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The map label for this gene is hemE

Identifier: 109947902

GI number: 109947902

Start: 1213027

End: 1214046

Strand: Reverse

Name: hemE

Synonym: Hac_1398

Alternate gene names: 109947902

Gene position: 1214046-1213027 (Counterclockwise)

Preceding gene: 109947903

Following gene: 109947901

Centisome position: 78.13

GC content: 39.61

Gene sequence:

>1020_bases
ATGATTTTCATTGATGCATGTTTTAAAAAAGAAACACCTTACACGCCTATTTGGATGATGAGGCAAGCGGGGCGTTATCT
TAGCGAATACCAAGAGAGCCGAAAGAAAGCTGGGAGTTTCTTGGAATTGTGTAAAAATAGCGATCTAGCCACAGAAGTGA
CTTTACAGCCGGTAGAGATCTTAGGCGTGGATGCGGCTATTTTGTTTAGCGATATTTTGGTAGTGCCTTTGGAAATGGGC
TTAGATTTGGAATTTATCCCTAAAAAGGGACCGCATTTTTTAGAGACTATTACGGATTTAAAAAGCGTGGATAGCCTTAA
AGTAGGGGCATATAAGCGGCTAAATTATGTCTATGATACGATCTCTCAAACGCGCCAAAAACTTTCTAAAGATAAGGCGT
TGATCGGTTTTTGCGGATCACCTTGGACTTTGGCGACTTACATGATAGAGAGTGAGGGGAGTAAATCGTATGCTAAAAGC
AAAAAAATGCTTTATAGCGAGCCTGAAGTTTTGCACACACTTTTAGAAAAGTTAAGCGCTGAATTGATAGAGTATTTGAG
CCTTCAAATCCAAGCTGGGGTCAATGCGGTGATGATCTTTGATTCATGGGCGAATGCTTTAGAAAAAGAAGCTTATTTGA
AATTCAGCTGGGATTATTTGAAAAAAATCTCCAAAGAGCTTAAAAAACGTTATGCACGCATTCCGGTCATCCTTTTCCCT
AAAGGGGTCGGTGCTTATTTGGATAGCATAGATGGGGAATTTGATGTGTTTGGGGTGGATTGGGGCACGCCTTTAGAAAT
GGCAAAAAAGATTTTAGGCGATAAATATGTTTTGCAAGGGAATTTAGAACCCACCCGCCTTTATGATAAAAACGCTTTAG
AAGAGGGCGTTGAAAAGATTCTAAAAATCATGGGCAATAAGGGGCATATTTTTAATTTAGGGCATGGGATGTTGCCGGAT
TTACCTAGAGAAAATGCGAAATATTTAGTGCAATTAGTGCATAATAAAACCAAGCACTAG

Upstream 100 bases:

>100_bases
CACCTTTTATGATTTTACTAGATTTTTAGGGTAAAATACTTTTTAAGAATTAACTATAAAGTATAAAAATAACCATTAAG
TAAAGTTTCAAGGATTTATG

Downstream 100 bases:

>100_bases
GGGGTTATTTTAATGAAGACGACTATAAGATTTGTTAGTTTGTGGGGCTTGTGTGCTGCTTTAGCTTTGGCGCAAACCCC
TTCTAAAACCCCAGATGAAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIFIDACFKKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMG
LDLEFIPKKGPHFLETITDLKSVDSLKVGAYKRLNYVYDTISQTRQKLSKDKALIGFCGSPWTLATYMIESEGSKSYAKS
KKMLYSEPEVLHTLLEKLSAELIEYLSLQIQAGVNAVMIFDSWANALEKEAYLKFSWDYLKKISKELKKRYARIPVILFP
KGVGAYLDSIDGEFDVFGVDWGTPLEMAKKILGDKYVLQGNLEPTRLYDKNALEEGVEKILKIMGNKGHIFNLGHGMLPD
LPRENAKYLVQLVHNKTKH

Sequences:

>Translated_339_residues
MIFIDACFKKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMG
LDLEFIPKKGPHFLETITDLKSVDSLKVGAYKRLNYVYDTISQTRQKLSKDKALIGFCGSPWTLATYMIESEGSKSYAKS
KKMLYSEPEVLHTLLEKLSAELIEYLSLQIQAGVNAVMIFDSWANALEKEAYLKFSWDYLKKISKELKKRYARIPVILFP
KGVGAYLDSIDGEFDVFGVDWGTPLEMAKKILGDKYVLQGNLEPTRLYDKNALEEGVEKILKIMGNKGHIFNLGHGMLPD
LPRENAKYLVQLVHNKTKH
>Mature_339_residues
MIFIDACFKKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMG
LDLEFIPKKGPHFLETITDLKSVDSLKVGAYKRLNYVYDTISQTRQKLSKDKALIGFCGSPWTLATYMIESEGSKSYAKS
KKMLYSEPEVLHTLLEKLSAELIEYLSLQIQAGVNAVMIFDSWANALEKEAYLKFSWDYLKKISKELKKRYARIPVILFP
KGVGAYLDSIDGEFDVFGVDWGTPLEMAKKILGDKYVLQGNLEPTRLYDKNALEEGVEKILKIMGNKGHIFNLGHGMLPD
LPRENAKYLVQLVHNKTKH

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=38.7931034482759, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI2367337, Length=339, Percent_Identity=45.7227138643068, Blast_Score=297, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6320252, Length=342, Percent_Identity=37.719298245614, Blast_Score=226, Evalue=3e-60,
Organism=Drosophila melanogaster, GI221330099, Length=331, Percent_Identity=40.785498489426, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI19921920, Length=331, Percent_Identity=40.785498489426, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_HELAH (Q17W45)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_665130.1
- ProteinModelPortal:   Q17W45
- SMR:   Q17W45
- STRING:   Q17W45
- GeneID:   4177425
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1398
- NMPDR:   fig|382638.8.peg.1354
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q17W45
- ProtClustDB:   PRK00115
- BioCyc:   HACI382638:HAC_1398-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38527; Mature: 38527

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 71-71 BINDING 147-147 BINDING 202-202 BINDING 315-315

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFIDACFKKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEI
CEEEECHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHH
LGVDAAILFSDILVVPLEMGLDLEFIPKKGPHFLETITDLKSVDSLKVGAYKRLNYVYDT
HCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ISQTRQKLSKDKALIGFCGSPWTLATYMIESEGSKSYAKSKKMLYSEPEVLHTLLEKLSA
HHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ELIEYLSLQIQAGVNAVMIFDSWANALEKEAYLKFSWDYLKKISKELKKRYARIPVILFP
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHCCCEEEEC
KGVGAYLDSIDGEFDVFGVDWGTPLEMAKKILGDKYVLQGNLEPTRLYDKNALEEGVEKI
CCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
LKIMGNKGHIFNLGHGMLPDLPRENAKYLVQLVHNKTKH
HHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIFIDACFKKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEI
CEEEECHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHH
LGVDAAILFSDILVVPLEMGLDLEFIPKKGPHFLETITDLKSVDSLKVGAYKRLNYVYDT
HCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ISQTRQKLSKDKALIGFCGSPWTLATYMIESEGSKSYAKSKKMLYSEPEVLHTLLEKLSA
HHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ELIEYLSLQIQAGVNAVMIFDSWANALEKEAYLKFSWDYLKKISKELKKRYARIPVILFP
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHCCCEEEEC
KGVGAYLDSIDGEFDVFGVDWGTPLEMAKKILGDKYVLQGNLEPTRLYDKNALEEGVEKI
CCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
LKIMGNKGHIFNLGHGMLPDLPRENAKYLVQLVHNKTKH
HHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA