Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 109947829

GI number: 109947829

Start: 1135479

End: 1136825

Strand: Reverse

Name: ffh [H]

Synonym: Hac_1319

Alternate gene names: 109947829

Gene position: 1136825-1135479 (Counterclockwise)

Preceding gene: 109947830

Following gene: 109947828

Centisome position: 73.16

GC content: 40.61

Gene sequence:

>1347_bases
ATGTTTCAAGCATTAAGCGATGGGTTTAAAAACGCATTAAATAAAATCCGCTTTCAAGATGATGAGAAGGCGTTAGACAG
GGCGTTAGATGAATTGAAAAAAACGCTCTTAAAAAATGATGTGCATCATAAGGCCGCTAGAGAATTGTTAAAAAAAGTGG
AAACGCAAACTAAAGCGAGTGGCATTGGTAGGCAGCAATTTTTAGACGCTTTAGAAAAGAGTTTGTTAGAAATTTTAAGC
GCTCAAGGGGGTAGTGGCTTTACTTTCGCTCAAACGCCCCCAACCGTGGTTTTAATGGCAGGTTTGCAAGGGAGCGGTAA
GACAACCACCACCGCTAAACTCGCCCACTATTTAAAAACTAAAAATAAAAAAGTGCTTTTATGTGCATGCGATTTGCAAC
GCCTAGCGGCGGTGGAGCAATTAAAGGTTTTGGGCGAACAAGTGGGCGTGGAAGTCTTTTATGAAGAAAATAAAAGCGTG
CAAGAAATCGCTAACAACGCTTTAAAAAGAGCTAAAGAAGCGCAATTTGATGTATTGATCGTGGATAGCGCGGGGCGTTT
AGCGATTGATAAAGAGCTTATGAAGGAATTAAAAGAAGTTAAAGAAATCTTAACCCCCCATGAAGTGCTTTATGTCGCAG
ACGCCTTGAGCGGGCAAGATGGGGTCAAAAGCGCAAACACATTTAATGAAGAAATAGGCGTGAGTGGGGTGGTATTAAGC
AAGTTTGATAGCGATTCTAAAGGGGGTATCGCCTTAGGCATCACTTACCAATTAGGCTTACCCTTGCGTTTCATTGGGAG
TGGGGAAAAAATCCCTGATTTAGATGTGTTTGTGCCTGAAAGGATTGTAGGGCGTTTAATGGGGGCTGGAGATATTATCT
CGCTCGCTGAAAAAACCGCTAGTGTTTTAAACCCTAATGAAGCCAAAGATTTAAGCAAAAAGCTCAAAAAAGGGCAATTC
ACTTTCAATGACTTTTTAAACCAAATTGAAAAGGTGAAAAAATTAGGCTCTATGAGTTCTATAATCTCTATGATCCCAGG
TTTAGGGAATATGGCAAGTGCGCTAAAAGACACGGATCTAGAAAATTCTTTAGAAGTGAAAAAGATCAAGGCGATGGTCA
ATTCCATGACAAAAAAAGAGCAAGAAAACCCCGAGATTTTAAACGGCAGCCGAAGAAAAAGGATCGCATTAGGGAGCGGT
TTAGAAGTGTCTGAAATCAATCGCATTATCAAACGCTTTGATCAAGCGAGCAAAATGGCCAAACGCTTAACCAATAAAAA
GGGCATTAGCGATTTGATGAATTTGATGAGTCAGGCTAAAAATCAAACACCCCCTAAAATGCGTTAG

Upstream 100 bases:

>100_bases
AGAAAAAGTGCAAGAGAATCTAAAAACGCTTTTAGAAAAAGAGAGTAAGATCAAGCAAGAATTAGACTTGTTAGAACAAC
CATAATCATAAGGATAGAAC

Downstream 100 bases:

>100_bases
ATTTAAGCATTTTTTGGGCGCTTTTGTTGTATAATCTCAAATTAATATGAATATTTTAGGAGATTTTTGTAATGACAGTC
ATTAGACTCACTCGCATTGG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKAARELLKKVETQTKASGIGRQQFLDALEKSLLEILS
AQGGSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
QEIANNALKRAKEAQFDVLIVDSAGRLAIDKELMKELKEVKEILTPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSIISMIPGLGNMASALKDTDLENSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Sequences:

>Translated_448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKAARELLKKVETQTKASGIGRQQFLDALEKSLLEILS
AQGGSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
QEIANNALKRAKEAQFDVLIVDSAGRLAIDKELMKELKEVKEILTPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSIISMIPGLGNMASALKDTDLENSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR
>Mature_448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKAARELLKKVETQTKASGIGRQQFLDALEKSLLEILS
AQGGSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
QEIANNALKRAKEAQFDVLIVDSAGRLAIDKELMKELKEVKEILTPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSIISMIPGLGNMASALKDTDLENSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=31.0961968680089, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI226371618, Length=411, Percent_Identity=31.1435523114355, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=29.5681063122924, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=29.5681063122924, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI89061728, Length=157, Percent_Identity=35.031847133758, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1788963, Length=428, Percent_Identity=39.4859813084112, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1789874, Length=231, Percent_Identity=37.6623376623377, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=31.0502283105023, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=200, Percent_Identity=35.5, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=426, Percent_Identity=30.5164319248826, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320498, Length=224, Percent_Identity=32.1428571428571, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=29.7727272727273, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24641198, Length=299, Percent_Identity=29.0969899665552, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49146; Mature: 49146

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKAARELLKKVETQTKAS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGRQQFLDALEKSLLEILSAQGGSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVQEIANNALKRAKEAQFDVLI
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMKELKEVKEILTPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSIISMIPGLGNMASALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
ENSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKAARELLKKVETQTKAS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGRQQFLDALEKSLLEILSAQGGSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVQEIANNALKRAKEAQFDVLI
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMKELKEVKEILTPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIISLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSIISMIPGLGNMASALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
ENSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
CCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]