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The map label for this gene is pbp2 [H]

Identifier: 109948146

GI number: 109948146

Start: 1455438

End: 1457180

Strand: Reverse

Name: pbp2 [H]

Synonym: Hac_1672

Alternate gene names: 109948146

Gene position: 1457180-1455438 (Counterclockwise)

Preceding gene: 109948147

Following gene: 109948143

Centisome position: 93.77

GC content: 40.28

Gene sequence:

>1743_bases
TTGCTTTTTGGTTTTATGGCGGTTTGGGGGTTACTAGCCTTAAATTTATTCATTTTAAGCGTTAAAAATCAAACATATTA
TGAAAAACTCGCCGAACGAAACATGACCAAAAAAGAATTTCTAATCCCTACAAGGGGCGATATTATAGACAGAAACCATG
AATTTTTAGCCCTTAATGAATTGGTTTTTGGCGTGTTTTTGCCTAGCAGATTGAAGCAAAAAGAGCTTTTGGAAAAAATT
GAAATCATCCAAAAATTTTTCCCTAATTTTTCCAAAGAAACGCTTCTAAACAACTACCAAAAAGAAAATTCACTTTATAA
CCATAACCTCATTAAAGTGGTTGGTTTCATTCCCTATGCCACCATGCAATCCCTTTATACCAAACTCATTCAAACTCAAG
GCATTTTTGTGCACCCTTTAGACAAGCGCTACTACCCCAATAATGCTTTAGCTTCTCATGTTTTAGGCTATGTAGGAATG
GCAAGTTTGCAAGATTTAAAAGACGATGAAGAGAATCAATACAGCCAAATTGTGGGCAAAACGGGCATTGAAAAAGAATA
TAACAAACTTTTACAAGGCAAGGTGGGCTATAAAATCATGCAAGTCAATGCTCTCAATCAAGAATTAGCCACTTTAGAAG
TCATGCCACCAAGCACCAATAACCACTTGCAATTAAGTTTAGACAAACGCTTGCAAGAAGAAGCGGACAAGCTCTTTGAG
AACAAAAGGGGGGCTATTTTGGTGATGAACGCAGAAAATGGGGAATTGCTCGTTGCAGGGAGTTACCCTGAATACAATTT
GAATGATTTTGTGGGCGGAATCAGCCAAGACAAATGGCAAAAACTTCAAGATGATATTTATAACCCCTTACTAAACCGCT
TCGCTAACGCTTTGTATCCGCCAGGATCTGTGGTTAAAATGGGCGTGGGCTTGAGTTTTTTAGAAAATCTCAATATCACA
GAAAACACCACCATACCCACCCCCCCTTTCATTGAAGTGGGTAAGCGCAAATTCAGAGATTGGAAAAAAACAGGGCATGG
CAATTCTAATTTGTATAAAGCCATTAGAGAGTCGGTGGATGTGTATTTTTATAGGTTTGGGCTTGAAATCTCCATAGAAA
AACTTTCTAAAACTTTAAGGGAAATGGGCTTTGGGGAAAAAACAGGCGTTGATTTGCCGAGCGAATTTGTGGGGATTGTG
CCGGATAATTTATGGAAACTCAAGCGCTTCAATCAAGACTGGCATGTTGGGGACACGCTCATTACCGCTATTGGGCAAGG
CTCTTTTTTAACCACGCCCTTACAAGTGCTCGCCTACACGGGACTCATTGCCACAGGCAAACTGGCAACGCCTCATTTTG
CTATCAATAACAAAACGCCCCTTAAAGATCCCTTGAATAGCTTTCAAAAAAAGAAGCTCCAAGCCTTGCGCGTGGGCATG
TATGAAGTGTGTAACCATAAAGACGGCACCGCTTATCATTCTACAAGAGGTTCTAAAGTCACTTTAGCGTGCAAAACCGG
CACCGCACAAGTCGTAGAGATCGCTCAAAACATCGTCGATCGTATTAAGGAAAAGGATATGGAATATTTCCATCGATCCC
ATGCATGGATCACGGCGTTCTTGCCTTATGAAAAACCCAAATACGCTATCACTATTTTAGTAGAGCATGGGGAAGGAGGG
TCAAAACTAGGGAGCTTGTTAGTGAAAATGAGCAACAAACTCTATGAGCTTGGCTATCTTTAA

Upstream 100 bases:

>100_bases
TCGGTATCTTTGAGTTTAGAAACGATAGGTTTTCTCGCTCTTTTTGTGCTCATAGAGGGCGTTTTGTGGGGTCTGTATGA
AAAATATTCGTTATAACCTT

Downstream 100 bases:

>100_bases
CATTTCTATCGCTTGAGGTTGCAAGCTTTTTATATAGTCAAATTAAAACGGTGCTTTTTGTTGAGCCCAACAAACACCAC
CTGCCTTAAAGATGGGTTTT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MLFGFMAVWGLLALNLFILSVKNQTYYEKLAERNMTKKEFLIPTRGDIIDRNHEFLALNELVFGVFLPSRLKQKELLEKI
EIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYATMQSLYTKLIQTQGIFVHPLDKRYYPNNALASHVLGYVGM
ASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMQVNALNQELATLEVMPPSTNNHLQLSLDKRLQEEADKLFE
NKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLSFLENLNIT
ENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYRFGLEISIEKLSKTLREMGFGEKTGVDLPSEFVGIV
PDNLWKLKRFNQDWHVGDTLITAIGQGSFLTTPLQVLAYTGLIATGKLATPHFAINNKTPLKDPLNSFQKKKLQALRVGM
YEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVDRIKEKDMEYFHRSHAWITAFLPYEKPKYAITILVEHGEGG
SKLGSLLVKMSNKLYELGYL

Sequences:

>Translated_580_residues
MLFGFMAVWGLLALNLFILSVKNQTYYEKLAERNMTKKEFLIPTRGDIIDRNHEFLALNELVFGVFLPSRLKQKELLEKI
EIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYATMQSLYTKLIQTQGIFVHPLDKRYYPNNALASHVLGYVGM
ASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMQVNALNQELATLEVMPPSTNNHLQLSLDKRLQEEADKLFE
NKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLSFLENLNIT
ENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYRFGLEISIEKLSKTLREMGFGEKTGVDLPSEFVGIV
PDNLWKLKRFNQDWHVGDTLITAIGQGSFLTTPLQVLAYTGLIATGKLATPHFAINNKTPLKDPLNSFQKKKLQALRVGM
YEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVDRIKEKDMEYFHRSHAWITAFLPYEKPKYAITILVEHGEGG
SKLGSLLVKMSNKLYELGYL
>Mature_580_residues
MLFGFMAVWGLLALNLFILSVKNQTYYEKLAERNMTKKEFLIPTRGDIIDRNHEFLALNELVFGVFLPSRLKQKELLEKI
EIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYATMQSLYTKLIQTQGIFVHPLDKRYYPNNALASHVLGYVGM
ASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMQVNALNQELATLEVMPPSTNNHLQLSLDKRLQEEADKLFE
NKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLSFLENLNIT
ENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVDVYFYRFGLEISIEKLSKTLREMGFGEKTGVDLPSEFVGIV
PDNLWKLKRFNQDWHVGDTLITAIGQGSFLTTPLQVLAYTGLIATGKLATPHFAINNKTPLKDPLNSFQKKKLQALRVGM
YEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVDRIKEKDMEYFHRSHAWITAFLPYEKPKYAITILVEHGEGG
SKLGSLLVKMSNKLYELGYL

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=600, Percent_Identity=30.1666666666667, Blast_Score=285, Evalue=8e-78,
Organism=Escherichia coli, GI1786272, Length=449, Percent_Identity=21.826280623608, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65967; Mature: 65967

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFGFMAVWGLLALNLFILSVKNQTYYEKLAERNMTKKEFLIPTRGDIIDRNHEFLALNE
CCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCHHHEECCCCCCCCCCCCCEEEHHH
LVFGVFLPSRLKQKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYA
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TMQSLYTKLIQTQGIFVHPLDKRYYPNNALASHVLGYVGMASLQDLKDDEENQYSQIVGK
HHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
TGIEKEYNKLLQGKVGYKIMQVNALNQELATLEVMPPSTNNHLQLSLDKRLQEEADKLFE
CCCHHHHHHHHCCCCCEEEEEEEHHCCCHHEEEEECCCCCCCEEEEHHHHHHHHHHHHHH
NKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYP
CCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PGSVVKMGVGLSFLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVD
CCCCEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VYFYRFGLEISIEKLSKTLREMGFGEKTGVDLPSEFVGIVPDNLWKLKRFNQDWHVGDTL
EEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCCCHHH
ITAIGQGSFLTTPLQVLAYTGLIATGKLATPHFAINNKTPLKDPLNSFQKKKLQALRVGM
HHHHCCCCCCHHHHHHHHHHHHHEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
YEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVDRIKEKDMEYFHRSHAWITAF
HHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LPYEKPKYAITILVEHGEGGSKLGSLLVKMSNKLYELGYL
ECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLFGFMAVWGLLALNLFILSVKNQTYYEKLAERNMTKKEFLIPTRGDIIDRNHEFLALNE
CCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCHHHEECCCCCCCCCCCCCEEEHHH
LVFGVFLPSRLKQKELLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYA
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TMQSLYTKLIQTQGIFVHPLDKRYYPNNALASHVLGYVGMASLQDLKDDEENQYSQIVGK
HHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
TGIEKEYNKLLQGKVGYKIMQVNALNQELATLEVMPPSTNNHLQLSLDKRLQEEADKLFE
CCCHHHHHHHHCCCCCEEEEEEEHHCCCHHEEEEECCCCCCCEEEEHHHHHHHHHHHHHH
NKRGAILVMNAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYP
CCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PGSVVKMGVGLSFLENLNITENTTIPTPPFIEVGKRKFRDWKKTGHGNSNLYKAIRESVD
CCCCEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VYFYRFGLEISIEKLSKTLREMGFGEKTGVDLPSEFVGIVPDNLWKLKRFNQDWHVGDTL
EEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCCCHHH
ITAIGQGSFLTTPLQVLAYTGLIATGKLATPHFAINNKTPLKDPLNSFQKKKLQALRVGM
HHHHCCCCCCHHHHHHHHHHHHHEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
YEVCNHKDGTAYHSTRGSKVTLACKTGTAQVVEIAQNIVDRIKEKDMEYFHRSHAWITAF
HHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LPYEKPKYAITILVEHGEGGSKLGSLLVKMSNKLYELGYL
ECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]