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The map label for this gene is glxR [C]

Identifier: 110633918

GI number: 110633918

Start: 1683054

End: 1683923

Strand: Direct

Name: glxR [C]

Synonym: Meso_1565

Alternate gene names: 110633918

Gene position: 1683054-1683923 (Clockwise)

Preceding gene: 110633917

Following gene: 110633921

Centisome position: 38.14

GC content: 59.31

Gene sequence:

>870_bases
ATGGCGAAAATTGCATTCATCGGGCTTGGCGTAATGGGCTACCCCATGGCCGCACATCTGAAAAACCGCGGCGGCCATGA
TGTGACGGTCTACAACCGCACAACCGCAAAGGCGGAAAAATGGGTGGGCGAGCATGGCGGGGCACTGGCGGAGACGCCGG
CCGAAGCCGCAAAGGATAAGGATTTCGTTTTCGCCTGTGTCGGCAACGATGAGGACCTGCGAGGGGTCACCACCGGGCCC
GAAGGCGCATTCCGAACAATGAAGCAGGGTTCGATCTTCATCGACAATACCACCGCGTCTGCCGAAGTAGCTCGGGAACT
TGCTGCTGATGCGGAGAAGCGCGGTTGCTCCTTCATCGACGCGCCTGTTTCCGGCGGCCAAGCCGGTGCGGAAAACGGCG
CCCTTACCGTAATGTGCGGCGGCGATAAGGCAGCATTCGAAAAGGCAAAGCCGGTGATCGAAGCCTATGCCCGCATGGTT
GGCCTGATGGGGCCATCAGGCGCCGGGCAGCTGACCAAGATGGTGAACCAGATCTGCATTGCAGGCCTCGTGCAAGGTCT
CGCGGAAGGCATTCATTTTGGCAAGAAGGCCGGCCTTGATATCGAGCAGGTGGTAGGGGTGATCTCAAAAGGGGCCGCTG
GTTCCTGGCAGATGGAGAACCGCCACAAGACGATGAATGAAGGCCGGTATGATTTCGGTTTCGCCGTCGATTGGATGCGC
AAGGATCTTGAAATCTGCCTTGCCGAGGCCGACCGCAACGGAGCCAAGCTGCCGATCACCGCGCTCATCGATCAGTTCTA
TAAGGAAGTTCAGGAGATGGGCGGCCGCCGCTGGGACACATCCTCGCTGCTGGCGCGGCTTGAGAGATAA

Upstream 100 bases:

>100_bases
TCTCGTACTCGTTGAATTGCTGCGGATCGCGACTGAGCGCATTGAGCGCCGACTGACGCGACATCTGGGCCGCTAACTTT
GCACAAGGAGGAACAGCCGA

Downstream 100 bases:

>100_bases
GAAAAGGTGGAAAAGGCCCGACCTATTCGGGCCATTTTCTTAGACCGTTAAACCGCTGCGCTTGCAGATTCCTTGTCGAG
CACAAGATAGTCGAGCGGCA

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: 2-methyl-3-oxopropanoate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MAKIAFIGLGVMGYPMAAHLKNRGGHDVTVYNRTTAKAEKWVGEHGGALAETPAEAAKDKDFVFACVGNDEDLRGVTTGP
EGAFRTMKQGSIFIDNTTASAEVARELAADAEKRGCSFIDAPVSGGQAGAENGALTVMCGGDKAAFEKAKPVIEAYARMV
GLMGPSGAGQLTKMVNQICIAGLVQGLAEGIHFGKKAGLDIEQVVGVISKGAAGSWQMENRHKTMNEGRYDFGFAVDWMR
KDLEICLAEADRNGAKLPITALIDQFYKEVQEMGGRRWDTSSLLARLER

Sequences:

>Translated_289_residues
MAKIAFIGLGVMGYPMAAHLKNRGGHDVTVYNRTTAKAEKWVGEHGGALAETPAEAAKDKDFVFACVGNDEDLRGVTTGP
EGAFRTMKQGSIFIDNTTASAEVARELAADAEKRGCSFIDAPVSGGQAGAENGALTVMCGGDKAAFEKAKPVIEAYARMV
GLMGPSGAGQLTKMVNQICIAGLVQGLAEGIHFGKKAGLDIEQVVGVISKGAAGSWQMENRHKTMNEGRYDFGFAVDWMR
KDLEICLAEADRNGAKLPITALIDQFYKEVQEMGGRRWDTSSLLARLER
>Mature_288_residues
AKIAFIGLGVMGYPMAAHLKNRGGHDVTVYNRTTAKAEKWVGEHGGALAETPAEAAKDKDFVFACVGNDEDLRGVTTGPE
GAFRTMKQGSIFIDNTTASAEVARELAADAEKRGCSFIDAPVSGGQAGAENGALTVMCGGDKAAFEKAKPVIEAYARMVG
LMGPSGAGQLTKMVNQICIAGLVQGLAEGIHFGKKAGLDIEQVVGVISKGAAGSWQMENRHKTMNEGRYDFGFAVDWMRK
DLEICLAEADRNGAKLPITALIDQFYKEVQEMGGRRWDTSSLLARLER

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=27.0462633451957, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=28.7671232876712, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=32.1678321678322, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=31.7073170731707, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=30.952380952381, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789092, Length=287, Percent_Identity=28.9198606271777, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788341, Length=214, Percent_Identity=30.8411214953271, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=276, Percent_Identity=27.536231884058, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=27.2108843537415, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=27.2108843537415, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=21.2765957446809, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.1.31

Molecular weight: Translated: 30823; Mature: 30691

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIAFIGLGVMGYPMAAHLKNRGGHDVTVYNRTTAKAEKWVGEHGGALAETPAEAAKDK
CCEEEEEECCHHHCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHCCCC
DFVFACVGNDEDLRGVTTGPEGAFRTMKQGSIFIDNTTASAEVARELAADAEKRGCSFID
CEEEEEECCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEE
APVSGGQAGAENGALTVMCGGDKAAFEKAKPVIEAYARMVGLMGPSGAGQLTKMVNQICI
CCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AGLVQGLAEGIHFGKKAGLDIEQVVGVISKGAAGSWQMENRHKTMNEGRYDFGFAVDWMR
HHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHH
KDLEICLAEADRNGAKLPITALIDQFYKEVQEMGGRRWDTSSLLARLER
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AKIAFIGLGVMGYPMAAHLKNRGGHDVTVYNRTTAKAEKWVGEHGGALAETPAEAAKDK
CEEEEEECCHHHCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCHHHCCCC
DFVFACVGNDEDLRGVTTGPEGAFRTMKQGSIFIDNTTASAEVARELAADAEKRGCSFID
CEEEEEECCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEE
APVSGGQAGAENGALTVMCGGDKAAFEKAKPVIEAYARMVGLMGPSGAGQLTKMVNQICI
CCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AGLVQGLAEGIHFGKKAGLDIEQVVGVISKGAAGSWQMENRHKTMNEGRYDFGFAVDWMR
HHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHH
KDLEICLAEADRNGAKLPITALIDQFYKEVQEMGGRRWDTSSLLARLER
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-hydroxy-2-methylpropanoate; NAD+

Specific reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA