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The map label for this gene is pdxA

Identifier: 109946667

GI number: 109946667

Start: 35692

End: 36624

Strand: Direct

Name: pdxA

Synonym: Hac_0032

Alternate gene names: 109946667

Gene position: 35692-36624 (Clockwise)

Preceding gene: 109946666

Following gene: 109946668

Centisome position: 2.3

GC content: 40.94

Gene sequence:

>933_bases
ATGGTTAAAAAGAAAATTGCGATCAGTTGTGGGGATATTCAAGGTATAGGCTTAGAATTGATTTTAAAAAGCCATAAGGA
AGTGAGCGTGCTTTGTGAGCCATTGTATCTCATTCATAGCGAACTTTTAGGGCGAGCCAATCAATTACTTACTAACGCTT
ATGAAGTAAAGCCGCTTAATGCTATCGCTATAAATTCCCCCTTACCTTCATTCAACTCTAGCACGATAGGCAAAGTCAGC
GCTCAAAGCGGAGCGTATAGCTTTGAGAGTTTTAGAAAAGCTTGCGAGTTAGCAGATGATAAAGAAGTGGATAGCATTTG
CACCATGCCTATCAATAAACTCGCATGGCAACAAGCTCAAATCCCTTTCGTGGGGCATACCGATTTTTTAAAACAACGCT
ACAAAGAGCATCAAATCATTATGATGCTTGGGTGTCCTAAACTCTTTGTGGGACTATTTAGCGACCATGTGCCTTTAAGG
GCGGTTTCTCAACTCATTCAAGTAAAAGCGTTAGTCCAGTTTTTATTGGCGTTTCAAAAAAGCACTCAAGCTCAAATTAT
TCAAGTGTGTGGTTTTAACCCTCATGCGGGCGAAGAGGGTTTGTTTGGAGAAGAAGATGAAAAGATTTTAAAAGCCATTC
AAGAGAGTAACCAAACGCTAGGCTTTGAATGTTTTCTAGGACCACTGCCGGCTGATAGCGCTTTTGCCCCCAATAAGCGC
CAAATAACGCCTTTTTATGTGAGCATGAGCCATGATGTGGGGTTAGCCCCTTTAAAGGCACTCTATTTTGATGAGAGCAT
CAATGTGAGTTTGAACGCCCCTATTTTGCGTGCTTCCACTGACCATGGCACTGCATTTGATATTGCTTATCAAAACAAAG
CGAACAATAAAAGCTATTTGAATGCGATCAAATACCTATCTCAAAGGCTTTAA

Upstream 100 bases:

>100_bases
TTAAGAGAGCTTAATATCGGTCATAGCGTGATTTCAAAAGCGGTTTTAGTGGGCTTAGAAAAAGCGATTTTAGAAATGGC
GCAACTCATTAAACGCTAAA

Downstream 100 bases:

>100_bases
ATAAAATTAAGATAAAATGAAAGCGATGCGCCAATAAGCGGCATCAAGCGAACTAAAAGGCGAATTTAAATGATTAAAAG
CGTAGAGATTGAAAATTACA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MVKKKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPLNAIAINSPLPSFNSSTIGKVS
AQSGAYSFESFRKACELADDKEVDSICTMPINKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLR
AVSQLIQVKALVQFLLAFQKSTQAQIIQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFECFLGPLPADSAFAPNKR
QITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYLNAIKYLSQRL

Sequences:

>Translated_310_residues
MVKKKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPLNAIAINSPLPSFNSSTIGKVS
AQSGAYSFESFRKACELADDKEVDSICTMPINKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLR
AVSQLIQVKALVQFLLAFQKSTQAQIIQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFECFLGPLPADSAFAPNKR
QITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYLNAIKYLSQRL
>Mature_310_residues
MVKKKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPLNAIAINSPLPSFNSSTIGKVS
AQSGAYSFESFRKACELADDKEVDSICTMPINKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLR
AVSQLIQVKALVQFLLAFQKSTQAQIIQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFECFLGPLPADSAFAPNKR
QITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYLNAIKYLSQRL

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=324, Percent_Identity=30.2469135802469, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_HELAH (Q17ZN0)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_663895.1
- ProteinModelPortal:   Q17ZN0
- SMR:   Q17ZN0
- STRING:   Q17ZN0
- GeneID:   4176742
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0032
- NMPDR:   fig|382638.8.peg.32
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   DSAFAPN
- PhylomeDB:   Q17ZN0
- ProtClustDB:   PRK03946
- BioCyc:   HACI382638:HAC_0032-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 34293; Mature: 34293

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 127-127 BINDING 259-259 BINDING 268-268 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPLN
CCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AIAINSPLPSFNSSTIGKVSAQSGAYSFESFRKACELADDKEVDSICTMPINKLAWQQAQ
EEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCC
IPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLRAVSQLIQVKALVQFLLAFQK
CCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
STQAQIIQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFECFLGPLPADSAFAPNKR
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCC
QITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYL
CCCEEEEEECCCCCCHHHHHHEECCCCCEEECCCEEEECCCCCCEEEEEECCCCCCHHHH
NAIKYLSQRL
HHHHHHHHCC
>Mature Secondary Structure
MVKKKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPLN
CCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AIAINSPLPSFNSSTIGKVSAQSGAYSFESFRKACELADDKEVDSICTMPINKLAWQQAQ
EEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCC
IPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLRAVSQLIQVKALVQFLLAFQK
CCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
STQAQIIQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFECFLGPLPADSAFAPNKR
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCC
QITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGTAFDIAYQNKANNKSYL
CCCEEEEEECCCCCCHHHHHHEECCCCCEEECCCEEEECCCCCCEEEEEECCCCCCHHHH
NAIKYLSQRL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA