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The map label for this gene is nuoL [H]

Identifier: 109946834

GI number: 109946834

Start: 183460

End: 185298

Strand: Reverse

Name: nuoL [H]

Synonym: Hac_0213

Alternate gene names: 109946834

Gene position: 185298-183460 (Counterclockwise)

Preceding gene: 109946835

Following gene: 109946833

Centisome position: 11.92

GC content: 41.87

Gene sequence:

>1839_bases
ATGCAGTATTCTTCTTGGCTGTCTGTCGTGTTGTTTTTGCCTTTAATCGGTGCGATTTATGCAGGGGTGTTTGGGGCTAA
AGCGAAAGCGTTGCATGTGGGTGTTTTTAATTCTTTATGCGTGCTAGTCTCTTTAATTGGTGCGGTGATCCTTTTCATTC
AAGCATGGCACCATCAAAGCTATGAAAAATATTTATTTGATTGGATCGTGGTGGGGAATTTTAAAGTGGGCTTTTCTCTC
ATGCTAGATAATGTCAATGCCGTCATGATTGTCGTGGTTACTTTAGTTTCTTTATTAGTGCATGTGTATTCCATAGGTTA
CATGGAGCATGATGAAGGGTTTAACCGCTATTTTTCCTATCTCAGTGGCTTTGTGTTTTCCATGCTGGTTTTGGTGTTGA
GCGATAATTTCTTAGGGCTTTTCATTGGCTGGGAAGGGGTGGGGCTATGCTCTTACTTGCTCATTGGCTTTTGGTATCAT
AAAGAGAGTGCAAACAACGCCTCCATTGAAGCCTTTGTGATGAACCGGATCACGGATTTAGGCATGCTCATGGGGATTAT
TTTGATTTATTGGAATTTTGGCACGCTCCAATATAAGGAAGTCTTTAGTGCCCTTAATACCACCGATTATACAATGCTCT
TTTACATCAGCGTGTTCCTTTTCATTGGCGCTATGGGTAAGAGCGCGCAATTCCCTATGCACACATGGCTAGCCAACGCT
ATGGAAGGGCCTACCCCTGTGTCTGCTCTCATCCATGCAGCGACGATGGTAACCGCTGGGGTGTATCTAGTCATTAGAGC
CAACCCTTTGTATAGTGCGGTTTTTGAAGTGGGTTATTTTATTGCATGCTTAGGGGCGTTTGTGGCTCTTTTTGGAGCGA
GCATGGCTTTAGTCAATAAGGATCTAAAACGCATTGTGGCTTATTCCACGCTTTCTCAATTGGGCTATATGTTTGTAGCA
GCCGGTCTTGGGGCTTATGCAATCGCGCTTTTCCATCTCTTTACGCATGCGTTTTTCAAATCGCTCCTTTTCTTAGGTTC
AGGGAATGTGATGCATGCGATGGAAGACAATTTGGATATTACTAAAATGGGTGCTTTATACAAACCCATGAAAGTTACGG
CTATTTTTATGATTATAGGCTCAGTGGCCTTGTGCGGGATTTATCCTTTTGCCGGATACTTTTCTAAAGACAAAATTTTA
GAAGTTGCCTTTGGCATGCACCACCACATTTTATGGTTTATGCTTTTAATTGGGGCGATCTTTACCGCTTTTTATAGCTT
TAGATTGATCATGCTTGTCTTTTTTGCACCCAAACAACACGAAATCAACCACCCCCATGAGGCTAAAAATTTCATGCTTT
TAAGCATGCTGCCATTAGGGATTTTAGCGGTCATTGCTGGGTTTTTTGAAGAGCCGTTTTTCCATTTTATTTCTCAAGTG
ATCCCTAGTGTTGGAGAATACCCCATCCCGCTCGCTCTTTTGATCAGTGTTACCACCATTGTGGTGTTATTGAGCATTGC
CTATGCTATCTTTAAATATAAAAATGGTATCACTTCCAAAAAAGAGGGGGGCTTTTTATACAAGCTCTTACTCAACCAAT
ACTATATCCCACAACTTTATCAAGGGATTGTAAAAATTTTTAGTGCCCTCGCTTTATTTTTGCACCAAGTCGTGGAGTTA
AGGATCATTGACGCGATCGTGGATACTATAGGGAGAAGCGTTTTTGTTATAGGGCGTGTGTTTAGAGCCAGTCAAGATGG
GAATTTAACCTCCATGCTGCGCTTCATGGTGGCTGGGGTTTTAATCTTATTAGCGTTTGTGGCTGTTTTTTGGAGATAA

Upstream 100 bases:

>100_bases
CCGCTAGTGAGGTTGCTATTGGTTTGGGATTGGTGATTTTATGGTTTAAGAAATTCAAAAGCCTAGATATTGATTCTTTA
AACGCTATGAAAGGTTAAGC

Downstream 100 bases:

>100_bases
ACAATGCAGTATTTACATGCACATCTTTTAAGCGTGGTGATCTTTTTCCCTATGCTAAGTGCCGTATTGGCGTTCTTTAT
GAGCGCTCAAGCGAGCAGGG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MQYSSWLSVVLFLPLIGAIYAGVFGAKAKALHVGVFNSLCVLVSLIGAVILFIQAWHHQSYEKYLFDWIVVGNFKVGFSL
MLDNVNAVMIVVVTLVSLLVHVYSIGYMEHDEGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KESANNASIEAFVMNRITDLGMLMGIILIYWNFGTLQYKEVFSALNTTDYTMLFYISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMKVTAIFMIIGSVALCGIYPFAGYFSKDKIL
EVAFGMHHHILWFMLLIGAIFTAFYSFRLIMLVFFAPKQHEINHPHEAKNFMLLSMLPLGILAVIAGFFEEPFFHFISQV
IPSVGEYPIPLALLISVTTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPQLYQGIVKIFSALALFLHQVVEL
RIIDAIVDTIGRSVFVIGRVFRASQDGNLTSMLRFMVAGVLILLAFVAVFWR

Sequences:

>Translated_612_residues
MQYSSWLSVVLFLPLIGAIYAGVFGAKAKALHVGVFNSLCVLVSLIGAVILFIQAWHHQSYEKYLFDWIVVGNFKVGFSL
MLDNVNAVMIVVVTLVSLLVHVYSIGYMEHDEGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KESANNASIEAFVMNRITDLGMLMGIILIYWNFGTLQYKEVFSALNTTDYTMLFYISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMKVTAIFMIIGSVALCGIYPFAGYFSKDKIL
EVAFGMHHHILWFMLLIGAIFTAFYSFRLIMLVFFAPKQHEINHPHEAKNFMLLSMLPLGILAVIAGFFEEPFFHFISQV
IPSVGEYPIPLALLISVTTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPQLYQGIVKIFSALALFLHQVVEL
RIIDAIVDTIGRSVFVIGRVFRASQDGNLTSMLRFMVAGVLILLAFVAVFWR
>Mature_612_residues
MQYSSWLSVVLFLPLIGAIYAGVFGAKAKALHVGVFNSLCVLVSLIGAVILFIQAWHHQSYEKYLFDWIVVGNFKVGFSL
MLDNVNAVMIVVVTLVSLLVHVYSIGYMEHDEGFNRYFSYLSGFVFSMLVLVLSDNFLGLFIGWEGVGLCSYLLIGFWYH
KESANNASIEAFVMNRITDLGMLMGIILIYWNFGTLQYKEVFSALNTTDYTMLFYISVFLFIGAMGKSAQFPMHTWLANA
MEGPTPVSALIHAATMVTAGVYLVIRANPLYSAVFEVGYFIACLGAFVALFGASMALVNKDLKRIVAYSTLSQLGYMFVA
AGLGAYAIALFHLFTHAFFKSLLFLGSGNVMHAMEDNLDITKMGALYKPMKVTAIFMIIGSVALCGIYPFAGYFSKDKIL
EVAFGMHHHILWFMLLIGAIFTAFYSFRLIMLVFFAPKQHEINHPHEAKNFMLLSMLPLGILAVIAGFFEEPFFHFISQV
IPSVGEYPIPLALLISVTTIVVLLSIAYAIFKYKNGITSKKEGGFLYKLLLNQYYIPQLYQGIVKIFSALALFLHQVVEL
RIIDAIVDTIGRSVFVIGRVFRASQDGNLTSMLRFMVAGVLILLAFVAVFWR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=421, Percent_Identity=37.7672209026128, Blast_Score=265, Evalue=9e-71,
Organism=Escherichia coli, GI1788614, Length=568, Percent_Identity=39.4366197183099, Blast_Score=345, Evalue=6e-96,
Organism=Escherichia coli, GI1788829, Length=418, Percent_Identity=30.622009569378, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1788831, Length=358, Percent_Identity=27.9329608938547, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788827, Length=427, Percent_Identity=27.6346604215457, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788613, Length=398, Percent_Identity=24.6231155778894, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI2367154, Length=443, Percent_Identity=23.9277652370203, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693160, Length=412, Percent_Identity=22.5728155339806, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68327; Mature: 68327

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]