Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 109948250

GI number: 109948250

Start: 1551184

End: 1552977

Strand: Reverse

Name: glmS [H]

Synonym: Hac_1787

Alternate gene names: 109948250

Gene position: 1552977-1551184 (Counterclockwise)

Preceding gene: 109948251

Following gene: 109948249

Centisome position: 99.94

GC content: 39.63

Gene sequence:

>1794_bases
ATGTGTGGGATTGTAGGTTATATAGGGAATAGTGAAAAAAAATCCATTCTTTTAGAGGGCTTGAAGGAATTAGAATACAG
AGGTTATGATAGTGCTGGTTTGGCCATATTGAGCGATAATCGTTTGGAAGTGTTTAAAGCTCAAGGGAAATTAGAAAACC
TTAGATCAGAGCTTAAAGATAAGGAGTTTTTGAATTTTGGCGTGAGTATCGCTCACACCAGATGGGCAACGCATGGGAAA
CCAAACAGCGTGAATGCCCATCCGCATTTTACAGAAAATTTAGCCTTAGTGCATAATGGGATCATTGAAAATTATGCGAG
TTTGAAAAAAGGATTAGAAAATAAAGGGCATGCGTTTTTGAGCCAAACGGACACGGAAGTCATTGCACATCTCTTAGAAG
AAACGCTTAAAAGCGAGAGCGATTTATTGAAAGCCTTTGAAAAAAGCATCAGCCTTTTAGAGGGGAGTTATGCGATTTTA
ATGCTCCATAAAAGGGCCAAAGAGAGCTTGTTTTACGCTAAATCTTCTTCACCTTTAATCGTGGGTAAGGGGCAAGAGGG
GTTGTTTTTTGCGTCAAGTTTGAGCGTGTTAGCCCCTAAAGTGGAGCAATTTGTCATCTTAGAAGAAAACAGCGTGGGGC
AAATTTCTTTAGAGAATTTTCAAGATTTAAAACACATTGAAAACATGAAAGATTACGCCTTTGACAATAAGGATTATTCT
AAAGGGAATTTTAGGAATTATTTAGAAAAAGAGATTTATGAGCAGCATAGCAGTTTGTTAGAGTGTTTAGAGGGGCGTTT
GGAAGCCTTGAATGTGTATTGCGAGATCGATCCTAAATTTTTAGAAAATGTGAGTGAGATCACGCTGTGTTCTTGTGGGA
GTAGCTATCATGCGAGTTTGGCGAGCGTGTATTTGTTTGAAAGGTTGGCCAAAATAAGAGCGAGAGCCATTTTAGCGAGC
GAATACCGCTACGCCAATTTCAAAAGCAACCCTAACGAGCTTTTTATAGCGATTTCTCAAAGCGGAGAAACCGCTGACAC
TTTAGAGGCTTTAAAATTAGCCAAAGCGCAAGGGCTTAAAACCATTAGTTTGTGTAACGCCCCTTTTAGCATGATGAACC
GCATTAGCGATCACACTTTGTTGATTAGAGCGGGGGTAGAAAGGAGCGTGGCATCTACTAAGGCGTTTTCTTCGCAAGTG
ATGCTTTTATGGCTTTTGAGCGTGTATGTGGGCAAACAACTAGGGACGATTTCTAAAGAAGAAGAAAAGATCCAAGCTAA
AAACATGTTAGATAGCGTGAATGCGATGAAAATAGAGTCTAAATTGCATGAAAAAATCAAGCGCCTATCCAAACGCTACT
TGCATGGGCATGGCTTTTTTTATATTGGGCGCGATGTGTTTTACCCGCTTGCTTTAGAGGGGGCGTTAAAACTTAAAGAG
ATTAGTTACTTGCACGCTGAAGGGTATGCGAGTGCAGAGATGAAGCATGGGCCTATTGCGTTGGTGGATTCTAACCTTTT
TACTATTGCGTTATTGTCTAAACATTTATTGTTTGATAAAACAAAAAGCAATATTGAAGAATTGAGCGCTAGGGATTCTA
CGATTTGCGTGTTAAGCTCTGAAGTTTTAGAAATCGCTGATGATTTTATCCAATTAGAAGAGAGTGAAAGCTACATGGAA
GAATTTTTCCGCATGAATTTAGCGATGCAACTTTTAGCTTTAGAAATCGCTATGCGCTTAAATCATGATGTGGATCACCC
AAGAAATCTGGCTAAAAGCGTAACCGTGGAATGA

Upstream 100 bases:

>100_bases
GAATGAAGCGTTTTTTACGCAATTAAGCGAAGAAGTGGAGCGCCTAAAGGAGCTTATCAACGCTTTAAATAAAATCAAAA
AAGGGTTATTGGTGTTTTAA

Downstream 100 bases:

>100_bases
GCTAATAGCGATACAGGAGTAAAATAATGGAAGTGATTTGTAAGCATCACACCCCTTTAGACATTGCAAGCCAAGCGATC
CGCACTTGCTGGCAAAGTTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MCGIVGYIGNSEKKSILLEGLKELEYRGYDSAGLAILSDNRLEVFKAQGKLENLRSELKDKEFLNFGVSIAHTRWATHGK
PNSVNAHPHFTENLALVHNGIIENYASLKKGLENKGHAFLSQTDTEVIAHLLEETLKSESDLLKAFEKSISLLEGSYAIL
MLHKRAKESLFYAKSSSPLIVGKGQEGLFFASSLSVLAPKVEQFVILEENSVGQISLENFQDLKHIENMKDYAFDNKDYS
KGNFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASLASVYLFERLAKIRARAILAS
EYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLKTISLCNAPFSMMNRISDHTLLIRAGVERSVASTKAFSSQV
MLLWLLSVYVGKQLGTISKEEEKIQAKNMLDSVNAMKIESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSSEVLEIADDFIQLEESESYME
EFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE

Sequences:

>Translated_597_residues
MCGIVGYIGNSEKKSILLEGLKELEYRGYDSAGLAILSDNRLEVFKAQGKLENLRSELKDKEFLNFGVSIAHTRWATHGK
PNSVNAHPHFTENLALVHNGIIENYASLKKGLENKGHAFLSQTDTEVIAHLLEETLKSESDLLKAFEKSISLLEGSYAIL
MLHKRAKESLFYAKSSSPLIVGKGQEGLFFASSLSVLAPKVEQFVILEENSVGQISLENFQDLKHIENMKDYAFDNKDYS
KGNFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASLASVYLFERLAKIRARAILAS
EYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLKTISLCNAPFSMMNRISDHTLLIRAGVERSVASTKAFSSQV
MLLWLLSVYVGKQLGTISKEEEKIQAKNMLDSVNAMKIESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSSEVLEIADDFIQLEESESYME
EFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE
>Mature_597_residues
MCGIVGYIGNSEKKSILLEGLKELEYRGYDSAGLAILSDNRLEVFKAQGKLENLRSELKDKEFLNFGVSIAHTRWATHGK
PNSVNAHPHFTENLALVHNGIIENYASLKKGLENKGHAFLSQTDTEVIAHLLEETLKSESDLLKAFEKSISLLEGSYAIL
MLHKRAKESLFYAKSSSPLIVGKGQEGLFFASSLSVLAPKVEQFVILEENSVGQISLENFQDLKHIENMKDYAFDNKDYS
KGNFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASLASVYLFERLAKIRARAILAS
EYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLKTISLCNAPFSMMNRISDHTLLIRAGVERSVASTKAFSSQV
MLLWLLSVYVGKQLGTISKEEEKIQAKNMLDSVNAMKIESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSSEVLEIADDFIQLEESESYME
EFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=694, Percent_Identity=30.9798270893372, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=29.7101449275362, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI29570798, Length=199, Percent_Identity=28.1407035175879, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=40.5186385737439, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788651, Length=196, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=29.3302540415704, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=29.3302540415704, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17539970, Length=513, Percent_Identity=27.6803118908382, Blast_Score=177, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322745, Length=376, Percent_Identity=33.5106382978723, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=26.4840182648402, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323730, Length=209, Percent_Identity=35.8851674641148, Blast_Score=113, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=30.5676855895196, Blast_Score=286, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67103; Mature: 67103

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGNSEKKSILLEGLKELEYRGYDSAGLAILSDNRLEVFKAQGKLENLRSELKD
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEHHHCCHHHHHHHHHCH
KEFLNFGVSIAHTRWATHGKPNSVNAHPHFTENLALVHNGIIENYASLKKGLENKGHAFL
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEH
SQTDTEVIAHLLEETLKSESDLLKAFEKSISLLEGSYAILMLHKRAKESLFYAKSSSPLI
HCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHEEEECCCCCEE
VGKGQEGLFFASSLSVLAPKVEQFVILEENSVGQISLENFQDLKHIENMKDYAFDNKDYS
EECCCCCEEEEHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCC
KGNFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHCCHHHEEEECCCCHHHHHH
ASVYLFERLAKIRARAILASEYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
TISLCNAPFSMMNRISDHTLLIRAGVERSVASTKAFSSQVMLLWLLSVYVGKQLGTISKE
EEEECCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EEKIQAKNMLDSVNAMKIESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCHHHHH
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSS
HHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
EVLEIADDFIQLEESESYMEEFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGNSEKKSILLEGLKELEYRGYDSAGLAILSDNRLEVFKAQGKLENLRSELKD
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEHHHCCHHHHHHHHHCH
KEFLNFGVSIAHTRWATHGKPNSVNAHPHFTENLALVHNGIIENYASLKKGLENKGHAFL
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEH
SQTDTEVIAHLLEETLKSESDLLKAFEKSISLLEGSYAILMLHKRAKESLFYAKSSSPLI
HCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHEEEECCCCCEE
VGKGQEGLFFASSLSVLAPKVEQFVILEENSVGQISLENFQDLKHIENMKDYAFDNKDYS
EECCCCCEEEEHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCC
KGNFRNYLEKEIYEQHSSLLECLEGRLEALNVYCEIDPKFLENVSEITLCSCGSSYHASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHHCCHHHEEEECCCCHHHHHH
ASVYLFERLAKIRARAILASEYRYANFKSNPNELFIAISQSGETADTLEALKLAKAQGLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCC
TISLCNAPFSMMNRISDHTLLIRAGVERSVASTKAFSSQVMLLWLLSVYVGKQLGTISKE
EEEECCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
EEKIQAKNMLDSVNAMKIESKLHEKIKRLSKRYLHGHGFFYIGRDVFYPLALEGALKLKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCHHHHH
ISYLHAEGYASAEMKHGPIALVDSNLFTIALLSKHLLFDKTKSNIEELSARDSTICVLSS
HHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
EVLEIADDFIQLEESESYMEEFFRMNLAMQLLALEIAMRLNHDVDHPRNLAKSVTVE
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]