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The map label for this gene is copA [H]

Identifier: 109946713

GI number: 109946713

Start: 79645

End: 81984

Strand: Direct

Name: copA [H]

Synonym: Hac_0081

Alternate gene names: 109946713

Gene position: 79645-81984 (Clockwise)

Preceding gene: 109946712

Following gene: 109946724

Centisome position: 5.13

GC content: 38.16

Gene sequence:

>2340_bases
ATGAAATGTTCGCATTGCCAATTAGAGTTTAAAGAAAGCGAGCTTTTTAAAGAGACTATCAACCATAAAGAATTGCATTT
TTGTTGTGCAGGGTGTGCTAGGGTGTATGCGTTGTTATTGGATTTGAATTTAGAGAGCTTTTATGACAAGTTAGGCGCTT
CTACTTTAGCCCCTGTAACGCATCAAGCTCCAGTGAATGCTTTAGAATTAGAGCAAGCTATTGAAGAAAACGATAAGGGC
GATTTTACCCTTAATCTTTTGTTAGAAAAAACGCATTGCAACGCTTGCTTGTGGCTCAATCAAAAGGTTTTAGAGCGCTT
AAGTGGGGTTAAAAAAGTGAGCGTGAATTTCACCACCCACCACTTACAAATCGTGTTTGAGAAGTCCTTAAACCCCAAAG
AAATCATTCAAAAAATTGAGAGTTTGGGCTATGGGGCTAAAGTCTATAACGCTAAAAATTACACCCTAAAAGCGCAAAAA
GAGCAACGATCTTACTTGCTCACTTTAAGCGTGGGGTTTTTTGCCACCATGAACTTGATGTTTATTGCAATTGCCAAATA
TGCGAGTTATGGTAGCAGTGGCATGGATAAGCTCATGCAAAGGAATTTGGATCTCGTATCGCTCTTTTTAAGCTTGTTGG
TGTTGGTGGTTGTGGGGCGCTTTTTCATTAAGGGGGCGTTTTATGGGCTAAAAAATGGTGTTTTTGGCATGGATTTGAGC
GTGTCTTTTGGGGCGTTGTCGGCGTTTGTTTATTCCGTTTATGCCATGTTTGTGTCTCAAGAGACTTATTTTGAAGCGAG
CAGTACCATTTTAACGCTTGTTTTTGGATCTAAGTTTTTGGAATTGAAGGCTAGGTTGTTTGCGAATGAAAAATGTTTGG
CCCTAGAATCGCATGAAATCCATAGCGTGATCGTTTTAGAAAAGGACAAACAAGTGGAAAAACACCCCAAAGATGTGGCG
ATAGGCTCTATTATTTTGGTGCCAAGTGGGGCTAAAATCGCACTGGATGGCGTGCTTTTAAATAATGCGAGCGTGGATGC
GTCTTTAATTAGTGGGGAGTTTAAACCTTTGGAATTGGGGGTTAATGATCAAATTTTAGGGGGTTATGTGAATGTGGGCG
TGCCTTTTAGCTATCAAGTGAGCGCGAATTTTCAAAACTCACGCCTTTCTAGTTTGCTAGAAACCTTAAAAAAGAGTTTT
TTAGAAAAGCCCTTAATTGAGAGCAGTGCGAATAAAATTGCAGATATTTTTTCTAAAACGGTGCTATTTTTAGCCTTTGT
GAGCTTAATTTTATGGCAATTTGGTTGGGGGGCTAATTTTGAAAAAGCGTTAATGGTATGCATTAGCGTGTTAGTCATAA
GCTGCCCTTGTGCATTCGCTCTAGCTACGCCCATTGCATTAGTGATAGGGGTGTTTAAAAACCCTTTGATTGTGTTTAAA
GAAGCGTTGTTTTTAGAAACTTTAGCCAAAGTGAAAAAAATCTTCATAGACAAAACCGGCACTCTCACGCAAAAAGAAGT
CCTTTTAAAAGAGAAAATTATTTATGAACATTTTGATGAAAGGCTTTTAAAGAGTCTTTTAAAAACCAGAGAGCATTTAG
CCCATAGTGCGATTCTTAAATCATTAGATGGCGATGAGGTTATTTTAGAAAAGATAGAATTTTTTGCCCATGGTTTGAAA
GCGCATTATCACAACGAAACCTTGATTGTAGGGAGTTTGAAATTTTTAAATGCTATGGGGGTTAGCGTAAAAGTTAAAGA
GAGTGCAAATATCATGGTAGGTTTTGCGAAGAATAAGACTTTATGCGCGTTATTCATTTTAGAAGAGCGTTTGAAGAATA
ACGCTAAAGAAGTCGTTCAAGCTTTGCACAACAAAGGCTTGGAATTAGAAATTTTAAGTGGGGATAATGAAAGTTCTGTT
AAAGAGTGCACGAAAAAATTAGGGATTTCTAAATACCATGCGAATTTGACCCCTGAAGATAAGGCGCAAATCATTAGTTC
TTATAAAGGCGTGTGCGCGATGATAGGCGATGGCAATAATGACGCACTAGCCTTGAAACAAGCGAGCGTTTCTTTAGGGT
TTGAAAAAAGCGCTTTGAGCAAAAGCGCATGCGATATTTTGCTTTTAGAAGAAGATTTGAGTTTGTTAGAAAAAGCGCTT
CATAACGCTCAAAAAGTCTATCAAGTGGTGTTACAAAACATTGTTTTGAGCTTGATTTATAACGCTATTTTAATCCCAGT
AGCTATGCTAGGCTATATTAACCCCTTAATAGCGAGTTTGAGCATGAGTGCAAGTTCTTTATTAGTGGTATTAAATTCTT
TGAGACTGAAACGCTCTTAA

Upstream 100 bases:

>100_bases
AATTCCAAAAACCAAAGCGACAACACTAAAGAAGTTTTAACAATTTATCAAACTTGTAATACTTATTCTATAAAAGCACT
TTTAGATTAAGGATTAAAAA

Downstream 100 bases:

>100_bases
GTGGATTTGTGGTTTTTACTGAAATAGTCGCTAACTATTAGAGTTTTTGCCACTCAAAAATCCGATTAAAACGACTCATA
AACCCTTAAAACCCTCTCTT

Product: cation transporter E1-E2 family ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MKCSHCQLEFKESELFKETINHKELHFCCAGCARVYALLLDLNLESFYDKLGASTLAPVTHQAPVNALELEQAIEENDKG
DFTLNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKVYNAKNYTLKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGSSGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVFGMDLS
VSFGALSAFVYSVYAMFVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVLEKDKQVEKHPKDVA
IGSIILVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDQILGGYVNVGVPFSYQVSANFQNSRLSSLLETLKKSF
LEKPLIESSANKIADIFSKTVLFLAFVSLILWQFGWGANFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFK
EALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEHFDERLLKSLLKTREHLAHSAILKSLDGDEVILEKIEFFAHGLK
AHYHNETLIVGSLKFLNAMGVSVKVKESANIMVGFAKNKTLCALFILEERLKNNAKEVVQALHNKGLELEILSGDNESSV
KECTKKLGISKYHANLTPEDKAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLEKAL
HNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Sequences:

>Translated_779_residues
MKCSHCQLEFKESELFKETINHKELHFCCAGCARVYALLLDLNLESFYDKLGASTLAPVTHQAPVNALELEQAIEENDKG
DFTLNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKVYNAKNYTLKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGSSGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVFGMDLS
VSFGALSAFVYSVYAMFVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVLEKDKQVEKHPKDVA
IGSIILVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDQILGGYVNVGVPFSYQVSANFQNSRLSSLLETLKKSF
LEKPLIESSANKIADIFSKTVLFLAFVSLILWQFGWGANFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFK
EALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEHFDERLLKSLLKTREHLAHSAILKSLDGDEVILEKIEFFAHGLK
AHYHNETLIVGSLKFLNAMGVSVKVKESANIMVGFAKNKTLCALFILEERLKNNAKEVVQALHNKGLELEILSGDNESSV
KECTKKLGISKYHANLTPEDKAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLEKAL
HNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
>Mature_779_residues
MKCSHCQLEFKESELFKETINHKELHFCCAGCARVYALLLDLNLESFYDKLGASTLAPVTHQAPVNALELEQAIEENDKG
DFTLNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTHHLQIVFEKSLNPKEIIQKIESLGYGAKVYNAKNYTLKAQK
EQRSYLLTLSVGFFATMNLMFIAIAKYASYGSSGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVFGMDLS
VSFGALSAFVYSVYAMFVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEIHSVIVLEKDKQVEKHPKDVA
IGSIILVPSGAKIALDGVLLNNASVDASLISGEFKPLELGVNDQILGGYVNVGVPFSYQVSANFQNSRLSSLLETLKKSF
LEKPLIESSANKIADIFSKTVLFLAFVSLILWQFGWGANFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFK
EALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEHFDERLLKSLLKTREHLAHSAILKSLDGDEVILEKIEFFAHGLK
AHYHNETLIVGSLKFLNAMGVSVKVKESANIMVGFAKNKTLCALFILEERLKNNAKEVVQALHNKGLELEILSGDNESSV
KECTKKLGISKYHANLTPEDKAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLEKAL
HNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=861, Percent_Identity=23.3449477351916, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI115529486, Length=540, Percent_Identity=25, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI55743073, Length=528, Percent_Identity=24.2424242424242, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1786691, Length=831, Percent_Identity=26.5944645006017, Blast_Score=230, Evalue=3e-61,
Organism=Escherichia coli, GI1789879, Length=715, Percent_Identity=23.2167832167832, Blast_Score=149, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17556548, Length=768, Percent_Identity=20.9635416666667, Blast_Score=107, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319772, Length=628, Percent_Identity=27.5477707006369, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6320475, Length=759, Percent_Identity=24.3741765480896, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221329854, Length=483, Percent_Identity=25.0517598343685, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86092; Mature: 86092

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSHCQLEFKESELFKETINHKELHFCCAGCARVYALLLDLNLESFYDKLGASTLAPVT
CCCCCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
HQAPVNALELEQAIEENDKGDFTLNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTH
CCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFEKSLNPKEIIQKIESLGYGAKVYNAKNYTLKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGSSGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVFGMDLS
HHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
VSFGALSAFVYSVYAMFVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEI
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHCCCCEEEEECCCC
HSVIVLEKDKQVEKHPKDVAIGSIILVPSGAKIALDGVLLNNASVDASLISGEFKPLELG
EEEEEEECCCHHHHCCCCEEECEEEEECCCCEEEEEEEEECCCCCCHHHHCCCCCEEEEC
VNDQILGGYVNVGVPFSYQVSANFQNSRLSSLLETLKKSFLEKPLIESSANKIADIFSKT
CCCCEECCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLFLAFVSLILWQFGWGANFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
EALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEHFDERLLKSLLKTREHLAHSAILK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLDGDEVILEKIEFFAHGLKAHYHNETLIVGSLKFLNAMGVSVKVKESANIMVGFAKNKT
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCEEEEECCCCEEEEEECCCC
LCALFILEERLKNNAKEVVQALHNKGLELEILSGDNESSVKECTKKLGISKYHANLTPED
EEHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCEECCCCCHH
KAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLEKAL
HHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCCEEEEHHHHHHHHHHH
HNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKCSHCQLEFKESELFKETINHKELHFCCAGCARVYALLLDLNLESFYDKLGASTLAPVT
CCCCCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
HQAPVNALELEQAIEENDKGDFTLNLLLEKTHCNACLWLNQKVLERLSGVKKVSVNFTTH
CCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHCCCEEEEEEEEEE
HLQIVFEKSLNPKEIIQKIESLGYGAKVYNAKNYTLKAQKEQRSYLLTLSVGFFATMNLM
EEEEEEECCCCHHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHHH
FIAIAKYASYGSSGMDKLMQRNLDLVSLFLSLLVLVVVGRFFIKGAFYGLKNGVFGMDLS
HHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
VSFGALSAFVYSVYAMFVSQETYFEASSTILTLVFGSKFLELKARLFANEKCLALESHEI
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHHCCCCEEEEECCCC
HSVIVLEKDKQVEKHPKDVAIGSIILVPSGAKIALDGVLLNNASVDASLISGEFKPLELG
EEEEEEECCCHHHHCCCCEEECEEEEECCCCEEEEEEEEECCCCCCHHHHCCCCCEEEEC
VNDQILGGYVNVGVPFSYQVSANFQNSRLSSLLETLKKSFLEKPLIESSANKIADIFSKT
CCCCEECCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLFLAFVSLILWQFGWGANFEKALMVCISVLVISCPCAFALATPIALVIGVFKNPLIVFK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
EALFLETLAKVKKIFIDKTGTLTQKEVLLKEKIIYEHFDERLLKSLLKTREHLAHSAILK
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLDGDEVILEKIEFFAHGLKAHYHNETLIVGSLKFLNAMGVSVKVKESANIMVGFAKNKT
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHCCCEEEEECCCCEEEEEECCCC
LCALFILEERLKNNAKEVVQALHNKGLELEILSGDNESSVKECTKKLGISKYHANLTPED
EEHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCEECCCCCHH
KAQIISSYKGVCAMIGDGNNDALALKQASVSLGFEKSALSKSACDILLLEEDLSLLEKAL
HHHHHHHCCCEEEEEECCCCCEEEEEEHHHHCCCCHHHCCCCCCCEEEEHHHHHHHHHHH
HNAQKVYQVVLQNIVLSLIYNAILIPVAMLGYINPLIASLSMSASSLLVVLNSLRLKRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA