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The map label for this gene is xseA

Identifier: 109947858

GI number: 109947858

Start: 1168879

End: 1170141

Strand: Reverse

Name: xseA

Synonym: Hac_1349

Alternate gene names: 109947858

Gene position: 1170141-1168879 (Counterclockwise)

Preceding gene: 109947859

Following gene: 109947854

Centisome position: 75.3

GC content: 39.35

Gene sequence:

>1263_bases
ATGGACGCATTGAGCGTGAGCGAAATCAATGCAAAAATTAAAGCCCTTTTGGAAGCGACTTTTTTGCAAGTTAGGGTTCA
AGGGGAAGTGAGTAATTTGACTATCCATAAGGTGAGTGGCCATGCGTATTTTTCGCTTAAAGACAGCCAATCAGTGATTC
GATGCACCTTGTTTAGGGGGAACGCTAGTAAGCTTAAATTCGCCTTAAAAGAAGGGCAGGAAGTGGCTGTTTTTGGGGCT
ATTAGCGTGTATCCTCCAAGGGGGGATTATCAAATCAATTGCTTTGAAATAGAGCCTAAAGATTGGGGTTCATTAGCTTT
GGCTTTAGAGCAATTGAAAGAAAAATTACGCCTTAAAGGCTATTTTGATAAAGAAAATAAATTACCCAAACCAAGTTTTC
CTAAACGAGTGGCAATCATCACTTCTCAAAATTCAGCCGCTTGGGCGGATATGCAAAAGATCGCTTTCAAACGATGGCCG
ATGTGTGAATTGGTTTGTATCAATACTTTAATGCAAGGGGAGGGGTGCGTTCAAAGCGTGGTGGAGAGTATCGCTTATGC
GGATAGTTTTTATAACACAAGAAACGCTTTTGATGCGATTGTGGTGGCTAGAGGTGGGGGGAGCATGGAGGATTTGTATT
CTTTTAATGATGAAAGAATCGCTGATGCATTGCATTTGGCTAAAACTTTCAGCATGTCAGCTATTGGGCATGAGAGCGAT
TTTTTGTTGAGCGATTCGGTAGCGGATTTAAGGGCTTCTACGCCTTCCAATGCGATGGAGATTTTACTCCCTAGCAGCGA
GGAATGGCAACAAAAGCTTGATGGGTTTAACTTGAAATTGCAACGCTCTTTTAAAATATTACTCCATCAAAAAAAGGTGC
ATTTAGAGCATTTAGCGGCTTCTTTAAAGCGATTGAGTTTTGAAAACAAGCACCATTTAAATTCTTTAAAACTAGAGAAA
TTAAAAATCGCTTTAGAAAATAAAACCTTAGAATTTTTACGCCTTAAAAAAACGCTTTTAGAGAAAATTTCTACCCAACT
TTCCACAAGCCCTTTTTTACAAACTAAAACAGAACGATTGAATGCACTAGACAACGCCCTTAAACTCGCTCATGCGCATT
TGAAATTGCCAAAATTCGGGGCGTTTGTGAGTAAAAACAATCAAGCGATAGAATTAGAGGAATTAAAAATTGGCGATAAA
ATTGAATTGAATAACGAAAAAGCCAGAGCGAGTGCTGCCATTTTGAGTGTTGATAAAGCGTAG

Upstream 100 bases:

>100_bases
GCAAAATGCGTTGTGGCTAGTGGGGGTGGGGTTTTTGGTTTTTGTCATGTTTTTAGGGCTTTTTAATGATATTACTCGTT
TGCTATAAAAGGGGGAATTT

Downstream 100 bases:

>100_bases
GGGTTTGAAAAATAATCTTTAAAATAGATTTTGTTTTTTAAAATTTCATATTTAAAATTTCGTATTCACTTCTTTTAATG
ATCTTTTCTAAACGCAGAAG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MDALSVSEINAKIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCTLFRGNASKLKFALKEGQEVAVFGA
ISVYPPRGDYQINCFEIEPKDWGSLALALEQLKEKLRLKGYFDKENKLPKPSFPKRVAIITSQNSAAWADMQKIAFKRWP
MCELVCINTLMQGEGCVQSVVESIAYADSFYNTRNAFDAIVVARGGGSMEDLYSFNDERIADALHLAKTFSMSAIGHESD
FLLSDSVADLRASTPSNAMEILLPSSEEWQQKLDGFNLKLQRSFKILLHQKKVHLEHLAASLKRLSFENKHHLNSLKLEK
LKIALENKTLEFLRLKKTLLEKISTQLSTSPFLQTKTERLNALDNALKLAHAHLKLPKFGAFVSKNNQAIELEELKIGDK
IELNNEKARASAAILSVDKA

Sequences:

>Translated_420_residues
MDALSVSEINAKIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCTLFRGNASKLKFALKEGQEVAVFGA
ISVYPPRGDYQINCFEIEPKDWGSLALALEQLKEKLRLKGYFDKENKLPKPSFPKRVAIITSQNSAAWADMQKIAFKRWP
MCELVCINTLMQGEGCVQSVVESIAYADSFYNTRNAFDAIVVARGGGSMEDLYSFNDERIADALHLAKTFSMSAIGHESD
FLLSDSVADLRASTPSNAMEILLPSSEEWQQKLDGFNLKLQRSFKILLHQKKVHLEHLAASLKRLSFENKHHLNSLKLEK
LKIALENKTLEFLRLKKTLLEKISTQLSTSPFLQTKTERLNALDNALKLAHAHLKLPKFGAFVSKNNQAIELEELKIGDK
IELNNEKARASAAILSVDKA
>Mature_420_residues
MDALSVSEINAKIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCTLFRGNASKLKFALKEGQEVAVFGA
ISVYPPRGDYQINCFEIEPKDWGSLALALEQLKEKLRLKGYFDKENKLPKPSFPKRVAIITSQNSAAWADMQKIAFKRWP
MCELVCINTLMQGEGCVQSVVESIAYADSFYNTRNAFDAIVVARGGGSMEDLYSFNDERIADALHLAKTFSMSAIGHESD
FLLSDSVADLRASTPSNAMEILLPSSEEWQQKLDGFNLKLQRSFKILLHQKKVHLEHLAASLKRLSFENKHHLNSLKLEK
LKIALENKTLEFLRLKKTLLEKISTQLSTSPFLQTKTERLNALDNALKLAHAHLKLPKFGAFVSKNNQAIELEELKIGDK
IELNNEKARASAAILSVDKA

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=344, Percent_Identity=36.3372093023256, Blast_Score=216, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_HELAH (Q17W89)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_665086.1
- STRING:   Q17W89
- GeneID:   4176641
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1349
- NMPDR:   fig|382638.8.peg.1308
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   HFPKRVA
- PhylomeDB:   Q17W89
- ProtClustDB:   PRK00286
- BioCyc:   HACI382638:HAC_1349-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 47038; Mature: 47038

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALSVSEINAKIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCTLFRG
CCCCCHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCEEEEEECCCCCEEEEEEEEC
NASKLKFALKEGQEVAVFGAISVYPPRGDYQINCFEIEPKDWGSLALALEQLKEKLRLKG
CHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
YFDKENKLPKPSFPKRVAIITSQNSAAWADMQKIAFKRWPMCELVCINTLMQGEGCVQSV
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHH
VESIAYADSFYNTRNAFDAIVVARGGGSMEDLYSFNDERIADALHLAKTFSMSAIGHESD
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
FLLSDSVADLRASTPSNAMEILLPSSEEWQQKLDGFNLKLQRSFKILLHQKKVHLEHLAA
CEECCCHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCEEEEHHHEEHHHHHHHHHHHHHH
SLKRLSFENKHHLNSLKLEKLKIALENKTLEFLRLKKTLLEKISTQLSTSPFLQTKTERL
HHHHHCCCCCCCCCCEEEEHEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NALDNALKLAHAHLKLPKFGAFVSKNNQAIELEELKIGDKIELNNEKARASAAILSVDKA
HHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCCCEEEECCCHHHHHEEEEEECCC
>Mature Secondary Structure
MDALSVSEINAKIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCTLFRG
CCCCCHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEECCEEEEEECCCCCEEEEEEEEC
NASKLKFALKEGQEVAVFGAISVYPPRGDYQINCFEIEPKDWGSLALALEQLKEKLRLKG
CHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
YFDKENKLPKPSFPKRVAIITSQNSAAWADMQKIAFKRWPMCELVCINTLMQGEGCVQSV
CCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHH
VESIAYADSFYNTRNAFDAIVVARGGGSMEDLYSFNDERIADALHLAKTFSMSAIGHESD
HHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
FLLSDSVADLRASTPSNAMEILLPSSEEWQQKLDGFNLKLQRSFKILLHQKKVHLEHLAA
CEECCCHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCEEEEHHHEEHHHHHHHHHHHHHH
SLKRLSFENKHHLNSLKLEKLKIALENKTLEFLRLKKTLLEKISTQLSTSPFLQTKTERL
HHHHHCCCCCCCCCCEEEEHEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
NALDNALKLAHAHLKLPKFGAFVSKNNQAIELEELKIGDKIELNNEKARASAAILSVDKA
HHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCCCEEEECCCHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA