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The map label for this gene is rnd [H]

Identifier: 110633474

GI number: 110633474

Start: 1226020

End: 1227198

Strand: Reverse

Name: rnd [H]

Synonym: Meso_1121

Alternate gene names: 110633474

Gene position: 1227198-1226020 (Counterclockwise)

Preceding gene: 110633476

Following gene: 110633471

Centisome position: 27.81

GC content: 63.87

Gene sequence:

>1179_bases
ATGGACCTGATCAAATCGCGCTCAGAGCTGGAAAATGCGGTCGCCGCGCTCGAGAACTCCGATTTCGTCACTGTTGACAC
TGAGTTCATCCGCGAAACCACATTCTGGCCGGAGCTGTGCCTCATCCAAATGGCCGCCCCCGGTGTCACGGCGCTGGTGG
ATCCGCTAGCCGATGGAATGGATCTTGCCCCGTTCTTCCGTCTCATGGGGAACGAGCAGGTCGTCAAAGTTTTCCACGCC
GCGCGGCAGGATATCGAAATCATCTACAATCGCGGCGGCCTCATTCCCCACCCCATCTTCGACACGCAGGTTGCCGCAAT
GGTGTGCGGGTTCGGGGACAGCATCTCCTACGACCAACTCGTGCTCAGGATCACTGGCGAGCACATCGACAAGACGTCCC
GCTTCACCGATTGGCGGCACCGGCCCCTGTCGGAGAAACAGCTTCGCTACGCCCTGGCGGATGTCACGCATCTCATCCCT
GTTTATGCGCATCTGACAACCGAGCTCCAGCGCGGAGGGCGCGAGGGGTGGCTGAAGGAGGAGATGGATGTCCTGACGGC
GCGGGAGACCTATGACCCGCACCCGGACGACGCCTGGAAACGGCTCAAGATGCGCGCGCGCAAGCCCGTCGAACTGGCTA
TCCTCCAGCGCATCGCCGCCTGGCGCGAGCGCGAAGCACGTGAGCGCAACGTGCCGCGCGGCCGCATTATGAAGGACGAT
GCCCTCTACGAGGTGGCCCAGCAGCAGCCTCGGGACATCGCGGCCTTGAGTCGCCTTAGAGCGGTTCCCAGGGGCTGGGA
ACGTTCGGGCTCTGCAGCCGCCTTGCTCAAAGCGGTGAACGACGCGCTGGCGCTGCCGAAGGAGGCACTGCCAAAACTGC
CGAGGCCGCATCACGCGCCGGAGGGAGCAGCGGCCGCGGCGGAGCTCATCAAGGTGCTGCTCAAGCTCGTGGCGGAGAAG
GAAGGCGTGGCTCCCAAAATGCTCGCTTCCACCGACGACATCGAAAAGATCGCGGCTGAAGGCGAGAAGGCCCAGGTTCC
GGCGCTTCATGGCTGGCGCCGCGAGGTTTTCGGCGAAGAGGCGCTCAAGCTCCTGCGCGGGGAGATCGCACTGCGCTTCG
CCAACCGTCGCATTGAAACCTTCGCGCCCGCGGACCAGATGCGCAGCGCGGCGGAATAG

Upstream 100 bases:

>100_bases
GTCAAGGCGCAGAAGCCATTCTCCGCCACATCTGGCAGACGAGGCAAGAAAGCTGTAGGGAATTCTTCACATTTGCGCCG
CCAGCGCCTAAAGAAGATGC

Downstream 100 bases:

>100_bases
CTAGTCTTTCGCCACCTTCAGCACGAGGCTCTTGCCCGTGAGCTTGGCCAGCTGCGCCATGCGGCCTTGCGGTCGTTCGC
CCATCAGGCTGGCACAGTCC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDLIKSRSELENAVAALENSDFVTVDTEFIRETTFWPELCLIQMAAPGVTALVDPLADGMDLAPFFRLMGNEQVVKVFHA
ARQDIEIIYNRGGLIPHPIFDTQVAAMVCGFGDSISYDQLVLRITGEHIDKTSRFTDWRHRPLSEKQLRYALADVTHLIP
VYAHLTTELQRGGREGWLKEEMDVLTARETYDPHPDDAWKRLKMRARKPVELAILQRIAAWREREARERNVPRGRIMKDD
ALYEVAQQQPRDIAALSRLRAVPRGWERSGSAAALLKAVNDALALPKEALPKLPRPHHAPEGAAAAAELIKVLLKLVAEK
EGVAPKMLASTDDIEKIAAEGEKAQVPALHGWRREVFGEEALKLLRGEIALRFANRRIETFAPADQMRSAAE

Sequences:

>Translated_392_residues
MDLIKSRSELENAVAALENSDFVTVDTEFIRETTFWPELCLIQMAAPGVTALVDPLADGMDLAPFFRLMGNEQVVKVFHA
ARQDIEIIYNRGGLIPHPIFDTQVAAMVCGFGDSISYDQLVLRITGEHIDKTSRFTDWRHRPLSEKQLRYALADVTHLIP
VYAHLTTELQRGGREGWLKEEMDVLTARETYDPHPDDAWKRLKMRARKPVELAILQRIAAWREREARERNVPRGRIMKDD
ALYEVAQQQPRDIAALSRLRAVPRGWERSGSAAALLKAVNDALALPKEALPKLPRPHHAPEGAAAAAELIKVLLKLVAEK
EGVAPKMLASTDDIEKIAAEGEKAQVPALHGWRREVFGEEALKLLRGEIALRFANRRIETFAPADQMRSAAE
>Mature_392_residues
MDLIKSRSELENAVAALENSDFVTVDTEFIRETTFWPELCLIQMAAPGVTALVDPLADGMDLAPFFRLMGNEQVVKVFHA
ARQDIEIIYNRGGLIPHPIFDTQVAAMVCGFGDSISYDQLVLRITGEHIDKTSRFTDWRHRPLSEKQLRYALADVTHLIP
VYAHLTTELQRGGREGWLKEEMDVLTARETYDPHPDDAWKRLKMRARKPVELAILQRIAAWREREARERNVPRGRIMKDD
ALYEVAQQQPRDIAALSRLRAVPRGWERSGSAAALLKAVNDALALPKEALPKLPRPHHAPEGAAAAAELIKVLLKLVAEK
EGVAPKMLASTDDIEKIAAEGEKAQVPALHGWRREVFGEEALKLLRGEIALRFANRRIETFAPADQMRSAAE

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=260, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4505917, Length=260, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788105, Length=376, Percent_Identity=31.9148936170213, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17531757, Length=269, Percent_Identity=23.4200743494424, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=273, Percent_Identity=27.4725274725275, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161078302, Length=264, Percent_Identity=25.7575757575758, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 44047; Mature: 44047

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLIKSRSELENAVAALENSDFVTVDTEFIRETTFWPELCLIQMAAPGVTALVDPLADGM
CCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCC
DLAPFFRLMGNEQVVKVFHAARQDIEIIYNRGGLIPHPIFDTQVAAMVCGFGDSISYDQL
CHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHH
VLRITGEHIDKTSRFTDWRHRPLSEKQLRYALADVTHLIPVYAHLTTELQRGGREGWLKE
HEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
EMDVLTARETYDPHPDDAWKRLKMRARKPVELAILQRIAAWREREARERNVPRGRIMKDD
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ALYEVAQQQPRDIAALSRLRAVPRGWERSGSAAALLKAVNDALALPKEALPKLPRPHHAP
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
EGAAAAAELIKVLLKLVAEKEGVAPKMLASTDDIEKIAAEGEKAQVPALHGWRREVFGEE
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ALKLLRGEIALRFANRRIETFAPADQMRSAAE
HHHHHHHHHHHHHHHCHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MDLIKSRSELENAVAALENSDFVTVDTEFIRETTFWPELCLIQMAAPGVTALVDPLADGM
CCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCC
DLAPFFRLMGNEQVVKVFHAARQDIEIIYNRGGLIPHPIFDTQVAAMVCGFGDSISYDQL
CHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHH
VLRITGEHIDKTSRFTDWRHRPLSEKQLRYALADVTHLIPVYAHLTTELQRGGREGWLKE
HEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
EMDVLTARETYDPHPDDAWKRLKMRARKPVELAILQRIAAWREREARERNVPRGRIMKDD
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ALYEVAQQQPRDIAALSRLRAVPRGWERSGSAAALLKAVNDALALPKEALPKLPRPHHAP
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
EGAAAAAELIKVLLKLVAEKEGVAPKMLASTDDIEKIAAEGEKAQVPALHGWRREVFGEE
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ALKLLRGEIALRFANRRIETFAPADQMRSAAE
HHHHHHHHHHHHHHHCHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]