTKEQELSSFREMLLIRRFEEKAGQLYGMGFIGGFCHL
YIGQEAVVIGMQMAMKEGDQVITGYRDHGHMLATGMDPRGVMAELTGRRSGYSRGKGGSMHMFSKEKNFFGGHGIVGAQV
PLGTGIALANRYRGNDSVSLTYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTAVSRSSAETNFAHRGLSFKI
PGVQVDGMDVRAVKAAGDMAVEWCRSGKGPIILEMQTYRYRGHSMSDPAKYRSKDEVQKMRSEHDPIEQVRKRLLDKKWA
SEDDLKAVDKEVRDIVADAADFAQSDPEPDPSELYTDILI
>Mature_359_residues
ARAATKTSAKPAPARAGTRPAKKTIPMLNDTPVLDIPKPEEFTKEQELSSFREMLLIRRFEEKAGQLYGMGFIGGFCHLY
IGQEAVVIGMQMAMKEGDQVITGYRDHGHMLATGMDPRGVMAELTGRRSGYSRGKGGSMHMFSKEKNFFGGHGIVGAQVP
LGTGIALANRYRGNDSVSLTYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTAVSRSSAETNFAHRGLSFKIP
GVQVDGMDVRAVKAAGDMAVEWCRSGKGPIILEMQTYRYRGHSMSDPAKYRSKDEVQKMRSEHDPIEQVRKRLLDKKWAS
EDDLKAVDKEVRDIVADAADFAQSDPEPDPSELYTDILI

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=333, Percent_Identity=51.9519519519519, Blast_Score=357, Evalue=8e-99,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=53.7735849056604, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=53.7735849056604, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=52.6153846153846, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=46.8553459119497, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI11386135, Length=315, Percent_Identity=30.7936507936508, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI258645172, Length=315, Percent_Identity=30.7936507936508, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32564172, Length=341, Percent_Identity=50.4398826979472, Blast_Score=337, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17536047, Length=341, Percent_Identity=50.4398826979472, Blast_Score=337, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI86563357, Length=327, Percent_Identity=27.82874617737, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI86563355, Length=327, Percent_Identity=27.82874617737, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=322, Percent_Identity=49.6894409937888, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24639744, Length=341, Percent_Identity=47.8005865102639, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI28571106, Length=341, Percent_Identity=47.8005865102639, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24639740, Length=341, Percent_Identity=47.8005865102639, Blast_Score=332, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=50.4918032786885, Blast_Score=320, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24639748, Length=331, Percent_Identity=50.4531722054381, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI21355903, Length=334, Percent_Identity=27.2455089820359, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39819; Mature: 39688

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAATKTSAKPAPARAGTRPAKKTIPMLNDTPVLDIPKPEEFTKEQELSSFREMLLIRR
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
FEEKAGQLYGMGFIGGFCHLYIGQEAVVIGMQMAMKEGDQVITGYRDHGHMLATGMDPRG
HHHHHCCEEEEHHHHHHHHEEECCCEEEHHHHHHHHCCCEEEEEECCCCEEEEECCCCCC
VMAELTGRRSGYSRGKGGSMHMFSKEKNFFGGHGIVGAQVPLGTGIALANRYRGNDSVSL
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHCCCCCCEEE
TYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTAVSRSSAETNFAHRGLSFKI
EEECCCCCCCCCHHHCCCHHHEECCCEEEEEECCCEEEEEECCCCCCCCHHHHCCCEEEC
PGVQVDGMDVRAVKAAGDMAVEWCRSGKGPIILEMQTYRYRGHSMSDPAKYRSKDEVQKM
CCEEECCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHH
RSEHDPIEQVRKRLLDKKWASEDDLKAVDKEVRDIVADAADFAQSDPEPDPSELYTDILI
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
ARAATKTSAKPAPARAGTRPAKKTIPMLNDTPVLDIPKPEEFTKEQELSSFREMLLIRR
CCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
FEEKAGQLYGMGFIGGFCHLYIGQEAVVIGMQMAMKEGDQVITGYRDHGHMLATGMDPRG
HHHHHCCEEEEHHHHHHHHEEECCCEEEHHHHHHHHCCCEEEEEECCCCEEEEECCCCCC
VMAELTGRRSGYSRGKGGSMHMFSKEKNFFGGHGIVGAQVPLGTGIALANRYRGNDSVSL
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHCCCCCCEEE
TYFGDGAANQGQVYESFNMASLWKLPVIYIIENNRYAMGTAVSRSSAETNFAHRGLSFKI
EEECCCCCCCCCHHHCCCHHHEECCCEEEEEECCCEEEEEECCCCCCCCHHHHCCCEEEC
PGVQVDGMDVRAVKAAGDMAVEWCRSGKGPIILEMQTYRYRGHSMSDPAKYRSKDEVQKM
CCEEECCCCEEEEHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHCCHHHHHHH
RSEHDPIEQVRKRLLDKKWASEDDLKAVDKEVRDIVADAADFAQSDPEPDPSELYTDILI
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]