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The map label for this gene is mutY [H]

Identifier: 109946935

GI number: 109946935

Start: 275114

End: 275983

Strand: Reverse

Name: mutY [H]

Synonym: Hac_0323

Alternate gene names: 109946935

Gene position: 275983-275114 (Counterclockwise)

Preceding gene: 109946936

Following gene: 109946934

Centisome position: 17.76

GC content: 34.94

Gene sequence:

>870_bases
ATGAGCCAACAAACCCAAATCAACACGGTAGTTGAGCGTTTTTATTTCCCTTTTTTAAAAGCCTTCCCCACTTTAAAAGA
CTTAGCGAACGCTCAATTAGAGGAGATTTTATTGTTATGGCGAGGGCTTGGCTATTATTCTAGGGCTAAAAATTTAAAAA
AAAGCGCTGAAATTTGTGCAAAAGAACATCATTCACAACTACCTAATGACTATCAAAGCCTATTAAAACTCCCCGGCATT
GGCGTATACACGGCTAATGCGATCTTGTGTTTTGGCTTTAGAAAAAAAACCGCATGCGTAGATGCTAATATCAAGCGCGC
ACTTTTAAGGCTTTTTGGTTTAGATCCTAACATTCAAGCTAAAGATTTGCAAAGAAAAGCGAATAACTTCCTCAATCTTA
ATGAAAGCTTTAATCATAACCAAGCTTTAATTGATCTAGGGGCTTTAATTTGCTCCCCTAAACCCAAGTGTGCGATTTGC
CCCTTAAACCCTTATTGTTTAGGTAAAAACCATTTAGAAAAACACACGCTTAAGAAAAAACAAGAAATCATTCAAGAAGA
GCGTTATTTAGGCGTTGTCATCAAAAATAACAAAATCGCTTTAGAAAAAATAGAGCAAAAACTTTATTTTGGCATGCACC
ATTTCCCTAACTTAAAAGAAAATTTAGAATTCAAGCTCCCCTTTTTAGGCGTAATCAAACACAGCCACACCAAATTCAAG
CTCAATTTAAACCTGTATTTGGCCGCTGCAAAAGATTTAAAAAACCCCATCAATTTTTATAGCCTTAAAGATTTAGAGAC
CTTACCCATAAGCTCTATGACGCTTAAAATCTTGAATTTTTTAAAACATAAAAACTTATTTGGGAGTTAA

Upstream 100 bases:

>100_bases
CGCCCTTTTAAAATGGTATGAAGAATTTGGGCGCAAGGATTTACCCTTTAGGAATTTAAAGGGCATTAACGCCCCTTATG
AAGTCTATATTAGCGAAGTG

Downstream 100 bases:

>100_bases
AGCCATGTTAAAAATACCCCTTTTTGTATTAGCGCTCATCCTTTTAAATGCATGCAAAAATCCGAGCATGAGCAAAAACA
ATCTGCAATGCTATAGAAGT

Product: DNA glycosylase MutY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSQQTQINTVVERFYFPFLKAFPTLKDLANAQLEEILLLWRGLGYYSRAKNLKKSAEICAKEHHSQLPNDYQSLLKLPGI
GVYTANAILCFGFRKKTACVDANIKRALLRLFGLDPNIQAKDLQRKANNFLNLNESFNHNQALIDLGALICSPKPKCAIC
PLNPYCLGKNHLEKHTLKKKQEIIQEERYLGVVIKNNKIALEKIEQKLYFGMHHFPNLKENLEFKLPFLGVIKHSHTKFK
LNLNLYLAAAKDLKNPINFYSLKDLETLPISSMTLKILNFLKHKNLFGS

Sequences:

>Translated_289_residues
MSQQTQINTVVERFYFPFLKAFPTLKDLANAQLEEILLLWRGLGYYSRAKNLKKSAEICAKEHHSQLPNDYQSLLKLPGI
GVYTANAILCFGFRKKTACVDANIKRALLRLFGLDPNIQAKDLQRKANNFLNLNESFNHNQALIDLGALICSPKPKCAIC
PLNPYCLGKNHLEKHTLKKKQEIIQEERYLGVVIKNNKIALEKIEQKLYFGMHHFPNLKENLEFKLPFLGVIKHSHTKFK
LNLNLYLAAAKDLKNPINFYSLKDLETLPISSMTLKILNFLKHKNLFGS
>Mature_288_residues
SQQTQINTVVERFYFPFLKAFPTLKDLANAQLEEILLLWRGLGYYSRAKNLKKSAEICAKEHHSQLPNDYQSLLKLPGIG
VYTANAILCFGFRKKTACVDANIKRALLRLFGLDPNIQAKDLQRKANNFLNLNESFNHNQALIDLGALICSPKPKCAICP
LNPYCLGKNHLEKHTLKKKQEIIQEERYLGVVIKNNKIALEKIEQKLYFGMHHFPNLKENLEFKLPFLGVIKHSHTKFKL
NLNLYLAAAKDLKNPINFYSLKDLETLPISSMTLKILNFLKHKNLFGS

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI115298654, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI115298652, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI115298650, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI6912520, Length=183, Percent_Identity=37.7049180327869, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI190358497, Length=183, Percent_Identity=37.7049180327869, Blast_Score=135, Evalue=3e-32,
Organism=Escherichia coli, GI1789331, Length=267, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 33166; Mature: 33035

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQTQINTVVERFYFPFLKAFPTLKDLANAQLEEILLLWRGLGYYSRAKNLKKSAEICA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHHSQLPNDYQSLLKLPGIGVYTANAILCFGFRKKTACVDANIKRALLRLFGLDPNIQA
HHHHHCCCHHHHHHHHCCCCCEEECCEEEEECCCCCCHHHCHHHHHHHHHHHCCCCCCCH
KDLQRKANNFLNLNESFNHNQALIDLGALICSPKPKCAICPLNPYCLGKNHLEKHTLKKK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
QEIIQEERYLGVVIKNNKIALEKIEQKLYFGMHHFPNLKENLEFKLPFLGVIKHSHTKFK
HHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHCCCCEEEE
LNLNLYLAAAKDLKNPINFYSLKDLETLPISSMTLKILNFLKHKNLFGS
EEEEEEEEEHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SQQTQINTVVERFYFPFLKAFPTLKDLANAQLEEILLLWRGLGYYSRAKNLKKSAEICA
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KEHHSQLPNDYQSLLKLPGIGVYTANAILCFGFRKKTACVDANIKRALLRLFGLDPNIQA
HHHHHCCCHHHHHHHHCCCCCEEECCEEEEECCCCCCHHHCHHHHHHHHHHHCCCCCCCH
KDLQRKANNFLNLNESFNHNQALIDLGALICSPKPKCAICPLNPYCLGKNHLEKHTLKKK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
QEIIQEERYLGVVIKNNKIALEKIEQKLYFGMHHFPNLKENLEFKLPFLGVIKHSHTKFK
HHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHCCCCEEEE
LNLNLYLAAAKDLKNPINFYSLKDLETLPISSMTLKILNFLKHKNLFGS
EEEEEEEEEHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]