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The map label for this gene is algA [H]

Identifier: 110632817

GI number: 110632817

Start: 503469

End: 504884

Strand: Reverse

Name: algA [H]

Synonym: Meso_0456

Alternate gene names: 110632817

Gene position: 504884-503469 (Counterclockwise)

Preceding gene: 110632819

Following gene: 110632814

Centisome position: 11.44

GC content: 62.22

Gene sequence:

>1416_bases
ATGACCGTTACGCCAATCATCATCAGCGGTGGAGCAGGCTCCCGCCTGTGGCCGCTGTCGAGAGACGCGCACCCGAAGCC
TTTCATCGAGTTGCCCGACGGCACAAGCCTCATCAGCCGGACCTATGGCCGGGCGGCGCGGCTTCAAGGCGTGGAGCGAA
TCGTCACCGTCACCAATCGCGATCTCCTCTTCCTTACCGCCGATGTCTACGCGGCTTCCGATGCTCCTCGGCGCAGCAAC
GGCTATCTCCTCGAGCCATTCGGGCGGGATACCGCCGCCGCCGTTGCTCTTGCCACGCTCCACGTAAACGAGGCCGAAGG
GCCTGATGCCGTCCTCCTCGTTCTTCCTGCGGATCACCTGATCGCCGACGAAGACGCGTTCGCAGAGGCAGTTGGCAAGG
CTGTCGAAATGGCGCAGACCGGGCGCATCGTCACCTTTGGCATTGTGCCGGAAAGGGCTGAGACCGGTTACGGCTATATC
GAGGCAAAGGGCGGCAGGGTGCTGCGCTTCGTGGAAAAGCCCGACGCCAAAAAGGCCGCCGATTATGTTGCAAGCGGGCG
TTTCTACTGGAACTCCGGCATGTTCTGTTTCCCTGCTCGCACGATGCTCGAGGCAATGGAAGCACACTGCCCCGAGGTGC
TGGTAGGGGCTCGCGCCGCCTATCGAGCCGCGCGCAAGTTCAACGCCGATGACCGCGAGGTGTTCGAGATCGACCGCGAC
AGCTTTGCGGCCACGCCCGCCATTTCTCTCGATTACGCAGTCATGGAGAAGGCCGAGAATGTGGGCTGCATCGCGCTCGA
CTGCGGCTGGTCCGACATTGGCTCCTGGTCCGCCGTGGCGGAGCTTACGCCCGCAGACGAGAACGGCAACCGCTTGCGCG
GGGAGGTCCTGCTCGAAGACACCAGCAACAGCTTCGTGCATTCGGAGCACCGCTTGGTCGGCCTTGTCGGGGTCTCCGAT
CTCCTGGTTGTCGACACGCCTGACGCCCTGCTCGTGGCTCATAAGGAGAAGGCGCAGGAGGTAAAACGCCTTTTCAACCG
GCTGAAGGAGCAGGGGCACCACGCGGCGAAGCTGCATTGCACGGCGCACCGCCCCTGGGGCACCTACACCGTTTTGGAGG
AGGGTGACCGCTTCAAGATCAAGCGCATCGAGGTAAAGCCCGGCGCCAGGTTGAGCCTGCAGGCGCATCATCACCGCTCC
GAGCACTGGGTTGTGGTGAGCGGCACCGCCAAAATTGTCAATGGCGATCAGGAAATCCTGCTTGCGACGAACCAGTCCAC
CTATATCCCCTGCGGTTTCAAGCACAGGCTCGAAAACCCCGGCATATTGCCGCTCGTACTCATAGAGGTGCAGAGCGGCG
ACTATCTGGGCGAGGATGACATCATCCGCTTCGACGATGTCTATGGGCGGAACTGA

Upstream 100 bases:

>100_bases
TTGACTTGCCTATGGCTTGAGGCCGATGCTTAAGCGATAGACCCGCAAACTGATAGCAGACCGGCGCTAAAGTTAAACCA
AAGGCCACGGAGATGGGGGA

Downstream 100 bases:

>100_bases
GGTGGCCTGAACGGCCGGCCTCAATCAATCTTATTGTCGCGCTGGAAAATCCAGTCGTGGTCGGGATGGTTCTTGAAGCG
CCACGCGCGGCGCGGACTCG

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTVTPIIISGGAGSRLWPLSRDAHPKPFIELPDGTSLISRTYGRAARLQGVERIVTVTNRDLLFLTADVYAASDAPRRSN
GYLLEPFGRDTAAAVALATLHVNEAEGPDAVLLVLPADHLIADEDAFAEAVGKAVEMAQTGRIVTFGIVPERAETGYGYI
EAKGGRVLRFVEKPDAKKAADYVASGRFYWNSGMFCFPARTMLEAMEAHCPEVLVGARAAYRAARKFNADDREVFEIDRD
SFAATPAISLDYAVMEKAENVGCIALDCGWSDIGSWSAVAELTPADENGNRLRGEVLLEDTSNSFVHSEHRLVGLVGVSD
LLVVDTPDALLVAHKEKAQEVKRLFNRLKEQGHHAAKLHCTAHRPWGTYTVLEEGDRFKIKRIEVKPGARLSLQAHHHRS
EHWVVVSGTAKIVNGDQEILLATNQSTYIPCGFKHRLENPGILPLVLIEVQSGDYLGEDDIIRFDDVYGRN

Sequences:

>Translated_471_residues
MTVTPIIISGGAGSRLWPLSRDAHPKPFIELPDGTSLISRTYGRAARLQGVERIVTVTNRDLLFLTADVYAASDAPRRSN
GYLLEPFGRDTAAAVALATLHVNEAEGPDAVLLVLPADHLIADEDAFAEAVGKAVEMAQTGRIVTFGIVPERAETGYGYI
EAKGGRVLRFVEKPDAKKAADYVASGRFYWNSGMFCFPARTMLEAMEAHCPEVLVGARAAYRAARKFNADDREVFEIDRD
SFAATPAISLDYAVMEKAENVGCIALDCGWSDIGSWSAVAELTPADENGNRLRGEVLLEDTSNSFVHSEHRLVGLVGVSD
LLVVDTPDALLVAHKEKAQEVKRLFNRLKEQGHHAAKLHCTAHRPWGTYTVLEEGDRFKIKRIEVKPGARLSLQAHHHRS
EHWVVVSGTAKIVNGDQEILLATNQSTYIPCGFKHRLENPGILPLVLIEVQSGDYLGEDDIIRFDDVYGRN
>Mature_470_residues
TVTPIIISGGAGSRLWPLSRDAHPKPFIELPDGTSLISRTYGRAARLQGVERIVTVTNRDLLFLTADVYAASDAPRRSNG
YLLEPFGRDTAAAVALATLHVNEAEGPDAVLLVLPADHLIADEDAFAEAVGKAVEMAQTGRIVTFGIVPERAETGYGYIE
AKGGRVLRFVEKPDAKKAADYVASGRFYWNSGMFCFPARTMLEAMEAHCPEVLVGARAAYRAARKFNADDREVFEIDRDS
FAATPAISLDYAVMEKAENVGCIALDCGWSDIGSWSAVAELTPADENGNRLRGEVLLEDTSNSFVHSEHRLVGLVGVSDL
LVVDTPDALLVAHKEKAQEVKRLFNRLKEQGHHAAKLHCTAHRPWGTYTVLEEGDRFKIKRIEVKPGARLSLQAHHHRSE
HWVVVSGTAKIVNGDQEILLATNQSTYIPCGFKHRLENPGILPLVLIEVQSGDYLGEDDIIRFDDVYGRN

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=480, Percent_Identity=45.625, Blast_Score=394, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 51692; Mature: 51561

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTPIIISGGAGSRLWPLSRDAHPKPFIELPDGTSLISRTYGRAARLQGVERIVTVTNR
CEEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCHHHHHHCCEEEEEEECC
DLLFLTADVYAASDAPRRSNGYLLEPFGRDTAAAVALATLHVNEAEGPDAVLLVLPADHL
CEEEEEEEEEECCCCCCCCCCEEECCCCCCHHHEEEEEEEEEECCCCCCEEEEEECCCCE
IADEDAFAEAVGKAVEMAQTGRIVTFGIVPERAETGYGYIEAKGGRVLRFVEKPDAKKAA
ECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCEEEEEECCCCHHHHH
DYVASGRFYWNSGMFCFPARTMLEAMEAHCPEVLVGARAAYRAARKFNADDREVFEIDRD
HHHHCCEEEECCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCC
SFAATPAISLDYAVMEKAENVGCIALDCGWSDIGSWSAVAELTPADENGNRLRGEVLLED
CCCCCCCEEECHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEE
TSNSFVHSEHRLVGLVGVSDLLVVDTPDALLVAHKEKAQEVKRLFNRLKEQGHHAAKLHC
CCCCEEECCCEEEEEECCCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEEEE
TAHRPWGTYTVLEEGDRFKIKRIEVKPGARLSLQAHHHRSEHWVVVSGTAKIVNGDQEIL
EEECCCCCEEEEECCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEECCCCEEE
LATNQSTYIPCGFKHRLENPGILPLVLIEVQSGDYLGEDDIIRFDDVYGRN
EEECCCEEECCCHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TVTPIIISGGAGSRLWPLSRDAHPKPFIELPDGTSLISRTYGRAARLQGVERIVTVTNR
EEEEEEEECCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCHHHHHHCCEEEEEEECC
DLLFLTADVYAASDAPRRSNGYLLEPFGRDTAAAVALATLHVNEAEGPDAVLLVLPADHL
CEEEEEEEEEECCCCCCCCCCEEECCCCCCHHHEEEEEEEEEECCCCCCEEEEEECCCCE
IADEDAFAEAVGKAVEMAQTGRIVTFGIVPERAETGYGYIEAKGGRVLRFVEKPDAKKAA
ECCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEECCCEEEEEECCCCHHHHH
DYVASGRFYWNSGMFCFPARTMLEAMEAHCPEVLVGARAAYRAARKFNADDREVFEIDRD
HHHHCCEEEECCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCC
SFAATPAISLDYAVMEKAENVGCIALDCGWSDIGSWSAVAELTPADENGNRLRGEVLLED
CCCCCCCEEECHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEE
TSNSFVHSEHRLVGLVGVSDLLVVDTPDALLVAHKEKAQEVKRLFNRLKEQGHHAAKLHC
CCCCEEECCCEEEEEECCCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHCCCCEEEEEE
TAHRPWGTYTVLEEGDRFKIKRIEVKPGARLSLQAHHHRSEHWVVVSGTAKIVNGDQEIL
EEECCCCCEEEEECCCEEEEEEEEECCCCEEEEEECCCCCCEEEEEECCEEEECCCCEEE
LATNQSTYIPCGFKHRLENPGILPLVLIEVQSGDYLGEDDIIRFDDVYGRN
EEECCCEEECCCHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]