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The map label for this gene is tktA [H]

Identifier: 109947354

GI number: 109947354

Start: 691331

End: 693256

Strand: Reverse

Name: tktA [H]

Synonym: Hac_0794

Alternate gene names: 109947354

Gene position: 693256-691331 (Counterclockwise)

Preceding gene: 109947355

Following gene: 109947353

Centisome position: 44.61

GC content: 41.02

Gene sequence:

>1926_bases
ATGCAATTAGATAACGCTGATTTAGAACGATTAAAAAGCATGGCTAACACGCTTCGTTTTTTATGTGCGGACATGATAGA
TAAAGCCAATAGTGGGCATCCGGGCGTGTGCTTGGGGTTGGCTGATGTGATGGTGGTTTTAAGCTTGCATCTCAATCTCA
ACCCTACTAACCCTAAATGGCTCAATAGGGACAGGTTGGTTTTTAGCGGAGGGCATGCGAGCGCACTAGCTTATAGCTTG
TTGCATTTGTGGGGCTTTGATTTGACTTTAGAAGATTTAAAGCATTTCAGGCAATTATACTCTAAAACCCCAGGACACCC
CGAATTACACCACACCGAAGGCATTGAAATCACGACAGGTCCCTTGGGGCAAGGTTTTGCTAACGCTGTGGGCTTTAGCA
TGGCGAGTCAATACGCTCAAAACCTTTTGGATAAAGAAACGATCTCTCATAAAGTCTATTGTTTGTGTGGCGATGGGGAT
TTGCAAGAAGGCATTAGTTATGAGAGTGCTTCTTTAGCCGGACACTTTCGCCTTGATAATCTCATTGTGATTTATGACAG
CAATCAAATCAGTATTGAAGGTGCTATTAATATTAGTTTTAGTGAACAGGTTAAAACACGCTTTTTAGCGCAAAATTGGG
AAGTGCTAGAATGCGATGGACATAACTATCAAGCCATTAATGACGCTTTAGAAAAAGCCAAAAAATCCACCAAACCCACG
CTTTTAATCGCTCACACGATTATTGGTAAGGGGGCTATTGGATTAGAAGGGAGTGAAAAAACGCATGGTTCGCCTTTGAA
TAAAGAAGTGTTAAAACAATCTAAAGAAAACGCCCGCATTAATCCTAATGAAAGCTTTGTGATTAGCCCAAAAAACAAAA
TGCATTTTGAAGAAGTGAAAGTTAGGGGTATCAGTTTAGAAGCCTTATGGGAAAAATCCTTAAACCCTAAAATAAAAGAA
AAAATCCATGCGTTAAAGAATTTTGACTTTAATACCATCAATTACCCTACCTTTAAAAAAGGCGAATCTCTAGCCACTAG
AGTGAGTAATGGCATGATTTTAAACGCTATCGCTAAAGAATGCGAAGGCTTTTTGGGGGGGAGTGCGGATTTAGCCCCAT
CTAATAATACGCATTTAAAACATTCTAGCGATTTCCCTTTAGGGCAAAACTTGCATTTTGGGATTAGAGAGCATGCCATG
GGGGCTATCACTAACGCTTTAGCGGCGTATGGCTTGTTTTTGCCTTTTTGCGCGACCTTTTTTGTGTTTAGCGATTATTT
AATGCCAAGCATGCGTTTGAGTGCTTTAATGCGATTAAAAGCCCTTTTCATTTTTACGCATGACAGCATTGGTGTGGGCG
AAGACGGGGCGACACACCAACCCATAGAGCAATTGAGCCATTTGCGTGCTTTGCCTAATTTCTATGCTTTCAGGCCTAGC
GACGCTTTTGAAAATACCGCTTGCATGCAAGTGGCGTTAAGCTTGAATGCCCCTAGTGCTTTTATTTTATCGCGCCAGAA
TTTGCCCATTCTAGATGAAGTCTCTAAAGAGCAAGTTTTAAAAGGGGCGTATGTTAAACACCACTCTAAAGATCCCATTA
TCACGCTAGTTGCAAGTGGGAGTGAGGTCTCTTTAGCTTTAGAGAGCGCTAAAGTTTTAGAGCGAGAAAATATCCCCACT
CAAGTCATCAGTGTGCCATGCTTTGATTTGTTAATAGGGCAAGATGAAAGCTATCTTAAAGCACTCTTTAAGGGTAAAAT
CTTAGTCATTGAAGCGAGTCGTGCGATAGAGTGGTATCGTTTTGCGGATAAAATCATTTGCATGGATTCTTTTGGGAGTT
CAGCAAAGGGCGATAAACTCTTTGAAAAATTTGGCTTTAGCGTTGAAAATATTACCGCTCAAGCGAAAAGGTTACTTAAC
GCATGA

Upstream 100 bases:

>100_bases
CTTAAAAATCAGATCCAGCAAGACATCTCAATAGCCAAAGAGATTTTGAGATAATTTGTGTTAAAATGGTTTTTAAAAAC
CTTAAAAATGGAAAAATTTG

Downstream 100 bases:

>100_bases
ATTTAGAAAAACTTTTTTTAGAAAACCCCCCCCTATTTGTTTTTAGCTCCACTAGGCGTTTAAGAAATTTCTATTTAGAG
CAAGGCGAAGGGTTTTTGCC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MQLDNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSL
LHLWGFDLTLEDLKHFRQLYSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKETISHKVYCLCGDGD
LQEGISYESASLAGHFRLDNLIVIYDSNQISIEGAINISFSEQVKTRFLAQNWEVLECDGHNYQAINDALEKAKKSTKPT
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENARINPNESFVISPKNKMHFEEVKVRGISLEALWEKSLNPKIKE
KIHALKNFDFNTINYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTHLKHSSDFPLGQNLHFGIREHAM
GAITNALAAYGLFLPFCATFFVFSDYLMPSMRLSALMRLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
DAFENTACMQVALSLNAPSAFILSRQNLPILDEVSKEQVLKGAYVKHHSKDPIITLVASGSEVSLALESAKVLERENIPT
QVISVPCFDLLIGQDESYLKALFKGKILVIEASRAIEWYRFADKIICMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLN
A

Sequences:

>Translated_641_residues
MQLDNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSL
LHLWGFDLTLEDLKHFRQLYSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKETISHKVYCLCGDGD
LQEGISYESASLAGHFRLDNLIVIYDSNQISIEGAINISFSEQVKTRFLAQNWEVLECDGHNYQAINDALEKAKKSTKPT
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENARINPNESFVISPKNKMHFEEVKVRGISLEALWEKSLNPKIKE
KIHALKNFDFNTINYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTHLKHSSDFPLGQNLHFGIREHAM
GAITNALAAYGLFLPFCATFFVFSDYLMPSMRLSALMRLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
DAFENTACMQVALSLNAPSAFILSRQNLPILDEVSKEQVLKGAYVKHHSKDPIITLVASGSEVSLALESAKVLERENIPT
QVISVPCFDLLIGQDESYLKALFKGKILVIEASRAIEWYRFADKIICMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLN
A
>Mature_641_residues
MQLDNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKWLNRDRLVFSGGHASALAYSL
LHLWGFDLTLEDLKHFRQLYSKTPGHPELHHTEGIEITTGPLGQGFANAVGFSMASQYAQNLLDKETISHKVYCLCGDGD
LQEGISYESASLAGHFRLDNLIVIYDSNQISIEGAINISFSEQVKTRFLAQNWEVLECDGHNYQAINDALEKAKKSTKPT
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENARINPNESFVISPKNKMHFEEVKVRGISLEALWEKSLNPKIKE
KIHALKNFDFNTINYPTFKKGESLATRVSNGMILNAIAKECEGFLGGSADLAPSNNTHLKHSSDFPLGQNLHFGIREHAM
GAITNALAAYGLFLPFCATFFVFSDYLMPSMRLSALMRLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
DAFENTACMQVALSLNAPSAFILSRQNLPILDEVSKEQVLKGAYVKHHSKDPIITLVASGSEVSLALESAKVLERENIPT
QVISVPCFDLLIGQDESYLKALFKGKILVIEASRAIEWYRFADKIICMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLN
A

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=26.9230769230769, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=26.9230769230769, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI133778974, Length=569, Percent_Identity=26.5377855887522, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI225637459, Length=655, Percent_Identity=23.3587786259542, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI225637461, Length=543, Percent_Identity=24.3093922651934, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI225637463, Length=543, Percent_Identity=24.3093922651934, Blast_Score=133, Evalue=5e-31,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=41.3897280966767, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=39.3072289156626, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17539652, Length=561, Percent_Identity=28.3422459893048, Blast_Score=192, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=41.566265060241, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=40.8408408408408, Blast_Score=465, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24666278, Length=660, Percent_Identity=26.6666666666667, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI45551847, Length=563, Percent_Identity=27.3534635879218, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI45550715, Length=563, Percent_Identity=27.3534635879218, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24645119, Length=525, Percent_Identity=26.8571428571429, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 70798; Mature: 70798

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLDNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCC
LNRDRLVFSGGHASALAYSLLHLWGFDLTLEDLKHFRQLYSKTPGHPELHHTEGIEITTG
CCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECC
PLGQGFANAVGFSMASQYAQNLLDKETISHKVYCLCGDGDLQEGISYESASLAGHFRLDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCCCCCEEEEEECC
LIVIYDSNQISIEGAINISFSEQVKTRFLAQNWEVLECDGHNYQAINDALEKAKKSTKPT
EEEEECCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCE
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENARINPNESFVISPKNKMHFEEVK
EEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHH
VRGISLEALWEKSLNPKIKEKIHALKNFDFNTINYPTFKKGESLATRVSNGMILNAIAKE
EECCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCEEHHHHHHH
CEGFLGGSADLAPSNNTHLKHSSDFPLGQNLHFGIREHAMGAITNALAAYGLFLPFCATF
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFSDYLMPSMRLSALMRLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCC
DAFENTACMQVALSLNAPSAFILSRQNLPILDEVSKEQVLKGAYVKHHSKDPIITLVASG
CCCCCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
SEVSLALESAKVLERENIPTQVISVPCFDLLIGQDESYLKALFKGKILVIEASRAIEWYR
CEEEEEHHHHHHHHHCCCCCEEEECCHHHHHCCCCHHHHHHHHCCCEEEEECCHHHHHHH
FADKIICMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLNA
HHCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLDNADLERLKSMANTLRFLCADMIDKANSGHPGVCLGLADVMVVLSLHLNLNPTNPKW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCC
LNRDRLVFSGGHASALAYSLLHLWGFDLTLEDLKHFRQLYSKTPGHPELHHTEGIEITTG
CCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECC
PLGQGFANAVGFSMASQYAQNLLDKETISHKVYCLCGDGDLQEGISYESASLAGHFRLDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHCCCCCCCCCEEEEEECC
LIVIYDSNQISIEGAINISFSEQVKTRFLAQNWEVLECDGHNYQAINDALEKAKKSTKPT
EEEEECCCEEEEEEEEEECHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCE
LLIAHTIIGKGAIGLEGSEKTHGSPLNKEVLKQSKENARINPNESFVISPKNKMHFEEVK
EEEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHH
VRGISLEALWEKSLNPKIKEKIHALKNFDFNTINYPTFKKGESLATRVSNGMILNAIAKE
EECCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCEEHHHHHHH
CEGFLGGSADLAPSNNTHLKHSSDFPLGQNLHFGIREHAMGAITNALAAYGLFLPFCATF
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FVFSDYLMPSMRLSALMRLKALFIFTHDSIGVGEDGATHQPIEQLSHLRALPNFYAFRPS
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCC
DAFENTACMQVALSLNAPSAFILSRQNLPILDEVSKEQVLKGAYVKHHSKDPIITLVASG
CCCCCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
SEVSLALESAKVLERENIPTQVISVPCFDLLIGQDESYLKALFKGKILVIEASRAIEWYR
CEEEEEHHHHHHHHHCCCCCEEEECCHHHHHCCCCHHHHHHHHCCCEEEEECCHHHHHHH
FADKIICMDSFGSSAKGDKLFEKFGFSVENITAQAKRLLNA
HHCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]