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The map label for this gene is lig [H]

Identifier: 110632394

GI number: 110632394

Start: 38306

End: 39916

Strand: Direct

Name: lig [H]

Synonym: Meso_0032

Alternate gene names: 110632394

Gene position: 38306-39916 (Clockwise)

Preceding gene: 110632393

Following gene: 110632396

Centisome position: 0.87

GC content: 63.38

Gene sequence:

>1611_bases
GTGGAACGCTTCGCCGAACTCCTCGACCGGCTGGTGCTGACGCCATCGCGAAACGGCAAGCTGCGGCTCCTGACCGACTA
TTTCGCAACCGTGCCCGACCCCGACCGCGGCTATGGGCTCGCTGCACTCACCGGGGGCATCGGCTTTCCCGCGGTGAAGC
CGGCCATGCTGCGCATGCTGGTGATGGAGCGGGTCGACCCTGTGCTTTTCGGCTATTCCTATGACTATGTGGGCGATCTT
GCCGAAACCGTCTCGCTCATCTGGCCGGCGGGCGAAAACGAGGAGGCGGAGGCGCCGTCGCTCTCGGAAGTGGTGGAGCG
GCTAGCGCAGGCAAGCCGCTCCGATGCGCCGGCGGTGGTGGCCCGGCTCCTCGACCAGCTTTCTCCCTCCGGCCGCTTCG
CCGCGATCAAGCTTGCCACGGGCGGCCTGCGCGTCGGCGTCTCCGCGAGGCTCACAAAGCAGGCGCTCGCCGATTTCGGC
CAGGTGGATGTGCAGGAGATCGAAGAACTCTGGCACGGGCTCTGGCCGCCCTATACCGAACTGTTCGCCTGGCTGGAAAA
GCGAGGGCCCAAGCCGGAAAATGCCGCCAAGGCGCCGTTCCGGCCCGTCATGCTGGCACATGCGATCGAGGAGGCGGACT
TTGCCAATCTTAAGCCTGCGGACTATGCCGCCGAATGGAAGTGGGACGGCATTCGCGTGCAAGCCGTGGCTGAAGATGGC
GTGCGCAGGCTCTATTCCCGCACGGGCGACGATATTTCCGGCGCCTTTCCCGACCTTGCTGAGGCCATGGATTTTGAAGC
AGCCCTCGACGGCGAGCTTCTGGTGGGCGACCCGCGCGAGAGGACCGGCACTTTTTCTGACCTGCAGCAGAGGCTGAACC
GCAAGAGCGTCTCGCAGAAGATGCTCAGGGACTATCCGGTTTTCATGCGCTGCTATGATGTCCTGTCGCTCGGCGGGCGC
GATACGCGGCCGCTGGCCTATGCGGAGCGCCGCGAGCTTCTGAAAGAGTTCCTGACCACGCTTCCACCTGATCGCTTCGA
CCTCTCGCCCGCAATTTCCTTCGAGACCTGGGAGGATCTTGACGACAAACGCTGCAACCCGCCGCATCCCATTATCGAAG
GGGTGATGCTGAAGCGCAGGGATTCACATTATCTGCCGGGCCGTCCGAAAGGACCTTGGTTCAAGTGGAAGCGCGATCCT
TTCACGGTGGACGCGGTTTTGATGTATGCCCAGCGCGGCCATGGCAAGCGGTCAAGCTTTTACTCCGACTATACGTTCGG
GGTATGGGCCGGACCGGAGGAGGAGCCGATGCTGGTGCCGGTGGGAAAAGCCTATTTCGGCTTCACCGACGAGGAGCTGA
AGCAGATTGACAAATACGTGCGGGATAACACGACAGAGCGTTTCGGCCCCGTGCGCGCGGTGCGCGCGGACCGCAATCAT
GGGCTCGTGCTCGAAGTGGCCTTCGAAGGCCTTGCCCGTTCCACGCGGCACAAATCCGGCATAGCCATGCGGTTCCCGCG
CATTTCGCGCCTGCGCTGGGATAAGCCGAGCCGAGAGGCGGACCGGATCGAAACGCTGGAGGCGATGATACCAAAGGGCG
CAGGTGCTTGA

Upstream 100 bases:

>100_bases
TGACGCATGGTCGCGAGGAGGCGCTTGTTCGCTGGTGCGAGATCAATGGCATCGCGGCGAAACCCTTGCATCTTGCGGGC
TACGAGGACGAGACGGAATA

Downstream 100 bases:

>100_bases
TGACCTCCGCTCCTTTCATTCCATTCGCTACTCGCTTTTTACTCCGCTTCCCGCACCCTTAATGAGAAAACATTCAACAT
CCTGCGTTGCCCACTGACAT

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MERFAELLDRLVLTPSRNGKLRLLTDYFATVPDPDRGYGLAALTGGIGFPAVKPAMLRMLVMERVDPVLFGYSYDYVGDL
AETVSLIWPAGENEEAEAPSLSEVVERLAQASRSDAPAVVARLLDQLSPSGRFAAIKLATGGLRVGVSARLTKQALADFG
QVDVQEIEELWHGLWPPYTELFAWLEKRGPKPENAAKAPFRPVMLAHAIEEADFANLKPADYAAEWKWDGIRVQAVAEDG
VRRLYSRTGDDISGAFPDLAEAMDFEAALDGELLVGDPRERTGTFSDLQQRLNRKSVSQKMLRDYPVFMRCYDVLSLGGR
DTRPLAYAERRELLKEFLTTLPPDRFDLSPAISFETWEDLDDKRCNPPHPIIEGVMLKRRDSHYLPGRPKGPWFKWKRDP
FTVDAVLMYAQRGHGKRSSFYSDYTFGVWAGPEEEPMLVPVGKAYFGFTDEELKQIDKYVRDNTTERFGPVRAVRADRNH
GLVLEVAFEGLARSTRHKSGIAMRFPRISRLRWDKPSREADRIETLEAMIPKGAGA

Sequences:

>Translated_536_residues
MERFAELLDRLVLTPSRNGKLRLLTDYFATVPDPDRGYGLAALTGGIGFPAVKPAMLRMLVMERVDPVLFGYSYDYVGDL
AETVSLIWPAGENEEAEAPSLSEVVERLAQASRSDAPAVVARLLDQLSPSGRFAAIKLATGGLRVGVSARLTKQALADFG
QVDVQEIEELWHGLWPPYTELFAWLEKRGPKPENAAKAPFRPVMLAHAIEEADFANLKPADYAAEWKWDGIRVQAVAEDG
VRRLYSRTGDDISGAFPDLAEAMDFEAALDGELLVGDPRERTGTFSDLQQRLNRKSVSQKMLRDYPVFMRCYDVLSLGGR
DTRPLAYAERRELLKEFLTTLPPDRFDLSPAISFETWEDLDDKRCNPPHPIIEGVMLKRRDSHYLPGRPKGPWFKWKRDP
FTVDAVLMYAQRGHGKRSSFYSDYTFGVWAGPEEEPMLVPVGKAYFGFTDEELKQIDKYVRDNTTERFGPVRAVRADRNH
GLVLEVAFEGLARSTRHKSGIAMRFPRISRLRWDKPSREADRIETLEAMIPKGAGA
>Mature_536_residues
MERFAELLDRLVLTPSRNGKLRLLTDYFATVPDPDRGYGLAALTGGIGFPAVKPAMLRMLVMERVDPVLFGYSYDYVGDL
AETVSLIWPAGENEEAEAPSLSEVVERLAQASRSDAPAVVARLLDQLSPSGRFAAIKLATGGLRVGVSARLTKQALADFG
QVDVQEIEELWHGLWPPYTELFAWLEKRGPKPENAAKAPFRPVMLAHAIEEADFANLKPADYAAEWKWDGIRVQAVAEDG
VRRLYSRTGDDISGAFPDLAEAMDFEAALDGELLVGDPRERTGTFSDLQQRLNRKSVSQKMLRDYPVFMRCYDVLSLGGR
DTRPLAYAERRELLKEFLTTLPPDRFDLSPAISFETWEDLDDKRCNPPHPIIEGVMLKRRDSHYLPGRPKGPWFKWKRDP
FTVDAVLMYAQRGHGKRSSFYSDYTFGVWAGPEEEPMLVPVGKAYFGFTDEELKQIDKYVRDNTTERFGPVRAVRADRNH
GLVLEVAFEGLARSTRHKSGIAMRFPRISRLRWDKPSREADRIETLEAMIPKGAGA

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=368, Percent_Identity=27.7173913043478, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71985269, Length=371, Percent_Identity=28.3018867924528, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320038, Length=357, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24762424, Length=364, Percent_Identity=26.6483516483516, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 60371; Mature: 60371

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERFAELLDRLVLTPSRNGKLRLLTDYFATVPDPDRGYGLAALTGGIGFPAVKPAMLRML
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCCCCCCEEHEEECCCCCCHHHHHHHHHH
VMERVDPVLFGYSYDYVGDLAETVSLIWPAGENEEAEAPSLSEVVERLAQASRSDAPAVV
HHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
ARLLDQLSPSGRFAAIKLATGGLRVGVSARLTKQALADFGQVDVQEIEELWHGLWPPYTE
HHHHHHCCCCCCEEEEEEECCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
LFAWLEKRGPKPENAAKAPFRPVMLAHAIEEADFANLKPADYAAEWKWDGIRVQAVAEDG
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCEEEEEHHHHH
VRRLYSRTGDDISGAFPDLAEAMDFEAALDGELLVGDPRERTGTFSDLQQRLNRKSVSQK
HHHHHHCCCCCCCCCCHHHHHHHCHHHHCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHH
MLRDYPVFMRCYDVLSLGGRDTRPLAYAERRELLKEFLTTLPPDRFDLSPAISFETWEDL
HHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCC
DDKRCNPPHPIIEGVMLKRRDSHYLPGRPKGPWFKWKRDPFTVDAVLMYAQRGHGKRSSF
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
YSDYTFGVWAGPEEEPMLVPVGKAYFGFTDEELKQIDKYVRDNTTERFGPVRAVRADRNH
CCCCCEEEECCCCCCCEEEECCHHHHCCCHHHHHHHHHHHHCCCHHHHCCHHHEECCCCC
GLVLEVAFEGLARSTRHKSGIAMRFPRISRLRWDKPSREADRIETLEAMIPKGAGA
CEEEEEHHHHHHHHHHHCCCCEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MERFAELLDRLVLTPSRNGKLRLLTDYFATVPDPDRGYGLAALTGGIGFPAVKPAMLRML
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCCCCCCEEHEEECCCCCCHHHHHHHHHH
VMERVDPVLFGYSYDYVGDLAETVSLIWPAGENEEAEAPSLSEVVERLAQASRSDAPAVV
HHHHCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
ARLLDQLSPSGRFAAIKLATGGLRVGVSARLTKQALADFGQVDVQEIEELWHGLWPPYTE
HHHHHHCCCCCCEEEEEEECCCEEECHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
LFAWLEKRGPKPENAAKAPFRPVMLAHAIEEADFANLKPADYAAEWKWDGIRVQAVAEDG
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCEEEEEHHHHH
VRRLYSRTGDDISGAFPDLAEAMDFEAALDGELLVGDPRERTGTFSDLQQRLNRKSVSQK
HHHHHHCCCCCCCCCCHHHHHHHCHHHHCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHH
MLRDYPVFMRCYDVLSLGGRDTRPLAYAERRELLKEFLTTLPPDRFDLSPAISFETWEDL
HHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCC
DDKRCNPPHPIIEGVMLKRRDSHYLPGRPKGPWFKWKRDPFTVDAVLMYAQRGHGKRSSF
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
YSDYTFGVWAGPEEEPMLVPVGKAYFGFTDEELKQIDKYVRDNTTERFGPVRAVRADRNH
CCCCCEEEECCCCCCCEEEECCHHHHCCCHHHHHHHHHHHHCCCHHHHCCHHHEECCCCC
GLVLEVAFEGLARSTRHKSGIAMRFPRISRLRWDKPSREADRIETLEAMIPKGAGA
CEEEEEHHHHHHHHHHHCCCCEEECCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA