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The map label for this gene is glpK

Identifier: 110633950

GI number: 110633950

Start: 1720848

End: 1722350

Strand: Direct

Name: glpK

Synonym: Meso_1598

Alternate gene names: 110633950

Gene position: 1720848-1722350 (Clockwise)

Preceding gene: 110633949

Following gene: 110633952

Centisome position: 39.0

GC content: 63.87

Gene sequence:

>1503_bases
ATGACAGGGTACATTTTGGCGATTGACCAGGGCACGACATCGAGCCGGGCCGTCATCTTCGACGGCGCGATGAAGATCGT
GGCGGTGGGCCAGAAGGAATTTCCGCAGCACTACCCCGCCTCCGGCTGGGTCGAGCACGACCCAGAGGACATCTGGAAGA
GCGTCGTGGCGACGGTGAAGACGGCGCTCAGGAAAGCGAAGCTGGAGGCCTCCCGGATCACCGCGATCGGCATCACCAAC
CAGCGCGAAACGGCGGTAATCTGGGATAGGGCGACCGGCATGCCCATTCACAACGCCATCGTCTGGCAGGACCGCCGCAC
CGCCCCCCTCTGCGCGAAGCTCAAGAAGGCCGGGCTGGAGCCGAAATTCACCCGCAAGACAGGGTTGCTGCTCGATCCTT
ATTTTTCCGGCACCAAATTTGCCTGGCTGCTGGACAATGTCAAAGGCGCGCGCCGGCGCGCTGAGAAGGGCGAGCTTCTG
GCCGGCACGATCGACACGTATCTCATTTGGCGGCTGACGGGCGGCAGGATGCACGCAACCGACGCGACTAACGCCTCGCG
CACGCTGCTCTACAACATTTCGAAGAATGCCTGGGACGCCGACCTTCTGAAGATCCTGCGCATTCCGACAGCCCTTTTGC
CGGAAGTGAAGGACTGCGCGGCGGAGTTCGGGGTGACGGAGAAGAAGATATTCGGCGCCGAGATCCCGATCCTTGGAGTG
GCCGGCGACCAGCAGGCGGCCACCATCGGGCAGGCCTGCTTCGAGCCTGGCATGCTGAAATCCACTTACGGCACCGGTTG
CTTCGCCGTGCTTAACACGGGCGAAAGGCTCATCCGCTCCAAGAACAGGCTGCTTTCCACCATCGCCTATCGGCTCGACG
GCAAGACTACCTATGCGCTGGAGGGCTCGATCTTCATCGCGGGTGCCGCCGTGCAGTGGCTGCGCGACGGGATCAAGGTG
ATCGGCAAGGCCGCGGAGAGCGGAGCGCTTGCGGAGCGTTCGGACGAAACGCAGCAGATCTATCTCGTGCCGGCCTTTGT
GGGGCTTGGCGCGCCGCACTGGGACGCCGATGCGCGCGGCGCGATTTTCGGACTGACCCGCAACTCAGGCCCGGCGGAAT
TCGCGCGCGCGGCTTTGGAATCCGTCGCCTACCAGACCCACGATCTTCTCGTGGCTATGAAAAGGGATTGCGGCAACACC
TTCGGAAAAACGGTGCTGCGGGTGGACGGCGGCATGGTCGCCTCCAGCTGGACTATGCAGTGCCTCGCCGACATTCTCGA
CGCGCCGGTGGATAGCCCGACAATCACGGAGACAACCGCGCTGGGGGCCGCCTGGCTTGCCGGTTCCAAGGCCGGCATCT
GGCCTGACAGGGCAACATTTGCCAAGAGCTGGGCGCTCGAGCGCCGTTTCGAGCCTCAGATGGATGGCAGGCAGCGCAAG
GCGAAGCTTGCCGGCTGGGCCGACGCGGTATCGCGCACGTTGACAGCGCGTGCGCCGTGCTAA

Upstream 100 bases:

>100_bases
GAGTTGGTAAGGAGCTGGCAGTAGCCGCAGGTCCACTGATACCGGTGGCTATGGAGGCGGCGATGAGCCGCCTCCATTCG
TGAGAGGACGCGGGGGAAGC

Downstream 100 bases:

>100_bases
GCGCCTGGGCGGCATCCTGCCAGCATAGCTCCCGAAGCACTGGGCTACAGCGCTTCTTGGGGTAGGGCGCTCAAGAGCAC
CTCCCAGAACAACAACGCAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTGYILAIDQGTTSSRAVIFDGAMKIVAVGQKEFPQHYPASGWVEHDPEDIWKSVVATVKTALRKAKLEASRITAIGITN
QRETAVIWDRATGMPIHNAIVWQDRRTAPLCAKLKKAGLEPKFTRKTGLLLDPYFSGTKFAWLLDNVKGARRRAEKGELL
AGTIDTYLIWRLTGGRMHATDATNASRTLLYNISKNAWDADLLKILRIPTALLPEVKDCAAEFGVTEKKIFGAEIPILGV
AGDQQAATIGQACFEPGMLKSTYGTGCFAVLNTGERLIRSKNRLLSTIAYRLDGKTTYALEGSIFIAGAAVQWLRDGIKV
IGKAAESGALAERSDETQQIYLVPAFVGLGAPHWDADARGAIFGLTRNSGPAEFARAALESVAYQTHDLLVAMKRDCGNT
FGKTVLRVDGGMVASSWTMQCLADILDAPVDSPTITETTALGAAWLAGSKAGIWPDRATFAKSWALERRFEPQMDGRQRK
AKLAGWADAVSRTLTARAPC

Sequences:

>Translated_500_residues
MTGYILAIDQGTTSSRAVIFDGAMKIVAVGQKEFPQHYPASGWVEHDPEDIWKSVVATVKTALRKAKLEASRITAIGITN
QRETAVIWDRATGMPIHNAIVWQDRRTAPLCAKLKKAGLEPKFTRKTGLLLDPYFSGTKFAWLLDNVKGARRRAEKGELL
AGTIDTYLIWRLTGGRMHATDATNASRTLLYNISKNAWDADLLKILRIPTALLPEVKDCAAEFGVTEKKIFGAEIPILGV
AGDQQAATIGQACFEPGMLKSTYGTGCFAVLNTGERLIRSKNRLLSTIAYRLDGKTTYALEGSIFIAGAAVQWLRDGIKV
IGKAAESGALAERSDETQQIYLVPAFVGLGAPHWDADARGAIFGLTRNSGPAEFARAALESVAYQTHDLLVAMKRDCGNT
FGKTVLRVDGGMVASSWTMQCLADILDAPVDSPTITETTALGAAWLAGSKAGIWPDRATFAKSWALERRFEPQMDGRQRK
AKLAGWADAVSRTLTARAPC
>Mature_499_residues
TGYILAIDQGTTSSRAVIFDGAMKIVAVGQKEFPQHYPASGWVEHDPEDIWKSVVATVKTALRKAKLEASRITAIGITNQ
RETAVIWDRATGMPIHNAIVWQDRRTAPLCAKLKKAGLEPKFTRKTGLLLDPYFSGTKFAWLLDNVKGARRRAEKGELLA
GTIDTYLIWRLTGGRMHATDATNASRTLLYNISKNAWDADLLKILRIPTALLPEVKDCAAEFGVTEKKIFGAEIPILGVA
GDQQAATIGQACFEPGMLKSTYGTGCFAVLNTGERLIRSKNRLLSTIAYRLDGKTTYALEGSIFIAGAAVQWLRDGIKVI
GKAAESGALAERSDETQQIYLVPAFVGLGAPHWDADARGAIFGLTRNSGPAEFARAALESVAYQTHDLLVAMKRDCGNTF
GKTVLRVDGGMVASSWTMQCLADILDAPVDSPTITETTALGAAWLAGSKAGIWPDRATFAKSWALERRFEPQMDGRQRKA
KLAGWADAVSRTLTARAPC

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI4504007, Length=509, Percent_Identity=41.6502946954813, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI189409120, Length=509, Percent_Identity=41.6502946954813, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI42794763, Length=514, Percent_Identity=41.6342412451362, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI41393575, Length=516, Percent_Identity=42.0542635658915, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI88196792, Length=509, Percent_Identity=31.6306483300589, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1790361, Length=492, Percent_Identity=52.0325203252033, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1789987, Length=452, Percent_Identity=26.1061946902655, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790005, Length=466, Percent_Identity=23.8197424892704, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787789, Length=499, Percent_Identity=25.250501002004, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17535599, Length=497, Percent_Identity=39.8390342052314, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71986140, Length=518, Percent_Identity=23.9382239382239, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71986147, Length=298, Percent_Identity=26.510067114094, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321755, Length=474, Percent_Identity=35.8649789029536, Blast_Score=260, Evalue=4e-70,
Organism=Drosophila melanogaster, GI17864214, Length=512, Percent_Identity=41.015625, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24655555, Length=504, Percent_Identity=35.9126984126984, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24655560, Length=504, Percent_Identity=35.9126984126984, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24655570, Length=504, Percent_Identity=35.9126984126984, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24655574, Length=504, Percent_Identity=35.9126984126984, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24655565, Length=504, Percent_Identity=35.9126984126984, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24654573, Length=441, Percent_Identity=41.7233560090703, Blast_Score=324, Evalue=1e-88,
Organism=Drosophila melanogaster, GI19922058, Length=528, Percent_Identity=32.9545454545455, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24652871, Length=495, Percent_Identity=33.7373737373737, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24656367, Length=513, Percent_Identity=27.4853801169591, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357867, Length=524, Percent_Identity=26.5267175572519, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24656372, Length=347, Percent_Identity=27.9538904899135, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45552909, Length=292, Percent_Identity=26.7123287671233, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GLPK_MESSB (Q11HY2)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674158.1
- ProteinModelPortal:   Q11HY2
- SMR:   Q11HY2
- STRING:   Q11HY2
- GeneID:   4180115
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1598
- NMPDR:   fig|266779.1.peg.344
- eggNOG:   COG0554
- HOGENOM:   HBG511469
- OMA:   GWVEHEP
- PhylomeDB:   Q11HY2
- ProtClustDB:   CLSK863056
- BioCyc:   MSP266779:MESO_1598-MONOMER
- HAMAP:   MF_00186
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999
- PANTHER:   PTHR10196
- PANTHER:   PTHR10196:SF9
- TIGRFAMs:   TIGR01311

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.30

Molecular weight: Translated: 54247; Mature: 54116

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: BINDING 12-12 BINDING 16-16 BINDING 82-82 BINDING 134-134 BINDING 243-243 BINDING 265-265 BINDING 308-308

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYILAIDQGTTSSRAVIFDGAMKIVAVGQKEFPQHYPASGWVEHDPEDIWKSVVATVK
CCEEEEEEECCCCCCCEEEEECCEEEEEECCHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
TALRKAKLEASRITAIGITNQRETAVIWDRATGMPIHNAIVWQDRRTAPLCAKLKKAGLE
HHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
PKFTRKTGLLLDPYFSGTKFAWLLDNVKGARRRAEKGELLAGTIDTYLIWRLTGGRMHAT
CCEECCCCCEECCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEECCEEEEEEEECCEEEEC
DATNASRTLLYNISKNAWDADLLKILRIPTALLPEVKDCAAEFGVTEKKIFGAEIPILGV
CCCCCCEEEEEECCCCCCHHHHHHHHHCCHHHCCHHHHHHHHHCCCHHHCCCCCCCEEEE
AGDQQAATIGQACFEPGMLKSTYGTGCFAVLNTGERLIRSKNRLLSTIAYRLDGKTTYAL
CCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEE
EGSIFIAGAAVQWLRDGIKVIGKAAESGALAERSDETQQIYLVPAFVGLGAPHWDADARG
ECCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCCCCCC
AIFGLTRNSGPAEFARAALESVAYQTHDLLVAMKRDCGNTFGKTVLRVDGGMVASSWTMQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEECCCEEEHHHHHH
CLADILDAPVDSPTITETTALGAAWLAGSKAGIWPDRATFAKSWALERRFEPQMDGRQRK
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
AKLAGWADAVSRTLTARAPC
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGYILAIDQGTTSSRAVIFDGAMKIVAVGQKEFPQHYPASGWVEHDPEDIWKSVVATVK
CEEEEEEECCCCCCCEEEEECCEEEEEECCHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
TALRKAKLEASRITAIGITNQRETAVIWDRATGMPIHNAIVWQDRRTAPLCAKLKKAGLE
HHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
PKFTRKTGLLLDPYFSGTKFAWLLDNVKGARRRAEKGELLAGTIDTYLIWRLTGGRMHAT
CCEECCCCCEECCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEECCEEEEEEEECCEEEEC
DATNASRTLLYNISKNAWDADLLKILRIPTALLPEVKDCAAEFGVTEKKIFGAEIPILGV
CCCCCCEEEEEECCCCCCHHHHHHHHHCCHHHCCHHHHHHHHHCCCHHHCCCCCCCEEEE
AGDQQAATIGQACFEPGMLKSTYGTGCFAVLNTGERLIRSKNRLLSTIAYRLDGKTTYAL
CCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEE
EGSIFIAGAAVQWLRDGIKVIGKAAESGALAERSDETQQIYLVPAFVGLGAPHWDADARG
ECCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCCCCCC
AIFGLTRNSGPAEFARAALESVAYQTHDLLVAMKRDCGNTFGKTVLRVDGGMVASSWTMQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEEEECCCEEEHHHHHH
CLADILDAPVDSPTITETTALGAAWLAGSKAGIWPDRATFAKSWALERRFEPQMDGRQRK
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHH
AKLAGWADAVSRTLTARAPC
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA