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The map label for this gene is degS [H]

Identifier: 110633152

GI number: 110633152

Start: 884253

End: 885737

Strand: Direct

Name: degS [H]

Synonym: Meso_0795

Alternate gene names: 110633152

Gene position: 884253-885737 (Clockwise)

Preceding gene: 110633151

Following gene: 110633156

Centisome position: 20.04

GC content: 57.64

Gene sequence:

>1485_bases
ATGACAATTTTTAGCCGCAGGGGGAGGGTTGCTGATGGCGCGGAATTTCTGCGGACAGCTATCCGCGGCTGGCGGAAGAA
CCTGAGCCTTTCGAACCAGTTCCTTCTTGCCGCCGGCCTGGTTCTGTGCGTCTCAATGACCGTCCTCGGCACCTGGGTCA
ATCATCAGATTACCCGCAGCGTGCTTGCGACCTCCGGTTCGGGCGGGGTCGCATTTATGGAAGCCTTTATCGAGCCTGAG
ATCCAAGGCATACGCGCCGACGGTACGCTTCCTCCAGAGGCCCATTTGGCACTCGATGCGCTTTTGGTGGAAGCGCCGAT
CGGCAAGAGCATCGTTTCGGTCAAGCTCTGGAAGCCGGACGGTGCCGTGATCTACAGCAGCATGGCAAAGGACGTGATCG
GCGACCACTTTGTCTCAACGGACGTGGCCAAAGCCGCATCGGGGAAGATCGTTTCGGAATTCGAGGATATGGTCAGCGCC
GAAAGCGCGTATGAACAAAGCCTCAAAATGTCGCTTATCGAGGTGTATGCACCTCTTTATAGAACCGGAACGGAAGAGAT
AATCGCCGTCGGCGAGGTCTATGAGAATGGCGAGGCGCTTGCCGCTCAACTGCGGGTGAGCCGGGCGCAGACTTGGCTGG
TCGTGTGCCTCACGACATTGCTCATGCTTTCGGTGCTCTATGGCATCGTCCGTCGCGGAAGCCATACCATCGCTGCCCAA
CGAGCTGAACTGCAACGGCAAATTGCGCAAGTCCGGCGAATGGCATCGCAAAATGAAGAACTTAGGATATTGGCCGAGAA
AACTCGCCTGGATGCGAACGAAGCCAATGAGGAACTTATCGGCCGTATAGGCCTCGACATCCACGACGGTCCTATCCAGT
TGCTCAGCCTTCTCATGCTGCGTCTGGGCAAGCTCAAGTCAGCCCGGCCGACCGAAAAGGACCGCGCCGCCATTCAGGAA
TTGACTGCTACCGTCATTCATGAACTGCGCACGCTGTCCACCGGACTTGTGCTTCCCGAAATACGCGATCTCTCCGTGGA
AGAGACAATCATGCTGGCGGCCGAAAGGCACGAAAATCTGACGGGCACGAAGGTCGCGATAGAACTGCAGCGGCTGCCGG
AGGCTCTGCCTTTGGCCATGAAAATCTGCATCTACAGGATTATTCAGGAATCGCTCAGCAACTCCTTCAAGCATGCAAGA
GGCGTGGGACAGAAGGTCCGCGCTGCCTATTCCGATGATTCAATCGAGCTGACCATTTCGGATGCCGGCGGCGGCGTCGC
CCCGGAGGAAATACAGAAACGGCAACCCACCAAACTGGGATTGCGAGGGATCCAGAACCGTGTGCAAGCCTTTGGCGGCG
TGGCAGAGGTGCGATCGGCGAGTGTGGGCACCAGTGTCGAGGTGCGCCTTCCGCTTAGATCTCCAATGCGAAGGAGCGAA
GCCGTTGAAGCCCCTGGTTCACCCGCTCAGGCCTCTCTCCTCTAG

Upstream 100 bases:

>100_bases
TAAGTCGTCGCTGAAGGGCTGCCTGCGCTTTTTCTCCGGCTATGCTAAATTGATCCTGCAGGTGCTGCCGAAGCCGTGCG
CGGGAGGTCGCGAAGGCACA

Downstream 100 bases:

>100_bases
GCCGTATTTCAGTTTATGAAGGAATGATCCCGGGCGCTCGACATGCCTTCCGGGCGATAGCTTCCCAGCTCCTGGGCGGC
CAGGACGACCTCGACCCGGT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTIFSRRGRVADGAEFLRTAIRGWRKNLSLSNQFLLAAGLVLCVSMTVLGTWVNHQITRSVLATSGSGGVAFMEAFIEPE
IQGIRADGTLPPEAHLALDALLVEAPIGKSIVSVKLWKPDGAVIYSSMAKDVIGDHFVSTDVAKAASGKIVSEFEDMVSA
ESAYEQSLKMSLIEVYAPLYRTGTEEIIAVGEVYENGEALAAQLRVSRAQTWLVVCLTTLLMLSVLYGIVRRGSHTIAAQ
RAELQRQIAQVRRMASQNEELRILAEKTRLDANEANEELIGRIGLDIHDGPIQLLSLLMLRLGKLKSARPTEKDRAAIQE
LTATVIHELRTLSTGLVLPEIRDLSVEETIMLAAERHENLTGTKVAIELQRLPEALPLAMKICIYRIIQESLSNSFKHAR
GVGQKVRAAYSDDSIELTISDAGGGVAPEEIQKRQPTKLGLRGIQNRVQAFGGVAEVRSASVGTSVEVRLPLRSPMRRSE
AVEAPGSPAQASLL

Sequences:

>Translated_494_residues
MTIFSRRGRVADGAEFLRTAIRGWRKNLSLSNQFLLAAGLVLCVSMTVLGTWVNHQITRSVLATSGSGGVAFMEAFIEPE
IQGIRADGTLPPEAHLALDALLVEAPIGKSIVSVKLWKPDGAVIYSSMAKDVIGDHFVSTDVAKAASGKIVSEFEDMVSA
ESAYEQSLKMSLIEVYAPLYRTGTEEIIAVGEVYENGEALAAQLRVSRAQTWLVVCLTTLLMLSVLYGIVRRGSHTIAAQ
RAELQRQIAQVRRMASQNEELRILAEKTRLDANEANEELIGRIGLDIHDGPIQLLSLLMLRLGKLKSARPTEKDRAAIQE
LTATVIHELRTLSTGLVLPEIRDLSVEETIMLAAERHENLTGTKVAIELQRLPEALPLAMKICIYRIIQESLSNSFKHAR
GVGQKVRAAYSDDSIELTISDAGGGVAPEEIQKRQPTKLGLRGIQNRVQAFGGVAEVRSASVGTSVEVRLPLRSPMRRSE
AVEAPGSPAQASLL
>Mature_493_residues
TIFSRRGRVADGAEFLRTAIRGWRKNLSLSNQFLLAAGLVLCVSMTVLGTWVNHQITRSVLATSGSGGVAFMEAFIEPEI
QGIRADGTLPPEAHLALDALLVEAPIGKSIVSVKLWKPDGAVIYSSMAKDVIGDHFVSTDVAKAASGKIVSEFEDMVSAE
SAYEQSLKMSLIEVYAPLYRTGTEEIIAVGEVYENGEALAAQLRVSRAQTWLVVCLTTLLMLSVLYGIVRRGSHTIAAQR
AELQRQIAQVRRMASQNEELRILAEKTRLDANEANEELIGRIGLDIHDGPIQLLSLLMLRLGKLKSARPTEKDRAAIQEL
TATVIHELRTLSTGLVLPEIRDLSVEETIMLAAERHENLTGTKVAIELQRLPEALPLAMKICIYRIIQESLSNSFKHARG
VGQKVRAAYSDDSIELTISDAGGGVAPEEIQKRQPTKLGLRGIQNRVQAFGGVAEVRSASVGTSVEVRLPLRSPMRRSEA
VEAPGSPAQASLL

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53726; Mature: 53595

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIFSRRGRVADGAEFLRTAIRGWRKNLSLSNQFLLAAGLVLCVSMTVLGTWVNHQITRS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLATSGSGGVAFMEAFIEPEIQGIRADGTLPPEAHLALDALLVEAPIGKSIVSVKLWKPD
HHHCCCCCCHHHHHHHHCHHHCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
GAVIYSSMAKDVIGDHFVSTDVAKAASGKIVSEFEDMVSAESAYEQSLKMSLIEVYAPLY
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTGTEEIIAVGEVYENGEALAAQLRVSRAQTWLVVCLTTLLMLSVLYGIVRRGSHTIAAQ
HCCCHHHEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RAELQRQIAQVRRMASQNEELRILAEKTRLDANEANEELIGRIGLDIHDGPIQLLSLLML
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
RLGKLKSARPTEKDRAAIQELTATVIHELRTLSTGLVLPEIRDLSVEETIMLAAERHENL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHCCCC
TGTKVAIELQRLPEALPLAMKICIYRIIQESLSNSFKHARGVGQKVRAAYSDDSIELTIS
CCHHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEE
DAGGGVAPEEIQKRQPTKLGLRGIQNRVQAFGGVAEVRSASVGTSVEVRLPLRSPMRRSE
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCHHHHH
AVEAPGSPAQASLL
CCCCCCCCCCCCCC
>Mature Secondary Structure 
TIFSRRGRVADGAEFLRTAIRGWRKNLSLSNQFLLAAGLVLCVSMTVLGTWVNHQITRS
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLATSGSGGVAFMEAFIEPEIQGIRADGTLPPEAHLALDALLVEAPIGKSIVSVKLWKPD
HHHCCCCCCHHHHHHHHCHHHCCEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
GAVIYSSMAKDVIGDHFVSTDVAKAASGKIVSEFEDMVSAESAYEQSLKMSLIEVYAPLY
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTGTEEIIAVGEVYENGEALAAQLRVSRAQTWLVVCLTTLLMLSVLYGIVRRGSHTIAAQ
HCCCHHHEEHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RAELQRQIAQVRRMASQNEELRILAEKTRLDANEANEELIGRIGLDIHDGPIQLLSLLML
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHH
RLGKLKSARPTEKDRAAIQELTATVIHELRTLSTGLVLPEIRDLSVEETIMLAAERHENL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHCCCC
TGTKVAIELQRLPEALPLAMKICIYRIIQESLSNSFKHARGVGQKVRAAYSDDSIELTIS
CCHHHEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEE
DAGGGVAPEEIQKRQPTKLGLRGIQNRVQAFGGVAEVRSASVGTSVEVRLPLRSPMRRSE
CCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCHHHHH
AVEAPGSPAQASLL
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]