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The map label for this gene is purQ

Identifier: 110633632

GI number: 110633632

Start: 1373410

End: 1374078

Strand: Reverse

Name: purQ

Synonym: Meso_1279

Alternate gene names: 110633632

Gene position: 1374078-1373410 (Counterclockwise)

Preceding gene: 110633633

Following gene: 110633631

Centisome position: 31.14

GC content: 64.87

Gene sequence:

>669_bases
ATGAAGTCAGCCGTCATCCAGCTTCCCGGCCTCAATCGCGACCGCGATATGATCGCCGCACTCACCAAGATCTCCGGCCA
GGCTCCGGTCACCGTCTGGCAAACCGAGACGGAACTGCCGGAGGTCGACCTGATCGTCATCCCAGGCGGGTTCTCCTACG
GCGACTACCTGCGCTGCGGTGCGATCGCCGCGCGCATGCCCGTCATGAAGGCGGTGGCGGAGAAAGCGGCAAAGGGCGTG
CTCGTCATCGGCGTCTGCAACGGTTTTCAGATCCTGCTTGAAGCCGGTCTCCTGCCCGGCGCGCTGATGCGCAATGCATC
GCTCAAATTCGTTTGCCGCGAGGTGAAGCTGCAGGTGGCCAACGCCAATACCGCATTTACCCGCGCTTACGCTCCCGGCC
AGATCATCCGCTGCCCCGTGGCGCACCATGACGGCAACTTCTTCGCCGCCCCCGAGACGCTGGCGCGCATTGAGGGCGAG
GGCCAGGTGGCCTTCCGCTATGCCGAGGGAACGAACCCCAACGGCTCCATCAACGACATCGCCGGTATCGTGAACGGTGC
CGGCAACGTCCTTGGCCTGATGCCGCATCCGGAAAATCTCGTCGAGGCCGCCCATGGCGGCACGGACGGGCGGGCGCTTT
TCGAAAGCGTGCTCGGACGTGCGGCCTGA

Upstream 100 bases:

>100_bases
CGAACACGGTGATCGAGAACTATAGTATCTCCATCACCTGAGATGCATTGAGGAAGTCGGCTGAACCCCCAGCCGACGAA
AAACCCTACGAATTGAGCGC

Downstream 100 bases:

>100_bases
TGCACCACGCTTCTTCTCATCGGAGTTCGCGCGAAAGCGGCTTGGGGCGAGGCATTTTGACCGCGACCTTCCTCTGCGGC
GTTGCTCTTCTGTCGGCCTG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKSAVIQLPGLNRDRDMIAALTKISGQAPVTVWQTETELPEVDLIVIPGGFSYGDYLRCGAIAARMPVMKAVAEKAAKGV
LVIGVCNGFQILLEAGLLPGALMRNASLKFVCREVKLQVANANTAFTRAYAPGQIIRCPVAHHDGNFFAAPETLARIEGE
GQVAFRYAEGTNPNGSINDIAGIVNGAGNVLGLMPHPENLVEAAHGGTDGRALFESVLGRAA

Sequences:

>Translated_222_residues
MKSAVIQLPGLNRDRDMIAALTKISGQAPVTVWQTETELPEVDLIVIPGGFSYGDYLRCGAIAARMPVMKAVAEKAAKGV
LVIGVCNGFQILLEAGLLPGALMRNASLKFVCREVKLQVANANTAFTRAYAPGQIIRCPVAHHDGNFFAAPETLARIEGE
GQVAFRYAEGTNPNGSINDIAGIVNGAGNVLGLMPHPENLVEAAHGGTDGRALFESVLGRAA
>Mature_222_residues
MKSAVIQLPGLNRDRDMIAALTKISGQAPVTVWQTETELPEVDLIVIPGGFSYGDYLRCGAIAARMPVMKAVAEKAAKGV
LVIGVCNGFQILLEAGLLPGALMRNASLKFVCREVKLQVANANTAFTRAYAPGQIIRCPVAHHDGNFFAAPETLARIEGE
GQVAFRYAEGTNPNGSINDIAGIVNGAGNVLGLMPHPENLVEAAHGGTDGRALFESVLGRAA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=226, Percent_Identity=29.646017699115, Blast_Score=68, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321498, Length=180, Percent_Identity=32.2222222222222, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582111, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24582109, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137292, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_MESSB (Q11IV0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673840.1
- ProteinModelPortal:   Q11IV0
- SMR:   Q11IV0
- STRING:   Q11IV0
- GeneID:   4180538
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1279
- NMPDR:   fig|266779.1.peg.2309
- eggNOG:   COG0047
- HOGENOM:   HBG302712
- OMA:   HPENHVE
- ProtClustDB:   PRK03619
- BioCyc:   MSP266779:MESO_1279-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23334; Mature: 23334

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 196-196 ACT_SITE 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAVIQLPGLNRDRDMIAALTKISGQAPVTVWQTETELPEVDLIVIPGGFSYGDYLRCG
CCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHH
AIAARMPVMKAVAEKAAKGVLVIGVCNGFQILLEAGLLPGALMRNASLKFVCREVKLQVA
HHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCHHHHHCCCHHEEEEEEEEEEE
NANTAFTRAYAPGQIIRCPVAHHDGNFFAAPETLARIEGEGQVAFRYAEGTNPNGSINDI
CCCCEEEEECCCCCEEEEEEEECCCCEEECCHHHHHCCCCCEEEEEEECCCCCCCCHHHH
AGIVNGAGNVLGLMPHPENLVEAAHGGTDGRALFESVLGRAA
HHHHCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKSAVIQLPGLNRDRDMIAALTKISGQAPVTVWQTETELPEVDLIVIPGGFSYGDYLRCG
CCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHH
AIAARMPVMKAVAEKAAKGVLVIGVCNGFQILLEAGLLPGALMRNASLKFVCREVKLQVA
HHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCHHHHHCCCHHEEEEEEEEEEE
NANTAFTRAYAPGQIIRCPVAHHDGNFFAAPETLARIEGEGQVAFRYAEGTNPNGSINDI
CCCCEEEEECCCCCEEEEEEEECCCCEEECCHHHHHCCCCCEEEEEEECCCCCCCCHHHH
AGIVNGAGNVLGLMPHPENLVEAAHGGTDGRALFESVLGRAA
HHHHCCCCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA