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The map label for this gene is nhaA

Identifier: 109946902

GI number: 109946902

Start: 241398

End: 242714

Strand: Direct

Name: nhaA

Synonym: Hac_0288

Alternate gene names: 109946902

Gene position: 241398-242714 (Clockwise)

Preceding gene: 109946901

Following gene: 109946903

Centisome position: 15.53

GC content: 40.39

Gene sequence:

>1317_bases
ATGAATTTTAAAAAAACAGAAAATGCACTCAGTTTGACGCTTAAAAACTTTATTAAAAGCGAGTCTTTTGGGGGGATTTT
CCTCTTTTTAAACGCTGTGCTAGCGATGGTGGTGGCTAATTCGTTTGTAAAAGAAAGTTATTTTGCTCTATGGCACACCC
CTTTTGGGTTTCAAATAGGGGATTTTTTTATCGGCTTTAGTTTGCATAATTGGATTGATGATGTCTTAATGGCGTTATTC
TTTTTGATGATAGGATTGGAAATCAAGCGAGAGTTGTTGTTTGGGGAATTATCCAGTTTTAAAAAAGCTTCTTTTCCTGT
GATTGCAGCCATTGGGGGCATGATAGCTCCAGGATTGATTTATTTTTTCCTTAACGCTGACACGCCCTCTCAACATGGTT
TTGGGATCCCTATGGCAACGGATATTGCGTTCGCTTTAGGCGTGATCATGCTTTTAGGCAAGAGAGTGCCTACCGCTCTA
AAGGTTTTTTTAATCACTCTAGCAGTGGCTGATGACTTGGGGGCTATTATGGTGATCGCACTCTTTTATACCACGAATTT
AAAATTCGCATGGCTTTTAGGGGCTTTAGGGGTGGTTCTTGTTTTAGCGCTATTGAACCGCTTGAATACCCACTCGCTTA
TCCCTTACTTGCTTTTAGGGGTGTTGCTTTGGTTTTGCGTGCATCAAAGCGGTATTCATGCCACGATCGCTGCGGTGGTT
CTAGCTTTTATGATACCGGTGAAAATCCCTAAAGATTCCAAAAATGTAGAGCTTTTAGAATTAGGCAAACGATACGCAGA
GACGAGCTCAGAAGTCCTTTTAACCAAAGAGCAGCAAGAAATTTTACATTCTATTGGAGAAAAAGCGAACGCTTTGCAAA
GCCCCTTGGAAAAATTGGAGCATTTTTTAGCGCCCATTAGCGGGTATTTCATCATGCCATTATTTGCGTTTGCAAATGCG
GGGGTGAGCGTTGATTCTAACATCAATTTAGAAGTCGATAAGGTGCTTTTAGGGGTCATTTTGGGGCTTTGTTTGGGTAA
GCCTTTAGGGATTTTCCTTATTACCTTTATAGGTGAAAAATTCAAAATCACCTCGCGCCCTAAAGGTATAAGTTGGTGGC
ATATTTTAGGGGCAGGGTTTTTAGCAGGGATTGGCTTTACTATGTCTATGTTCATTTCCAATTTGGCTTTCACTGGCGAG
CATAAGGACGCTATGGAAGTGGCAAAAATTGCGATTTTACTGGGATCTTTGATTTCTGGGATCATAGGGGCTTTGTATTT
ATTTTTACTAGACAAAAAAGCGACTTTAAAGAAATAG

Upstream 100 bases:

>100_bases
CTCAAGCCCCCCATTTTAAGATACAAGCGGGCATTATTTACGCTCATAAAAGACTGCTTGAAAAATTATGGGTTTGAAAT
TAAAAATTTTAAGGTTGTCT

Downstream 100 bases:

>100_bases
CTAAAAATGCTATAATTTGAGATTAAAATATCTTTATAAGGAAATTGAATGGGAACAAGAGACATTATAACGACGCTTTT
ACCCTTTGTGGTGTTTCTTC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MNFKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFVKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIMVIALFYTTNLKFAWLLGALGVVLVLALLNRLNTHSLIPYLLLGVLLWFCVHQSGIHATIAAVV
LAFMIPVKIPKDSKNVELLELGKRYAETSSEVLLTKEQQEILHSIGEKANALQSPLEKLEHFLAPISGYFIMPLFAFANA
GVSVDSNINLEVDKVLLGVILGLCLGKPLGIFLITFIGEKFKITSRPKGISWWHILGAGFLAGIGFTMSMFISNLAFTGE
HKDAMEVAKIAILLGSLISGIIGALYLFLLDKKATLKK

Sequences:

>Translated_438_residues
MNFKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFVKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIMVIALFYTTNLKFAWLLGALGVVLVLALLNRLNTHSLIPYLLLGVLLWFCVHQSGIHATIAAVV
LAFMIPVKIPKDSKNVELLELGKRYAETSSEVLLTKEQQEILHSIGEKANALQSPLEKLEHFLAPISGYFIMPLFAFANA
GVSVDSNINLEVDKVLLGVILGLCLGKPLGIFLITFIGEKFKITSRPKGISWWHILGAGFLAGIGFTMSMFISNLAFTGE
HKDAMEVAKIAILLGSLISGIIGALYLFLLDKKATLKK
>Mature_438_residues
MNFKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFVKESYFALWHTPFGFQIGDFFIGFSLHNWIDDVLMALF
FLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLIYFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTAL
KVFLITLAVADDLGAIMVIALFYTTNLKFAWLLGALGVVLVLALLNRLNTHSLIPYLLLGVLLWFCVHQSGIHATIAAVV
LAFMIPVKIPKDSKNVELLELGKRYAETSSEVLLTKEQQEILHSIGEKANALQSPLEKLEHFLAPISGYFIMPLFAFANA
GVSVDSNINLEVDKVLLGVILGLCLGKPLGIFLITFIGEKFKITSRPKGISWWHILGAGFLAGIGFTMSMFISNLAFTGE
HKDAMEVAKIAILLGSLISGIIGALYLFLLDKKATLKK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=417, Percent_Identity=44.1247002398081, Blast_Score=281, Evalue=5e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_HELAH (Q17YZ5)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664130.1
- ProteinModelPortal:   Q17YZ5
- SMR:   Q17YZ5
- STRING:   Q17YZ5
- GeneID:   4177444
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0288
- NMPDR:   fig|382638.8.peg.277
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   HGFGIPM
- PhylomeDB:   Q17YZ5
- ProtClustDB:   PRK14856
- BioCyc:   HACI382638:HAC_0288-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 47900; Mature: 47900

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe29bc60)-; HASH(0x122a8828)-; HASH(0x12148f54)-; HASH(0x122e6ea0)-; HASH(0x1292b738)-; HASH(0x958917c)-; HASH(0x12ae5c84)-; HASH(0xc2c59cc)-; HASH(0x12b0886c)-; HASH(0x12ad2774)-; HASH(0x12a2adec)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFVKESYFALWHTPFGFQIG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DFFIGFSLHNWIDDVLMALFFLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDLGAIMVIA
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFYTTNLKFAWLLGALGVVLVLALLNRLNTHSLIPYLLLGVLLWFCVHQSGIHATIAAVV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAFMIPVKIPKDSKNVELLELGKRYAETSSEVLLTKEQQEILHSIGEKANALQSPLEKLE
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
HFLAPISGYFIMPLFAFANAGVSVDSNINLEVDKVLLGVILGLCLGKPLGIFLITFIGEK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
FKITSRPKGISWWHILGAGFLAGIGFTMSMFISNLAFTGEHKDAMEVAKIAILLGSLISG
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IIGALYLFLLDKKATLKK
HHHHHHHHHHCCHHHCCH
>Mature Secondary Structure
MNFKKTENALSLTLKNFIKSESFGGIFLFLNAVLAMVVANSFVKESYFALWHTPFGFQIG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
DFFIGFSLHNWIDDVLMALFFLMIGLEIKRELLFGELSSFKKASFPVIAAIGGMIAPGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
YFFLNADTPSQHGFGIPMATDIAFALGVIMLLGKRVPTALKVFLITLAVADDLGAIMVIA
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFYTTNLKFAWLLGALGVVLVLALLNRLNTHSLIPYLLLGVLLWFCVHQSGIHATIAAVV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAFMIPVKIPKDSKNVELLELGKRYAETSSEVLLTKEQQEILHSIGEKANALQSPLEKLE
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
HFLAPISGYFIMPLFAFANAGVSVDSNINLEVDKVLLGVILGLCLGKPLGIFLITFIGEK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
FKITSRPKGISWWHILGAGFLAGIGFTMSMFISNLAFTGEHKDAMEVAKIAILLGSLISG
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
IIGALYLFLLDKKATLKK
HHHHHHHHHHCCHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA