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The map label for this gene is ycgM [H]

Identifier: 110632416

GI number: 110632416

Start: 75422

End: 76120

Strand: Direct

Name: ycgM [H]

Synonym: Meso_0054

Alternate gene names: 110632416

Gene position: 75422-76120 (Clockwise)

Preceding gene: 110632415

Following gene: 110632417

Centisome position: 1.71

GC content: 62.66

Gene sequence:

>699_bases
ATGACCAACTATATCTTCACACCGCCTGAGCGGCCCAGCCTTCCCGTGCGTGGCCTTTCGGCGCGCTTCCCCGTCCGCCG
CATCTTTTGTGTCGGACGGAACTACGCCGAACATGTGCGCGAGATGGGCCGCGACCCGGACCGCAACCCGCCATTCTTCT
TCACCAAGCCATCCGATGCGCTGGTGCAAAACGGGAGCACGATTCCTTATCCTGCCGCGACAGGCAACTTGCAGCACGAA
ATCGAACTGGTCGCTGCCATCGGAACGGCAGGCGCCAACATCTCCGAGCAAGATGCCCTTTCTCATGTCATGGGCTACGC
CGTGGGTAATGACCTGACCCGGCGAGATCTACAGACGCAGGCGCGCGACGATGGCCGTCCCTGGGACACCGGCAAGGCCT
TTGACGCATCCGCTCCAATGACGGAGATCCTCCGCAGCGAAGAAATCGGCCACCCTCAAAGCGGGGAAATCTGGCTCGAC
GTCGACGGCGAGCGGAAGCAGGAGGGAGATTTGGCGCAATTGATCTGGAAGCTCGACGAGATCGTTGCCGCCTGCTCACG
CCTCTGGCGACTGGAGCCGGGCGATCTCATTATGACGGGTACACCAGCCGGGATCGGGCCGGTCACTGCCGGGCAGACCA
TGACCGGCGGAATCGCAGGGTTCCCCGTCCTCACCACGACGATCGGGCCCGCGATATGA

Upstream 100 bases:

>100_bases
GAAGCGCGCGGCAACGAGGCACCGTCTTTCCCACCCTCGCATTGACGAGATCTGAGCCCCACCAGTCGGCAGGCTGGTGC
TGGCTCCAAAGGATACAGAT

Downstream 100 bases:

>100_bases
AACCCGTTCTCTACGACTTCTTCCGTTCGACCGCGGCTTGGCGGGTGCGGATCGCGTTCAATTTGAAGGGCGTAGCCTAT
GACCGCCACGGTGTTTGGAT

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTNYIFTPPERPSLPVRGLSARFPVRRIFCVGRNYAEHVREMGRDPDRNPPFFFTKPSDALVQNGSTIPYPAATGNLQHE
IELVAAIGTAGANISEQDALSHVMGYAVGNDLTRRDLQTQARDDGRPWDTGKAFDASAPMTEILRSEEIGHPQSGEIWLD
VDGERKQEGDLAQLIWKLDEIVAACSRLWRLEPGDLIMTGTPAGIGPVTAGQTMTGGIAGFPVLTTTIGPAI

Sequences:

>Translated_232_residues
MTNYIFTPPERPSLPVRGLSARFPVRRIFCVGRNYAEHVREMGRDPDRNPPFFFTKPSDALVQNGSTIPYPAATGNLQHE
IELVAAIGTAGANISEQDALSHVMGYAVGNDLTRRDLQTQARDDGRPWDTGKAFDASAPMTEILRSEEIGHPQSGEIWLD
VDGERKQEGDLAQLIWKLDEIVAACSRLWRLEPGDLIMTGTPAGIGPVTAGQTMTGGIAGFPVLTTTIGPAI
>Mature_231_residues
TNYIFTPPERPSLPVRGLSARFPVRRIFCVGRNYAEHVREMGRDPDRNPPFFFTKPSDALVQNGSTIPYPAATGNLQHEI
ELVAAIGTAGANISEQDALSHVMGYAVGNDLTRRDLQTQARDDGRPWDTGKAFDASAPMTEILRSEEIGHPQSGEIWLDV
DGERKQEGDLAQLIWKLDEIVAACSRLWRLEPGDLIMTGTPAGIGPVTAGQTMTGGIAGFPVLTTTIGPAI

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI215422413, Length=206, Percent_Identity=40.7766990291262, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI13654274, Length=203, Percent_Identity=40.8866995073892, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI66348062, Length=196, Percent_Identity=41.8367346938776, Blast_Score=166, Evalue=1e-41,
Organism=Homo sapiens, GI156231349, Length=201, Percent_Identity=32.8358208955224, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI40786394, Length=201, Percent_Identity=31.3432835820896, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1787428, Length=214, Percent_Identity=35.5140186915888, Blast_Score=151, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17557057, Length=192, Percent_Identity=32.2916666666667, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324161, Length=218, Percent_Identity=30.7339449541284, Blast_Score=113, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571789, Length=204, Percent_Identity=35.7843137254902, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28572127, Length=183, Percent_Identity=32.7868852459016, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24663695, Length=187, Percent_Identity=26.7379679144385, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 25182; Mature: 25051

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYIFTPPERPSLPVRGLSARFPVRRIFCVGRNYAEHVREMGRDPDRNPPFFFTKPSDA
CCCCEECCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCHH
LVQNGSTIPYPAATGNLQHEIELVAAIGTAGANISEQDALSHVMGYAVGNDLTRRDLQTQ
HHHCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ARDDGRPWDTGKAFDASAPMTEILRSEEIGHPQSGEIWLDVDGERKQEGDLAQLIWKLDE
HHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
IVAACSRLWRLEPGDLIMTGTPAGIGPVTAGQTMTGGIAGFPVLTTTIGPAI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
TNYIFTPPERPSLPVRGLSARFPVRRIFCVGRNYAEHVREMGRDPDRNPPFFFTKPSDA
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCHH
LVQNGSTIPYPAATGNLQHEIELVAAIGTAGANISEQDALSHVMGYAVGNDLTRRDLQTQ
HHHCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
ARDDGRPWDTGKAFDASAPMTEILRSEEIGHPQSGEIWLDVDGERKQEGDLAQLIWKLDE
HHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHH
IVAACSRLWRLEPGDLIMTGTPAGIGPVTAGQTMTGGIAGFPVLTTTIGPAI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10806384 [H]