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The map label for this gene is mdh [H]

Identifier: 110633419

GI number: 110633419

Start: 1169569

End: 1170696

Strand: Direct

Name: mdh [H]

Synonym: Meso_1065

Alternate gene names: 110633419

Gene position: 1169569-1170696 (Clockwise)

Preceding gene: 110633408

Following gene: 110633420

Centisome position: 26.51

GC content: 62.85

Gene sequence:

>1128_bases
ATGGCGTGCCCTTATCCTCAACACCGCCGGCAGATCGAAACCATTCTCCTGGCCTGGGGGATGCCCGAAGCCCAGGCCGC
GCGCACCGCCGATATTCTTGGCTGGGCCGATCTCCACGGCGTTGAAAGTCACGGCATCTCCATGCTGGTGGAATATGACA
TGCGCTTTCGGGCTGGCCGCCTGAAGATGAATGCCGATTTCAAGGTGGTCCGCGAAACGCCGGTTTCGGTCCTGATCGAC
GGCGATGGCGGTATGGGGCACATTGCCTATGCAATGGCAGCCGACGCAGCGATAGAGAAAGCGAAGGCGAGCGGCATCGC
CGTGGCTTCGGTACGCAATTCCTCGCATTTCGGCGCCGTCGGCTATTTCACCGAGCTTGCGGCCCGCGCGGGCCTGATCG
CCATGGGCGCGACGAGCGCAGCCGGCATCCGCGTGGCGCCGACCAATGGCGCGGAAGCGAAGCTGGGCACGGATCCGCTG
TCCTTTGCCGCGCCAAGCACCGACGAGAACCCTTTTCTGCTCGATATGGCGACTACCACTGTCGCCTATGGCAAGATTCG
TAATAAGATGAACGAAAACGCTTCGATGCCGATCGGTTGGGGCACGGATAGCAATGGCGAGCCCACCACGGACCCCCTCG
ATGTGACGCGGCGTGGCGGCTTCATGTCCCCGCTCGGCGGCACGCCGGAAGGCGCGAGTTACAAGGGGTATGGTCTTTCT
GTGATGGTCAATATCCTGTCCTCCTGCCTCTCGGGCTCAACCCTTATTACGGACCCGATGCACACGAAGAAGCCGAAGGG
TTTCGACATTGGCCACTTCTACCTTGCGCTCGATCCGAAGCTTTTCCGGGATGCCGGCGAATTCGAAACCGATGTCGGCA
CGTTCTGCGCCGCCCTGCGCAACACCAAGCCGGTGGAGGAGGGAACGCCGGTCATGGTTGCCGGCGACCCGCAATGGAAA
ATGGCGGAGGAGCGGCTGCGCGAAGGTGTCCCGATAGGCAAGGGCCTGCGCGCGAAGCTTATCGCGGTGGCTGAGGCAGC
GGGCGTGGAATGGCTGCTCGACGGCGCCGATGACGGCCCGAGCGGGCTGGCACCGGCGGGCAAACTGGAGCTTGCACGCT
CAAAATGA

Upstream 100 bases:

>100_bases
CTGACCGGAAAGGCGAAACAGCGCTCGGGGCGGGCTTTGCCATTCAGCGCGGCCCGTTCCCAATCTTCCCGCGCTGGATA
ATTGGAAGGAGTCGAGGCTG

Downstream 100 bases:

>100_bases
GTGACGGGCCGCCATGCGGCGGCCGAAGTGAAAATCGTTCCCGTTGGGAACAGTCGGACCGCCCGGCAAAACAGGCGGAG
CGTTCAGGGAGGAAGAATGC

Product: malate/L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGRLKMNADFKVVRETPVSVLID
GDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAVGYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPL
SFAAPSTDENPFLLDMATTTVAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLS
VMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALRNTKPVEEGTPVMVAGDPQWK
MAEERLREGVPIGKGLRAKLIAVAEAAGVEWLLDGADDGPSGLAPAGKLELARSK

Sequences:

>Translated_375_residues
MACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGRLKMNADFKVVRETPVSVLID
GDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAVGYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPL
SFAAPSTDENPFLLDMATTTVAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLS
VMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALRNTKPVEEGTPVMVAGDPQWK
MAEERLREGVPIGKGLRAKLIAVAEAAGVEWLLDGADDGPSGLAPAGKLELARSK
>Mature_374_residues
ACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGRLKMNADFKVVRETPVSVLIDG
DGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAVGYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPLS
FAAPSTDENPFLLDMATTTVAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLSV
MVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALRNTKPVEEGTPVMVAGDPQWKM
AEERLREGVPIGKGLRAKLIAVAEAAGVEWLLDGADDGPSGLAPAGKLELARSK

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=325, Percent_Identity=32.9230769230769, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786727, Length=333, Percent_Identity=30.9309309309309, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790000, Length=344, Percent_Identity=21.2209302325581, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17507179, Length=297, Percent_Identity=34.6801346801347, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17536633, Length=334, Percent_Identity=32.0359281437126, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24667908, Length=317, Percent_Identity=36.9085173501577, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI45553211, Length=317, Percent_Identity=36.9085173501577, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24667912, Length=317, Percent_Identity=36.9085173501577, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24667904, Length=317, Percent_Identity=36.9085173501577, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24658010, Length=309, Percent_Identity=27.5080906148867, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648360, Length=329, Percent_Identity=27.355623100304, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 39573; Mature: 39441

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGR
CCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCEECCE
LKMNADFKVVRETPVSVLIDGDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAV
EEECCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
GYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPLSFAAPSTDENPFLLDMATTT
HHHHHHHHHCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHH
VAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLS
HHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHH
VMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALR
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEECHHHHHCCCCCHHHHHHHHHHHH
NTKPVEEGTPVMVAGDPQWKMAEERLREGVPIGKGLRAKLIAVAEAAGVEWLLDGADDGP
CCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCHHHEEEHHHHCCCEEEEECCCCCC
SGLAPAGKLELARSK
CCCCCCCCEEECCCC
>Mature Secondary Structure 
ACPYPQHRRQIETILLAWGMPEAQAARTADILGWADLHGVESHGISMLVEYDMRFRAGR
CCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCEECCE
LKMNADFKVVRETPVSVLIDGDGGMGHIAYAMAADAAIEKAKASGIAVASVRNSSHFGAV
EEECCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
GYFTELAARAGLIAMGATSAAGIRVAPTNGAEAKLGTDPLSFAAPSTDENPFLLDMATTT
HHHHHHHHHCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHH
VAYGKIRNKMNENASMPIGWGTDSNGEPTTDPLDVTRRGGFMSPLGGTPEGASYKGYGLS
HHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHH
VMVNILSSCLSGSTLITDPMHTKKPKGFDIGHFYLALDPKLFRDAGEFETDVGTFCAALR
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEECHHHHHCCCCCHHHHHHHHHHHH
NTKPVEEGTPVMVAGDPQWKMAEERLREGVPIGKGLRAKLIAVAEAAGVEWLLDGADDGP
CCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCHHHEEEHHHHCCCEEEEECCCCCC
SGLAPAGKLELARSK
CCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]