Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 110633711

GI number: 110633711

Start: 1450909

End: 1452195

Strand: Reverse

Name: pyrC [H]

Synonym: Meso_1358

Alternate gene names: 110633711

Gene position: 1452195-1450909 (Counterclockwise)

Preceding gene: 110633712

Following gene: 110633710

Centisome position: 32.91

GC content: 63.17

Gene sequence:

>1287_bases
ATGAGCGTCACCGTCTTCACCAACGCACGCCTGGTCGACCCCTCGCGCGGTCTCGACGAAATCGGCACGCTGATCGTCGA
TGGCGAAAACATCGTCGCCTCCGGCGCGTCCGCACAAAATCAGGGACATCCCGACGGCGCCTCGGTGGTCAACTGCGGCG
GCAAGGCCATTCTCCCCGGTCTTGTTGATTCTCGCGTCTTCATCGGCGAACCCGGTGCGGAGCACCGCGAGACCATCGCC
TCGGCGGGCCGCGCAGCCGCGGCGGGCGGCGTAACCTCCATCATCATGATGCCGGACACCTCGCCCGTGATCGATGATGT
GGCGCTGGTGGAATTCGTGCTGCGGACCGCGCGGGAGACATCCTGTGTCAATATTTTCCCCGCCGCCGCCATCACGAAGG
GGCTGGCGGGACACGAAATGAGCGAGTTTGGCCTGCTGCGCGATGCCGGCGCGGTAATGGTCACTGAAGGCCGCCACACG
ATCGCAGATTCCCTCGTCATGCGCCGGGCGCTTACTTATGCGCGCGACATGGACATGGTGATTTCCCATTCGACGCAGGA
CCCGGATCTCGGCTCCTCTGGCGTCATGAACGAAGGATTGCTTGCAAGTTGGCTGGGCCTTCCCGGCATTCCTCGCGAGG
CCGAGGCCATTCCGCTGAGCCGTGACCTGATGCTGGCCGCCCTCACCCAGAGCCGCTATCACGCCGCCGAGATTTCGACC
GCCATGTCGTCGGCGGCGGTCAAACGCGCAAAGGACGAGGGCACGCGGGCCACGGCTGGGGTCAGCATCAACAATCTCTG
CCTGAACGAGAACGATGTGGGCGAATACCGGACCTTCTTCCGGCTCTCGCCTCCGCTACGCTGCGAAGAAGATCGCCTGG
CGATGGTCGAAGCCGTCAAGGACGGGACCATCGACGTGATCCATTCGGCTCACGACCCGCAGGACGTGGACACGAAGCGT
CTTCCTTTTTCCGACGCCGCGGTCGGTGCAATCGGGCTCGAAACTTTTCTTTCGGCCGCCTTGCGGCTCTACCATTCCGG
CGATGTGCCGCTTCTTCGCCTTGTCGAGGCGCTGTCTACTGCACCCGCCCGCCTCTTCGGCCTGCCGGGGGGAAGTTTGA
AGCCGGGTGCGCCGGCCGATCTCATTCTTGTCGACCTCGATGCGCCATGGATCGTGCGAGAGGAAAATATCCGCTCGCTC
TCGAAGAACACCTCCTTCGAGGAGGCGCGGATGCAAGGCCGAGTATTGCAAACCATGGTTGCAGGCTCCACAGTATTCAC
AACCTGA

Upstream 100 bases:

>100_bases
GTCCGCAAAGCGTGATCCAGGAACAGGTGGAGATGGGCGTTGCCGTACGCATGGCGGTGATGGAAGCCCTGCTCGATCCG
CGCCGCAACGGGGACGGAGC

Downstream 100 bases:

>100_bases
TTCTGGGGAGGGCGAATGGATATGACGGGCTGGTCGGCTTCGCTGCCACTATTATTGGCCGCGGTTCTTTGGGGTTATCT
TCTCGGCTCAATCCCCTTCG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSVTVFTNARLVDPSRGLDEIGTLIVDGENIVASGASAQNQGHPDGASVVNCGGKAILPGLVDSRVFIGEPGAEHRETIA
SAGRAAAAGGVTSIIMMPDTSPVIDDVALVEFVLRTARETSCVNIFPAAAITKGLAGHEMSEFGLLRDAGAVMVTEGRHT
IADSLVMRRALTYARDMDMVISHSTQDPDLGSSGVMNEGLLASWLGLPGIPREAEAIPLSRDLMLAALTQSRYHAAEIST
AMSSAAVKRAKDEGTRATAGVSINNLCLNENDVGEYRTFFRLSPPLRCEEDRLAMVEAVKDGTIDVIHSAHDPQDVDTKR
LPFSDAAVGAIGLETFLSAALRLYHSGDVPLLRLVEALSTAPARLFGLPGGSLKPGAPADLILVDLDAPWIVREENIRSL
SKNTSFEEARMQGRVLQTMVAGSTVFTT

Sequences:

>Translated_428_residues
MSVTVFTNARLVDPSRGLDEIGTLIVDGENIVASGASAQNQGHPDGASVVNCGGKAILPGLVDSRVFIGEPGAEHRETIA
SAGRAAAAGGVTSIIMMPDTSPVIDDVALVEFVLRTARETSCVNIFPAAAITKGLAGHEMSEFGLLRDAGAVMVTEGRHT
IADSLVMRRALTYARDMDMVISHSTQDPDLGSSGVMNEGLLASWLGLPGIPREAEAIPLSRDLMLAALTQSRYHAAEIST
AMSSAAVKRAKDEGTRATAGVSINNLCLNENDVGEYRTFFRLSPPLRCEEDRLAMVEAVKDGTIDVIHSAHDPQDVDTKR
LPFSDAAVGAIGLETFLSAALRLYHSGDVPLLRLVEALSTAPARLFGLPGGSLKPGAPADLILVDLDAPWIVREENIRSL
SKNTSFEEARMQGRVLQTMVAGSTVFTT
>Mature_427_residues
SVTVFTNARLVDPSRGLDEIGTLIVDGENIVASGASAQNQGHPDGASVVNCGGKAILPGLVDSRVFIGEPGAEHRETIAS
AGRAAAAGGVTSIIMMPDTSPVIDDVALVEFVLRTARETSCVNIFPAAAITKGLAGHEMSEFGLLRDAGAVMVTEGRHTI
ADSLVMRRALTYARDMDMVISHSTQDPDLGSSGVMNEGLLASWLGLPGIPREAEAIPLSRDLMLAALTQSRYHAAEISTA
MSSAAVKRAKDEGTRATAGVSINNLCLNENDVGEYRTFFRLSPPLRCEEDRLAMVEAVKDGTIDVIHSAHDPQDVDTKRL
PFSDAAVGAIGLETFLSAALRLYHSGDVPLLRLVEALSTAPARLFGLPGGSLKPGAPADLILVDLDAPWIVREENIRSLS
KNTSFEEARMQGRVLQTMVAGSTVFTT

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786722, Length=429, Percent_Identity=24.4755244755245, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI193204318, Length=384, Percent_Identity=27.6041666666667, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=404, Percent_Identity=23.019801980198, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24642586, Length=377, Percent_Identity=25.7294429708223, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45240; Mature: 45109

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTVFTNARLVDPSRGLDEIGTLIVDGENIVASGASAQNQGHPDGASVVNCGGKAILPG
CEEEEEECCEEECCCCCHHHHCEEEECCCCEEECCCCCCCCCCCCCCCEEECCCCEECCC
LVDSRVFIGEPGAEHRETIASAGRAAAAGGVTSIIMMPDTSPVIDDVALVEFVLRTARET
HHCCEEEECCCCHHHHHHHHHCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
SCVNIFPAAAITKGLAGHEMSEFGLLRDAGAVMVTEGRHTIADSLVMRRALTYARDMDMV
CEEEEECHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ISHSTQDPDLGSSGVMNEGLLASWLGLPGIPREAEAIPLSRDLMLAALTQSRYHAAEIST
EECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AMSSAAVKRAKDEGTRATAGVSINNLCLNENDVGEYRTFFRLSPPLRCEEDRLAMVEAVK
HHHHHHHHHHHCCCCEEECCCEEEEEEECCCCCCHHHHEEECCCCCCCCHHHHHHHHHHC
DGTIDVIHSAHDPQDVDTKRLPFSDAAVGAIGLETFLSAALRLYHSGDVPLLRLVEALST
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
APARLFGLPGGSLKPGAPADLILVDLDAPWIVREENIRSLSKNTSFEEARMQGRVLQTMV
CCCEEEECCCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGSTVFTT
CCCEEECC
>Mature Secondary Structure 
SVTVFTNARLVDPSRGLDEIGTLIVDGENIVASGASAQNQGHPDGASVVNCGGKAILPG
EEEEEECCEEECCCCCHHHHCEEEECCCCEEECCCCCCCCCCCCCCCEEECCCCEECCC
LVDSRVFIGEPGAEHRETIASAGRAAAAGGVTSIIMMPDTSPVIDDVALVEFVLRTARET
HHCCEEEECCCCHHHHHHHHHCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
SCVNIFPAAAITKGLAGHEMSEFGLLRDAGAVMVTEGRHTIADSLVMRRALTYARDMDMV
CEEEEECHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ISHSTQDPDLGSSGVMNEGLLASWLGLPGIPREAEAIPLSRDLMLAALTQSRYHAAEIST
EECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
AMSSAAVKRAKDEGTRATAGVSINNLCLNENDVGEYRTFFRLSPPLRCEEDRLAMVEAVK
HHHHHHHHHHHCCCCEEECCCEEEEEEECCCCCCHHHHEEECCCCCCCCHHHHHHHHHHC
DGTIDVIHSAHDPQDVDTKRLPFSDAAVGAIGLETFLSAALRLYHSGDVPLLRLVEALST
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
APARLFGLPGGSLKPGAPADLILVDLDAPWIVREENIRSLSKNTSFEEARMQGRVLQTMV
CCCEEEECCCCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGSTVFTT
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA