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The map label for this gene is yafV [C]

Identifier: 110632441

GI number: 110632441

Start: 106211

End: 107029

Strand: Direct

Name: yafV [C]

Synonym: Meso_0079

Alternate gene names: 110632441

Gene position: 106211-107029 (Clockwise)

Preceding gene: 110632440

Following gene: 110632447

Centisome position: 2.41

GC content: 62.15

Gene sequence:

>819_bases
ATGAAGAAAATTACCGTCGTCCAGATCAATACGCGCGACGACAAGGCCGCCAACCTTGCAAAGCTGGAATCCCTGGTCCG
TGCCGCCCACGAGGCGGATCACTCCGACTATATCCTCACTCCAGAGCACAGCTTCTGCCTGACCGCCAATAAGGCCACGA
TGCATGCCGCGGCCGAAACCCTGGAAGACGGCGAGGGCTTGCGACGCATGGCCAGCCTGGCCCGCGAACTGGGCACCACC
ATCCACATCGGCAGCATCCTGACCACGCGGAACGGCCGCTATTATAACACATCGGTGGTGATCGGCCCGGATGGGAAGCA
GCTTGCTACCTATGACAAGATACACCGCTATGATGTCGACCTTCCCAGCGGGCTTTCCTATCGCGAATCCGACACGAATG
ATGCCGGCAACGTTGCTGTGACTTACGACCATAACGGCACCAATGTAGGCCTGTCGGTATGCTACGATGTCCGCTTCGGG
TCCCTTTACCTCGAACTCGCAGCGCGCGGCGCCCAGGTCATCACTATCCCCGCCGCCTTTACCTTCGAAACCGGCGCGGC
CCACTGGGATACCTTGGTTCGCGCCCGCGCCATCGAAACCCAATGTTACGTCGCTGCGGCCGGGCAGGTCGGCAGCTTCC
CCGCCTCGGGCGGCGACCGCGCCAGTTTCGGCAATTCACAGATTGTCGACCCCTGGGGCAAGGTGCTGGCCCGCTGTAGC
GACGTGGAAGGCTGGGCCTCGGCGGCCATCGACCCGTCCTATCAAAATCGCGTGCGTCAGAATCTGCCGGTGGCTCGTCA
CCGGCGCGCGATCGCCTGA

Upstream 100 bases:

>100_bases
ATGCTGGTCGAGCGGCTCACGGCGCTCGGGGCCGGCTACATCCGAGACCACGTCAGTAAGAACTTCGCCGCGTGACCCGG
CGCCAGACAGGAAGAGAGAA

Downstream 100 bases:

>100_bases
GCCAAAGCCTCCCTAGGCTGGCAGGAATGTGGCGTAGGTCGGGTGCTTCTCGCACCAGTCCTGCGCCACTTCCTCGGCAA
TGGCATAGATGTCGCGTGCC

Product: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKKITVVQINTRDDKAANLAKLESLVRAAHEADHSDYILTPEHSFCLTANKATMHAAAETLEDGEGLRRMASLARELGTT
IHIGSILTTRNGRYYNTSVVIGPDGKQLATYDKIHRYDVDLPSGLSYRESDTNDAGNVAVTYDHNGTNVGLSVCYDVRFG
SLYLELAARGAQVITIPAAFTFETGAAHWDTLVRARAIETQCYVAAAGQVGSFPASGGDRASFGNSQIVDPWGKVLARCS
DVEGWASAAIDPSYQNRVRQNLPVARHRRAIA

Sequences:

>Translated_272_residues
MKKITVVQINTRDDKAANLAKLESLVRAAHEADHSDYILTPEHSFCLTANKATMHAAAETLEDGEGLRRMASLARELGTT
IHIGSILTTRNGRYYNTSVVIGPDGKQLATYDKIHRYDVDLPSGLSYRESDTNDAGNVAVTYDHNGTNVGLSVCYDVRFG
SLYLELAARGAQVITIPAAFTFETGAAHWDTLVRARAIETQCYVAAAGQVGSFPASGGDRASFGNSQIVDPWGKVLARCS
DVEGWASAAIDPSYQNRVRQNLPVARHRRAIA
>Mature_272_residues
MKKITVVQINTRDDKAANLAKLESLVRAAHEADHSDYILTPEHSFCLTANKATMHAAAETLEDGEGLRRMASLARELGTT
IHIGSILTTRNGRYYNTSVVIGPDGKQLATYDKIHRYDVDLPSGLSYRESDTNDAGNVAVTYDHNGTNVGLSVCYDVRFG
SLYLELAARGAQVITIPAAFTFETGAAHWDTLVRARAIETQCYVAAAGQVGSFPASGGDRASFGNSQIVDPWGKVLARCS
DVEGWASAAIDPSYQNRVRQNLPVARHRRAIA

Specific function: Unknown

COG id: COG0388

COG function: function code R; Predicted amidohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 CN hydrolase domain [H]

Homologues:

Organism=Homo sapiens, GI5031947, Length=275, Percent_Identity=37.8181818181818, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI297632350, Length=275, Percent_Identity=37.8181818181818, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI297632348, Length=275, Percent_Identity=37.8181818181818, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI9910460, Length=271, Percent_Identity=35.0553505535055, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI297632346, Length=198, Percent_Identity=30.8080808080808, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1786412, Length=238, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556280, Length=272, Percent_Identity=36.7647058823529, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323383, Length=276, Percent_Identity=30.7971014492754, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322335, Length=301, Percent_Identity=29.5681063122924, Blast_Score=139, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17933642, Length=268, Percent_Identity=35.8208955223881, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355835, Length=274, Percent_Identity=32.1167883211679, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003010
- InterPro:   IPR001110 [H]

Pfam domain/function: PF00795 CN_hydrolase [H]

EC number: 3.5.-.- [C]

Molecular weight: Translated: 29484; Mature: 29484

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50263 CN_HYDROLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITVVQINTRDDKAANLAKLESLVRAAHEADHSDYILTPEHSFCLTANKATMHAAAET
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEECCHHHHHHHHH
LEDGEGLRRMASLARELGTTIHIGSILTTRNGRYYNTSVVIGPDGKQLATYDKIHRYDVD
HHCCHHHHHHHHHHHHHCCEEEECEEEEECCCCEEEEEEEECCCCCCHHHHHHHHEECCC
LPSGLSYRESDTNDAGNVAVTYDHNGTNVGLSVCYDVRFGSLYLELAARGAQVITIPAAF
CCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEEEEHHHEEEEEHHCCCEEEEEEEEE
TFETGAAHWDTLVRARAIETQCYVAAAGQVGSFPASGGDRASFGNSQIVDPWGKVLARCS
EECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHC
DVEGWASAAIDPSYQNRVRQNLPVARHRRAIA
CCCCHHHHCCCHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MKKITVVQINTRDDKAANLAKLESLVRAAHEADHSDYILTPEHSFCLTANKATMHAAAET
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEECCHHHHHHHHH
LEDGEGLRRMASLARELGTTIHIGSILTTRNGRYYNTSVVIGPDGKQLATYDKIHRYDVD
HHCCHHHHHHHHHHHHHCCEEEECEEEEECCCCEEEEEEEECCCCCCHHHHHHHHEECCC
LPSGLSYRESDTNDAGNVAVTYDHNGTNVGLSVCYDVRFGSLYLELAARGAQVITIPAAF
CCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEEEEHHHEEEEEHHCCCEEEEEEEEE
TFETGAAHWDTLVRARAIETQCYVAAAGQVGSFPASGGDRASFGNSQIVDPWGKVLARCS
EECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHC
DVEGWASAAIDPSYQNRVRQNLPVARHRRAIA
CCCCHHHHCCCHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]