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The map label for this gene is gcvT [H]

Identifier: 110633372

GI number: 110633372

Start: 1117642

End: 1118736

Strand: Reverse

Name: gcvT [H]

Synonym: Meso_1018

Alternate gene names: 110633372

Gene position: 1118736-1117642 (Counterclockwise)

Preceding gene: 110633373

Following gene: 110633371

Centisome position: 25.35

GC content: 62.47

Gene sequence:

>1095_bases
ATGAGCGACCTGAAACATCTTCCCCTTGAATCCTTGCATGAGGAAGCCGGCGCGCGCTTCGGCGCCTTTGCCGGCTGGCG
CATGCCGCTTACCTATCCCGCCGGCGTGATGAAGGAGCATCTTCACACCCGCGAGAAGGCGGGCCTTTTCGACATTTCCC
ACATGCAGCTCTTTACCATAGAGGGCGCGAATACCGCAGCCTTCCTTTCGCGCGCCTGCCCGCTCGACGCGGCGGCGCTC
GAGGCCGGCAAGTCGAAATACACCGTGCTGCTCAACGAAAAGGCGGGCATCATTGACGATCTGATCGTCACCCGCCTTGG
GAGCGACCGCTTTATGGTCGTCGCCAATGCCGGCAATGCTGCAAAGGATGAAGCGCATTTCCGCTTCGTTGCACGCGATT
TTGACGTAAAAATCGATGCTTTAGACCGCGTTTTCCTGGCTTTGCAGGGTCCGGAAGCTGAAAGCATTCTGCTGGGCGCG
GGCCTCGATCTTGCCGATCTTTCCTTCATGACCGCCGCCGAGCCGCGAGAGAACTGGTTCGCCGCGCGCTCGGGCTATAC
CGGCGAAGACGGCTTCGAAGTCGCGCTTCCAGAGGAGGAAGCGCGGAGATTTGCGGAGAAAATTCTCGCCGACGAGCGAG
TTATATGGATCGGGCTCGCCGCACGCGACAGCCTGCGGCTTGAAGCAGGGCTCTGCCTGCACGGGCAGGACCTTGACGAG
ACGATCGACCCGGCGAGCGCCGCAATCCTCTGGGCGATCCCGAAAAAAATACGCGAGAGCGGAGATTTCATCGGTGCGGA
AGCCTTGCGGCGTACTATCGCCGAAGGCCCCGTGCGAGTGCGCGTCGGCCTCAAGCCCGATGGACGCCAGCCCGTCCGCA
CGGGCGCCCTGCTTCTGAATGAGGAGGGCCAGACGGTTGGCAAGGTCACGTCCGGCGGCTTTGGTCCTTCTGTCGGCCAC
CCGATCGCCATGGGCTTTGTCGCGCCCGGCTATCGCGAGCCGGGAACCATGCTCGTGGCGGAGGTGCGCGGAAACCGCCT
GCCGATTGCCGTTCACCCCCTGCCCTTCACGCCCCATCGCTATCGCAAAGGATAA

Upstream 100 bases:

>100_bases
AGCGTGGCCGACAGGGTTCCGGCGCGCGAGTCTCTCAGGCTTCAGACAGAGGGGCACGGACACGTTGCGAAGGCAGCGTG
CGTGCATCTTTGGAGGCTTG

Downstream 100 bases:

>100_bases
AAAGAATGAGCAAGACCTATTTCACAGAAGACCACGAGTGGATCCGCGTCGAAGGAGAGACGGCGACCGTGGGCATCACC
GATTATGCCCAGGAGCAACT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSDLKHLPLESLHEEAGARFGAFAGWRMPLTYPAGVMKEHLHTREKAGLFDISHMQLFTIEGANTAAFLSRACPLDAAAL
EAGKSKYTVLLNEKAGIIDDLIVTRLGSDRFMVVANAGNAAKDEAHFRFVARDFDVKIDALDRVFLALQGPEAESILLGA
GLDLADLSFMTAAEPRENWFAARSGYTGEDGFEVALPEEEARRFAEKILADERVIWIGLAARDSLRLEAGLCLHGQDLDE
TIDPASAAILWAIPKKIRESGDFIGAEALRRTIAEGPVRVRVGLKPDGRQPVRTGALLLNEEGQTVGKVTSGGFGPSVGH
PIAMGFVAPGYREPGTMLVAEVRGNRLPIAVHPLPFTPHRYRKG

Sequences:

>Translated_364_residues
MSDLKHLPLESLHEEAGARFGAFAGWRMPLTYPAGVMKEHLHTREKAGLFDISHMQLFTIEGANTAAFLSRACPLDAAAL
EAGKSKYTVLLNEKAGIIDDLIVTRLGSDRFMVVANAGNAAKDEAHFRFVARDFDVKIDALDRVFLALQGPEAESILLGA
GLDLADLSFMTAAEPRENWFAARSGYTGEDGFEVALPEEEARRFAEKILADERVIWIGLAARDSLRLEAGLCLHGQDLDE
TIDPASAAILWAIPKKIRESGDFIGAEALRRTIAEGPVRVRVGLKPDGRQPVRTGALLLNEEGQTVGKVTSGGFGPSVGH
PIAMGFVAPGYREPGTMLVAEVRGNRLPIAVHPLPFTPHRYRKG
>Mature_363_residues
SDLKHLPLESLHEEAGARFGAFAGWRMPLTYPAGVMKEHLHTREKAGLFDISHMQLFTIEGANTAAFLSRACPLDAAALE
AGKSKYTVLLNEKAGIIDDLIVTRLGSDRFMVVANAGNAAKDEAHFRFVARDFDVKIDALDRVFLALQGPEAESILLGAG
LDLADLSFMTAAEPRENWFAARSGYTGEDGFEVALPEEEARRFAEKILADERVIWIGLAARDSLRLEAGLCLHGQDLDET
IDPASAAILWAIPKKIRESGDFIGAEALRRTIAEGPVRVRVGLKPDGRQPVRTGALLLNEEGQTVGKVTSGGFGPSVGHP
IAMGFVAPGYREPGTMLVAEVRGNRLPIAVHPLPFTPHRYRKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=39.945652173913, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI257796258, Length=349, Percent_Identity=40.1146131805158, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI257796254, Length=363, Percent_Identity=35.8126721763085, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI257796256, Length=296, Percent_Identity=41.2162162162162, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI24797151, Length=388, Percent_Identity=24.4845360824742, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI197927446, Length=318, Percent_Identity=25.7861635220126, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI21361378, Length=318, Percent_Identity=25.7861635220126, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789272, Length=360, Percent_Identity=35.5555555555556, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=36.0742705570292, Blast_Score=214, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=38.1074168797954, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI20129441, Length=371, Percent_Identity=36.9272237196765, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39484; Mature: 39352

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLKHLPLESLHEEAGARFGAFAGWRMPLTYPAGVMKEHLHTREKAGLFDISHMQLFTI
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCEEEEEE
EGANTAAFLSRACPLDAAALEAGKSKYTVLLNEKAGIIDDLIVTRLGSDRFMVVANAGNA
ECCCHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCC
AKDEAHFRFVARDFDVKIDALDRVFLALQGPEAESILLGAGLDLADLSFMTAAEPRENWF
CCCCCEEEEEEECCCEEEHHHCEEEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCHHEE
AARSGYTGEDGFEVALPEEEARRFAEKILADERVIWIGLAARDSLRLEAGLCLHGQDLDE
EECCCCCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCEEECCCCCHH
TIDPASAAILWAIPKKIRESGDFIGAEALRRTIAEGPVRVRVGLKPDGRQPVRTGALLLN
HCCCHHHEEEEHHHHHHHHCCCEECHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEC
EEGQTVGKVTSGGFGPSVGHPIAMGFVAPGYREPGTMLVAEVRGNRLPIAVHPLPFTPHR
CCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEECCCCCCCC
YRKG
CCCC
>Mature Secondary Structure 
SDLKHLPLESLHEEAGARFGAFAGWRMPLTYPAGVMKEHLHTREKAGLFDISHMQLFTI
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCEEEEEE
EGANTAAFLSRACPLDAAALEAGKSKYTVLLNEKAGIIDDLIVTRLGSDRFMVVANAGNA
ECCCHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCC
AKDEAHFRFVARDFDVKIDALDRVFLALQGPEAESILLGAGLDLADLSFMTAAEPRENWF
CCCCCEEEEEEECCCEEEHHHCEEEEEECCCCCCEEEEECCCCHHHHHHHHCCCCCHHEE
AARSGYTGEDGFEVALPEEEARRFAEKILADERVIWIGLAARDSLRLEAGLCLHGQDLDE
EECCCCCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCEEECCCCCHH
TIDPASAAILWAIPKKIRESGDFIGAEALRRTIAEGPVRVRVGLKPDGRQPVRTGALLLN
HCCCHHHEEEEHHHHHHHHCCCEECHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEC
EEGQTVGKVTSGGFGPSVGHPIAMGFVAPGYREPGTMLVAEVRGNRLPIAVHPLPFTPHR
CCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCEEEECCCCCCCC
YRKG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA