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The map label for this gene is clpA [H]

Identifier: 109946680

GI number: 109946680

Start: 44082

End: 46301

Strand: Direct

Name: clpA [H]

Synonym: Hac_0046

Alternate gene names: 109946680

Gene position: 44082-46301 (Clockwise)

Preceding gene: 109946679

Following gene: 109946681

Centisome position: 2.84

GC content: 39.59

Gene sequence:

>2220_bases
ATGGATAAATTCAATAAAGATTTAAATGAGGTATTATCCCATTCTTTAGATTTAGCCCTAGAATTCAACCATGCCCTTTG
CACCACAGAGCATGTGCTATTAGCCGTATTAGAGCATGAGATTGGGGTAAGGATCTTTAACACTTTAGAAGAAGATGAAT
ACCACAAAATGGGGCAAATCCTTAAAGACTATTTGCAACAATATATCCCTTTAAAAAATGATCCGACCAAAGTCCCAGAC
AGAAGCCCCGTATTAGCAAGGGTGTTTAAAAAACTGCGTGTGAGCTATTTAGAGAGCGTGGGCGTGGAAGAATTGTTGAT
TTTTATCCTAGAATACGCCGATTGCTACGCTTCGAAGCTCATGGATAGTTTTGGCATCACTCGTTTGTATTTCAAGTCTG
CTTTATTGGATCTTGATATTTCTAGCGAGACGAACGCCAACCAAGAGGAAACGCCCAAAAATAACGCCCTAAAAAAATAC
GCTAAAAATTTGAGCGCTTTAGCCCAAGATAACGCTTTAGATCCGGTCATTGGGAGAGAAAAAGAGATTTTAAGGGTCAT
AGAAATTTTAGGGTGCCGCAAAAAAAATAATCCGCTTTTAATTGGCGAAGCAGGGGTAGGCAAAACCGCTATCGCTGAAG
CTTTAGCCCTAAAAATCGCCCACAAAGAAGTGCCAGAATTTTTGCAAGAATATGAAATTTATTCTTTAGATTTAGCTTTA
ATGGTGGCTGGGGCGAAGTACAGAGGGGATTTTGAAAAACGCCTGAAAAAAACGATTAAAGAGATCCAACAAAACGGTCG
TGTCATTTTATTCATTGATGAAATCCACACCCTTTTAGGTGCAGGGAGCAGTAGTGCAGGGACTTTAGATGCAGCAAACA
TGCTAAAACCGCTTTTAACGGATGGGAGTTTGAAATGTTTGGGGGCGACCACTTTTGAAGAATACCGTAGCGTGTTTGAA
AAAGACAAGGCTTTAAACAGGCGCTTTTCGGTAGTGAAAGTTGAAGAGCCCACTAAAGAAGCGTGCTATTTGATTTTAAA
AAAGATTGCCCCCCTTTATGAAGAGCACCACCAGGTGCGTTATGATGAGAGCGTGTTTAAGGCATGCGTGGACTTGACGA
GTTACTACATACATGATAAATTTTTGCCGGATAAGGCGATTGAATTACTAGATGAGGTGGGATCAAGGAAAAAGATTAAC
CCCAAAAAAGGTAAAAAAATCAGCGTTGATGATGTGCAAGAAGCGCTCGCTCTAAAGCTTAAAATCCCTAAAATGCGTTT
GAGTGGCGATAAAAAAGCCCTTTTAAGAAACTTGGAAAAATCGCTAAAAAATAAGATTGTCGCCCAAACACAAGCGATCA
ATCTCATCAGTAATGCGATTAAAATCCAACATTGTGGGCTTTCTTCTAAAAATAAGCCTGTGGGGAGCTTTTTATTCGTG
GGACCTAGTGGGGTGGGGAAAACAGAGTTGGCTAAAGAATTGGCCTTGAATTTGGGTTTGCATTTTGAACGCTTTGACAT
GAGCGAATACAAAGAAGCCCATAGCGTGGCAAAGCTTATTGGTAGCCCTAGCGGTTATGTGGGGTTTGAACAAGGGGGGT
TATTGGTGAATGCGATCAAAAAACATCCGCATTGTTTGTTGCTTTTAGATGAGATAGAAAAAGCCCACACCGATGTGTAT
GATTTGTTGTTGCAAGTGATGGATAACGCCACTTTGAGCGATAATCTAGGCAATAAAGCGAGTTTTAAACATGTGATATT
GATTATGACTTCAAATGTGGGGAGTAAGGATAAGGATACGCTAGGGTTTTTTAGTGCTAAAAACACTAAGTATGATAGAG
CCATTAAAGAGCTTTTAACCCCTGAATTACGCTCCAGGATTGATGCGATTGTGCCATTTAGAGCGCTGAGTTTGGAGGAT
TTTGAACGCATTGTTTGGGTGGAATTGAATGAGTTAAAAGCTTTGGTGCTAGAGCAAGGTATAACCTTAAATTTCCATAA
AGAAGCGGTGAAATTTATCGTGCAAAAGAGCTATCAAACGACTTTGGGGGCGAGAGAAATTAAAAAAATCATCTATCATG
AAATCAAAACAAAATTAAGCGACATGCTGCTCTTACAATCGTTTAAAAAACCTTGTAAGATCGCTTGCTTGTTGGAAAAC
AATCAATTGGTTTTAAAAGAAATCAAGCGTGCACAAAAGGTGAAAGAAAATGACTTTTGA

Upstream 100 bases:

>100_bases
TCTATCCTTATGAAATTGCCATATATAAAGCGGTATGCGTGAGGGATAAAGCCAGAGCGTTAAAATTCCCTTTAAGATTA
ATGGTGCAAGAGATAAGATA

Downstream 100 bases:

>100_bases
AATGCTTTATAGCAAAATCCACAGAGCGACTATCACAGATGCTAACCTCAACTATGTGGGCTCGATCACCATAGATGAAA
ATTTAGCCAAGCTCGCTAAA

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MDKFNKDLNEVLSHSLDLALEFNHALCTTEHVLLAVLEHEIGVRIFNTLEEDEYHKMGQILKDYLQQYIPLKNDPTKVPD
RSPVLARVFKKLRVSYLESVGVEELLIFILEYADCYASKLMDSFGITRLYFKSALLDLDISSETNANQEETPKNNALKKY
AKNLSALAQDNALDPVIGREKEILRVIEILGCRKKNNPLLIGEAGVGKTAIAEALALKIAHKEVPEFLQEYEIYSLDLAL
MVAGAKYRGDFEKRLKKTIKEIQQNGRVILFIDEIHTLLGAGSSSAGTLDAANMLKPLLTDGSLKCLGATTFEEYRSVFE
KDKALNRRFSVVKVEEPTKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSYYIHDKFLPDKAIELLDEVGSRKKIN
PKKGKKISVDDVQEALALKLKIPKMRLSGDKKALLRNLEKSLKNKIVAQTQAINLISNAIKIQHCGLSSKNKPVGSFLFV
GPSGVGKTELAKELALNLGLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHTDVY
DLLLQVMDNATLSDNLGNKASFKHVILIMTSNVGSKDKDTLGFFSAKNTKYDRAIKELLTPELRSRIDAIVPFRALSLED
FERIVWVELNELKALVLEQGITLNFHKEAVKFIVQKSYQTTLGAREIKKIIYHEIKTKLSDMLLLQSFKKPCKIACLLEN
NQLVLKEIKRAQKVKENDF

Sequences:

>Translated_739_residues
MDKFNKDLNEVLSHSLDLALEFNHALCTTEHVLLAVLEHEIGVRIFNTLEEDEYHKMGQILKDYLQQYIPLKNDPTKVPD
RSPVLARVFKKLRVSYLESVGVEELLIFILEYADCYASKLMDSFGITRLYFKSALLDLDISSETNANQEETPKNNALKKY
AKNLSALAQDNALDPVIGREKEILRVIEILGCRKKNNPLLIGEAGVGKTAIAEALALKIAHKEVPEFLQEYEIYSLDLAL
MVAGAKYRGDFEKRLKKTIKEIQQNGRVILFIDEIHTLLGAGSSSAGTLDAANMLKPLLTDGSLKCLGATTFEEYRSVFE
KDKALNRRFSVVKVEEPTKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSYYIHDKFLPDKAIELLDEVGSRKKIN
PKKGKKISVDDVQEALALKLKIPKMRLSGDKKALLRNLEKSLKNKIVAQTQAINLISNAIKIQHCGLSSKNKPVGSFLFV
GPSGVGKTELAKELALNLGLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHTDVY
DLLLQVMDNATLSDNLGNKASFKHVILIMTSNVGSKDKDTLGFFSAKNTKYDRAIKELLTPELRSRIDAIVPFRALSLED
FERIVWVELNELKALVLEQGITLNFHKEAVKFIVQKSYQTTLGAREIKKIIYHEIKTKLSDMLLLQSFKKPCKIACLLEN
NQLVLKEIKRAQKVKENDF
>Mature_739_residues
MDKFNKDLNEVLSHSLDLALEFNHALCTTEHVLLAVLEHEIGVRIFNTLEEDEYHKMGQILKDYLQQYIPLKNDPTKVPD
RSPVLARVFKKLRVSYLESVGVEELLIFILEYADCYASKLMDSFGITRLYFKSALLDLDISSETNANQEETPKNNALKKY
AKNLSALAQDNALDPVIGREKEILRVIEILGCRKKNNPLLIGEAGVGKTAIAEALALKIAHKEVPEFLQEYEIYSLDLAL
MVAGAKYRGDFEKRLKKTIKEIQQNGRVILFIDEIHTLLGAGSSSAGTLDAANMLKPLLTDGSLKCLGATTFEEYRSVFE
KDKALNRRFSVVKVEEPTKEACYLILKKIAPLYEEHHQVRYDESVFKACVDLTSYYIHDKFLPDKAIELLDEVGSRKKIN
PKKGKKISVDDVQEALALKLKIPKMRLSGDKKALLRNLEKSLKNKIVAQTQAINLISNAIKIQHCGLSSKNKPVGSFLFV
GPSGVGKTELAKELALNLGLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIKKHPHCLLLLDEIEKAHTDVY
DLLLQVMDNATLSDNLGNKASFKHVILIMTSNVGSKDKDTLGFFSAKNTKYDRAIKELLTPELRSRIDAIVPFRALSLED
FERIVWVELNELKALVLEQGITLNFHKEAVKFIVQKSYQTTLGAREIKKIIYHEIKTKLSDMLLLQSFKKPCKIACLLEN
NQLVLKEIKRAQKVKENDF

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=305, Percent_Identity=35.0819672131148, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI1787109, Length=756, Percent_Identity=40.6084656084656, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1788943, Length=323, Percent_Identity=44.8916408668731, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6320464, Length=249, Percent_Identity=49.3975903614458, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6323002, Length=236, Percent_Identity=48.3050847457627, Blast_Score=219, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83375; Mature: 83375

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKFNKDLNEVLSHSLDLALEFNHALCTTEHVLLAVLEHEIGVRIFNTLEEDEYHKMGQI
CCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LKDYLQQYIPLKNDPTKVPDRSPVLARVFKKLRVSYLESVGVEELLIFILEYADCYASKL
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MDSFGITRLYFKSALLDLDISSETNANQEETPKNNALKKYAKNLSALAQDNALDPVIGRE
HHHHCHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
KEILRVIEILGCRKKNNPLLIGEAGVGKTAIAEALALKIAHKEVPEFLQEYEIYSLDLAL
HHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVAGAKYRGDFEKRLKKTIKEIQQNGRVILFIDEIHTLLGAGSSSAGTLDAANMLKPLLT
HHHCCHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
DGSLKCLGATTFEEYRSVFEKDKALNRRFSVVKVEEPTKEACYLILKKIAPLYEEHHQVR
CCCCEEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
YDESVFKACVDLTSYYIHDKFLPDKAIELLDEVGSRKKINPKKGKKISVDDVQEALALKL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHH
KIPKMRLSGDKKALLRNLEKSLKNKIVAQTQAINLISNAIKIQHCGLSSKNKPVGSFLFV
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEE
GPSGVGKTELAKELALNLGLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIK
CCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHH
KHPHCLLLLDEIEKAHTDVYDLLLQVMDNATLSDNLGNKASFKHVILIMTSNVGSKDKDT
CCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
LGFFSAKNTKYDRAIKELLTPELRSRIDAIVPFRALSLEDFERIVWVELNELKALVLEQG
CCEEECCCCHHHHHHHHHHCHHHHHHHHHHCCHHHCCHHHHHHEEEEEHHHHHHHHHHCC
ITLNFHKEAVKFIVQKSYQTTLGAREIKKIIYHEIKTKLSDMLLLQSFKKPCKIACLLEN
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
NQLVLKEIKRAQKVKENDF
CHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKFNKDLNEVLSHSLDLALEFNHALCTTEHVLLAVLEHEIGVRIFNTLEEDEYHKMGQI
CCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LKDYLQQYIPLKNDPTKVPDRSPVLARVFKKLRVSYLESVGVEELLIFILEYADCYASKL
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
MDSFGITRLYFKSALLDLDISSETNANQEETPKNNALKKYAKNLSALAQDNALDPVIGRE
HHHHCHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCH
KEILRVIEILGCRKKNNPLLIGEAGVGKTAIAEALALKIAHKEVPEFLQEYEIYSLDLAL
HHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVAGAKYRGDFEKRLKKTIKEIQQNGRVILFIDEIHTLLGAGSSSAGTLDAANMLKPLLT
HHHCCHHCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
DGSLKCLGATTFEEYRSVFEKDKALNRRFSVVKVEEPTKEACYLILKKIAPLYEEHHQVR
CCCCEEEECHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
YDESVFKACVDLTSYYIHDKFLPDKAIELLDEVGSRKKINPKKGKKISVDDVQEALALKL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHH
KIPKMRLSGDKKALLRNLEKSLKNKIVAQTQAINLISNAIKIQHCGLSSKNKPVGSFLFV
CCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCEEEEE
GPSGVGKTELAKELALNLGLHFERFDMSEYKEAHSVAKLIGSPSGYVGFEQGGLLVNAIK
CCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHH
KHPHCLLLLDEIEKAHTDVYDLLLQVMDNATLSDNLGNKASFKHVILIMTSNVGSKDKDT
CCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
LGFFSAKNTKYDRAIKELLTPELRSRIDAIVPFRALSLEDFERIVWVELNELKALVLEQG
CCEEECCCCHHHHHHHHHHCHHHHHHHHHHCCHHHCCHHHHHHEEEEEHHHHHHHHHHCC
ITLNFHKEAVKFIVQKSYQTTLGAREIKKIIYHEIKTKLSDMLLLQSFKKPCKIACLLEN
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
NQLVLKEIKRAQKVKENDF
CHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]