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The map label for this gene is vacA beta fragment 7 [H]

Identifier: 109947104

GI number: 109947104

Start: 441532

End: 442062

Strand: Reverse

Name: vacA beta fragment 7 [H]

Synonym: Hac_0508

Alternate gene names: 109947104

Gene position: 442062-441532 (Counterclockwise)

Preceding gene: 109947105

Following gene: 109947103

Centisome position: 28.45

GC content: 42.75

Gene sequence:

>531_bases
ATGAGTGCGGGAAAATGCTCTCCATTTAGCGGGGATATAGGCGATAAATCGCGCATTACTACCGTGCGTTTAGAAACGGG
ATATAGCCCGCTCTATGCTAGAGGGGTTAAATTTAAAAGCGGTAAAAAACCCGTTATAGATGGGATGTGCCATGCTCCTT
GGAATTATTTTGACGCCAGAAACACTACCGGTGTTGAAACCACCAAGAAAATTCTTTTTGGAGCCCTAGGAAACCTTGCA
GGCAAGATAGGGCTTAATAACCTAACCTTGGGTCATCATGCAAGCATGGATTATGGTAAAGATTTGGATTTAACCCTTCA
GGGGCATTTTATTAACAATCAAGGCGTGATGGATCTTTTTGTTCAAAACTGGCGTGCAGCAACCTTGAATGCAAGCCATC
AAGCAAGCATGCTGTTTAATAACATGACAGACAACACAACCGGATTTTACAAACCGCTCATTAAGATCAATAACGCTCAA
AACCTCACTAAAAGCACAGAGCATGTTTTTGGTGGGAGCGCGAAACATTGA

Upstream 100 bases:

>100_bases
GGAACGTTATTAGGCATGGCCAATACCAACAAGCACAGCTTCCACTCATGCTGCCATTGAAAACTTCAGTATTAAGGAAT
TGGTTGTTACAACCCATGGT

Downstream 100 bases:

>100_bases
TGATCATTGAGCGGGAGTGCAAGGCGTTAGTTATGATGCTGTTTTTGCAAGCAATGCTAATCTGCAAGAGCAATTCAAAG
AGTGCCTAGCCCTTTATAAC

Product: vacuolating cytotoxin fragment 7

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MSAGKCSPFSGDIGDKSRITTVRLETGYSPLYARGVKFKSGKKPVIDGMCHAPWNYFDARNTTGVETTKKILFGALGNLA
GKIGLNNLTLGHHASMDYGKDLDLTLQGHFINNQGVMDLFVQNWRAATLNASHQASMLFNNMTDNTTGFYKPLIKINNAQ
NLTKSTEHVFGGSAKH

Sequences:

>Translated_176_residues
MSAGKCSPFSGDIGDKSRITTVRLETGYSPLYARGVKFKSGKKPVIDGMCHAPWNYFDARNTTGVETTKKILFGALGNLA
GKIGLNNLTLGHHASMDYGKDLDLTLQGHFINNQGVMDLFVQNWRAATLNASHQASMLFNNMTDNTTGFYKPLIKINNAQ
NLTKSTEHVFGGSAKH
>Mature_175_residues
SAGKCSPFSGDIGDKSRITTVRLETGYSPLYARGVKFKSGKKPVIDGMCHAPWNYFDARNTTGVETTKKILFGALGNLAG
KIGLNNLTLGHHASMDYGKDLDLTLQGHFINNQGVMDLFVQNWRAATLNASHQASMLFNNMTDNTTGFYKPLIKINNAQN
LTKSTEHVFGGSAKH

Specific function: Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Vacuolating cytotoxin translocator:Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR003842 [H]

Pfam domain/function: PF03797 Autotransporter; PF02691 VacA [H]

EC number: NA

Molecular weight: Translated: 19213; Mature: 19082

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGKCSPFSGDIGDKSRITTVRLETGYSPLYARGVKFKSGKKPVIDGMCHAPWNYFDAR
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCEEECCCCCCCCCCCCCCCCCCCCCC
NTTGVETTKKILFGALGNLAGKIGLNNLTLGHHASMDYGKDLDLTLQGHFINNQGVMDLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEEEEECCCCHHHHH
VQNWRAATLNASHQASMLFNNMTDNTTGFYKPLIKINNAQNLTKSTEHVFGGSAKH
HHCCCEEECCCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAGKCSPFSGDIGDKSRITTVRLETGYSPLYARGVKFKSGKKPVIDGMCHAPWNYFDAR
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCEEECCCCCCCCCCCCCCCCCCCCCC
NTTGVETTKKILFGALGNLAGKIGLNNLTLGHHASMDYGKDLDLTLQGHFINNQGVMDLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEEEEECCCCHHHHH
VQNWRAATLNASHQASMLFNNMTDNTTGFYKPLIKINNAQNLTKSTEHVFGGSAKH
HHCCCEEECCCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7629077 [H]