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The map label for this gene is argH [H]

Identifier: 110632923

GI number: 110632923

Start: 623337

End: 624845

Strand: Reverse

Name: argH [H]

Synonym: Meso_0564

Alternate gene names: 110632923

Gene position: 624845-623337 (Counterclockwise)

Preceding gene: 110632924

Following gene: 110632922

Centisome position: 14.16

GC content: 56.79

Gene sequence:

>1509_bases
ATGAACATTAATGTCCCGGATGCCACCCGGATCGGCCGCGCCACGGGAGCAAAAGCGCCTGAGTTCCAAGAGCTATATGA
CTTCGACGCGGCAGCGCTGACCCTTACGAGCGCGGTCTTTCCCTACGACAGTCAAATACATCGTGCGCATGTCGTGATGC
TGACGGAACAGGGAATTCTCACTGTAGAGGAATCAGCAACCATTCTCAGTGGACTGGCCCAGGTGGACGAGCTCGCCGCC
ACTGATGGGTCATTGCGCACCTATCTTCCTTACGAGGCTGCGTTGAAGCGAACAATCGGCTCGGTTGCGGGAAAAATGCA
TATCGGACGAAGCCGTAACGATCTCGCAAATGCCGGAAAGCGGATGTTTCTGCGCGATCAGCTCTTGCGCACTATTGAGG
CGGTGATCGGCTATCGCGAAGCGGTTGTGCACAAGGCGGCCGACCATCTCGATACGGTGATGGTAGTATATACTCAGCGC
AAGGAGGCGCAGCCTATTACGCTCGGCCATTATCTCATGGCGATAAGCGAAAATCTTGCGAAGAACCTCGACAGATATCG
CGAACTATATGCGCGCATCAACCTGTGCCCGTTGGGAGCGGCTGCCACCGCCGGCACAGGCTGGCCGTTGAACCGCGACC
GCACGTCAGCTCTGCTGGGTTTTGATGGGTTGGTCGTGAATTCGATCGAGGGCGTCGCGGGCTGGGACCACGTCGCGGAG
CATGCCTTTGTCAATGCCGTCTTCCTGAGCGGCCTCAGCCGTCTGGCTTCGGAAATCCAGCTCTGGTCCACTGACGAATA
TCAAGTAGCGGAACTGGATGCGTCATTCGCAGGCACGAGCAGCATCATGCCGCAGAAGAAGAATCCAGACTCGCTGGAAC
GCAGCCGAAAAGCGGCATTTGCAGCGATGGGTCCGCTTGTAGGTATCCTCACCTCGCTAAATGCCATCGAATATCAATAT
AGCGCTGCCCGCGTTGAGTTGGAACCACGCTCCATCGACGCCTTGATCGCCGCAACGCACGCGATGACAGGGGTAGTGCG
GACACTGCATCCTAACAAGGAACGCATGCGGCAATACGCTGCAGAAAACTATTCGACCATGACCGACCTCACCGACATGC
TCGTTAGACGCGTGGGAATCGACTATCGCGAAGCGCACGAGATAGTGGCTCATGTCGTGATCACAGCCATCGAAAAAGGC
ATCAAGGCAAACAAAATTGGTCTCGATCTGGTCCAGGAGGCGGCAGTTGCCCAGACCGGCGCGGGAATAAATGTGAGTGC
CGACGACATCAAGGACGCGCTCGACCCGTGGCAGAACGTCCTACGGCGCGAAGGCAAGGGAATGCCGGCCCCGATGTCCG
TGAAGGCCAGCATCGATGATGCAATGGCGGAACTTCACAAAGATCGTGCATGGCTCGCAAATGCGACGCAAGCTCTTGCG
AACGCAAAGCAAACACTGGCGGACAGCGTGCAGCAGATCATCCAAACCGACAGAAAATACCTGCGCTGA

Upstream 100 bases:

>100_bases
CGGGCAGCAATTCTGGAGCAGGATGGGATTTGCTCCCTATTCCCACCTCCTGGAAAGCAGGTCCGTGAACTCACCCAGAA
GCAAATAGAGAGAGCAATCG

Downstream 100 bases:

>100_bases
GGCTGATGGATGATCGGTCACTTCAAGGAGAAAAAAGGTCTAGTTATCCAATGAGTTAGAATAACTAAAAACAGGGGATT
CGCAATGCGCATTCAAATGG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MNINVPDATRIGRATGAKAPEFQELYDFDAAALTLTSAVFPYDSQIHRAHVVMLTEQGILTVEESATILSGLAQVDELAA
TDGSLRTYLPYEAALKRTIGSVAGKMHIGRSRNDLANAGKRMFLRDQLLRTIEAVIGYREAVVHKAADHLDTVMVVYTQR
KEAQPITLGHYLMAISENLAKNLDRYRELYARINLCPLGAAATAGTGWPLNRDRTSALLGFDGLVVNSIEGVAGWDHVAE
HAFVNAVFLSGLSRLASEIQLWSTDEYQVAELDASFAGTSSIMPQKKNPDSLERSRKAAFAAMGPLVGILTSLNAIEYQY
SAARVELEPRSIDALIAATHAMTGVVRTLHPNKERMRQYAAENYSTMTDLTDMLVRRVGIDYREAHEIVAHVVITAIEKG
IKANKIGLDLVQEAAVAQTGAGINVSADDIKDALDPWQNVLRREGKGMPAPMSVKASIDDAMAELHKDRAWLANATQALA
NAKQTLADSVQQIIQTDRKYLR

Sequences:

>Translated_502_residues
MNINVPDATRIGRATGAKAPEFQELYDFDAAALTLTSAVFPYDSQIHRAHVVMLTEQGILTVEESATILSGLAQVDELAA
TDGSLRTYLPYEAALKRTIGSVAGKMHIGRSRNDLANAGKRMFLRDQLLRTIEAVIGYREAVVHKAADHLDTVMVVYTQR
KEAQPITLGHYLMAISENLAKNLDRYRELYARINLCPLGAAATAGTGWPLNRDRTSALLGFDGLVVNSIEGVAGWDHVAE
HAFVNAVFLSGLSRLASEIQLWSTDEYQVAELDASFAGTSSIMPQKKNPDSLERSRKAAFAAMGPLVGILTSLNAIEYQY
SAARVELEPRSIDALIAATHAMTGVVRTLHPNKERMRQYAAENYSTMTDLTDMLVRRVGIDYREAHEIVAHVVITAIEKG
IKANKIGLDLVQEAAVAQTGAGINVSADDIKDALDPWQNVLRREGKGMPAPMSVKASIDDAMAELHKDRAWLANATQALA
NAKQTLADSVQQIIQTDRKYLR
>Mature_502_residues
MNINVPDATRIGRATGAKAPEFQELYDFDAAALTLTSAVFPYDSQIHRAHVVMLTEQGILTVEESATILSGLAQVDELAA
TDGSLRTYLPYEAALKRTIGSVAGKMHIGRSRNDLANAGKRMFLRDQLLRTIEAVIGYREAVVHKAADHLDTVMVVYTQR
KEAQPITLGHYLMAISENLAKNLDRYRELYARINLCPLGAAATAGTGWPLNRDRTSALLGFDGLVVNSIEGVAGWDHVAE
HAFVNAVFLSGLSRLASEIQLWSTDEYQVAELDASFAGTSSIMPQKKNPDSLERSRKAAFAAMGPLVGILTSLNAIEYQY
SAARVELEPRSIDALIAATHAMTGVVRTLHPNKERMRQYAAENYSTMTDLTDMLVRRVGIDYREAHEIVAHVVITAIEKG
IKANKIGLDLVQEAAVAQTGAGINVSADDIKDALDPWQNVLRREGKGMPAPMSVKASIDDAMAELHKDRAWLANATQALA
NAKQTLADSVQQIIQTDRKYLR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=426, Percent_Identity=31.6901408450704, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI68303542, Length=426, Percent_Identity=31.6901408450704, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI68303547, Length=423, Percent_Identity=31.2056737588652, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI68303549, Length=426, Percent_Identity=30.2816901408451, Blast_Score=152, Evalue=5e-37,
Organism=Escherichia coli, GI1790398, Length=420, Percent_Identity=29.7619047619048, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321806, Length=474, Percent_Identity=31.0126582278481, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI221473854, Length=390, Percent_Identity=28.4615384615385, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI78706858, Length=390, Percent_Identity=28.4615384615385, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 54864; Mature: 54864

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINVPDATRIGRATGAKAPEFQELYDFDAAALTLTSAVFPYDSQIHRAHVVMLTEQGIL
CCCCCCCCHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCE
TVEESATILSGLAQVDELAATDGSLRTYLPYEAALKRTIGSVAGKMHIGRSRNDLANAGK
EEHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RMFLRDQLLRTIEAVIGYREAVVHKAADHLDTVMVVYTQRKEAQPITLGHYLMAISENLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHH
KNLDRYRELYARINLCPLGAAATAGTGWPLNRDRTSALLGFDGLVVNSIEGVAGWDHVAE
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCHHHHHH
HAFVNAVFLSGLSRLASEIQLWSTDEYQVAELDASFAGTSSIMPQKKNPDSLERSRKAAF
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHCCCCCCCCCCCCCHHHHHHHHHHH
AAMGPLVGILTSLNAIEYQYSAARVELEPRSIDALIAATHAMTGVVRTLHPNKERMRQYA
HHHHHHHHHHHHHHHHHEEEHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AENYSTMTDLTDMLVRRVGIDYREAHEIVAHVVITAIEKGIKANKIGLDLVQEAAVAQTG
HHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
AGINVSADDIKDALDPWQNVLRREGKGMPAPMSVKASIDDAMAELHKDRAWLANATQALA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
NAKQTLADSVQQIIQTDRKYLR
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNINVPDATRIGRATGAKAPEFQELYDFDAAALTLTSAVFPYDSQIHRAHVVMLTEQGIL
CCCCCCCCHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCE
TVEESATILSGLAQVDELAATDGSLRTYLPYEAALKRTIGSVAGKMHIGRSRNDLANAGK
EEHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RMFLRDQLLRTIEAVIGYREAVVHKAADHLDTVMVVYTQRKEAQPITLGHYLMAISENLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHH
KNLDRYRELYARINLCPLGAAATAGTGWPLNRDRTSALLGFDGLVVNSIEGVAGWDHVAE
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCHHHHHH
HAFVNAVFLSGLSRLASEIQLWSTDEYQVAELDASFAGTSSIMPQKKNPDSLERSRKAAF
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHCCCCCCCCCCCCCHHHHHHHHHHH
AAMGPLVGILTSLNAIEYQYSAARVELEPRSIDALIAATHAMTGVVRTLHPNKERMRQYA
HHHHHHHHHHHHHHHHHEEEHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AENYSTMTDLTDMLVRRVGIDYREAHEIVAHVVITAIEKGIKANKIGLDLVQEAAVAQTG
HHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
AGINVSADDIKDALDPWQNVLRREGKGMPAPMSVKASIDDAMAELHKDRAWLANATQALA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
NAKQTLADSVQQIIQTDRKYLR
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]