Click here to switch to the map view.

The map label for this gene is gcp

Identifier: 109946896

GI number: 109946896

Start: 231805

End: 232833

Strand: Direct

Name: gcp

Synonym: Hac_0281

Alternate gene names: 109946896

Gene position: 231805-232833 (Clockwise)

Preceding gene: 109946887

Following gene: 109946901

Centisome position: 14.92

GC content: 38.78

Gene sequence:

>1029_bases
ATGATTTTAAGCATTGAAAGTTCTTGCGATGACAGCTCTTTAGCCCTTACAAGAATAGAGGACGCTAAACTTATCGCTCA
TTTTAAAATCTCTCAAGAAAAGCACCATAGCTCTTATGGGGGCGTTGTACCTGAGCTTGCATCGCGCCTGCATGCTGAGA
ATTTGCCGTTGCTATTAGAACGCATTAAAATAAGCTTGAATAAGGATTTTTCTAAACTTAAAGCCATCGCTATCACCAAC
CAGCCAGGTTTGAGCGTTACTCTAATAGAGGGCTTGATGATGGCAAAAGCCTTGAGCTTGTCCTTAAATTTACCCTTAAT
TTTAGAAGACCATTTGAGAGGGCATGTGTATTCGCTCTTTATCAATGAAAAAAAAACTTGCATGCCTTTAAGCGTGTTGT
TAGTCTCTGGGGGGCATTCTTTGATTTTAGAGGCTAGAAATTATGAAGACATTAAAATTATGGCTACGAGTTTAGACGAT
AGCTTTGGGGAGAGCTTTGATAAGGTTTCTAAAATGCTAAATCTAGGCTATCCAGGAGGTCCTGTAATAGAAAAATTAGC
CTTGGATTATGCACATAAAAATGAGCCTTTAATGTTCCCTATCCCTTTAAAAAACAGCCTGAATTTGGCTTTTAGTTTTT
CAGGTTTAAAAAATGCGGTGCGTTTGGAGATTGAAAAAAACGCCCCCAATTTGAATGAAATAACCAAACAAAAGATTGGC
TATCATTTCCAAAGCGTGGCCATAGAGCATTTAATCCAGCAAACCAAACGCTATTTTAAAACCAAACGCCCTAAAATTTT
TGGCATTGTGGGGGGAGCAAGCCAAAATTTGGTCTTAAGAAAGGCGTTTGAAAATTTGTGCGATGAGTTTGATTGCAAGC
TTGTTTTAGCTCCGTTGGAATTTTGCAGTGATAATGCCGCCATGATAGGGCGATCAAGCCTAGAAGCTTATCAAAAAAAG
CACTTTGTCCCTTTAGAAAAAGCTAGCATTTCGCCAAGAACGCTGTTAAAAAAGGCTTTGAGTGAATAG

Upstream 100 bases:

>100_bases
TGGGTTTGAGTATAATAACCAAGGAAAACTTGTGTCAAGTTTTACTCAAAGAGATTAAAAATTTGATTGAGTCTAAAACA
CCATCATTCAAAGATAAGGC

Downstream 100 bases:

>100_bases
AGATAAAATAAGGAGTGCATGATAAAAATTCTAAAAGTTGTCAATTTTTATTTGCATTTTATAGAATTAATAAAGAAAGC
AAGATGTAAACCATAGCGTA

Product: DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MILSIESSCDDSSLALTRIEDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKLKAIAITN
QPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKKTCMPLSVLLVSGGHSLILEARNYEDIKIMATSLDD
SFGESFDKVSKMLNLGYPGGPVIEKLALDYAHKNEPLMFPIPLKNSLNLAFSFSGLKNAVRLEIEKNAPNLNEITKQKIG
YHFQSVAIEHLIQQTKRYFKTKRPKIFGIVGGASQNLVLRKAFENLCDEFDCKLVLAPLEFCSDNAAMIGRSSLEAYQKK
HFVPLEKASISPRTLLKKALSE

Sequences:

>Translated_342_residues
MILSIESSCDDSSLALTRIEDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKLKAIAITN
QPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKKTCMPLSVLLVSGGHSLILEARNYEDIKIMATSLDD
SFGESFDKVSKMLNLGYPGGPVIEKLALDYAHKNEPLMFPIPLKNSLNLAFSFSGLKNAVRLEIEKNAPNLNEITKQKIG
YHFQSVAIEHLIQQTKRYFKTKRPKIFGIVGGASQNLVLRKAFENLCDEFDCKLVLAPLEFCSDNAAMIGRSSLEAYQKK
HFVPLEKASISPRTLLKKALSE
>Mature_342_residues
MILSIESSCDDSSLALTRIEDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERIKISLNKDFSKLKAIAITN
QPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKKTCMPLSVLLVSGGHSLILEARNYEDIKIMATSLDD
SFGESFDKVSKMLNLGYPGGPVIEKLALDYAHKNEPLMFPIPLKNSLNLAFSFSGLKNAVRLEIEKNAPNLNEITKQKIG
YHFQSVAIEHLIQQTKRYFKTKRPKIFGIVGGASQNLVLRKAFENLCDEFDCKLVLAPLEFCSDNAAMIGRSSLEAYQKK
HFVPLEKASISPRTLLKKALSE

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=30.7692307692308, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI8923380, Length=335, Percent_Identity=22.9850746268657, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789445, Length=340, Percent_Identity=32.9411764705882, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17557464, Length=325, Percent_Identity=29.8461538461538, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71995670, Length=323, Percent_Identity=26.9349845201238, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320099, Length=354, Percent_Identity=29.0960451977401, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322891, Length=269, Percent_Identity=24.907063197026, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129063, Length=343, Percent_Identity=28.2798833819242, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI21357207, Length=345, Percent_Identity=24.3478260869565, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_HELAH (Q17Z01)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664124.1
- STRING:   Q17Z01
- MEROPS:   M22.001
- GeneID:   4177759
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0281
- NMPDR:   fig|382638.8.peg.270
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   HACI382638:HAC_0281-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 38058; Mature: 38058

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSIESSCDDSSLALTRIEDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLE
CEEEECCCCCCCCEEEEEECCCEEEEEEEECHHHCCCCCCCHHHHHHHHHCCCCCHHHHH
RIKISLNKDFSKLKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLF
HHHHHCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEE
INEKKTCMPLSVLLVSGGHSLILEARNYEDIKIMATSLDDSFGESFDKVSKMLNLGYPGG
ECCCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
PVIEKLALDYAHKNEPLMFPIPLKNSLNLAFSFSGLKNAVRLEIEKNAPNLNEITKQKIG
HHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHC
YHFQSVAIEHLIQQTKRYFKTKRPKIFGIVGGASQNLVLRKAFENLCDEFDCKLVLAPLE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEHH
FCSDNAAMIGRSSLEAYQKKHFVPLEKASISPRTLLKKALSE
HCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MILSIESSCDDSSLALTRIEDAKLIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLE
CEEEECCCCCCCCEEEEEECCCEEEEEEEECHHHCCCCCCCHHHHHHHHHCCCCCHHHHH
RIKISLNKDFSKLKAIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLF
HHHHHCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEE
INEKKTCMPLSVLLVSGGHSLILEARNYEDIKIMATSLDDSFGESFDKVSKMLNLGYPGG
ECCCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
PVIEKLALDYAHKNEPLMFPIPLKNSLNLAFSFSGLKNAVRLEIEKNAPNLNEITKQKIG
HHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHC
YHFQSVAIEHLIQQTKRYFKTKRPKIFGIVGGASQNLVLRKAFENLCDEFDCKLVLAPLE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEHH
FCSDNAAMIGRSSLEAYQKKHFVPLEKASISPRTLLKKALSE
HCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA