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The map label for this gene is mrpA [H]

Identifier: 110633221

GI number: 110633221

Start: 959528

End: 961873

Strand: Direct

Name: mrpA [H]

Synonym: Meso_0864

Alternate gene names: 110633221

Gene position: 959528-961873 (Clockwise)

Preceding gene: 110633218

Following gene: 110633222

Centisome position: 21.75

GC content: 62.87

Gene sequence:

>2346_bases
ATGGCAGCAGACGGGCAATGGTTGACTTTCCTTGCTCTCATCCTGCCGTTTTTGGGAGCTGCTGCCGCTCCCCCCCTGGT
CCGTGCTTTCGGCCACAACGCCGCCTGGATACTGGCACTCGTCCCCGCATTCCTCTTTTATCACTTCGCTGGTTTTCTCG
GCATTATTGCCGGTGGTCAAGCGGTCAGCGGCGGCTATAGGTGGATCGAAAGCCTGAGCGTAGATTTCTCCTGGTATCTC
GACGGTCTGTCGCTCACTTTCGCGCTCCTGATCTCCGGCATCGGCACGCTGATCGTGCTCTATTCGGGCGGTTACCTGAA
GGACCACCCGCATCTGGGCCGCTTCTTCTCCTTCATCCTCATGTTCATGGGAGCGATGCAAGGCCTGGTCGTGGCCGACT
CCTTCCTGATGCTCTTCGTATTTTGGGAACTCACCTCGATCGCCTCTTTCCTGCTGATCGGCTTCGATCACCGGCGTGAG
GCGGCGCGGCGCGCCGCACTGCAGGCACTGATCGTAACTGGCGCGGGCGGGCTGGCGCTGCTTGCCGGTCTTCTGGTTAT
CACGCTGGCAACCGGCGCGAATTCGCTGTCGGCGCTGCTCCAGTCGGGGGATGCACTCCGGCAGGCGCCGCTCTATCTGA
CGGCGCTGCTTCTTGTCCTTGGTGGTGCCTTCACCAAGTCGGCGCAGTTCCCGCTGCATTTCTGGCTTCCCAACGCGATG
GAAGCGCCGACTCCTGTCTCCGCCTACCTGCATTCCGCGACCATGGTGAAGGCAGGCGTCTACCTCCTCATGCGGCTCAA
TCCCGTAATGGGCGATACGGTCCTTTGGGAAACGATCCTGCCCATCTTCGGCGGCACGACCCTGATCGTCGGCACGCTGC
TTGCGCTGCGGCAGACAGATTTAAAGCTCATGCTCGCCTACACGACCGTGGCCTCGCTCGGCCTGCTCGTGATGCTGACG
GGCTTCGGCTCGGAAATCGCCATTGAGGCTGCGGTGCTCTACCTCGTCGCGCATTCCATGTTCAAGGGCGCGCTCTTCAT
GGTGGCCGGCTCCGTCGACCACGAGACGGGGACGCGCGACATCACGAAGCTTGGCGGCATCGGCCGGGCCATGCCCATCA
CCTTCGCCGCCGCCGTGCTGGCTGCCCTGTCCATGGGCGGCCTGCCGCCGTTCTTCGGCTTTCTGGCGAAGGAGGAAATC
TATGCCGGCCTGGGCTTTGGCAGCAACTGGAGTACACTTGTCACGCTGGTGGCGCTTCTCGGAAACGCGCTGATGTTCGC
CATCGGCTTCGCCGTTGCGCTGAAACCCTTTACGGGACGCTTCATTGCCACGCCGAAAACCGCCCACGAGGGGCCGGTGC
TGCTGTGGCTCGGGCCGGTGGTGCTCGCGCTCTGCGGTTTGTTGACGGCGATCTTTTCGGAGATCAGCCACCGCTTCATC
TCAACTCCAATGGCGAGCGCGGTGGCGGGCGAGAGCGTCTCCGTCTCGATCTCGGTGATCCCGCATGTAGGGCTGCCGCT
GCTCCTGTCCCTCGCAACGATCGGGCTTGGCATCATTCTTTATCTGGCGATCGACAGGGGCCGCGCAGCGATGGCCTCGC
TTCTGGCCGCGATCGGCTGGGGGCCGGATCGGGGCTTCGATCAGTTCGTGCGTGGAGCGGTCCGCATCTCGGCGGCGATC
ACGGCCATCGTGCAGAACGGCCGCCTCGACATCTACATGACCGTCACATTCATCTTCCTGGCGGCGGCGCTTCTGGTGCC
GATGATCGGCTTTGGAGAACTGCCGGAGATGCCGGCTTTTGTCGCGATGCATTTCTATGAGGCGACGATCCTCGTCATCG
CGATCATCGGCCTTGCCGCGGTGGTTTACGCGAGGGACCGGCTGACGGCGATTGTCTCGCTCGGCATTCAGGGATTCGCC
GTGGCATTGCTCTTCATGCTGCTCGGCGCGCCGGACCTCTCCTTCACCCAGTTCATGGTCGAGACATTGTCGGTGGTCAT
CCTTGCGCTGGTGATGACGCGGCTCAGGCTTTCCCCCGCGGATCACCGGCCGCTCGGGCAGAAGACGCTCGATTTCTCCG
TCGCAAGCCTCTGCGGCGCGGCGCTCGGCCTTCTTCTCCTGCGCATCACGCAGGTGCCCTTCGACCCGGTGCTCAGCGAA
TTCTTCGCCGCCAATTCGCGTGTGATCGCGCACGGACGCAACATCGTGAACGTCATCATCGTGGATTTCCGCGGGCTCGA
TACGCTGGGCGAAATCGCTGTAGTGATGATCGCGGGCCTGGCAATCCTGGCGCTTGTCCGCATTCGCGCCGGCCGGCCAG
CCGATAAGCCAGTGAAGGAGGCTTAG

Upstream 100 bases:

>100_bases
CGCCTGCCTTGCCCGCACGGACATGAACGTCTATGTCACGACCACGTTTGGGGAGCGCGGCGACGCGCTTTCGGGGTAGG
ATCAAAGCTAAGGGGGACCG

Downstream 100 bases:

>100_bases
GCTTCAGATGCGCACGCTGATCTTCCGAACCACCGCGCCTTACCTGGCGAGCCTGATGGTGCTCTTCTCCATCTTTGTTC
TCCTGCGCGGCCACAATGAG

Product: putative monovalent cation/H+ antiporter subunit A

Products: NA

Alternate protein names: Mrp complex subunit A; Multiple resistance and pH homeostasis protein A [H]

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MAADGQWLTFLALILPFLGAAAAPPLVRAFGHNAAWILALVPAFLFYHFAGFLGIIAGGQAVSGGYRWIESLSVDFSWYL
DGLSLTFALLISGIGTLIVLYSGGYLKDHPHLGRFFSFILMFMGAMQGLVVADSFLMLFVFWELTSIASFLLIGFDHRRE
AARRAALQALIVTGAGGLALLAGLLVITLATGANSLSALLQSGDALRQAPLYLTALLLVLGGAFTKSAQFPLHFWLPNAM
EAPTPVSAYLHSATMVKAGVYLLMRLNPVMGDTVLWETILPIFGGTTLIVGTLLALRQTDLKLMLAYTTVASLGLLVMLT
GFGSEIAIEAAVLYLVAHSMFKGALFMVAGSVDHETGTRDITKLGGIGRAMPITFAAAVLAALSMGGLPPFFGFLAKEEI
YAGLGFGSNWSTLVTLVALLGNALMFAIGFAVALKPFTGRFIATPKTAHEGPVLLWLGPVVLALCGLLTAIFSEISHRFI
STPMASAVAGESVSVSISVIPHVGLPLLLSLATIGLGIILYLAIDRGRAAMASLLAAIGWGPDRGFDQFVRGAVRISAAI
TAIVQNGRLDIYMTVTFIFLAAALLVPMIGFGELPEMPAFVAMHFYEATILVIAIIGLAAVVYARDRLTAIVSLGIQGFA
VALLFMLLGAPDLSFTQFMVETLSVVILALVMTRLRLSPADHRPLGQKTLDFSVASLCGAALGLLLLRITQVPFDPVLSE
FFAANSRVIAHGRNIVNVIIVDFRGLDTLGEIAVVMIAGLAILALVRIRAGRPADKPVKEA

Sequences:

>Translated_781_residues
MAADGQWLTFLALILPFLGAAAAPPLVRAFGHNAAWILALVPAFLFYHFAGFLGIIAGGQAVSGGYRWIESLSVDFSWYL
DGLSLTFALLISGIGTLIVLYSGGYLKDHPHLGRFFSFILMFMGAMQGLVVADSFLMLFVFWELTSIASFLLIGFDHRRE
AARRAALQALIVTGAGGLALLAGLLVITLATGANSLSALLQSGDALRQAPLYLTALLLVLGGAFTKSAQFPLHFWLPNAM
EAPTPVSAYLHSATMVKAGVYLLMRLNPVMGDTVLWETILPIFGGTTLIVGTLLALRQTDLKLMLAYTTVASLGLLVMLT
GFGSEIAIEAAVLYLVAHSMFKGALFMVAGSVDHETGTRDITKLGGIGRAMPITFAAAVLAALSMGGLPPFFGFLAKEEI
YAGLGFGSNWSTLVTLVALLGNALMFAIGFAVALKPFTGRFIATPKTAHEGPVLLWLGPVVLALCGLLTAIFSEISHRFI
STPMASAVAGESVSVSISVIPHVGLPLLLSLATIGLGIILYLAIDRGRAAMASLLAAIGWGPDRGFDQFVRGAVRISAAI
TAIVQNGRLDIYMTVTFIFLAAALLVPMIGFGELPEMPAFVAMHFYEATILVIAIIGLAAVVYARDRLTAIVSLGIQGFA
VALLFMLLGAPDLSFTQFMVETLSVVILALVMTRLRLSPADHRPLGQKTLDFSVASLCGAALGLLLLRITQVPFDPVLSE
FFAANSRVIAHGRNIVNVIIVDFRGLDTLGEIAVVMIAGLAILALVRIRAGRPADKPVKEA
>Mature_780_residues
AADGQWLTFLALILPFLGAAAAPPLVRAFGHNAAWILALVPAFLFYHFAGFLGIIAGGQAVSGGYRWIESLSVDFSWYLD
GLSLTFALLISGIGTLIVLYSGGYLKDHPHLGRFFSFILMFMGAMQGLVVADSFLMLFVFWELTSIASFLLIGFDHRREA
ARRAALQALIVTGAGGLALLAGLLVITLATGANSLSALLQSGDALRQAPLYLTALLLVLGGAFTKSAQFPLHFWLPNAME
APTPVSAYLHSATMVKAGVYLLMRLNPVMGDTVLWETILPIFGGTTLIVGTLLALRQTDLKLMLAYTTVASLGLLVMLTG
FGSEIAIEAAVLYLVAHSMFKGALFMVAGSVDHETGTRDITKLGGIGRAMPITFAAAVLAALSMGGLPPFFGFLAKEEIY
AGLGFGSNWSTLVTLVALLGNALMFAIGFAVALKPFTGRFIATPKTAHEGPVLLWLGPVVLALCGLLTAIFSEISHRFIS
TPMASAVAGESVSVSISVIPHVGLPLLLSLATIGLGIILYLAIDRGRAAMASLLAAIGWGPDRGFDQFVRGAVRISAAIT
AIVQNGRLDIYMTVTFIFLAAALLVPMIGFGELPEMPAFVAMHFYEATILVIAIIGLAAVVYARDRLTAIVSLGIQGFAV
ALLFMLLGAPDLSFTQFMVETLSVVILALVMTRLRLSPADHRPLGQKTLDFSVASLCGAALGLLLLRITQVPFDPVLSEF
FAANSRVIAHGRNIVNVIIVDFRGLDTLGEIAVVMIAGLAILALVRIRAGRPADKPVKEA

Specific function: Mnh complex is a Na(+)Li(+)/H(+) antiporter involved in Na(+) and/or Li(+) excretion and Na(+) resistance. Na(+)/H(+) antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic. Does not transport K(+), Ca(2+) or Mg(2+

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=449, Percent_Identity=31.4031180400891, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI251831116, Length=336, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1788829, Length=343, Percent_Identity=37.6093294460641, Blast_Score=201, Evalue=2e-52,
Organism=Escherichia coli, GI1788614, Length=347, Percent_Identity=34.8703170028818, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788831, Length=353, Percent_Identity=31.4447592067989, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788827, Length=460, Percent_Identity=26.0869565217391, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788613, Length=340, Percent_Identity=27.9411764705882, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI2367154, Length=260, Percent_Identity=33.8461538461538, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI145693160, Length=295, Percent_Identity=29.1525423728814, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005663
- InterPro:   IPR001750
- InterPro:   IPR001516 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 82719; Mature: 82588

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADGQWLTFLALILPFLGAAAAPPLVRAFGHNAAWILALVPAFLFYHFAGFLGIIAGGQ
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVSGGYRWIESLSVDFSWYLDGLSLTFALLISGIGTLIVLYSGGYLKDHPHLGRFFSFIL
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHH
MFMGAMQGLVVADSFLMLFVFWELTSIASFLLIGFDHRREAARRAALQALIVTGAGGLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHH
LAGLLVITLATGANSLSALLQSGDALRQAPLYLTALLLVLGGAFTKSAQFPLHFWLPNAM
HHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
EAPTPVSAYLHSATMVKAGVYLLMRLNPVMGDTVLWETILPIFGGTTLIVGTLLALRQTD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LKLMLAYTTVASLGLLVMLTGFGSEIAIEAAVLYLVAHSMFKGALFMVAGSVDHETGTRD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHH
ITKLGGIGRAMPITFAAAVLAALSMGGLPPFFGFLAKEEIYAGLGFGSNWSTLVTLVALL
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GNALMFAIGFAVALKPFTGRFIATPKTAHEGPVLLWLGPVVLALCGLLTAIFSEISHRFI
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
STPMASAVAGESVSVSISVIPHVGLPLLLSLATIGLGIILYLAIDRGRAAMASLLAAIGW
CCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GPDRGFDQFVRGAVRISAAITAIVQNGRLDIYMTVTFIFLAAALLVPMIGFGELPEMPAF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
VAMHFYEATILVIAIIGLAAVVYARDRLTAIVSLGIQGFAVALLFMLLGAPDLSFTQFMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHH
ETLSVVILALVMTRLRLSPADHRPLGQKTLDFSVASLCGAALGLLLLRITQVPFDPVLSE
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFAANSRVIAHGRNIVNVIIVDFRGLDTLGEIAVVMIAGLAILALVRIRAGRPADKPVKE
HHHCCCEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
A
C
>Mature Secondary Structure 
AADGQWLTFLALILPFLGAAAAPPLVRAFGHNAAWILALVPAFLFYHFAGFLGIIAGGQ
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVSGGYRWIESLSVDFSWYLDGLSLTFALLISGIGTLIVLYSGGYLKDHPHLGRFFSFIL
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHH
MFMGAMQGLVVADSFLMLFVFWELTSIASFLLIGFDHRREAARRAALQALIVTGAGGLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHH
LAGLLVITLATGANSLSALLQSGDALRQAPLYLTALLLVLGGAFTKSAQFPLHFWLPNAM
HHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
EAPTPVSAYLHSATMVKAGVYLLMRLNPVMGDTVLWETILPIFGGTTLIVGTLLALRQTD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LKLMLAYTTVASLGLLVMLTGFGSEIAIEAAVLYLVAHSMFKGALFMVAGSVDHETGTRD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHH
ITKLGGIGRAMPITFAAAVLAALSMGGLPPFFGFLAKEEIYAGLGFGSNWSTLVTLVALL
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GNALMFAIGFAVALKPFTGRFIATPKTAHEGPVLLWLGPVVLALCGLLTAIFSEISHRFI
HHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
STPMASAVAGESVSVSISVIPHVGLPLLLSLATIGLGIILYLAIDRGRAAMASLLAAIGW
CCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GPDRGFDQFVRGAVRISAAITAIVQNGRLDIYMTVTFIFLAAALLVPMIGFGELPEMPAF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
VAMHFYEATILVIAIIGLAAVVYARDRLTAIVSLGIQGFAVALLFMLLGAPDLSFTQFMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHH
ETLSVVILALVMTRLRLSPADHRPLGQKTLDFSVASLCGAALGLLLLRITQVPFDPVLSE
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFAANSRVIAHGRNIVNVIIVDFRGLDTLGEIAVVMIAGLAILALVRIRAGRPADKPVKE
HHHCCCEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]