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The map label for this gene is map [H]

Identifier: 110633808

GI number: 110633808

Start: 1551037

End: 1551861

Strand: Reverse

Name: map [H]

Synonym: Meso_1455

Alternate gene names: 110633808

Gene position: 1551861-1551037 (Counterclockwise)

Preceding gene: 110633809

Following gene: 110633807

Centisome position: 35.17

GC content: 62.06

Gene sequence:

>825_bases
ATGGTCACCTATCTCGATGCGGACACGGCTCCGCTGCGCAACACCGGCCAGATCCGCCTATACGGCAAAGACGGCTTCGA
GGGCATGCGCAGGGCCTGCCAGCTCACCGCGCGCTGCCTGGACGAACTCGTCTCGATCGTGAAACCGGGCGTGACGACGA
ACGCGATCGATCAGTTCGTCTTCGAGTTCGGGATGGACCATGGGGCGCTTCCCGCCACGCTCAACTACCGCGGCTACACG
AAGTCCACCTGTACCTCGATCAACCACGTCGTCTGTCACGGCATCCCCGACGATAAGCCGCTTCGCGAAGGCGACATCGT
CAATATCGACGTGACCTATGTGCTCGACGGGTGGCACGGAGATTCAAGCCGCATGTACCCCGTGGGGCAGATCAAGCGAG
CCGCCGAACGGCTTCTGGAAGTTACCCACGAATGCCTCATGCGCGGCGTGGAGGCGGTGAAACCGGGCGCGCGAACGGGC
GCTATCGGCGCTGCGATCCAGACTTATGCTGAAAATCAGCGCTGCTCGGTGGTGCGCGATTTCTGCGGACATGGCGTTGG
CCGTCTGTTCCACGATGCGCCAAACATCCTGCATTACGGCAGCCCCAACGAGGGCGTCGAGATGCGGCCGGGCATGATCT
TCACGATCGAGCCCATGATCAATCTTGGCAGGCCGCATGTGAAGGTGCTGTCGGATGGCTGGACCGCCGTCACGCGGGAC
CGTTCCCTCTCCGCCCAATACGAGCACAGCGTGGGTGTCACCGAAACAGGCTGTGAAATTTTCACTCTCTCTCCAGCAGG
GCTTGATCGCCCCGGCCTCCCATAG

Upstream 100 bases:

>100_bases
GAGGGATGCGGGGGTTGAAGCTTTCGTGATAGGGTGCCAAATCTCTGCCGACGCGATCGCTCCCGATCGCCTGATCGATT
TGGATTTTTAGGACGCCTCA

Downstream 100 bases:

>100_bases
TTACCCTGTAGTCGATTGGGGACGGGGCAAAGCTGATCATGGCGGAAAGCGGCAACGGCGGGTTCAGCGAAGGTGCGCTG
CGCACAACAGAGAACGTACC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MVTYLDADTAPLRNTGQIRLYGKDGFEGMRRACQLTARCLDELVSIVKPGVTTNAIDQFVFEFGMDHGALPATLNYRGYT
KSTCTSINHVVCHGIPDDKPLREGDIVNIDVTYVLDGWHGDSSRMYPVGQIKRAAERLLEVTHECLMRGVEAVKPGARTG
AIGAAIQTYAENQRCSVVRDFCGHGVGRLFHDAPNILHYGSPNEGVEMRPGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
RSLSAQYEHSVGVTETGCEIFTLSPAGLDRPGLP

Sequences:

>Translated_274_residues
MVTYLDADTAPLRNTGQIRLYGKDGFEGMRRACQLTARCLDELVSIVKPGVTTNAIDQFVFEFGMDHGALPATLNYRGYT
KSTCTSINHVVCHGIPDDKPLREGDIVNIDVTYVLDGWHGDSSRMYPVGQIKRAAERLLEVTHECLMRGVEAVKPGARTG
AIGAAIQTYAENQRCSVVRDFCGHGVGRLFHDAPNILHYGSPNEGVEMRPGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
RSLSAQYEHSVGVTETGCEIFTLSPAGLDRPGLP
>Mature_274_residues
MVTYLDADTAPLRNTGQIRLYGKDGFEGMRRACQLTARCLDELVSIVKPGVTTNAIDQFVFEFGMDHGALPATLNYRGYT
KSTCTSINHVVCHGIPDDKPLREGDIVNIDVTYVLDGWHGDSSRMYPVGQIKRAAERLLEVTHECLMRGVEAVKPGARTG
AIGAAIQTYAENQRCSVVRDFCGHGVGRLFHDAPNILHYGSPNEGVEMRPGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
RSLSAQYEHSVGVTETGCEIFTLSPAGLDRPGLP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=47.808764940239, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=40.7258064516129, Blast_Score=200, Evalue=9e-52,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=50.4032258064516, Blast_Score=253, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI71996291, Length=246, Percent_Identity=45.1219512195122, Blast_Score=220, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6323273, Length=257, Percent_Identity=44.3579766536965, Blast_Score=227, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=45.4183266932271, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24583427, Length=259, Percent_Identity=41.6988416988417, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30004; Mature: 30004

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYLDADTAPLRNTGQIRLYGKDGFEGMRRACQLTARCLDELVSIVKPGVTTNAIDQFV
CEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FEFGMDHGALPATLNYRGYTKSTCTSINHVVCHGIPDDKPLREGDIVNIDVTYVLDGWHG
HHHCCCCCCCCEEEECCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECEEC
DSSRMYPVGQIKRAAERLLEVTHECLMRGVEAVKPGARTGAIGAAIQTYAENQRCSVVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHH
FCGHGVGRLFHDAPNILHYGSPNEGVEMRPGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
HHCCCHHHHHHCCCCEEECCCCCCCCEECCCEEEEECHHHCCCCCCEEEEECCCEEEECC
RSLSAQYEHSVGVTETGCEIFTLSPAGLDRPGLP
CCCCCHHHCCCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVTYLDADTAPLRNTGQIRLYGKDGFEGMRRACQLTARCLDELVSIVKPGVTTNAIDQFV
CEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FEFGMDHGALPATLNYRGYTKSTCTSINHVVCHGIPDDKPLREGDIVNIDVTYVLDGWHG
HHHCCCCCCCCEEEECCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECEEC
DSSRMYPVGQIKRAAERLLEVTHECLMRGVEAVKPGARTGAIGAAIQTYAENQRCSVVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHH
FCGHGVGRLFHDAPNILHYGSPNEGVEMRPGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
HHCCCHHHHHHCCCCEEECCCCCCCCEECCCEEEEECHHHCCCCCCEEEEECCCEEEECC
RSLSAQYEHSVGVTETGCEIFTLSPAGLDRPGLP
CCCCCHHHCCCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]