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The map label for this gene is lpxB

Identifier: 109947755

GI number: 109947755

Start: 1064484

End: 1065566

Strand: Reverse

Name: lpxB

Synonym: Hac_1230

Alternate gene names: 109947755

Gene position: 1065566-1064484 (Counterclockwise)

Preceding gene: 109947756

Following gene: 109947754

Centisome position: 68.57

GC content: 37.77

Gene sequence:

>1083_bases
ATGCCCACAATTTTAGTGAGCGCTTTAGAAACGAGCTCCAATGTGCATTTGGAGGAATTACGCCGTAATTTGCCTAAAGA
TTATCGTTTCATTGGCGTGTTTGAAGGTAGTGGTGCGCTTTATAGCCCAAGGGAATTTTCTGTCATGGGTTTTAGAGATG
TGATAGGTCGTTTAGGGTTTTTATTCAAAGTGTATAAAGAAATGATCCAATTAGCCAAGCAAGCGGACATGGTGCTTTTA
ATGGATTCTTCTTCTTTTAATATCCCCCTAGCCAAAAAGATCAAAAAGCAAGACTCTCATAAAAAAATCATGTATTATAT
TTTACCACAAGTTTGGGCATGGAAGAAATGGCGCGCTAAAACCCTTGAAAAATATTGCGATTTTTTGGGCGCGATTTTGC
CTTTTGAAGTGAGTTATTACCAAAAAAAAGCCCAATATGTAGGACACCCCTTACTAGATGAAATTAAATATTATAAAAAA
GATATTAAGGGCGAAACTTTAGTTTTTATGCCGGGGAGTAGAAAAAGTGAAATCGCTAAAATATTCCCTTTGTTTGTTGA
AGTGGCTCGCATTTTAGAACAAAACGAAGGGTTTAAAAGGCGTGTGTTGGTAGTGCCAAGTTTCTTTAAGGGGTTGGATT
TAAAAGCTCTTTATGGAGAAGGCATTGAATGGTTTGAAATTTCTTATGATGCACATAAGAGTTTATTTGAAGCGGAGTTT
GCATTCATTTGCAGCGGCACAGCGACTTTAGAAGCCGCTCTTATTGGCACGCCTTTTGTGTTAGCGTATAGGGCTAAAAC
GATGGATTTTTTGATCGCTAGAATGTTTGTCAATTTGCATTACATAGGATTAGCCAATATCTTTTATAACGCCTTAAATG
ATGAGACTCCAGGGCTTGGGGAGAGCCAGTTACACCCAGAGTTGATCCAGCATTTTTTGAGCGTGGAGAGTTTGATTAGG
GCTTATAAGGACATGGATAGAGAGCGTTATTTTAAAGAAAGCTTGAAATTGAGAGAATATTTAATGCATGGGAGCGCGAG
AAAAATCGCTAGTGAAATAGCTTTTTTGCTGAATTTAACTTAA

Upstream 100 bases:

>100_bases
CTAAAAAAGATTTTGAAATTGCGTTGCTCAAAATTGAATTAAGGGATTTGCATAAAGAAATCAAGCTCTATCAAGTCCAA
AACCTTTTGGAAGACAAATA

Downstream 100 bases:

>100_bases
TTTTTACTATAATCTCTACTGAGTAGGATTAGGAGATTGAATGAATAGAGAACCTATGAGTATGCATGGATACAATAAAA
TCTGTGCGGAATTGAAGCAA

Product: ipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MPTILVSALETSSNVHLEELRRNLPKDYRFIGVFEGSGALYSPREFSVMGFRDVIGRLGFLFKVYKEMIQLAKQADMVLL
MDSSSFNIPLAKKIKKQDSHKKIMYYILPQVWAWKKWRAKTLEKYCDFLGAILPFEVSYYQKKAQYVGHPLLDEIKYYKK
DIKGETLVFMPGSRKSEIAKIFPLFVEVARILEQNEGFKRRVLVVPSFFKGLDLKALYGEGIEWFEISYDAHKSLFEAEF
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNDETPGLGESQLHPELIQHFLSVESLIR
AYKDMDRERYFKESLKLREYLMHGSARKIASEIAFLLNLT

Sequences:

>Translated_360_residues
MPTILVSALETSSNVHLEELRRNLPKDYRFIGVFEGSGALYSPREFSVMGFRDVIGRLGFLFKVYKEMIQLAKQADMVLL
MDSSSFNIPLAKKIKKQDSHKKIMYYILPQVWAWKKWRAKTLEKYCDFLGAILPFEVSYYQKKAQYVGHPLLDEIKYYKK
DIKGETLVFMPGSRKSEIAKIFPLFVEVARILEQNEGFKRRVLVVPSFFKGLDLKALYGEGIEWFEISYDAHKSLFEAEF
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNDETPGLGESQLHPELIQHFLSVESLIR
AYKDMDRERYFKESLKLREYLMHGSARKIASEIAFLLNLT
>Mature_359_residues
PTILVSALETSSNVHLEELRRNLPKDYRFIGVFEGSGALYSPREFSVMGFRDVIGRLGFLFKVYKEMIQLAKQADMVLLM
DSSSFNIPLAKKIKKQDSHKKIMYYILPQVWAWKKWRAKTLEKYCDFLGAILPFEVSYYQKKAQYVGHPLLDEIKYYKKD
IKGETLVFMPGSRKSEIAKIFPLFVEVARILEQNEGFKRRVLVVPSFFKGLDLKALYGEGIEWFEISYDAHKSLFEAEFA
FICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNDETPGLGESQLHPELIQHFLSVESLIRA
YKDMDRERYFKESLKLREYLMHGSARKIASEIAFLLNLT

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=319, Percent_Identity=28.8401253918495, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_HELAH (Q17WJ2)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664983.1
- STRING:   Q17WJ2
- GeneID:   4177621
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1230
- NMPDR:   fig|382638.8.peg.1195
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   EFAFICS
- PhylomeDB:   Q17WJ2
- ProtClustDB:   PRK14089
- BioCyc:   HACI382638:HAC_1230-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41656; Mature: 41525

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTILVSALETSSNVHLEELRRNLPKDYRFIGVFEGSGALYSPREFSVMGFRDVIGRLGF
CCCEEEEEHHCCCCCCHHHHHHHCCCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHHH
LFKVYKEMIQLAKQADMVLLMDSSSFNIPLAKKIKKQDSHKKIMYYILPQVWAWKKWRAK
HHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TLEKYCDFLGAILPFEVSYYQKKAQYVGHPLLDEIKYYKKDIKGETLVFMPGSRKSEIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
IFPLFVEVARILEQNEGFKRRVLVVPSFFKGLDLKALYGEGIEWFEISYDAHKSLFEAEF
HHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCCEEHHCCCCEEEEECHHHHHHHHHHHH
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNDETPGLG
HHEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ESQLHPELIQHFLSVESLIRAYKDMDRERYFKESLKLREYLMHGSARKIASEIAFLLNLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTILVSALETSSNVHLEELRRNLPKDYRFIGVFEGSGALYSPREFSVMGFRDVIGRLGF
CCEEEEEHHCCCCCCHHHHHHHCCCCCEEEEEEECCCCEECCCCCCCCCHHHHHHHHHH
LFKVYKEMIQLAKQADMVLLMDSSSFNIPLAKKIKKQDSHKKIMYYILPQVWAWKKWRAK
HHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TLEKYCDFLGAILPFEVSYYQKKAQYVGHPLLDEIKYYKKDIKGETLVFMPGSRKSEIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
IFPLFVEVARILEQNEGFKRRVLVVPSFFKGLDLKALYGEGIEWFEISYDAHKSLFEAEF
HHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCCEEHHCCCCEEEEECHHHHHHHHHHHH
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNDETPGLG
HHEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ESQLHPELIQHFLSVESLIRAYKDMDRERYFKESLKLREYLMHGSARKIASEIAFLLNLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA