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The map label for this gene is ubiE [H]

Identifier: 109948210

GI number: 109948210

Start: 1518326

End: 1519066

Strand: Reverse

Name: ubiE [H]

Synonym: Hac_1743

Alternate gene names: 109948210

Gene position: 1519066-1518326 (Counterclockwise)

Preceding gene: 109948211

Following gene: 109948209

Centisome position: 97.76

GC content: 36.57

Gene sequence:

>741_bases
ATGAAAAAAGAAAAGCATCTCAAGCAAGAAAAAATCATCAACATGTTTGATGATATAGCTAGCTCTTATGATCAAGCGAA
TCGCTTGATAAGTTTTGGTTTAGATGTTAAATGGCGTGAAAGGGCTTGCGAGCATGCGTTTTTGTTTTTAGAAAATAAGA
AAGCTTTAAAGCTTGTGGATGTGGCATGCGGGACAGGGGATATGCTTTTGGCTTGGCAAAAAAGCGCTCTAAATTGCAAT
ATAGAGTTTAAAGAATGTTTGGGGATTGACCCATCAAACAACATGCTAGAATTGGCCATTAAAAAATGTGAGAAGCTTGG
AAACAAAACTTCTTTTATCCAGGCTCAAGCCAAAGATTTAAAAGGCGTTGAAAGTAACAGCGTGGATATTCTCTCCATTG
CGTATGGCTTGCGTAATATCGTGGAAAGACAAGAGGCTTTAAAAGAGTTTTTTAGGGTGTTAAAGCCTAGGGGCGTTTTA
GTGATTGTAGAATTTTTAAAAAAAGACAACCCCACATGGTTAGATAAAATCTCATGGTTTTACACGAATAAGGTTTTGCC
TTTAGTGGGAGGGGCTATCAGTAAAAATTATGGTGCTTATTCTTATTTACCGCAATCCATTGAAGGGTTTTTGAGTTTAG
AGAGTTTGAAAAGTGAATTAAAAAACGCAGGGTTTGAGATTTTAAGAACCGAAGATTCTATCGCTCAAATTTCAACGACC
ATGCTTGTGAAAAAAAGCTAA

Upstream 100 bases:

>100_bases
AAAAAGCGGGAAGTTTTATCGTATGTTTAATGAAATACCCACGATTTTAATGATACTCATTGTGATTTTAGTGGTTGTCA
AGCCCTTTTAAAGACTGATC

Downstream 100 bases:

>100_bases
AGGAATGCCCCATGCAAGATGAATTGTTTGAGGTTGAAAAAGCCCCCAAAAAAAGCGTTAAAAACGCTCCTAAAAAAAGT
TTTGAAGAGCATGTTGATTC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLISFGLDVKWRERACEHAFLFLENKKALKLVDVACGTGDMLLAWQKSALNCN
IEFKECLGIDPSNNMLELAIKKCEKLGNKTSFIQAQAKDLKGVESNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVL
VIVEFLKKDNPTWLDKISWFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLESLKSELKNAGFEILRTEDSIAQISTT
MLVKKS

Sequences:

>Translated_246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLISFGLDVKWRERACEHAFLFLENKKALKLVDVACGTGDMLLAWQKSALNCN
IEFKECLGIDPSNNMLELAIKKCEKLGNKTSFIQAQAKDLKGVESNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVL
VIVEFLKKDNPTWLDKISWFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLESLKSELKNAGFEILRTEDSIAQISTT
MLVKKS
>Mature_246_residues
MKKEKHLKQEKIINMFDDIASSYDQANRLISFGLDVKWRERACEHAFLFLENKKALKLVDVACGTGDMLLAWQKSALNCN
IEFKECLGIDPSNNMLELAIKKCEKLGNKTSFIQAQAKDLKGVESNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVL
VIVEFLKKDNPTWLDKISWFYTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLESLKSELKNAGFEILRTEDSIAQISTT
MLVKKS

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=265, Percent_Identity=27.5471698113208, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI48994983, Length=226, Percent_Identity=29.646017699115, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17557039, Length=229, Percent_Identity=26.6375545851528, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323526, Length=232, Percent_Identity=30.6034482758621, Blast_Score=108, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24641702, Length=239, Percent_Identity=27.6150627615063, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27881; Mature: 27881

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEKHLKQEKIINMFDDIASSYDQANRLISFGLDVKWRERACEHAFLFLENKKALKLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLLAWQKSALNCNIEFKECLGIDPSNNMLELAIKKCEKLGNKTSFIQAQAKDL
EECCCCCEEEEEEHHHEECCEEHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
KGVESNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVLVIVEFLKKDNPTWLDKISWF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCHHHHHHHH
YTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLESLKSELKNAGFEILRTEDSIAQISTT
HHCCHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
MLVKKS
HEEECC
>Mature Secondary Structure
MKKEKHLKQEKIINMFDDIASSYDQANRLISFGLDVKWRERACEHAFLFLENKKALKLVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCEEEEE
VACGTGDMLLAWQKSALNCNIEFKECLGIDPSNNMLELAIKKCEKLGNKTSFIQAQAKDL
EECCCCCEEEEEEHHHEECCEEHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
KGVESNSVDILSIAYGLRNIVERQEALKEFFRVLKPRGVLVIVEFLKKDNPTWLDKISWF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCHHHHHHHH
YTNKVLPLVGGAISKNYGAYSYLPQSIEGFLSLESLKSELKNAGFEILRTEDSIAQISTT
HHCCHHHHHCCHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHH
MLVKKS
HEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA