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The map label for this gene is ilvD [H]

Identifier: 110633199

GI number: 110633199

Start: 935441

End: 937186

Strand: Direct

Name: ilvD [H]

Synonym: Meso_0842

Alternate gene names: 110633199

Gene position: 935441-937186 (Clockwise)

Preceding gene: 110633198

Following gene: 110633200

Centisome position: 21.2

GC content: 65.18

Gene sequence:

>1746_bases
ATGACCACCTTCACCCCAAAACCCTGGCCGCGAAAGCTTCGGTCGCAGGAATGGTTCGGCGGCACGTCCCGCGACCACAT
CTATCACCGTTCCTGGATGAAGAATCAGGGTTTGCCGGCCGATCTCTTCGACGGGCGGCCGGTGATCGGCATCTGCAATA
CCTGGTCGCAGCTCACTCCCTGCAATGCGCATTTGCGCGATCTTGCCGAGCGGGTGAAGCACGGCATCTACGAGGCGGGC
GGCCTGCCGCTGGAATTCCCGGTCTTCTCGCCAAGCGAAAGCGCGCTGCGCCCCACGGCCATGATGTACCGCAACCTCGC
CGCCATGGATGTGGAGGAGGCGCTGCGCGCCAATCCGCTCGATGGCGTCGTTCTGCTTGCGGGCTGCGACAAGACCACGC
CGGCGCTGCTGATGGGCGCGGCCAGTGTCGACATTCCGGCCATCCTGGTCTCCGGCGGGCCGATGCTCAACGGCTGGTTC
CGCGGCGAGCGCGTGGGTTCCGGCACTGCGCTCTGGCAGATGTCCGAGGCGATCAAGGCAGGCACAATGAGCCAGGAGGA
TTTCCTCGACGCCGAGCAGGCTATGAGCCGTTCGCCCGGTTCCTGCAACACAATGGGTACGGCCTCCACCATGGCTTCCA
TGTCCGAGGCGCTGGGCATGGCGCTTTCGGGCAACGCGGCCATCCCGGCCGCGGACAGCCGCCGCCGCGTGGTGGCGCAT
CTGTCGGGCCGGCGCATCGTCCAGATGGTGAAGGACGAACTGAAACCATCGGACATCCTTACGCGTCAAGCTTTCGAGAA
CGCCATCCGCGTCAATGGCGCCATCGGCGGTTCCACCAATGCGGTGATCCACCTGCTGGCGATCGCCGGGCGCGTGGGCG
TTGACCTGACGCTGGACGACTGGGATCGGCTCGGCCGCGACATCCCCACCATCGTCAACCTGATGCCTTCGGGCAAATAC
CTGATGGAGGAGTTCTTCTACGCCGGCGGCCTGCCCGTGGTGATCAAACTGCTGGGCGAGGGCGGTAGGCTCCACAAAGA
AGCGCTCACCGTCTCCGGCGGCCCGATATGGGACGAGGTTAAGGACGTCAAGAACTGGAACGACGATGTCATTCGCCCGG
TGGAAAGGGCGCTCACCCCGCAGGGCGGCATTGCGGTGCTGCGCGGCAATCTCGCGCCCAAGGGCGCGGTGCTGAAGCCG
TCCGCCGCCTCGCCGCATCTGATGCATCATCGCGGCCGCGCGGTCGTCTTCGAGGACATCGACGACTACAAGGCCAAGAT
CAACGACGAAAGGCTCGAAGTCGACGAGACCTGCGTCCTCGTGCTGAAGAACTGCGGGCCTCGTGGCTATCCCGGTATGG
CGGAGGTGGGCAATATGGGCCTGCCGCCGAAGGTACTCAGAAAGGGCATCACAGACATGGTGCGCATTTCCGATGCCCGC
ATGTCCGGCACGGCCTATGGCACCGTGGTGCTCCACACCTCGCCGGAGGCTGCCGCGGGCGGCCCGCTCGCCGTGGTGAG
AAACGGCGATATGATCGAGCTCGATGTGTCCAGCCGGCGCATTCACCTCGATATTTCAGACGCGGAGCTGGCGCGCCGGC
TGGCCGAATGGAAGCCGAATGTCGCGCGGCCGGAAGGCGGCTACGCTCAGCTCTTTCACGACCATGTGCAGGGCGCGGAC
ACGGGCGCCGATTTCGACTTCCTCAAGGGCTGCCGCGGCAGCCCGGTAGCCAGGGATTCGCATTGA

Upstream 100 bases:

>100_bases
GGCCGGCAGGCCAGAGGGGGGTGTGCAGGGGCGCTTTCTTTCCCATTTTCGAAACATCAAACCCACACTCCGGGCGGCGA
ACCCGGAAAGGACCTCACGC

Downstream 100 bases:

>100_bases
CTTAGAATGTGAACGACCCCCTCTGTCCGGCAGGGCAGAGAGGGGATGATCTACGGCGCGCAGTGCTGAAGGGATGCACA
TGGTAAATGAGGCTGGCACG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTTFTPKPWPRKLRSQEWFGGTSRDHIYHRSWMKNQGLPADLFDGRPVIGICNTWSQLTPCNAHLRDLAERVKHGIYEAG
GLPLEFPVFSPSESALRPTAMMYRNLAAMDVEEALRANPLDGVVLLAGCDKTTPALLMGAASVDIPAILVSGGPMLNGWF
RGERVGSGTALWQMSEAIKAGTMSQEDFLDAEQAMSRSPGSCNTMGTASTMASMSEALGMALSGNAAIPAADSRRRVVAH
LSGRRIVQMVKDELKPSDILTRQAFENAIRVNGAIGGSTNAVIHLLAIAGRVGVDLTLDDWDRLGRDIPTIVNLMPSGKY
LMEEFFYAGGLPVVIKLLGEGGRLHKEALTVSGGPIWDEVKDVKNWNDDVIRPVERALTPQGGIAVLRGNLAPKGAVLKP
SAASPHLMHHRGRAVVFEDIDDYKAKINDERLEVDETCVLVLKNCGPRGYPGMAEVGNMGLPPKVLRKGITDMVRISDAR
MSGTAYGTVVLHTSPEAAAGGPLAVVRNGDMIELDVSSRRIHLDISDAELARRLAEWKPNVARPEGGYAQLFHDHVQGAD
TGADFDFLKGCRGSPVARDSH

Sequences:

>Translated_581_residues
MTTFTPKPWPRKLRSQEWFGGTSRDHIYHRSWMKNQGLPADLFDGRPVIGICNTWSQLTPCNAHLRDLAERVKHGIYEAG
GLPLEFPVFSPSESALRPTAMMYRNLAAMDVEEALRANPLDGVVLLAGCDKTTPALLMGAASVDIPAILVSGGPMLNGWF
RGERVGSGTALWQMSEAIKAGTMSQEDFLDAEQAMSRSPGSCNTMGTASTMASMSEALGMALSGNAAIPAADSRRRVVAH
LSGRRIVQMVKDELKPSDILTRQAFENAIRVNGAIGGSTNAVIHLLAIAGRVGVDLTLDDWDRLGRDIPTIVNLMPSGKY
LMEEFFYAGGLPVVIKLLGEGGRLHKEALTVSGGPIWDEVKDVKNWNDDVIRPVERALTPQGGIAVLRGNLAPKGAVLKP
SAASPHLMHHRGRAVVFEDIDDYKAKINDERLEVDETCVLVLKNCGPRGYPGMAEVGNMGLPPKVLRKGITDMVRISDAR
MSGTAYGTVVLHTSPEAAAGGPLAVVRNGDMIELDVSSRRIHLDISDAELARRLAEWKPNVARPEGGYAQLFHDHVQGAD
TGADFDFLKGCRGSPVARDSH
>Mature_580_residues
TTFTPKPWPRKLRSQEWFGGTSRDHIYHRSWMKNQGLPADLFDGRPVIGICNTWSQLTPCNAHLRDLAERVKHGIYEAGG
LPLEFPVFSPSESALRPTAMMYRNLAAMDVEEALRANPLDGVVLLAGCDKTTPALLMGAASVDIPAILVSGGPMLNGWFR
GERVGSGTALWQMSEAIKAGTMSQEDFLDAEQAMSRSPGSCNTMGTASTMASMSEALGMALSGNAAIPAADSRRRVVAHL
SGRRIVQMVKDELKPSDILTRQAFENAIRVNGAIGGSTNAVIHLLAIAGRVGVDLTLDDWDRLGRDIPTIVNLMPSGKYL
MEEFFYAGGLPVVIKLLGEGGRLHKEALTVSGGPIWDEVKDVKNWNDDVIRPVERALTPQGGIAVLRGNLAPKGAVLKPS
AASPHLMHHRGRAVVFEDIDDYKAKINDERLEVDETCVLVLKNCGPRGYPGMAEVGNMGLPPKVLRKGITDMVRISDARM
SGTAYGTVVLHTSPEAAAGGPLAVVRNGDMIELDVSSRRIHLDISDAELARRLAEWKPNVARPEGGYAQLFHDHVQGADT
GADFDFLKGCRGSPVARDSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=588, Percent_Identity=31.8027210884354, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI2367371, Length=489, Percent_Identity=30.4703476482618, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1788157, Length=549, Percent_Identity=28.9617486338798, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1786464, Length=477, Percent_Identity=31.4465408805031, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=537, Percent_Identity=32.4022346368715, Blast_Score=267, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62773; Mature: 62641

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFTPKPWPRKLRSQEWFGGTSRDHIYHRSWMKNQGLPADLFDGRPVIGICNTWSQLTP
CCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCEEEECCCCCCCCC
CNAHLRDLAERVKHGIYEAGGLPLEFPVFSPSESALRPTAMMYRNLAAMDVEEALRANPL
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHCHHHHHHHHHHHHCHHHHHHCCCC
DGVVLLAGCDKTTPALLMGAASVDIPAILVSGGPMLNGWFRGERVGSGTALWQMSEAIKA
CCEEEEECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHHH
GTMSQEDFLDAEQAMSRSPGSCNTMGTASTMASMSEALGMALSGNAAIPAADSRRRVVAH
CCCCHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHH
LSGRRIVQMVKDELKPSDILTRQAFENAIRVNGAIGGSTNAVIHLLAIAGRVGVDLTLDD
HCCHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCEEEEEHH
WDRLGRDIPTIVNLMPSGKYLMEEFFYAGGLPVVIKLLGEGGRLHKEALTVSGGPIWDEV
HHHHCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEHHEEEECCCCCHHHH
KDVKNWNDDVIRPVERALTPQGGIAVLRGNLAPKGAVLKPSAASPHLMHHRGRAVVFEDI
HHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCCCCCCHHHHHCCCEEEEECC
DDYKAKINDERLEVDETCVLVLKNCGPRGYPGMAEVGNMGLPPKVLRKGITDMVRISDAR
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCC
MSGTAYGTVVLHTSPEAAAGGPLAVVRNGDMIELDVSSRRIHLDISDAELARRLAEWKPN
CCCCEEEEEEEECCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHCCCC
VARPEGGYAQLFHDHVQGADTGADFDFLKGCRGSPVARDSH
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTFTPKPWPRKLRSQEWFGGTSRDHIYHRSWMKNQGLPADLFDGRPVIGICNTWSQLTP
CCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCEEEECCCCCCCCC
CNAHLRDLAERVKHGIYEAGGLPLEFPVFSPSESALRPTAMMYRNLAAMDVEEALRANPL
CHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHCHHHHHHHHHHHHCHHHHHHCCCC
DGVVLLAGCDKTTPALLMGAASVDIPAILVSGGPMLNGWFRGERVGSGTALWQMSEAIKA
CCEEEEECCCCCCHHHEEECCCCCCCEEEEECCCEECCEECCCCCCCCHHHHHHHHHHHH
GTMSQEDFLDAEQAMSRSPGSCNTMGTASTMASMSEALGMALSGNAAIPAADSRRRVVAH
CCCCHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEEECCCCCCCCCCCCHHHHHH
LSGRRIVQMVKDELKPSDILTRQAFENAIRVNGAIGGSTNAVIHLLAIAGRVGVDLTLDD
HCCHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHCCEEEEEHH
WDRLGRDIPTIVNLMPSGKYLMEEFFYAGGLPVVIKLLGEGGRLHKEALTVSGGPIWDEV
HHHHCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEHHEEEECCCCCHHHH
KDVKNWNDDVIRPVERALTPQGGIAVLRGNLAPKGAVLKPSAASPHLMHHRGRAVVFEDI
HHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCCCCCCHHHHHCCCEEEEECC
DDYKAKINDERLEVDETCVLVLKNCGPRGYPGMAEVGNMGLPPKVLRKGITDMVRISDAR
HHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCC
MSGTAYGTVVLHTSPEAAAGGPLAVVRNGDMIELDVSSRRIHLDISDAELARRLAEWKPN
CCCCEEEEEEEECCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHHHHHCCCC
VARPEGGYAQLFHDHVQGADTGADFDFLKGCRGSPVARDSH
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]