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The map label for this gene is serS

Identifier: 109948207

GI number: 109948207

Start: 1516019

End: 1517266

Strand: Reverse

Name: serS

Synonym: Hac_1740

Alternate gene names: 109948207

Gene position: 1517266-1516019 (Counterclockwise)

Preceding gene: 109948208

Following gene: 109948206

Centisome position: 97.64

GC content: 38.94

Gene sequence:

>1248_bases
ATGATTGATAGAAAACTTTTATTACAAGATTTTGATAAGGTGGCTCATTCTTTAAAAAAGCGTAACAGCGTGATAGATGA
TGGGTTGGAGCGTTTGCGCGAAATCATCACGCATTATAAAAAACAACTCATTGAGTTAGAAAGCTTGCAAGCCTTTCAAA
ACAAGGTTTCTAAAGAATTTGGTATCAAAATGACTCAAAAAGTGGATGCAAGCGATCTCAAAAAAGAGCTAGAAAACAAT
AAAATCAAGTTGAATGAGCTTTCCAAAAGCGTGAGCGAGTTGGAGCAAAAAATTGATTTAAAGCTTTCAATAATCCCTAA
TCTAGTGGATGAAAAAACCCCTTTAGGCACAAGCGAAGAAGATAATATAGAAATTAAAAAAATCTTAACCCCAAGAGATT
TCACTTTCACGCCTAAAGAGCATTTTGAACTCGCTCAAAAAAATGGCTGGATTGATTTTGAAAGCGGCGTGAAACTCGCT
AAAAGCCGTTTTTCAGTTATTAGGGGTTTTGGGGCCAAAGTTTATCGCGCGCTCATTCATTTAATGTTAGATTTTAATGA
AAAAAATGGCTTTGAAATCATCTACACGCCGGCTTTAGTGAATGAAAAAATGCTTTTTGGGACTGGGCAATTACCCAAAT
TCAAAGAAGATGTTTTTAAAATAGAAAATGAAAATTTGTATTTGATCCCCACCGCTGAAGTAACGCTCACCAATTTATAC
AACGACACGATCATCAGCGTTGAAAAACTCCCGATTAAAATGACCGCACACACGCCTTGTTTCAGGAGCGAAGCAGGGAG
TGCGGGAAAAGACACAAGGGGGATGATAAGACAACACCAATTTGATAAGGTGGAATTAGTGGCTATCACACACCCTAAAG
AAAGCGATGTCATGCAAGAGTATATGCTAGAGAGCGCGAGTGGGATCTTAAAGGCTTTGGAATTACCTCATCGGTTTGTG
CAATTATGCAGTGGGGATTTGGGTTTTAGTGCAAGTAATACGATAGATATTGAAGTGTGGTTGCCTGGGCAAAATTGTTA
TAGAGAAATCAGCTCGGTGTCTAACACGAGAGATTTTCAAGCCAGGCGGGCTAAAATCCGCTTCAAGGAAAATCAAAAAA
ACCAATTAGTGCACACTCTAAATGGCTCTTCTTTAGCGGTAGGAAGGACGATGGTCGCTTTAATGGAAAACCACCAGCAA
GCGGATGGGAGCATCCACATTCCTAAGGCGTTAGAAAAATACCTTTAA

Upstream 100 bases:

>100_bases
AATTCTTTGGAGGGTAAAATGGGGGCTTTGAGCGTTCAAATTGATAAAAATGATATAGATGAATGGGCTAAATTATGGCA
TTTTAGAACGAGAGGGTTAA

Downstream 100 bases:

>100_bases
GGCTAGTTTGTGCTAAATGAAGAGCAAAATCCTCAAAAATTAGAAGAATTAGAGCAAAAAGGGAGCGAAAACAAGGCTGA
AAAAGAAACCCCTTTAAAGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MIDRKLLLQDFDKVAHSLKKRNSVIDDGLERLREIITHYKKQLIELESLQAFQNKVSKEFGIKMTQKVDASDLKKELENN
KIKLNELSKSVSELEQKIDLKLSIIPNLVDEKTPLGTSEEDNIEIKKILTPRDFTFTPKEHFELAQKNGWIDFESGVKLA
KSRFSVIRGFGAKVYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIISVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDVMQEYMLESASGILKALELPHRFV
QLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQ
ADGSIHIPKALEKYL

Sequences:

>Translated_415_residues
MIDRKLLLQDFDKVAHSLKKRNSVIDDGLERLREIITHYKKQLIELESLQAFQNKVSKEFGIKMTQKVDASDLKKELENN
KIKLNELSKSVSELEQKIDLKLSIIPNLVDEKTPLGTSEEDNIEIKKILTPRDFTFTPKEHFELAQKNGWIDFESGVKLA
KSRFSVIRGFGAKVYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIISVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDVMQEYMLESASGILKALELPHRFV
QLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQ
ADGSIHIPKALEKYL
>Mature_415_residues
MIDRKLLLQDFDKVAHSLKKRNSVIDDGLERLREIITHYKKQLIELESLQAFQNKVSKEFGIKMTQKVDASDLKKELENN
KIKLNELSKSVSELEQKIDLKLSIIPNLVDEKTPLGTSEEDNIEIKKILTPRDFTFTPKEHFELAQKNGWIDFESGVKLA
KSRFSVIRGFGAKVYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
NDTIISVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDVMQEYMLESASGILKALELPHRFV
QLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQ
ADGSIHIPKALEKYL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=435, Percent_Identity=29.4252873563218, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI8923421, Length=331, Percent_Identity=30.8157099697885, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI225579074, Length=331, Percent_Identity=30.8157099697885, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=46.7136150234742, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539260, Length=426, Percent_Identity=27.9342723004695, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17542084, Length=315, Percent_Identity=27.3015873015873, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=429, Percent_Identity=32.8671328671329, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=345, Percent_Identity=29.2753623188406, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24581334, Length=353, Percent_Identity=31.1614730878187, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17737985, Length=247, Percent_Identity=31.9838056680162, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HELAH (Q17V90)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_665435.1
- ProteinModelPortal:   Q17V90
- SMR:   Q17V90
- STRING:   Q17V90
- GeneID:   4177178
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1740
- NMPDR:   fig|382638.8.peg.1683
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   HACI382638:HAC_1740-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47369; Mature: 47369

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRKLLLQDFDKVAHSLKKRNSVIDDGLERLREIITHYKKQLIELESLQAFQNKVSKEF
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKMTQKVDASDLKKELENNKIKLNELSKSVSELEQKIDLKLSIIPNLVDEKTPLGTSEE
CCCHHCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCEEEEECCHHHCCCCCCCCCCC
DNIEIKKILTPRDFTFTPKEHFELAQKNGWIDFESGVKLAKSRFSVIRGFGAKVYRALIH
CCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
HHHHCCCCCCCEEEEECHHHCCEEEECCCCCCHHHHHHHEECCCCEEEEECCCEEEEECC
NDTIISVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDVMQE
CCCEEEEEECEEEEECCCCCHHCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHH
YMLESASGILKALELPHRFVQLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHH
ARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQADGSIHIPKALEKYL
HHHHHEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHCC
>Mature Secondary Structure
MIDRKLLLQDFDKVAHSLKKRNSVIDDGLERLREIITHYKKQLIELESLQAFQNKVSKEF
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIKMTQKVDASDLKKELENNKIKLNELSKSVSELEQKIDLKLSIIPNLVDEKTPLGTSEE
CCCHHCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHCEEEEECCHHHCCCCCCCCCCC
DNIEIKKILTPRDFTFTPKEHFELAQKNGWIDFESGVKLAKSRFSVIRGFGAKVYRALIH
CCEEEEEEECCCCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLY
HHHHCCCCCCCEEEEECHHHCCEEEECCCCCCHHHHHHHEECCCCEEEEECCCEEEEECC
NDTIISVEKLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDVMQE
CCCEEEEEECEEEEECCCCCHHCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHH
YMLESASGILKALELPHRFVQLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHH
ARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQADGSIHIPKALEKYL
HHHHHEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA