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The map label for this gene is hisI

Identifier: 110633357

GI number: 110633357

Start: 1101316

End: 1101735

Strand: Reverse

Name: hisI

Synonym: Meso_1003

Alternate gene names: 110633357

Gene position: 1101735-1101316 (Counterclockwise)

Preceding gene: 110633358

Following gene: 110633356

Centisome position: 24.97

GC content: 60.71

Gene sequence:

>420_bases
ATGCAAGCCTCGGAACTTCGCTTCGCGCCTCCCTCAGCCGACAAAAGCGCGCTGGAGGAAGGCAGGCTTTTTACGCCGCG
CTTCGATGCGAACGGCCTTATCACGGCGGTTGTCACCGACGCCGGGGACGGCACGCTCCTCATGGTGGCGCATATGAACG
CCGAGGCGCTGGCGAAGACACTAGAAACGGGCATCGCCCATTACTGGTCGCGTTCCCGCTCAAGCCTCTGGAAGAAGGGG
GAAACCTCCGGCAACCTGCAGCATGTGGAGTCGATCAGCACCGACTGCGATCAGGATGCTGTTCTTCTCAAGGTGCGCGT
CGGGGGCGAGGGTGCAACTTGTCATACCGGCCGACGTTCCTGCTTCTATAGGAACGTGAAAGTTGAGGACGGCCGCCCAA
TTCTGACCGAAAACGGGTGA

Upstream 100 bases:

>100_bases
CAGCACGCTTACGACAACATTTACCGGAGCCTTCAAGACGCGACCTGAAGACCAGGCGCGCTTTATCACCATGGTCCGCG
ATTCGCGCAGCGGTTAAGCC

Downstream 100 bases:

>100_bases
AATTCTCGCTTTCGGGTGAGCGGAGTCACCAATTCGGATCTTTGCCGTCCCGGATTCATGAATTTATTACGGTCCCTTGG
CATTGTTGCCTGGGGCGTAG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MQASELRFAPPSADKSALEEGRLFTPRFDANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKG
ETSGNLQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRNVKVEDGRPILTENG

Sequences:

>Translated_139_residues
MQASELRFAPPSADKSALEEGRLFTPRFDANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKG
ETSGNLQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRNVKVEDGRPILTENG
>Mature_139_residues
MQASELRFAPPSADKSALEEGRLFTPRFDANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKG
ETSGNLQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRNVKVEDGRPILTENG

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=48.9130434782609, Blast_Score=91, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=102, Percent_Identity=42.156862745098, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_MESSB (Q11JM5)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673565.1
- ProteinModelPortal:   Q11JM5
- SMR:   Q11JM5
- STRING:   Q11JM5
- GeneID:   4181688
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1003
- NMPDR:   fig|266779.1.peg.3974
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- BioCyc:   MSP266779:MESO_1003-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15066; Mature: 15066

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASELRFAPPSADKSALEEGRLFTPRFDANGLITAVVTDAGDGTLLMVAHMNAEALAKT
CCCCCCEECCCCCCHHHHHCCCEECCCCCCCCEEEEEEECCCCCEEEEEEECCHHHHHHH
LETGIAHYWSRSRSSLWKKGETSGNLQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCEEECCCCC
CFYRNVKVEDGRPILTENG
EEEECEEECCCCEEEECCC
>Mature Secondary Structure
MQASELRFAPPSADKSALEEGRLFTPRFDANGLITAVVTDAGDGTLLMVAHMNAEALAKT
CCCCCCEECCCCCCHHHHHCCCEECCCCCCCCEEEEEEECCCCCEEEEEEECCHHHHHHH
LETGIAHYWSRSRSSLWKKGETSGNLQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCEEECCCCC
CFYRNVKVEDGRPILTENG
EEEECEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA