Click here to switch to the map view.

The map label for this gene is rsh [H]

Identifier: 110633300

GI number: 110633300

Start: 1042957

End: 1045194

Strand: Direct

Name: rsh [H]

Synonym: Meso_0946

Alternate gene names: 110633300

Gene position: 1042957-1045194 (Clockwise)

Preceding gene: 110633299

Following gene: 110633301

Centisome position: 23.64

GC content: 59.74

Gene sequence:

>2238_bases
ATGATGCGTCAGTACGAGCTTGTCGAGCGTGTACAACGCTACAAGCCTGACGTGAACGAGGCGCTTTTGAACAAGGCCTA
TGTCTACGCCATGCAGAAGCATGGTCATCAAAAGCGTGCTTCGGGCGATCCCTATTTTTCCCATCCGCTCGAAGTGGCCG
CTATCCTGACCGACATGCACCTGGACGAGGCCACGATCGCCGTTGCCCTGCTGCACGACACGATCGAGGATACGTCCGCC
ACGCGCGATGAAATCGACGAGCTCTTCGGCTCCGAGATCGGAAAGCTGGTCGAGGGGTTGACCAAGCTGAAGAAGCTGGA
CCTGGTTTCCTCCAGGGCCGAGCAGGCGGAGAACCTGCGCAAGCTGCTCCTGGCCATATCCGAGGATGTCCGCGTACTTC
TCGTGAAGCTTGCCGACCGGCTGCACAATATGCGCACGCTCGATCACATGCCGTCTCATAAGCGCCTGAGGATCGCCGAA
GAGACCATGGAGATCTATGCACCGCTGGCCGGCCGCATGGGCATGCAGGACATGCGCGAGGAGCTGGAGGAACTGGCCTT
CCGCTACATAAATCCCGAGGCCTATCATGCCGTGACCGAGCGCCTTGCCGATCTGACGGAGCGGAACCGCGGCGTCATCG
GCGAGATCGAACAGGCGCTCCAGCATCTGTTCGAGAATTATAAGATAAATGCGGCAGTGAAGAGCCGGCAGAAAAAGCCG
TGGTCCGTTTTCCGCAAAATGGAGGCAAAGGCGCTCTCTTTCGAGCAATTGTCGGATATCTTCGGCTTTCGCGTGATCGT
AGAAACCGTTGAGGATTGCTACCGCGCCCTTGGCGCCATTCACACCACATGGTCGCTCGTTCCGGGCCGCTTCAAGGACT
ATATCTCGACCCCGAAGCAGAACGACTACCGCTCCATCCACACGACGATCGTCGGTCCCTCGCGCCAGCGCGTGGAGCTG
CAGATCCGCACGCGGGAGATGGACCGGATCGCCGAATATGGCGTGGCGGCACATTCGCTCTACAAGGATTTCGGTCCCAA
GCTGAACGGCACCGGTCACCAGATCTCCAAGGACACCAACGCTTATGCATGGCTGCGTCATACGATCGAGCAGCTTTCCG
AGGGCGACAATCCTGAAGAGTTCCTGGAAAACACAAAGCTCGAGCTTTTCCAGGATCAGGTCTTCTGCTTCACGCCCAAG
GGACGGTTGATCGCGCTGCCGCGCGGGGCCACGCCCATCGACTTTGCCTATGCCGTCCATACGGATGTCGGCGATACCTG
CGTGGGCGCCAAGGTCAACGGCCGCATCATGCCTTTGATGACTGAATTGAAGAACGGCGACGAGGTGGAGATCATCCGCT
CCAAGGCACAGGTGCCGCCCGCCGCCTGGGAATCGGTCGTGGTCACGGGCAAGGCGCGATCGGCCATCCGTCGCGCCACG
AGAAACGCCATCCGCAGACAATATTCAGGGCTCGGCGCGCGCATTCTCGAACGTGCCTTCGAACGGGCGGGCAAGGTCTT
CAACAAGGATCTGTTGAAGCCGGTGATGCATCGCCTTGCCCGAAAGGACGTTGAGGACGTGCTGGCTGCCGTCGGCCGCG
GCGAGATAACGTCACAGGACGTGCTGCGCGCCGTCTTCCCCGATTACAAGGATGAGCGCGTAACGGTGCAATATCCCAAG
CGGCGGGAAGAGGGCTGGTTCAACCTGCGCAACGCGGCGGGCATGCTTTTCAAGATTCCCGGACGTGCATCCCGCCGGAA
GGGAAAGGAAGCAGTGTCCAGCGAGAATGGGGCGATTCCCATCCGCGGCGTTTCCGGCGACCTTCCGGTGCGCTTCGCGC
CCGAAGGGGCGGTGCCGGGAGATCGCATTGTAGGCATCCTCTCACCGGGAGCCGGCATTACGATCTATCCGATCCAGTCG
CCATCGCTGACGGCCTTCGACGATCAGCCGGAGCGTTGGATCGACGTTCGCTGGGACATCGACGAAAACATGAAAGAGCG
GTTTCCGGCGCGCATCCGGGTGACCGCCATCAACGAACCCGGCTCACTTGCCACCATCGCCCAGGTGATGGCCTCCAATG
ATGCGAATATCCACACCCTTTCGATGCAGCATACCGCCCCCGATTTCACCGAAATGGTGTTTGATATCGAGGTCTGGGAC
CTGAAGCATCTCAACCGTTTGATTTCACAGCTAAGGGAAACGAGCTGCGTGGGCAATGTCCACCGGGTGAACGGATAG

Upstream 100 bases:

>100_bases
TATAGGCTGCATTGCATTGGCCCTAGAAGCACGATGCGTGGGTTCAATTATTTACAGCGTCCGTCCTAATGAACGCATGG
CGTTGTAGGAGAAGCCGCCC

Downstream 100 bases:

>100_bases
ACGTCATTACCCGCCCTGCAACCTCCATATTTGTGTAGAGAGACAAACCGGGGTTTGCTGTTGCCGGTTTGCGGCGGCGC
GGTCGAGGCTTACATAGTGA

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTDMHLDEATIAVALLHDTIEDTSA
TRDEIDELFGSEIGKLVEGLTKLKKLDLVSSRAEQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLDHMPSHKRLRIAE
ETMEIYAPLAGRMGMQDMREELEELAFRYINPEAYHAVTERLADLTERNRGVIGEIEQALQHLFENYKINAAVKSRQKKP
WSVFRKMEAKALSFEQLSDIFGFRVIVETVEDCYRALGAIHTTWSLVPGRFKDYISTPKQNDYRSIHTTIVGPSRQRVEL
QIRTREMDRIAEYGVAAHSLYKDFGPKLNGTGHQISKDTNAYAWLRHTIEQLSEGDNPEEFLENTKLELFQDQVFCFTPK
GRLIALPRGATPIDFAYAVHTDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARSAIRRAT
RNAIRRQYSGLGARILERAFERAGKVFNKDLLKPVMHRLARKDVEDVLAAVGRGEITSQDVLRAVFPDYKDERVTVQYPK
RREEGWFNLRNAAGMLFKIPGRASRRKGKEAVSSENGAIPIRGVSGDLPVRFAPEGAVPGDRIVGILSPGAGITIYPIQS
PSLTAFDDQPERWIDVRWDIDENMKERFPARIRVTAINEPGSLATIAQVMASNDANIHTLSMQHTAPDFTEMVFDIEVWD
LKHLNRLISQLRETSCVGNVHRVNG

Sequences:

>Translated_745_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTDMHLDEATIAVALLHDTIEDTSA
TRDEIDELFGSEIGKLVEGLTKLKKLDLVSSRAEQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLDHMPSHKRLRIAE
ETMEIYAPLAGRMGMQDMREELEELAFRYINPEAYHAVTERLADLTERNRGVIGEIEQALQHLFENYKINAAVKSRQKKP
WSVFRKMEAKALSFEQLSDIFGFRVIVETVEDCYRALGAIHTTWSLVPGRFKDYISTPKQNDYRSIHTTIVGPSRQRVEL
QIRTREMDRIAEYGVAAHSLYKDFGPKLNGTGHQISKDTNAYAWLRHTIEQLSEGDNPEEFLENTKLELFQDQVFCFTPK
GRLIALPRGATPIDFAYAVHTDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARSAIRRAT
RNAIRRQYSGLGARILERAFERAGKVFNKDLLKPVMHRLARKDVEDVLAAVGRGEITSQDVLRAVFPDYKDERVTVQYPK
RREEGWFNLRNAAGMLFKIPGRASRRKGKEAVSSENGAIPIRGVSGDLPVRFAPEGAVPGDRIVGILSPGAGITIYPIQS
PSLTAFDDQPERWIDVRWDIDENMKERFPARIRVTAINEPGSLATIAQVMASNDANIHTLSMQHTAPDFTEMVFDIEVWD
LKHLNRLISQLRETSCVGNVHRVNG
>Mature_745_residues
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTDMHLDEATIAVALLHDTIEDTSA
TRDEIDELFGSEIGKLVEGLTKLKKLDLVSSRAEQAENLRKLLLAISEDVRVLLVKLADRLHNMRTLDHMPSHKRLRIAE
ETMEIYAPLAGRMGMQDMREELEELAFRYINPEAYHAVTERLADLTERNRGVIGEIEQALQHLFENYKINAAVKSRQKKP
WSVFRKMEAKALSFEQLSDIFGFRVIVETVEDCYRALGAIHTTWSLVPGRFKDYISTPKQNDYRSIHTTIVGPSRQRVEL
QIRTREMDRIAEYGVAAHSLYKDFGPKLNGTGHQISKDTNAYAWLRHTIEQLSEGDNPEEFLENTKLELFQDQVFCFTPK
GRLIALPRGATPIDFAYAVHTDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARSAIRRAT
RNAIRRQYSGLGARILERAFERAGKVFNKDLLKPVMHRLARKDVEDVLAAVGRGEITSQDVLRAVFPDYKDERVTVQYPK
RREEGWFNLRNAAGMLFKIPGRASRRKGKEAVSSENGAIPIRGVSGDLPVRFAPEGAVPGDRIVGILSPGAGITIYPIQS
PSLTAFDDQPERWIDVRWDIDENMKERFPARIRVTAINEPGSLATIAQVMASNDANIHTLSMQHTAPDFTEMVFDIEVWD
LKHLNRLISQLRETSCVGNVHRVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=132, Percent_Identity=39.3939393939394, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1790082, Length=728, Percent_Identity=36.1263736263736, Blast_Score=467, Evalue=1e-132,
Organism=Escherichia coli, GI1789147, Length=742, Percent_Identity=31.6711590296496, Blast_Score=357, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25143118, Length=130, Percent_Identity=38.4615384615385, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650996, Length=123, Percent_Identity=36.5853658536585, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84352; Mature: 84352

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTDMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
LDEATIAVALLHDTIEDTSATRDEIDELFGSEIGKLVEGLTKLKKLDLVSSRAEQAENLR
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISEDVRVLLVKLADRLHNMRTLDHMPSHKRLRIAEETMEIYAPLAGRMGMQDMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
ELEELAFRYINPEAYHAVTERLADLTERNRGVIGEIEQALQHLFENYKINAAVKSRQKKP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEHHHHHCCCCH
WSVFRKMEAKALSFEQLSDIFGFRVIVETVEDCYRALGAIHTTWSLVPGRFKDYISTPKQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NDYRSIHTTIVGPSRQRVELQIRTREMDRIAEYGVAAHSLYKDFGPKLNGTGHQISKDTN
CCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AYAWLRHTIEQLSEGDNPEEFLENTKLELFQDQVFCFTPKGRLIALPRGATPIDFAYAVH
HHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCEEEECCCCCEEEECCCCCCCEEEEEEE
TDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARSAIRRAT
CCCCCCEECCEECCEEEHHHHHCCCCCHHHHHHHHCCCCCHHHCCEEEECHHHHHHHHHH
RNAIRRQYSGLGARILERAFERAGKVFNKDLLKPVMHRLARKDVEDVLAAVGRGEITSQD
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHH
VLRAVFPDYKDERVTVQYPKRREEGWFNLRNAAGMLFKIPGRASRRKGKEAVSSENGAIP
HHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCEEEECCCCHHHHCCHHHHCCCCCCEE
IRGVSGDLPVRFAPEGAVPGDRIVGILSPGAGITIYPIQSPSLTAFDDQPERWIDVRWDI
EEECCCCCCEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEEEECC
DENMKERFPARIRVTAINEPGSLATIAQVMASNDANIHTLSMQHTAPDFTEMVFDIEVWD
CCCHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHEEEEHHHH
LKHLNRLISQLRETSCVGNVHRVNG
HHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MMRQYELVERVQRYKPDVNEALLNKAYVYAMQKHGHQKRASGDPYFSHPLEVAAILTDMH
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHC
LDEATIAVALLHDTIEDTSATRDEIDELFGSEIGKLVEGLTKLKKLDLVSSRAEQAENLR
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAISEDVRVLLVKLADRLHNMRTLDHMPSHKRLRIAEETMEIYAPLAGRMGMQDMRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
ELEELAFRYINPEAYHAVTERLADLTERNRGVIGEIEQALQHLFENYKINAAVKSRQKKP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEHHHHHCCCCH
WSVFRKMEAKALSFEQLSDIFGFRVIVETVEDCYRALGAIHTTWSLVPGRFKDYISTPKQ
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
NDYRSIHTTIVGPSRQRVELQIRTREMDRIAEYGVAAHSLYKDFGPKLNGTGHQISKDTN
CCCCEEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AYAWLRHTIEQLSEGDNPEEFLENTKLELFQDQVFCFTPKGRLIALPRGATPIDFAYAVH
HHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCEEEECCCCCEEEECCCCCCCEEEEEEE
TDVGDTCVGAKVNGRIMPLMTELKNGDEVEIIRSKAQVPPAAWESVVVTGKARSAIRRAT
CCCCCCEECCEECCEEEHHHHHCCCCCHHHHHHHHCCCCCHHHCCEEEECHHHHHHHHHH
RNAIRRQYSGLGARILERAFERAGKVFNKDLLKPVMHRLARKDVEDVLAAVGRGEITSQD
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHH
VLRAVFPDYKDERVTVQYPKRREEGWFNLRNAAGMLFKIPGRASRRKGKEAVSSENGAIP
HHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCEEEECCCCHHHHCCHHHHCCCCCCEE
IRGVSGDLPVRFAPEGAVPGDRIVGILSPGAGITIYPIQSPSLTAFDDQPERWIDVRWDI
EEECCCCCCEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEEEECC
DENMKERFPARIRVTAINEPGSLATIAQVMASNDANIHTLSMQHTAPDFTEMVFDIEVWD
CCCHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHEEEEHHHH
LKHLNRLISQLRETSCVGNVHRVNG
HHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA