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The map label for this gene is icdA [H]

Identifier: 109946675

GI number: 109946675

Start: 40811

End: 42088

Strand: Direct

Name: icdA [H]

Synonym: Hac_0041

Alternate gene names: 109946675

Gene position: 40811-42088 (Clockwise)

Preceding gene: 109946669

Following gene: 109946676

Centisome position: 2.63

GC content: 42.02

Gene sequence:

>1278_bases
ATGGCTTACAACCCTAAATTTTTAGAAAAACCTAAAGAGGGCGAAGAAATTACGATTAAAAATGGCAAATTGTATGTGCC
AAATTGCCCTATTATCCCTTTTATTGAAGGCGATGGCATTGGATCGGATATTACCCCAGCGATGATTAAAGTGGTGGATA
GTGCGGTTCAAAAAGCTTACAAGGGCGAGAAGAAAATCGCATGGTATGAAGTGTTTGTAGGCGAAAAATGCTATCAAAAA
TTTAAAGATCATAAGGAATTAAGCCCAGAAGAGCAATGGCTCTTACCGGACACTATTGAAGCAATCAACCATTATAAAGT
TTCTATTAAAGGGCCTTTGACCACGCCTATTGGTGAGGGGTTTAGATCGTTAAATGTGGCGTTACGCCAAAAAATGGATT
TGTATGTGTGCTTGAGACCAGTAAGGTGGTATGGGAGTCCAAGTCCGGTTAAAGAGCCTCAAAAAGTGGATATGGTGATC
TTTAGAGAAAATTCTGAAGACATTTATGCGGGCATTGAATGGCAAGAAGGCAGCACGGAAGCGAAAAAACTCATCCATTT
TTTACAAAACGAACTAAAGGTTAAAAAAATCCGTTTCCCTGAAAGCAGTGGCATAGGGGTAAAACCCATCAGTAAAGAAG
GCACAGAAAGATTGGTAAGAAAAGCGATTGAATACGCTATTGATAACGACAAGCCAAGCGTAACTTTTGTGCATAAGGGC
AATATCATGAAGTACACTGAAGGGGCGTTCATGAAATGGGGCTATGCGCTCGCTCAAAAAGAGTTTAACGCTCAAGTCAT
TGATAAAGGTCCATGGTGTTCTTTGAAAAACCCTAAAACCGGTAAAGAAATCATCATTAAAGACATGATCGCTGATGCGT
TCTTGCAACAAATCCTTTTGCGCCCGGATGAATACAGCGTCATTGCGACCATGAATTTAAACGGAGACTATATCTCTGAT
GCACTAGCGGCGATGGTAGGGGGCATTGGGATCGCTCCTGGGGCTAATCTTAACGACACAGTGGGCATGTTTGAAGCCAC
CCATGGCACCGCCCCTAAATACGCTGGGCTAGATAAAGTCAATCCGGGGTCTATTATTTTGAGTGCAGAAATGATGTTAA
GGCATATGGGTTGGGTGGAAGCGGCTGATTTGATTGTCTCTGCTATGGAAAAAGCGATTAAGAGCAAGAAAGTGACTTAT
GATTTCGCTCGTTTGATGGATGGGGCTAAAGAAGTCAAATGCTCTGAATTCGCTAGCGTGATGATCGAACACATGTAA

Upstream 100 bases:

>100_bases
TTTTAAACACGCCTCTAAAAAAGATTAAAAGATTTGATTAAGGGTTAAGTCATGTTTTTATGCTAGTATAATCACCTAAA
TTTATAAAAAAGGATGAGAG

Downstream 100 bases:

>100_bases
AAAATAAAGAGCGTTAGGGCTGATATTTTTATTAAGGAATAAAGTTGGTAAAAGTAGTGCGTAATGTGGTTTTATCCCTT
GTAACGATAATCTTTTTAGC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAYNPKFLEKPKEGEEITIKNGKLYVPNCPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQK
FKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVI
FRENSEDIYAGIEWQEGSTEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPDEYSVIATMNLNGDYISD
ALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTY
DFARLMDGAKEVKCSEFASVMIEHM

Sequences:

>Translated_425_residues
MAYNPKFLEKPKEGEEITIKNGKLYVPNCPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQK
FKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVI
FRENSEDIYAGIEWQEGSTEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPDEYSVIATMNLNGDYISD
ALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTY
DFARLMDGAKEVKCSEFASVMIEHM
>Mature_424_residues
AYNPKFLEKPKEGEEITIKNGKLYVPNCPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKF
KDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIF
RENSEDIYAGIEWQEGSTEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGN
IMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPDEYSVIATMNLNGDYISDA
LAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYD
FARLMDGAKEVKCSEFASVMIEHM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=390, Percent_Identity=32.0512820512821, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI28178838, Length=374, Percent_Identity=25.668449197861, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28178821, Length=367, Percent_Identity=25.0681198910082, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI28178816, Length=401, Percent_Identity=25.1870324189526, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI4758582, Length=350, Percent_Identity=26.2857142857143, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI28178819, Length=184, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787381, Length=416, Percent_Identity=69.9519230769231, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1788101, Length=386, Percent_Identity=25.9067357512953, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081683, Length=410, Percent_Identity=24.6341463414634, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71986051, Length=390, Percent_Identity=31.7948717948718, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17505779, Length=302, Percent_Identity=29.8013245033113, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI25144293, Length=373, Percent_Identity=27.0777479892761, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=398, Percent_Identity=23.8693467336683, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324709, Length=398, Percent_Identity=30.1507537688442, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6324291, Length=378, Percent_Identity=28.042328042328, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322097, Length=374, Percent_Identity=27.2727272727273, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24643270, Length=392, Percent_Identity=32.3979591836735, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24643268, Length=392, Percent_Identity=32.3979591836735, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=30.5970149253731, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161078635, Length=301, Percent_Identity=27.5747508305648, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI161078637, Length=301, Percent_Identity=27.5747508305648, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078633, Length=301, Percent_Identity=27.5747508305648, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24650122, Length=301, Percent_Identity=27.5747508305648, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078639, Length=306, Percent_Identity=27.1241830065359, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130355, Length=396, Percent_Identity=24.2424242424242, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281362242, Length=405, Percent_Identity=25.679012345679, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24648872, Length=405, Percent_Identity=25.679012345679, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 47543; Mature: 47412

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNPKFLEKPKEGEEITIKNGKLYVPNCPIIPFIEGDGIGSDITPAMIKVVDSAVQKAY
CCCCCCHHCCCCCCCEEEEECCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
KGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEG
CCCCCEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCHHHH
FRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSTE
HHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHH
AKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECC
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILL
CEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
RPDEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCC
NPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASV
CCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
MIEHM
HHHCC
>Mature Secondary Structure 
AYNPKFLEKPKEGEEITIKNGKLYVPNCPIIPFIEGDGIGSDITPAMIKVVDSAVQKAY
CCCCCHHCCCCCCCEEEEECCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
KGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEG
CCCCCEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEEEEECCCCCCHHHH
FRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSTE
HHHHHHHHHHCCCEEEEEEHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHH
AKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKG
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECC
NIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILL
CEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
RPDEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKV
CCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCC
NPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASV
CCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHH
MIEHM
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]