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The map label for this gene is uhpB [H]

Identifier: 108813816

GI number: 108813816

Start: 4194795

End: 4195505

Strand: Reverse

Name: uhpB [H]

Synonym: YPN_3656

Alternate gene names: 108813816

Gene position: 4195505-4194795 (Counterclockwise)

Preceding gene: 108813817

Following gene: 108813815

Centisome position: 92.52

GC content: 48.1

Gene sequence:

>711_bases
TTGGGATCCGGCATTCAACGACAGCGGGAGTTGAACGATCAACTACAAATAAAATTGAACGAAAACCGTGAGTTGGCTAA
AGCATTAGTGGTTTCTGAGGAGCATACACGGCACGATGTCGCGCGTGAGTTACATGATGAAGTGGGGCAAACCGTAACGG
TTATCCGTACCCAAGCCAGTATTATTAAACGTCTGACCACCCAGCAACCGGTACTGACCAGTGCAGAGATGATAGAAACT
GCGGCATTGCGGGTTTATGATGGTGTCCATGACGTATTGGCTAAATTATGGCCAGCGGCATTAAATAATTTGCCGCTGTC
GGCCGCCATCGCTGCATTGATGCGCGAACTCATTCCGCAAGACCAGTCGGTGCTCGGTGTGCTTAACTGGCAGGTCAATG
ACCATCCGATGGATGAGACGTTGAAAATTACGCTTTACCGTATATGTCAGGAGGGGGTGACCAATGCTTATCGGCATGGT
GCCGCCAGCCGAATTGAAATTAATGCACGGCAGGATAACCAACAGATATATCTAACGATTAGCGATAATGGTAAAGGTAT
CGATTTAGCCTCAATTACTCCAGGCTATGGGCTACGGGGTATTCAGTCACGGGTCAGTGCGTTTGGGGGCAATGTGAGCC
TAAGCGTTGATAACGGTACTTGCTTAAATGTGACCCTGCCCACAGTTTCTTTGTCTACAAAAGGAAACTAA

Upstream 100 bases:

>100_bases
GAGTAAAACGGTGGATCAATATTGGGCCGTTGGTGGAGATATAAGTGGATCACTTTTCATCCGTCGTTGACAGTTGGCAC
AAAGTCTAACAGGTCTGCTC

Downstream 100 bases:

>100_bases
GAAATATTCTCGTTGGTAGCGAGAATTCCCCCGTGTGTTTTCATACACATGCAGATGATGATTATTGCACTTACAAAATA
CCCTGAGGCCCGAGATGTGG

Product: ATP-binding region, ATPase-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPVLTSAEMIET
AALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHG
AASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSLSTKGN

Sequences:

>Translated_236_residues
MGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPVLTSAEMIET
AALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHG
AASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSLSTKGN
>Mature_235_residues
GSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPVLTSAEMIETA
ALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHGA
ASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSLSTKGN

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=228, Percent_Identity=42.1052631578947, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1788812, Length=209, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 25871; Mature: 25740

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQAS
CCCCCCHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHH
IIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQ
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
DQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQDNQQIYLTI
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEE
SDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSLSTKGN
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECEEEECCCCC
>Mature Secondary Structure 
GSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDEVGQTVTVIRTQAS
CCCCCHHHHCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHH
IIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQ
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
DQSVLGVLNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQDNQQIYLTI
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEE
SDNGKGIDLASITPGYGLRGIQSRVSAFGGNVSLSVDNGTCLNVTLPTVSLSTKGN
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEECEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]