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The map label for this gene is gor [H]

Identifier: 110633814

GI number: 110633814

Start: 1557523

End: 1558905

Strand: Direct

Name: gor [H]

Synonym: Meso_1461

Alternate gene names: 110633814

Gene position: 1557523-1558905 (Clockwise)

Preceding gene: 110633813

Following gene: 110633815

Centisome position: 35.3

GC content: 62.98

Gene sequence:

>1383_bases
ATGGCGAAATACGACCTCGACCTCTTCGTGATCGGCGGCGGCTCCGGGGGCGTGCGGGCCGGGCGGGTCGCGGCCTCCAT
GGGCAAGCGTGTCGCGATCGCGGAGGAATACCGTTTCGGCGGCACCTGCGTGATCCGCGGCTGTGTGCCCAAGAAGCTTT
TTGTCTACGCCTCTCAATTTCCCGAGCATTTCGAGGATGCCGCCGGTTACGGCTGGGCTGTGGGCGAGAGCCGCTTCGAC
TGGGCGACCCTAATAGCCAATAAGGACAAGGAGATCGCACGGCTTGAAGGTCTCTACCGCAAAGGCCTCGAGAATGCCGG
CGCTCGCCTGATCGACGGCAGGGCGGTTCTCGTCGACAGCCATACGGTGCGTGTCGGCGGTGAAACTTTCACGGCTGAAC
ATATCCTGGTCGCCACCGGCGGCAGGCCAAATCCGCATGTGGCGCTCCCGGGCCGGGAGCACTGCATCACCTCGAACGAA
GCTTTTCACCTCGAAGAACTGCCCGCCTCGATCGCCATCGAGGGCGGCGGCTATATTGCCGTCGAGTTCGCCAACATCTT
CCACGGCCTCGGCGTGAAGACGACGCTGATTTACCGCGGCAGGGAAATTCTGAGCCGGTTCGACGGCGATCTCCGCAAGG
GCCTGCACGAAGCAATGGAAGCCAAGGGCATCCGCATCCTCTGCCAGGACATTATCGAGCAGGTGGAGAAGCAGCCCGAT
GGCCGGCTTGCCGCCCATTTGATGTCGGGAGGCGTCGAGACCTTCGACAAGATCATGCTCGCCATCGGCCGCGTTCCGAA
TACCGAGGGCCTGGGGCTGGAAGCCGCGGGTGTCGAGACGGGCGTGCGTGGCGAGATCCTCGTCGACGGCTATTCGCGCA
CCAATGTCGAGAACATCTGGGCGATCGGCGACGTGACGGACCGGGTGCAACTGACGCCCGTCGCGATCCACGAGGCCATG
TGCTTCATCGAGACCGCCTTCAAGGACAACCCGACCACTGTCGATCATCGGGATATCGCCACGGCGGTTTTCTCACAGCC
GGAGATCGGCACCGTGGGCCTAGCGGAGGAGGAGGCGGGAAAGCATTTCGAGGAGCTGGAGATTTACCGCGCCAGCTTCC
GCCCGATGCGGCATACGCTTGCCGGCCGGCAGGACAAGATGATCATGAAGCTCGTGGTGGATGCCGCTTCCAAGCGCGTT
GTTGGCGCGCACATATTGGGGCCCGATGCCGGCGAAATGGCGCAGCTTCTTGGGATCGCGATCAAAGGCAGGCTCACGAA
GGACGTCTTCGACCGCACCATGGCCGTCCACCCGACGGCGGCGGAGGAATTGGTGACCATGTACCAGCCCTCCTATCGCG
TTAGAAACGGTGAGCGGGTGTAA

Upstream 100 bases:

>100_bases
ATATTGAATAGAATTGAAGGCCCGGCCCTAGCGCCGGGCTTTCTTTTTGCGCTGCAAAGTCATAGCTGCGAGGAAGCGGA
ACGAGAGCAGCGGGAGAATC

Downstream 100 bases:

>100_bases
AGGCATGCCTCCTCTCGCTCGCCAACCAATGGCGAGCGGGAATCGCCGCATAGGACCCCGAAAGACGATTTTACGTCGAT
TCACGGCGAAATGCGGGGTA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAKYDLDLFVIGGGSGGVRAGRVAASMGKRVAIAEEYRFGGTCVIRGCVPKKLFVYASQFPEHFEDAAGYGWAVGESRFD
WATLIANKDKEIARLEGLYRKGLENAGARLIDGRAVLVDSHTVRVGGETFTAEHILVATGGRPNPHVALPGREHCITSNE
AFHLEELPASIAIEGGGYIAVEFANIFHGLGVKTTLIYRGREILSRFDGDLRKGLHEAMEAKGIRILCQDIIEQVEKQPD
GRLAAHLMSGGVETFDKIMLAIGRVPNTEGLGLEAAGVETGVRGEILVDGYSRTNVENIWAIGDVTDRVQLTPVAIHEAM
CFIETAFKDNPTTVDHRDIATAVFSQPEIGTVGLAEEEAGKHFEELEIYRASFRPMRHTLAGRQDKMIMKLVVDAASKRV
VGAHILGPDAGEMAQLLGIAIKGRLTKDVFDRTMAVHPTAAEELVTMYQPSYRVRNGERV

Sequences:

>Translated_460_residues
MAKYDLDLFVIGGGSGGVRAGRVAASMGKRVAIAEEYRFGGTCVIRGCVPKKLFVYASQFPEHFEDAAGYGWAVGESRFD
WATLIANKDKEIARLEGLYRKGLENAGARLIDGRAVLVDSHTVRVGGETFTAEHILVATGGRPNPHVALPGREHCITSNE
AFHLEELPASIAIEGGGYIAVEFANIFHGLGVKTTLIYRGREILSRFDGDLRKGLHEAMEAKGIRILCQDIIEQVEKQPD
GRLAAHLMSGGVETFDKIMLAIGRVPNTEGLGLEAAGVETGVRGEILVDGYSRTNVENIWAIGDVTDRVQLTPVAIHEAM
CFIETAFKDNPTTVDHRDIATAVFSQPEIGTVGLAEEEAGKHFEELEIYRASFRPMRHTLAGRQDKMIMKLVVDAASKRV
VGAHILGPDAGEMAQLLGIAIKGRLTKDVFDRTMAVHPTAAEELVTMYQPSYRVRNGERV
>Mature_459_residues
AKYDLDLFVIGGGSGGVRAGRVAASMGKRVAIAEEYRFGGTCVIRGCVPKKLFVYASQFPEHFEDAAGYGWAVGESRFDW
ATLIANKDKEIARLEGLYRKGLENAGARLIDGRAVLVDSHTVRVGGETFTAEHILVATGGRPNPHVALPGREHCITSNEA
FHLEELPASIAIEGGGYIAVEFANIFHGLGVKTTLIYRGREILSRFDGDLRKGLHEAMEAKGIRILCQDIIEQVEKQPDG
RLAAHLMSGGVETFDKIMLAIGRVPNTEGLGLEAAGVETGVRGEILVDGYSRTNVENIWAIGDVTDRVQLTPVAIHEAMC
FIETAFKDNPTTVDHRDIATAVFSQPEIGTVGLAEEEAGKHFEELEIYRASFRPMRHTLAGRQDKMIMKLVVDAASKRVV
GAHILGPDAGEMAQLLGIAIKGRLTKDVFDRTMAVHPTAAEELVTMYQPSYRVRNGERV

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=39.6514161220044, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI22035672, Length=451, Percent_Identity=35.4767184035477, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=34.5991561181435, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=34.5991561181435, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=34.5991561181435, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=34.5991561181435, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=34.5991561181435, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=33.9662447257384, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=31.9238900634249, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI91199540, Length=453, Percent_Identity=27.5938189845475, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=41.8224299065421, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=27.3542600896861, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI87082354, Length=451, Percent_Identity=28.3813747228381, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=26.304347826087, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=434, Percent_Identity=39.1705069124424, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71983419, Length=434, Percent_Identity=39.1705069124424, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=30.7036247334755, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=32.1503131524008, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=26.8980477223427, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325166, Length=459, Percent_Identity=35.7298474945534, Blast_Score=259, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6321091, Length=472, Percent_Identity=27.3305084745763, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=462, Percent_Identity=26.6233766233766, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=34.9576271186441, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=34.9576271186441, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=34.9576271186441, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=33.4038054968288, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=27.765726681128, Blast_Score=158, Evalue=8e-39,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50093; Mature: 49962

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYDLDLFVIGGGSGGVRAGRVAASMGKRVAIAEEYRFGGTCVIRGCVPKKLFVYASQF
CCCEEEEEEEEECCCCCCCHHHHHHHHCCEEEEEHHCCCCCEEEEECCCCCHHHHHHHHC
PEHFEDAAGYGWAVGESRFDWATLIANKDKEIARLEGLYRKGLENAGARLIDGRAVLVDS
HHHHHHHCCCCEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEECCEEEEEEC
HTVRVGGETFTAEHILVATGGRPNPHVALPGREHCITSNEAFHLEELPASIAIEGGGYIA
EEEEECCCEEEECEEEEEECCCCCCEEECCCCHHEECCCCCEEHHHCCCEEEEECCCEEE
VEFANIFHGLGVKTTLIYRGREILSRFDGDLRKGLHEAMEAKGIRILCQDIIEQVEKQPD
EEHHHHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
GRLAAHLMSGGVETFDKIMLAIGRVPNTEGLGLEAAGVETGVRGEILVDGYSRTNVENIW
CHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCEE
AIGDVTDRVQLTPVAIHEAMCFIETAFKDNPTTVDHRDIATAVFSQPEIGTVGLAEEEAG
EECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHC
KHFEELEIYRASFRPMRHTLAGRQDKMIMKLVVDAASKRVVGAHILGPDAGEMAQLLGIA
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHH
IKGRLTKDVFDRTMAVHPTAAEELVTMYQPSYRVRNGERV
HCCCCCHHHHHHHEEECCCHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
AKYDLDLFVIGGGSGGVRAGRVAASMGKRVAIAEEYRFGGTCVIRGCVPKKLFVYASQF
CCEEEEEEEEECCCCCCCHHHHHHHHCCEEEEEHHCCCCCEEEEECCCCCHHHHHHHHC
PEHFEDAAGYGWAVGESRFDWATLIANKDKEIARLEGLYRKGLENAGARLIDGRAVLVDS
HHHHHHHCCCCEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCEEECCEEEEEEC
HTVRVGGETFTAEHILVATGGRPNPHVALPGREHCITSNEAFHLEELPASIAIEGGGYIA
EEEEECCCEEEECEEEEEECCCCCCEEECCCCHHEECCCCCEEHHHCCCEEEEECCCEEE
VEFANIFHGLGVKTTLIYRGREILSRFDGDLRKGLHEAMEAKGIRILCQDIIEQVEKQPD
EEHHHHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
GRLAAHLMSGGVETFDKIMLAIGRVPNTEGLGLEAAGVETGVRGEILVDGYSRTNVENIW
CHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCEE
AIGDVTDRVQLTPVAIHEAMCFIETAFKDNPTTVDHRDIATAVFSQPEIGTVGLAEEEAG
EECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHC
KHFEELEIYRASFRPMRHTLAGRQDKMIMKLVVDAASKRVVGAHILGPDAGEMAQLLGIA
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHH
IKGRLTKDVFDRTMAVHPTAAEELVTMYQPSYRVRNGERV
HCCCCCHHHHHHHEEECCCHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]