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The map label for this gene is nuoD

Identifier: 109946842

GI number: 109946842

Start: 191504

End: 192733

Strand: Reverse

Name: nuoD

Synonym: Hac_0221

Alternate gene names: 109946842

Gene position: 192733-191504 (Counterclockwise)

Preceding gene: 109946843

Following gene: 109946841

Centisome position: 12.4

GC content: 43.74

Gene sequence:

>1230_bases
ATGGCTCAAAATTTCACGAAACTCAACCCCCAATTTGAAAACATCATTTTTGAACATGACGATAACCAAATGGTGCTAAA
CTTTGGCCCCCAACACCCCTCTAGCCATGGGCAATTGCGCTTGATTTTAGAATTAGAGGGCGAAAGAATCATTAAGGCTA
CCCCTGAAATTGGCTACTTGCACAGGGGTTGTGAGAAGTTGGGCGAAAACATGACCTATAATGAATACATGCCCACTACT
GATAGGTTGGATTACACTTCTTCTGCTAGCAATAATTACGCTTACGCCCATGCGGTAGAGACCTTGCTCAATTTAGAAAT
CCCACGCCGAGCGCAAGTGATCCGCACGATTTTACTAGAGCTTAACCGCATGATTTCACACATCTTTTTTATCAGCGTGC
ATGCTTTAGATGTGGGGGCGATGAGCGTGTTTTTGTATGCGTTTAAGACAAGGGAACATGGGTTGGATTTGATGGAGGAT
TATTGCGGAGCTAGGCTCACGCATAACGCTATAAGGATTGGGGGCGTGCCTTTAGATTTACCCCCTAACTGGCTAGAAGG
CTTGAAAAAATTCTTAGGCGAAATGAGGGAATGCAAAAAACTCATTCAAGGCTTATTGGATAAAAACCGCATTTGGCGGA
TGCGTTTGGAAAATGTGGGCGTTGTCACGCCAAAAATGGCGCAAAGTTGGGGCATGAGCGGTATCATGTTAAGAGGAACG
GGAATTGCCTATGATATTAGAAAAGAAGAGCCTTACGAACTTTATAGAGAGCTTGATTTTGATGTGCCGGTGGGCAATTA
TGGCGATAGCTATGACAGGTATTGTTTGTATATGTTAGAAATTGATGAAAGCATTCGCATCATTGAACAACTCATTCCTA
TGTATGCCAAAACCGATACGCCTATTATGGCTCAAAATCCGCATTACATTTCTGCCCCTAAAGAAGATATAATGACGCAA
AACTACGCCTTGATGCAGCATTTTGTTTTAGTCGCTCAAGGCATGCGTCCGCCCATTGGGGAAGTGTATGCTCCCACAGA
AAGCCCTAAAGGGGAATTAGGGTTTTTTATCCATTCAGAGGGCGAGTCTTACCCACATAGATTAAAAATCAGAGCCCCAA
GCTTTTATCACATTGGATCGTTAGGCGATATTTTAGTGGGGCAGTATTTAGCGGATGCGGTAACCGTGATTGGATCAACC
AATGCGGTATTTGGCGAGGTGGATAGATGA

Upstream 100 bases:

>100_bases
GAGTTGAAAGAAATAGAAGAAAAACATGTGTTTAAAAAAATCCCTTTTGTCAAAGATTTACACAAAATGACCCCTACTAT
CTTAAAAAAGAGATTATAAA

Downstream 100 bases:

>100_bases
AACGCTTTGATTTACGCCCCTTAAAAGCGGATATTTTTGAACGATTAGAAGAATTGATTGAAAAAGAAATGCAATTTGGT
GAAGTCGCCATTTTTATGTT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAQNFTKLNPQFENIIFEHDDNQMVLNFGPQHPSSHGQLRLILELEGERIIKATPEIGYLHRGCEKLGENMTYNEYMPTT
DRLDYTSSASNNYAYAHAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREHGLDLMED
YCGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGT
GIAYDIRKEEPYELYRELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQ
NYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSEGESYPHRLKIRAPSFYHIGSLGDILVGQYLADAVTVIGST
NAVFGEVDR

Sequences:

>Translated_409_residues
MAQNFTKLNPQFENIIFEHDDNQMVLNFGPQHPSSHGQLRLILELEGERIIKATPEIGYLHRGCEKLGENMTYNEYMPTT
DRLDYTSSASNNYAYAHAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREHGLDLMED
YCGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGT
GIAYDIRKEEPYELYRELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQ
NYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSEGESYPHRLKIRAPSFYHIGSLGDILVGQYLADAVTVIGST
NAVFGEVDR
>Mature_408_residues
AQNFTKLNPQFENIIFEHDDNQMVLNFGPQHPSSHGQLRLILELEGERIIKATPEIGYLHRGCEKLGENMTYNEYMPTTD
RLDYTSSASNNYAYAHAVETLLNLEIPRRAQVIRTILLELNRMISHIFFISVHALDVGAMSVFLYAFKTREHGLDLMEDY
CGARLTHNAIRIGGVPLDLPPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGTG
IAYDIRKEEPYELYRELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDTPIMAQNPHYISAPKEDIMTQN
YALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSEGESYPHRLKIRAPSFYHIGSLGDILVGQYLADAVTVIGSTN
AVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=406, Percent_Identity=42.6108374384236, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI260898743, Length=400, Percent_Identity=41.75, Blast_Score=315, Evalue=7e-86,
Organism=Escherichia coli, GI145693162, Length=391, Percent_Identity=37.0843989769821, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1789076, Length=394, Percent_Identity=27.6649746192893, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788832, Length=399, Percent_Identity=28.0701754385965, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=43.2569974554707, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17555284, Length=403, Percent_Identity=42.1836228287841, Blast_Score=339, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=43.1122448979592, Blast_Score=346, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=43.0051813471503, Blast_Score=322, Evalue=3e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_HELAH (Q17Z55)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664070.1
- ProteinModelPortal:   Q17Z55
- SMR:   Q17Z55
- STRING:   Q17Z55
- GeneID:   4177455
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0221
- NMPDR:   fig|382638.8.peg.215
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   GVFIQGN
- ProtClustDB:   PRK06075
- BioCyc:   HACI382638:HAC_0221-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 46690; Mature: 46559

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNFTKLNPQFENIIFEHDDNQMVLNFGPQHPSSHGQLRLILELEGERIIKATPEIGYL
CCCCCCCCCCCHHCEEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCEEEEECCCHHHH
HRGCEKLGENMTYNEYMPTTDRLDYTSSASNNYAYAHAVETLLNLEIPRRAQVIRTILLE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
LNRMISHIFFISVHALDVGAMSVFLYAFKTREHGLDLMEDYCGARLTHNAIRIGGVPLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCEEEECCEECCC
PPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECC
GIAYDIRKEEPYELYRELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDT
CEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCC
PIMAQNPHYISAPKEDIMTQNYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEECC
GESYPHRLKIRAPSFYHIGSLGDILVGQYLADAVTVIGSTNAVFGEVDR
CCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQNFTKLNPQFENIIFEHDDNQMVLNFGPQHPSSHGQLRLILELEGERIIKATPEIGYL
CCCCCCCCCCHHCEEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCEEEEECCCHHHH
HRGCEKLGENMTYNEYMPTTDRLDYTSSASNNYAYAHAVETLLNLEIPRRAQVIRTILLE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
LNRMISHIFFISVHALDVGAMSVFLYAFKTREHGLDLMEDYCGARLTHNAIRIGGVPLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCEEEECCEECCC
PPNWLEGLKKFLGEMRECKKLIQGLLDKNRIWRMRLENVGVVTPKMAQSWGMSGIMLRGT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEECC
GIAYDIRKEEPYELYRELDFDVPVGNYGDSYDRYCLYMLEIDESIRIIEQLIPMYAKTDT
CEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCC
PIMAQNPHYISAPKEDIMTQNYALMQHFVLVAQGMRPPIGEVYAPTESPKGELGFFIHSE
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCEEEEEECC
GESYPHRLKIRAPSFYHIGSLGDILVGQYLADAVTVIGSTNAVFGEVDR
CCCCCCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA