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The map label for this gene is bcr [H]

Identifier: 110633913

GI number: 110633913

Start: 1678401

End: 1679606

Strand: Direct

Name: bcr [H]

Synonym: Meso_1560

Alternate gene names: 110633913

Gene position: 1678401-1679606 (Clockwise)

Preceding gene: 110633912

Following gene: 110633914

Centisome position: 38.04

GC content: 59.95

Gene sequence:

>1206_bases
ATGATCATCCCCACATTCGACAAGACGACGCCACCGCACATCCTGACGCTTGTCGCCGTGGCCGCCACGGCATCTTCAGC
GACCAATATATTTCTACCATCCCTGCCGGGCATGGCCGAGCAATTTGGCGCCGATTACGGCATCGTGCAGATGACCGTTT
CTCTTTATCTCGCCGCTACCGCGGTGCTGCAACTCGGGATCGGCCCGGCCTCGGACCGCTTTGGCCGTCGGCCAGTGATG
CTGGTCAGCTTTGCGGTCTTCTGCATCGCCACACTTGCTGGGGCCTATGCACCGACCATAGAGGCGCTGCTTGCCTGCCG
TGTTCTGCAGGCTTTTTCGGCTTCCGGCCTGGTTCTGTCGCGCGCGATCGTGCGGGATATTGTGGGCACTGACGAGGCGG
CCAGCCGCATTGGCTATGTCACTATGGGCATGACCTTGGGCCCGATGGTCGCGCCGCTGGTAGGGGGCATTCTGGACGAG
GCCTACGGCTGGCGCTCCACCTTCCTCCTCACATTCGGCTTTGGGATCGTTGCCCTTATCCTGATCTATGTCGATCTTGG
CGAAACGAATAGGCATCGCTCGTCTAGCTTGACAGCCCAGTTCCGGGGATATCGCGAGCTGGTGCGCTCACACCGTTTTT
GGGGTTATGTGGCTACGGCGGGGTTCGCCTCAGGCACGTTCTTCGCCTTTCTTGGCGGAGGACCCTATGTGGCGGCAGAG
ATCCTCGGCCTTTCTCCATTCACCTACGGGCTCTATTTTGGCGTCGTCTCGCTCGGATACATGCTTGGCAACTTCATTTC
CGGCCGCTATTCGCGCGCTATCGGCATCAATCGAATGATGCTATCGGGAAATGCGATCGCCGCGCTGGGCATGGGATTGT
CGATCGTCCTGTTCCTTGGCGGTTACGATCATCCTCTTTCCTTCTTCGGCCCAACATTCTTTGTCGGTATGGGCAATGGC
ATTGCGCTTCCAAGCGCGACTGCCGGCATGGTGAGCGTCAGACCGCACCTGGCGGGCTCCGCATCCGGTCTCGGCGGTGC
TTTGCAGATCGGCGTCGGAGCAGCTTTGGCGACGCTTGCCGGCGGGCTGCTGTCACAGGAAACCGGCGCCTACCCGTTGA
TGGTCCTGATGTTAGCTTCGTCGTCGCTTGGCATTGCGGCCACACTTTACGTGATACGGGTTGCCAGGACTAAGGGAGAG
CTCTGA

Upstream 100 bases:

>100_bases
GGGAGCGGATCGTCGGCCATGATCTTCCGATCACCGAAAGCACTGCGCCTGCCATAACTACGAGCGGGCTCGATACAAAG
CCTGTCCACGATCGCCGCAT

Downstream 100 bases:

>100_bases
AAAGGAAGGACCATGACAGGGTTAGGGCCGGGAGCGTCACTCTGCCAGAGGCTTTTCGGTACGTATGCGAAGGCAAAAAG
TACCGGGGCCTGCTTGTGCT

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MIIPTFDKTTPPHILTLVAVAATASSATNIFLPSLPGMAEQFGADYGIVQMTVSLYLAATAVLQLGIGPASDRFGRRPVM
LVSFAVFCIATLAGAYAPTIEALLACRVLQAFSASGLVLSRAIVRDIVGTDEAASRIGYVTMGMTLGPMVAPLVGGILDE
AYGWRSTFLLTFGFGIVALILIYVDLGETNRHRSSSLTAQFRGYRELVRSHRFWGYVATAGFASGTFFAFLGGGPYVAAE
ILGLSPFTYGLYFGVVSLGYMLGNFISGRYSRAIGINRMMLSGNAIAALGMGLSIVLFLGGYDHPLSFFGPTFFVGMGNG
IALPSATAGMVSVRPHLAGSASGLGGALQIGVGAALATLAGGLLSQETGAYPLMVLMLASSSLGIAATLYVIRVARTKGE
L

Sequences:

>Translated_401_residues
MIIPTFDKTTPPHILTLVAVAATASSATNIFLPSLPGMAEQFGADYGIVQMTVSLYLAATAVLQLGIGPASDRFGRRPVM
LVSFAVFCIATLAGAYAPTIEALLACRVLQAFSASGLVLSRAIVRDIVGTDEAASRIGYVTMGMTLGPMVAPLVGGILDE
AYGWRSTFLLTFGFGIVALILIYVDLGETNRHRSSSLTAQFRGYRELVRSHRFWGYVATAGFASGTFFAFLGGGPYVAAE
ILGLSPFTYGLYFGVVSLGYMLGNFISGRYSRAIGINRMMLSGNAIAALGMGLSIVLFLGGYDHPLSFFGPTFFVGMGNG
IALPSATAGMVSVRPHLAGSASGLGGALQIGVGAALATLAGGLLSQETGAYPLMVLMLASSSLGIAATLYVIRVARTKGE
L
>Mature_401_residues
MIIPTFDKTTPPHILTLVAVAATASSATNIFLPSLPGMAEQFGADYGIVQMTVSLYLAATAVLQLGIGPASDRFGRRPVM
LVSFAVFCIATLAGAYAPTIEALLACRVLQAFSASGLVLSRAIVRDIVGTDEAASRIGYVTMGMTLGPMVAPLVGGILDE
AYGWRSTFLLTFGFGIVALILIYVDLGETNRHRSSSLTAQFRGYRELVRSHRFWGYVATAGFASGTFFAFLGGGPYVAAE
ILGLSPFTYGLYFGVVSLGYMLGNFISGRYSRAIGINRMMLSGNAIAALGMGLSIVLFLGGYDHPLSFFGPTFFVGMGNG
IALPSATAGMVSVRPHLAGSASGLGGALQIGVGAALATLAGGLLSQETGAYPLMVLMLASSSLGIAATLYVIRVARTKGE
L

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=385, Percent_Identity=31.1688311688312, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI48994889, Length=347, Percent_Identity=27.3775216138329, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87082312, Length=347, Percent_Identity=29.6829971181556, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790146, Length=361, Percent_Identity=25.7617728531856, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790794, Length=277, Percent_Identity=23.4657039711191, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787065, Length=243, Percent_Identity=27.9835390946502, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319657, Length=166, Percent_Identity=33.7349397590361, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324264, Length=189, Percent_Identity=29.1005291005291, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319517, Length=203, Percent_Identity=27.5862068965517, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41711; Mature: 41711

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPTFDKTTPPHILTLVAVAATASSATNIFLPSLPGMAEQFGADYGIVQMTVSLYLAAT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHH
AVLQLGIGPASDRFGRRPVMLVSFAVFCIATLAGAYAPTIEALLACRVLQAFSASGLVLS
HHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RAIVRDIVGTDEAASRIGYVTMGMTLGPMVAPLVGGILDEAYGWRSTFLLTFGFGIVALI
HHHHHHHHCCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LIYVDLGETNRHRSSSLTAQFRGYRELVRSHRFWGYVATAGFASGTFFAFLGGGPYVAAE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCEEEEECCCHHHHHH
ILGLSPFTYGLYFGVVSLGYMLGNFISGRYSRAIGINRMMLSGNAIAALGMGLSIVLFLG
HHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCHHHHHHCCCEEEEEEC
GYDHPLSFFGPTFFVGMGNGIALPSATAGMVSVRPHLAGSASGLGGALQIGVGAALATLA
CCCCCHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
GGLLSQETGAYPLMVLMLASSSLGIAATLYVIRVARTKGEL
HHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIIPTFDKTTPPHILTLVAVAATASSATNIFLPSLPGMAEQFGADYGIVQMTVSLYLAAT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHH
AVLQLGIGPASDRFGRRPVMLVSFAVFCIATLAGAYAPTIEALLACRVLQAFSASGLVLS
HHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RAIVRDIVGTDEAASRIGYVTMGMTLGPMVAPLVGGILDEAYGWRSTFLLTFGFGIVALI
HHHHHHHHCCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LIYVDLGETNRHRSSSLTAQFRGYRELVRSHRFWGYVATAGFASGTFFAFLGGGPYVAAE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCEEEEECCCHHHHHH
ILGLSPFTYGLYFGVVSLGYMLGNFISGRYSRAIGINRMMLSGNAIAALGMGLSIVLFLG
HHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCCHHHHHHCCCEEEEEEC
GYDHPLSFFGPTFFVGMGNGIALPSATAGMVSVRPHLAGSASGLGGALQIGVGAALATLA
CCCCCHHHCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
GGLLSQETGAYPLMVLMLASSSLGIAATLYVIRVARTKGEL
HHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]