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The map label for this gene is purL

Identifier: 110633630

GI number: 110633630

Start: 1370674

End: 1372908

Strand: Reverse

Name: purL

Synonym: Meso_1277

Alternate gene names: 110633630

Gene position: 1372908-1370674 (Counterclockwise)

Preceding gene: 110633631

Following gene: 110633629

Centisome position: 31.11

GC content: 63.27

Gene sequence:

>2235_bases
ATGACGATCCCCAACGATATCAGGATCACACCCGAGCTGGTGGCTGCGCACGGACTTAAGCCAGACGAGTATCAACGCAT
CCTCGATCTGATCGGCCGCGAGCCGACCTTCACCGAGCTTGGCATCTTCTCGGCCATGTGGAACGAGCATTGCTCGTACA
AAAGTTCCAAGAGGTGGCTCAGGACATTGCCCACCTCCGGCCCGCAGGTGATCCAGGGACCCGGCGAGAATGCCGGCGTG
GTGGATATCGGTGACGGACAGTGCGTTGTCTTCAAGATGGAGAGCCACAACCACCCCTCCTATATCGAGCCCTACCAGGG
CGCGGCGACAGGCGTGGGCGGCATCCTCCGCGACGTCTTCACCATGGGCGCGCGGCCGATCGCTGCCATGAACGCGCTGC
GCTTCGGCGCGCCCGATCATCCCAAGACGCAGCATCTTGTGGCGGGCGTCGTGGCCGGCATCGGCGGCTACGGCAACTCC
TTCGGCGTGCCGACTGTCGGCGGCGAGGTCAATTTCGACCCGCGCTACAACGGCAATTGCCTGGTCAACGCCTTTGCGGC
AGGCCTCGCCCGCACCGATGGGATCTTTTATTCCAAGGCCGAGGGCGTCGGCTTGCCGGTGGTCTATCTGGGCGCGAAAA
CCGGCCGCGACGGGGTGGGCGGCGCCACCATGGCTTCGGCCGAGTTCGACGAAACCATTGAGGAGAAGCGCCCAACGGTG
CAGGTGGGCGATCCATTCACCGAGAAGTGCCTTCTCGAAGCCTGCCTGGAGTTGATGGCGACCGGTGCCGTTATCGCGAT
TCAGGATATGGGCGCAGCGGGCCTGACCTGCTCGGCGGTCGAAATGGGCGCCAAAGGCGATCTCGGTATTGAACTCGACC
TGGACAAGGTGCCGGTGCGCGAGGAGCGCATGTCGGCCTATGAGATGATGCTGTCGGAAAGCCAGGAGCGCATGCTCATG
GTGCTCAGGCCCGAAAAGGAGCCGGAGGCAGAGGAAATCTTCCGCAAATGGGGGCTTGATTTCGCGATCGTCGGCCGCAC
GACGGACGATCTACGCTTCCGCATCCTGCATGGAGGAGAGGAGGTCGCGAACCTTCCCATCAAGGAGCTGGGCGACGAGG
CGCCGGAATATGACCGGCCCTGGGCGGAGCCTAAAATGCCCCCTGCCCTCGATGCCGCCACGGTGCCCGCAGCAGATGTC
GCGGATTCGCTTCTGAAGCTCCTGGGTTCGCCCGATCTCTCCTCACGCCGCTGGGTGTGGGAACAGTATGACACGCTGAT
CCAGGGCAATTCGCTGCAGATCCCCGGCGGCGATGCCGGTGTCGTGCGCGTGGAGGATCACCCGACCAAAGCGCTTGCCT
TTTCTTCCGATGTAACGCCGCGATACTGCGAGGCCGATTCCTTCGAAGGCGGCAAGCAGGCGGTGGCGGAGTGCTGGCGC
AACCTGACCGCCACCGGGGCGGACCCTCTCGCTGTCACCGACAACCTCAATTTCGGCAATCCGGAACGGCCGGAGATCAT
GGGGCAGTTCGTGCGCGCCATAAAGGGCATAGGCGAGGCCTGCCGCGCCCTCTCCTTCCCCATCGTTTCCGGCAATGTTT
CGCTCTACAACGAGACGCTTGGCCAGGCGATACCGCCGACGCCCACCATTGCCGGTGTCGGGCTCATTCCGGATTGGTCT
AAGATGGCCCGCATCGCCTTTGCAGGCGAAGGCCAGGCGATTCTTCTTGCCGGTGCCCCGGAAAGCTGGGGAACGCATCT
CGGCCAATCGGCCTATCTTCGCGACGTCCATGGACGCGCGGAAGGCGCACCGCCGCCCGTGGATCTGGCACATGAAAAGC
GCGTGGGCGATTTCGTGCGCGGCGTGATCCGCTCAGGCACTGTTACGGCCGCTCATGACTGCTCCGACGGCGGACTTGCG
GTCGCCTTGGCAGAAATGGCGATGGCATCCGGTATCGGCGCCAGGATCGATGCCCCGGTAAACAGCGCATCGGCGGCTTT
CTTCGGCGAAGATCAAGGCCGTTACGTGCTTACGGCAGCCCTTGCGCGAGAGGACGCGCAGCTGGCGACGCTTATCGAGG
ACGCAAGAAAAGCGGGGGTATCGCTGATCGCGATCGGCGTCACCGGGGGGCGCGAATTGAAACTGGGCGAGGCACGTGCC
ATATCGGTTGAAGAACTAAAAGAAGCCCATGAGGGCTGGTTCCCGAGGTTCATGCAGGACGGAAGCTTGCAATGA

Upstream 100 bases:

>100_bases
TCGGATGTTGCTCGCTGGGCATCCGGTAACAATTCCTGCGGCGGGGCTGCTTGAGCTCATGCGCCGCCCGCCTCAGACTC
TCCGCAACGGATAACGGACG

Downstream 100 bases:

>100_bases
ATGGGCGGGCCGAAGGGGAGATTGATCATGGCCATGAGCGCGGGCGACATTGAACGCCTGATCAAGGAAGCCATACCGGA
TGCGAAGGTCACCATCCGCG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MTIPNDIRITPELVAAHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKRWLRTLPTSGPQVIQGPGENAGV
VDIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTQHLVAGVVAGIGGYGNS
FGVPTVGGEVNFDPRYNGNCLVNAFAAGLARTDGIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDETIEEKRPTV
QVGDPFTEKCLLEACLELMATGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLM
VLRPEKEPEAEEIFRKWGLDFAIVGRTTDDLRFRILHGGEEVANLPIKELGDEAPEYDRPWAEPKMPPALDAATVPAADV
ADSLLKLLGSPDLSSRRWVWEQYDTLIQGNSLQIPGGDAGVVRVEDHPTKALAFSSDVTPRYCEADSFEGGKQAVAECWR
NLTATGADPLAVTDNLNFGNPERPEIMGQFVRAIKGIGEACRALSFPIVSGNVSLYNETLGQAIPPTPTIAGVGLIPDWS
KMARIAFAGEGQAILLAGAPESWGTHLGQSAYLRDVHGRAEGAPPPVDLAHEKRVGDFVRGVIRSGTVTAAHDCSDGGLA
VALAEMAMASGIGARIDAPVNSASAAFFGEDQGRYVLTAALAREDAQLATLIEDARKAGVSLIAIGVTGGRELKLGEARA
ISVEELKEAHEGWFPRFMQDGSLQ

Sequences:

>Translated_744_residues
MTIPNDIRITPELVAAHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKRWLRTLPTSGPQVIQGPGENAGV
VDIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTQHLVAGVVAGIGGYGNS
FGVPTVGGEVNFDPRYNGNCLVNAFAAGLARTDGIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDETIEEKRPTV
QVGDPFTEKCLLEACLELMATGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLM
VLRPEKEPEAEEIFRKWGLDFAIVGRTTDDLRFRILHGGEEVANLPIKELGDEAPEYDRPWAEPKMPPALDAATVPAADV
ADSLLKLLGSPDLSSRRWVWEQYDTLIQGNSLQIPGGDAGVVRVEDHPTKALAFSSDVTPRYCEADSFEGGKQAVAECWR
NLTATGADPLAVTDNLNFGNPERPEIMGQFVRAIKGIGEACRALSFPIVSGNVSLYNETLGQAIPPTPTIAGVGLIPDWS
KMARIAFAGEGQAILLAGAPESWGTHLGQSAYLRDVHGRAEGAPPPVDLAHEKRVGDFVRGVIRSGTVTAAHDCSDGGLA
VALAEMAMASGIGARIDAPVNSASAAFFGEDQGRYVLTAALAREDAQLATLIEDARKAGVSLIAIGVTGGRELKLGEARA
ISVEELKEAHEGWFPRFMQDGSLQ
>Mature_743_residues
TIPNDIRITPELVAAHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKRWLRTLPTSGPQVIQGPGENAGVV
DIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTQHLVAGVVAGIGGYGNSF
GVPTVGGEVNFDPRYNGNCLVNAFAAGLARTDGIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDETIEEKRPTVQ
VGDPFTEKCLLEACLELMATGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLMV
LRPEKEPEAEEIFRKWGLDFAIVGRTTDDLRFRILHGGEEVANLPIKELGDEAPEYDRPWAEPKMPPALDAATVPAADVA
DSLLKLLGSPDLSSRRWVWEQYDTLIQGNSLQIPGGDAGVVRVEDHPTKALAFSSDVTPRYCEADSFEGGKQAVAECWRN
LTATGADPLAVTDNLNFGNPERPEIMGQFVRAIKGIGEACRALSFPIVSGNVSLYNETLGQAIPPTPTIAGVGLIPDWSK
MARIAFAGEGQAILLAGAPESWGTHLGQSAYLRDVHGRAEGAPPPVDLAHEKRVGDFVRGVIRSGTVTAAHDCSDGGLAV
ALAEMAMASGIGARIDAPVNSASAAFFGEDQGRYVLTAALAREDAQLATLIEDARKAGVSLIAIGVTGGRELKLGEARAI
SVEELKEAHEGWFPRFMQDGSLQ

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=704, Percent_Identity=24.8579545454545, Blast_Score=103, Evalue=7e-22,
Organism=Escherichia coli, GI48994899, Length=790, Percent_Identity=25.4430379746835, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17553022, Length=651, Percent_Identity=23.1950844854071, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321498, Length=804, Percent_Identity=23.134328358209, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_MESSB (Q11IV2)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673838.1
- ProteinModelPortal:   Q11IV2
- SMR:   Q11IV2
- STRING:   Q11IV2
- GeneID:   4180575
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1277
- NMPDR:   fig|266779.1.peg.2311
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   Q11IV2
- ProtClustDB:   PRK01213
- BioCyc:   MSP266779:MESO_1277-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79325; Mature: 79194

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPNDIRITPELVAAHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKRWL
CCCCCCCEECHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
RTLPTSGPQVIQGPGENAGVVDIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCCEEECCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGAPDHPKTQHLVAGVVAGIGGYGNSFGVPTVGGEVNFDPRYNGNC
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCE
LVNAFAAGLARTDGIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDETIEEKRPTV
EHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCEECCHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMATGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHHCCCCCCCCEEECCCCCCCH
EERMSAYEMMLSESQERMLMVLRPEKEPEAEEIFRKWGLDFAIVGRTTDDLRFRILHGGE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCEEEEEEECCH
EVANLPIKELGDEAPEYDRPWAEPKMPPALDAATVPAADVADSLLKLLGSPDLSSRRWVW
HHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHH
EQYDTLIQGNSLQIPGGDAGVVRVEDHPTKALAFSSDVTPRYCEADSFEGGKQAVAECWR
HHHHHHHCCCEEECCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
NLTATGADPLAVTDNLNFGNPERPEIMGQFVRAIKGIGEACRALSFPIVSGNVSLYNETL
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
GQAIPPTPTIAGVGLIPDWSKMARIAFAGEGQAILLAGAPESWGTHLGQSAYLRDVHGRA
CCCCCCCCCEECCCCCCCHHHHEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHCCCC
EGAPPPVDLAHEKRVGDFVRGVIRSGTVTAAHDCSDGGLAVALAEMAMASGIGARIDAPV
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEECCCC
NSASAAFFGEDQGRYVLTAALAREDAQLATLIEDARKAGVSLIAIGVTGGRELKLGEARA
CCCCEEEEECCCCCEEEEEEHHHCCHHHHHHHHHHHHCCEEEEEEEECCCCEEECCCCCC
ISVEELKEAHEGWFPRFMQDGSLQ
CCHHHHHHHHCCCCHHHHCCCCCC
>Mature Secondary Structure 
TIPNDIRITPELVAAHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKRWL
CCCCCCEECHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
RTLPTSGPQVIQGPGENAGVVDIGDGQCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCCEEECCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGAPDHPKTQHLVAGVVAGIGGYGNSFGVPTVGGEVNFDPRYNGNC
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCE
LVNAFAAGLARTDGIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDETIEEKRPTV
EHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCEECCHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMATGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHHCCCCCCCCEEECCCCCCCH
EERMSAYEMMLSESQERMLMVLRPEKEPEAEEIFRKWGLDFAIVGRTTDDLRFRILHGGE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCEEEEEEECCH
EVANLPIKELGDEAPEYDRPWAEPKMPPALDAATVPAADVADSLLKLLGSPDLSSRRWVW
HHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHH
EQYDTLIQGNSLQIPGGDAGVVRVEDHPTKALAFSSDVTPRYCEADSFEGGKQAVAECWR
HHHHHHHCCCEEECCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
NLTATGADPLAVTDNLNFGNPERPEIMGQFVRAIKGIGEACRALSFPIVSGNVSLYNETL
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
GQAIPPTPTIAGVGLIPDWSKMARIAFAGEGQAILLAGAPESWGTHLGQSAYLRDVHGRA
CCCCCCCCCEECCCCCCCHHHHEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHCCCC
EGAPPPVDLAHEKRVGDFVRGVIRSGTVTAAHDCSDGGLAVALAEMAMASGIGARIDAPV
CCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEECCCC
NSASAAFFGEDQGRYVLTAALAREDAQLATLIEDARKAGVSLIAIGVTGGRELKLGEARA
CCCCEEEEECCCCCEEEEEEHHHCCHHHHHHHHHHHHCCEEEEEEEECCCCEEECCCCCC
ISVEELKEAHEGWFPRFMQDGSLQ
CCHHHHHHHHCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA