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The map label for this gene is fabH

Identifier: 109946995

GI number: 109946995

Start: 331712

End: 332707

Strand: Direct

Name: fabH

Synonym: Hac_0387

Alternate gene names: 109946995

Gene position: 331712-332707 (Clockwise)

Preceding gene: 109946994

Following gene: 109946996

Centisome position: 21.35

GC content: 42.47

Gene sequence:

>996_bases
ATGGAATTTTACGCTTCTCTTAAATCCATTGCTATGCACGCTCCAAGCGAATGCATAAAGAATGTAGCGTTTCAAGAATT
TTTGGATACTAGCGATGAATGGATAGAAAAAAGGACCGGTATCAAAGAACGCCGTTTTGCTAGTGTTGGAGAAAAAAGCA
GTGATTTAGGGGTGATAGCGGCTAAACAAGCCATAGAAAGGGCACATTTAACCCCACAAGACATTGACTTAGTGGTTGTA
GCGACCTTAAGCCCTGATTTTTTAGCCATGCCTTCAACCGCTTGCGTGTTGAGCGCGAAACTAGGCATTGAAAACAAGCC
GGCGTTTGATATTTCAGCCGCTTGCACCGGTTTTATTTATCTCTTGTCCGTGGCTAAAGCTTATGTGGAAAGCGGGATGT
ATGAAAATGTGCTGATCGTGGGGGCAGAAAAAACGAGTAGCGTGTTGGATTTTAAGGATAGGGGGACTTGTATTTTATTT
GGTGATGGGGCTGGGGCGTGTGTGATAGGCAGGACAAAGCATTTAAAAGAAAGCATTTTGGATGTGCAGATTTCAGCGAA
TGGGAATTTTTCTAATTACCTCTATACGCCAAGGACTCTCAAACCCACGCCTTTTAACGCTAAAGAAGAGACTTCAGATC
CTTTTTTGTGCATGAAAGGCAATGAAGTGTTTAAACTAGCGGTGAAAACGCTTTTAAAAGATGTGGAAATGATCTTAGAA
AAAAATGCTCTCAAACCTGAAGATGTTCGTTTGTTTATCCCACATCAAGCTAATTTGAGAATCATTCAAGCCGTGCGAGA
GCATTTGGATTTTAAAGATGAGCAAGTGGTTTTGACCGTGCATAAATACGGCAACACTTCAGCAGCTAGTATCCCTATGG
CCATGGGTGAAGCTTATGAAGAAGGGCGTTTGAAAAAGGGCGATTTGATGCTTTTAGACGCTTTTGGTGGGGGATTGACT
TGGGGTTCAGCATTGGTGTATTTTGGAGGCAGTTAG

Upstream 100 bases:

>100_bases
TTTGAGGATTACAAAAGCGTTTGAGAGTTTGAAGCCTAGTGCTTCTACGCATCAAAGCGATCAACAAGACGCTTAAAGAT
GACTATGTTAAGGGGATTGA

Downstream 100 bases:

>100_bases
AAAAGGGTTAAAAGGAGCGTTAATGAAAAAGGTTGTTTTTTTATTGTTGGTTATGCTAGGGGGTTTGGGAGCACAAAGTA
CTTATTGCAGTGATCATTGC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MEFYASLKSIAMHAPSECIKNVAFQEFLDTSDEWIEKRTGIKERRFASVGEKSSDLGVIAAKQAIERAHLTPQDIDLVVV
ATLSPDFLAMPSTACVLSAKLGIENKPAFDISAACTGFIYLLSVAKAYVESGMYENVLIVGAEKTSSVLDFKDRGTCILF
GDGAGACVIGRTKHLKESILDVQISANGNFSNYLYTPRTLKPTPFNAKEETSDPFLCMKGNEVFKLAVKTLLKDVEMILE
KNALKPEDVRLFIPHQANLRIIQAVREHLDFKDEQVVLTVHKYGNTSAASIPMAMGEAYEEGRLKKGDLMLLDAFGGGLT
WGSALVYFGGS

Sequences:

>Translated_331_residues
MEFYASLKSIAMHAPSECIKNVAFQEFLDTSDEWIEKRTGIKERRFASVGEKSSDLGVIAAKQAIERAHLTPQDIDLVVV
ATLSPDFLAMPSTACVLSAKLGIENKPAFDISAACTGFIYLLSVAKAYVESGMYENVLIVGAEKTSSVLDFKDRGTCILF
GDGAGACVIGRTKHLKESILDVQISANGNFSNYLYTPRTLKPTPFNAKEETSDPFLCMKGNEVFKLAVKTLLKDVEMILE
KNALKPEDVRLFIPHQANLRIIQAVREHLDFKDEQVVLTVHKYGNTSAASIPMAMGEAYEEGRLKKGDLMLLDAFGGGLT
WGSALVYFGGS
>Mature_331_residues
MEFYASLKSIAMHAPSECIKNVAFQEFLDTSDEWIEKRTGIKERRFASVGEKSSDLGVIAAKQAIERAHLTPQDIDLVVV
ATLSPDFLAMPSTACVLSAKLGIENKPAFDISAACTGFIYLLSVAKAYVESGMYENVLIVGAEKTSSVLDFKDRGTCILF
GDGAGACVIGRTKHLKESILDVQISANGNFSNYLYTPRTLKPTPFNAKEETSDPFLCMKGNEVFKLAVKTLLKDVEMILE
KNALKPEDVRLFIPHQANLRIIQAVREHLDFKDEQVVLTVHKYGNTSAASIPMAMGEAYEEGRLKKGDLMLLDAFGGGLT
WGSALVYFGGS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=326, Percent_Identity=43.8650306748466, Blast_Score=264, Evalue=6e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_HELAH (Q17YQ2)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664223.1
- ProteinModelPortal:   Q17YQ2
- SMR:   Q17YQ2
- STRING:   Q17YQ2
- GeneID:   4177410
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0387
- NMPDR:   fig|382638.8.peg.376
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   Q17YQ2
- ProtClustDB:   PRK09352
- BioCyc:   HACI382638:HAC_0387-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 36221; Mature: 36221

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: ACT_SITE 115-115 ACT_SITE 255-255 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFYASLKSIAMHAPSECIKNVAFQEFLDTSDEWIEKRTGIKERRFASVGEKSSDLGVIA
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCCHHH
AKQAIERAHLTPQDIDLVVVATLSPDFLAMPSTACVLSAKLGIENKPAFDISAACTGFIY
HHHHHHHHCCCCCCCCEEEEEECCCCCEECCCHHEEEEEECCCCCCCCCCHHHHHHHHHH
LLSVAKAYVESGMYENVLIVGAEKTSSVLDFKDRGTCILFGDGAGACVIGRTKHLKESIL
HHHHHHHHHHCCCCCCEEEEECCCCCCCEEECCCCEEEEEECCCCEEEECCHHHHHHHHE
DVQISANGNFSNYLYTPRTLKPTPFNAKEETSDPFLCMKGNEVFKLAVKTLLKDVEMILE
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
KNALKPEDVRLFIPHQANLRIIQAVREHLDFKDEQVVLTVHKYGNTSAASIPMAMGEAYE
HCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHH
EGRLKKGDLMLLDAFGGGLTWGSALVYFGGS
HCCCCCCCEEEEECCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MEFYASLKSIAMHAPSECIKNVAFQEFLDTSDEWIEKRTGIKERRFASVGEKSSDLGVIA
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHCCCCCCCCCHHH
AKQAIERAHLTPQDIDLVVVATLSPDFLAMPSTACVLSAKLGIENKPAFDISAACTGFIY
HHHHHHHHCCCCCCCCEEEEEECCCCCEECCCHHEEEEEECCCCCCCCCCHHHHHHHHHH
LLSVAKAYVESGMYENVLIVGAEKTSSVLDFKDRGTCILFGDGAGACVIGRTKHLKESIL
HHHHHHHHHHCCCCCCEEEEECCCCCCCEEECCCCEEEEEECCCCEEEECCHHHHHHHHE
DVQISANGNFSNYLYTPRTLKPTPFNAKEETSDPFLCMKGNEVFKLAVKTLLKDVEMILE
EEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
KNALKPEDVRLFIPHQANLRIIQAVREHLDFKDEQVVLTVHKYGNTSAASIPMAMGEAYE
HCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHH
EGRLKKGDLMLLDAFGGGLTWGSALVYFGGS
HCCCCCCCEEEEECCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA