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The map label for this gene is siaT [H]

Identifier: 110632411

GI number: 110632411

Start: 69133

End: 70908

Strand: Reverse

Name: siaT [H]

Synonym: Meso_0049

Alternate gene names: 110632411

Gene position: 70908-69133 (Counterclockwise)

Preceding gene: 110632412

Following gene: 110632410

Centisome position: 1.61

GC content: 61.37

Gene sequence:

>1776_bases
GTGGTCTGCGCGGATGTCGTGCTTCGCCTTGGCGCTGATCTGCCAATGGCGGGTCTATACGAGATTTCAGCTCTTGTTGC
TGCGATGGCAATGGCGGCTTCCTTCGTTCGCCCGACACTTCTATCCGATCACATTGGAATGGACCTCCTGGCGGAACGCG
GGGATTTTCTCTCGCGGCTGATCCCCGCAGCCGTGACCTCCATCTTCATCGGGCTCGCCACGTGGGCGTTGTTCCGCATG
GCAATGCATGCCTTTGCCAGCGCGGAGACGACGCTGGTGGTCCGGTGGCCCACATGGCCATTCTGGTTTGCCGCGCTTTT
CCTACTTTTCCCGGCTCTTCTCACCATGGCCGTGAATTTCGGCGCCGTGCGGGAGAAACTGCCGGCATGGGATCGAGGCG
CCTTGATCGTGCCATTCTTCCTCCTGCTTGCGATCGGGATTTTGGTGGCGATCTTTGTCTATCAGGACCAGCTTGGCCCG
GTTGCCAAGGGCGGACTTCTTTTCGGGGCGGTCTATGCGCTTGCCATGGCGCAAGTCCCCATCGGGATTTCAATGGGCAT
CGTCGGCGTTACGGGTGTTTGGGCCCTGCTCAGCACGCGTGCAGCAGAACGGGTGTTGCAGAACGAAGTCCGCGACGTGT
TGTCGAGCAATGAACTAATAGCGATCCCTCTGTTCCTAATGATGGGCAGTTTCGCCATCCGGGCCGGGCTGGCGGCGCGG
ATCTTCACGGCAGCCCGTGCGATATTCGGTCCGGTGCGCGGCGGCCTGGCCATCGCGACAGTCGTCGGCTGCGGCGGGTT
TGGGGCAGTCAGCGGGTCATCCGTGGCCACGACGGCGACACTCGGACGTGTGGCCTTCGACGAGATGAGGGTGAACGGTT
ACCGCCAAAGCTTTGCTTGCGGTACGATTGCGGCAGGGGGAACTCTGGGCGCGCTGATCCCGCCTTCGGTCATTCTCATC
ATCTACTGCGTGGTGGCGGAGCAATCCATCGAGCGGGCCTTCGCGGCAGCGCTGTTTCCGGGATTACTGGCGATCTTGCT
CTATGCCGCCACCATCGCCGTCATGGTGCGGCTGCGCCCGGACGTAGCGCCACAGATGGCACAGAAACCGCTGCGCGAGA
TCCTGCGCGATGTTCTTGGGGCCTGGCCACCCGCGCTGCTCTTCATCATTGTCCTGGCCGGTCTTTACGGAGGCCTTTTC
ACTTCGAGCGAAGCGGCAGCCGTGGGGTGCATCCTTGCGCTCATATTCTGGGTTGTCGGCGGGTCGTTTACATTCGGTGC
TCTCAGCGCCTCGCTTTTGGATGCCATGACCTCCAGTGCCAAGCTCTACATGGTTATACTTGGCGCCAGCCTGTTCGCGG
CTCTTCTAAACCTAACCGGGCTTGCCCGCGTCGTCCTCACATGGGCAGATCCCGCGACCACCCCGCAGATCGTGGTGCTG
CTGGCCTTCGTCGCGGTTTACCTCATTCTTGGGGCGATCTTTGATTCCGTTGCAGCCCTTCTAGTTACCGCGCCAATCGT
CATTCCCGTAATCGAGGGGTACGGCCTCGACCTCGTCTGGTGGGGCATCGTGACGCTCAGCATGATCGAGACGGGAATGA
TCACGCCACCGATCGGGATGAATGTTTTCGTTCTGCGGGGGGTGCTTGGCGGCGAGATCCGGCTGCAGGACATCTATCGC
GGGATCTGGCCTTTCGTCTGCGCGGATCTGGTGCGGCTGGCACTGCTGCTCGCCATACCTTCCATCGCCCTTTGGTTGCC
GAGCGCGATAGGCTAG

Upstream 100 bases:

>100_bases
GGCGTGTGGCGCCAACATAAACCTCTGGTCCCCGATTCGAGCAGTGGTTCTCGACCAGTTCGCGCTTTGGGCGGGTTTTC
TTCTTCTCGGGCTGGCGGTT

Downstream 100 bases:

>100_bases
GCCGTTTGGAGGTCAGTGATGTCCATGGAGCCTTCCGTTAAAAATGGCAGGCTTCGGCAGACGTCGCGCCAGGAGTAATT
GGCGAGCTTCGTTTCGCGCA

Product: TRAP dicarboxylate transporter, DctM subunit

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MVCADVVLRLGADLPMAGLYEISALVAAMAMAASFVRPTLLSDHIGMDLLAERGDFLSRLIPAAVTSIFIGLATWALFRM
AMHAFASAETTLVVRWPTWPFWFAALFLLFPALLTMAVNFGAVREKLPAWDRGALIVPFFLLLAIGILVAIFVYQDQLGP
VAKGGLLFGAVYALAMAQVPIGISMGIVGVTGVWALLSTRAAERVLQNEVRDVLSSNELIAIPLFLMMGSFAIRAGLAAR
IFTAARAIFGPVRGGLAIATVVGCGGFGAVSGSSVATTATLGRVAFDEMRVNGYRQSFACGTIAAGGTLGALIPPSVILI
IYCVVAEQSIERAFAAALFPGLLAILLYAATIAVMVRLRPDVAPQMAQKPLREILRDVLGAWPPALLFIIVLAGLYGGLF
TSSEAAAVGCILALIFWVVGGSFTFGALSASLLDAMTSSAKLYMVILGASLFAALLNLTGLARVVLTWADPATTPQIVVL
LAFVAVYLILGAIFDSVAALLVTAPIVIPVIEGYGLDLVWWGIVTLSMIETGMITPPIGMNVFVLRGVLGGEIRLQDIYR
GIWPFVCADLVRLALLLAIPSIALWLPSAIG

Sequences:

>Translated_591_residues
MVCADVVLRLGADLPMAGLYEISALVAAMAMAASFVRPTLLSDHIGMDLLAERGDFLSRLIPAAVTSIFIGLATWALFRM
AMHAFASAETTLVVRWPTWPFWFAALFLLFPALLTMAVNFGAVREKLPAWDRGALIVPFFLLLAIGILVAIFVYQDQLGP
VAKGGLLFGAVYALAMAQVPIGISMGIVGVTGVWALLSTRAAERVLQNEVRDVLSSNELIAIPLFLMMGSFAIRAGLAAR
IFTAARAIFGPVRGGLAIATVVGCGGFGAVSGSSVATTATLGRVAFDEMRVNGYRQSFACGTIAAGGTLGALIPPSVILI
IYCVVAEQSIERAFAAALFPGLLAILLYAATIAVMVRLRPDVAPQMAQKPLREILRDVLGAWPPALLFIIVLAGLYGGLF
TSSEAAAVGCILALIFWVVGGSFTFGALSASLLDAMTSSAKLYMVILGASLFAALLNLTGLARVVLTWADPATTPQIVVL
LAFVAVYLILGAIFDSVAALLVTAPIVIPVIEGYGLDLVWWGIVTLSMIETGMITPPIGMNVFVLRGVLGGEIRLQDIYR
GIWPFVCADLVRLALLLAIPSIALWLPSAIG
>Mature_591_residues
MVCADVVLRLGADLPMAGLYEISALVAAMAMAASFVRPTLLSDHIGMDLLAERGDFLSRLIPAAVTSIFIGLATWALFRM
AMHAFASAETTLVVRWPTWPFWFAALFLLFPALLTMAVNFGAVREKLPAWDRGALIVPFFLLLAIGILVAIFVYQDQLGP
VAKGGLLFGAVYALAMAQVPIGISMGIVGVTGVWALLSTRAAERVLQNEVRDVLSSNELIAIPLFLMMGSFAIRAGLAAR
IFTAARAIFGPVRGGLAIATVVGCGGFGAVSGSSVATTATLGRVAFDEMRVNGYRQSFACGTIAAGGTLGALIPPSVILI
IYCVVAEQSIERAFAAALFPGLLAILLYAATIAVMVRLRPDVAPQMAQKPLREILRDVLGAWPPALLFIIVLAGLYGGLF
TSSEAAAVGCILALIFWVVGGSFTFGALSASLLDAMTSSAKLYMVILGASLFAALLNLTGLARVVLTWADPATTPQIVVL
LAFVAVYLILGAIFDSVAALLVTAPIVIPVIEGYGLDLVWWGIVTLSMIETGMITPPIGMNVFVLRGVLGGEIRLQDIYR
GIWPFVCADLVRLALLLAIPSIALWLPSAIG

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=394, Percent_Identity=28.9340101522843, Blast_Score=106, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 62285; Mature: 62285

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCADVVLRLGADLPMAGLYEISALVAAMAMAASFVRPTLLSDHIGMDLLAERGDFLSRL
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IPAAVTSIFIGLATWALFRMAMHAFASAETTLVVRWPTWPFWFAALFLLFPALLTMAVNF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
GAVREKLPAWDRGALIVPFFLLLAIGILVAIFVYQDQLGPVAKGGLLFGAVYALAMAQVP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IGISMGIVGVTGVWALLSTRAAERVLQNEVRDVLSSNELIAIPLFLMMGSFAIRAGLAAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IFTAARAIFGPVRGGLAIATVVGCGGFGAVSGSSVATTATLGRVAFDEMRVNGYRQSFAC
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GTIAAGGTLGALIPPSVILIIYCVVAEQSIERAFAAALFPGLLAILLYAATIAVMVRLRP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVAPQMAQKPLREILRDVLGAWPPALLFIIVLAGLYGGLFTSSEAAAVGCILALIFWVVG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GSFTFGALSASLLDAMTSSAKLYMVILGASLFAALLNLTGLARVVLTWADPATTPQIVVL
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LAFVAVYLILGAIFDSVAALLVTAPIVIPVIEGYGLDLVWWGIVTLSMIETGMITPPIGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
NVFVLRGVLGGEIRLQDIYRGIWPFVCADLVRLALLLAIPSIALWLPSAIG
HHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVCADVVLRLGADLPMAGLYEISALVAAMAMAASFVRPTLLSDHIGMDLLAERGDFLSRL
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
IPAAVTSIFIGLATWALFRMAMHAFASAETTLVVRWPTWPFWFAALFLLFPALLTMAVNF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
GAVREKLPAWDRGALIVPFFLLLAIGILVAIFVYQDQLGPVAKGGLLFGAVYALAMAQVP
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
IGISMGIVGVTGVWALLSTRAAERVLQNEVRDVLSSNELIAIPLFLMMGSFAIRAGLAAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IFTAARAIFGPVRGGLAIATVVGCGGFGAVSGSSVATTATLGRVAFDEMRVNGYRQSFAC
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GTIAAGGTLGALIPPSVILIIYCVVAEQSIERAFAAALFPGLLAILLYAATIAVMVRLRP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DVAPQMAQKPLREILRDVLGAWPPALLFIIVLAGLYGGLFTSSEAAAVGCILALIFWVVG
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GSFTFGALSASLLDAMTSSAKLYMVILGASLFAALLNLTGLARVVLTWADPATTPQIVVL
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LAFVAVYLILGAIFDSVAALLVTAPIVIPVIEGYGLDLVWWGIVTLSMIETGMITPPIGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
NVFVLRGVLGGEIRLQDIYRGIWPFVCADLVRLALLLAIPSIALWLPSAIG
HHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]