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The map label for this gene is aas [H]

Identifier: 108813156

GI number: 108813156

Start: 3367035

End: 3368993

Strand: Reverse

Name: aas [H]

Synonym: YPN_2996

Alternate gene names: 108813156

Gene position: 3368993-3367035 (Counterclockwise)

Preceding gene: 108813157

Following gene: 108813155

Centisome position: 74.3

GC content: 51.91

Gene sequence:

>1959_bases
ATGCGTTGGCTAAAGCCTTATGTGGATTTTGTTGCGCTGGATCCGACCAACCCGATGGCCATCAAACATCTGGTCAGAAT
GGTCGAACAGGGCAGGCCAGTAGTCATTTTCCCTGAAGGGCGCATCACTGTGACCGGCTCCTTGATGAAAATTTATGATG
GGGCGGCATTTGTTGCGGCAAAATCAGGTGCGGCGGTGGTCCCTATCCGTTTAGATGGCCCTGAATTTACTCATTTTGGG
CGATTGCAGGGCGTGCTAAAAACACGCTGGTTCCCAAAAATCAGTATTCATGTGTTACCGGCCACCACCATTCCTATGCC
ACAAGCGCCACGCTCGCGCGAACGGCGAGTTCTGGCCGGTGAGCACCTGCATACCATTATGATGGCGGCCCGCATGGCCA
CGGTGCCACGGGAAACGCTGTTTGAAGCGTTGCTATCGGCACAAACCCGTTATGGTCGCTTTAAACCTTGCATTGAAGAT
GTCTCATTTAAAGAGGACAGCTACCAGACGCTACTGAAGAAAACGCTCGGTGTGAGCCGTATTTTGCAACGCTTTACCGT
GCCGGGTGAGCATGTCGGGATGTTGCTGCCCAATGCCACCATTACTGCGGCTGCTATTTTTGGCGCATCGTTACGTGGAC
GAATTCCGGCACTGCTCAACTACACCTCGGGTGCTAAAGGGCTACAGAGCGCTATCATTGCGGCTTCACTTAAAACCATC
GTCACCTCGCGCCAGTTTTTGGAAAAAGGCAAACTGACGCACCTGCCGGAACAGGTCAATGAGGTGAACTGGGTCTATCT
GGAAGATTTAAAAGACACGGTGACACTGACGGATAAGCTGTGGATCTTATTCCACTTGTGTTTCCCGCGTAGGGCGATGT
TGCCGCAGCAGGCTGATGGCAGCGCGTTAATCTTGTTTACCTCTGGATCGGAAGGCAACCCTAAAGGCGTGGTGCATTCT
CATGCCAGTTTGTTGGCTAACGTCGAACAAATCCGAACCATTGCTGACTTCACGCCACGTGATCGCTTCATGTCATCATT
GCCGCTGTTTCATGCTTTTGGTCTGACGGTGGGATTATTCACACCACTGATGACCGGTAGCCGAGTATTCCTTTACCCTA
GTCCGCTGCATTACCGCGTGGTACCTGAACTGGTATATGACCGTAACTGTACCGTGCTCTTTGGGACCTCAACATTCTTG
GGGAATTATGCGCGCTTTGCTCATCCATATGATTTCGCCCGCGTGCGTTATGTGGTTGCTGGCGCTGAAAAGTTGGCTGA
AAGCACCAAACAGATTTGGCAGGATAAATTTGGTATCCGTATTCTGGAAGGGTATGGCGTAACCGAGTGCGCGCCCGTTG
TGGCGATTAACGTACCGATGGCGGCTAAAGTGAACACGGTAGGGCGCATTTTACCGGGGATGGAAGCCCGATTGATTAAC
GTACCGGGGATTGCTCAAGGTGGCCGCTTACAATTACGCGGCCCTAATATTATGCGTGGTTACTTACGGGTAGAGAATCC
CGGTGTATTGGAGCAGCCATCAGCAGAAAATGCTCAGGGTGAACTTGACGCTAATTGGTATGACACCGGTGATATTGTGA
CCCTCGACGAACAAGGGTTCTGCGCGATCCGTGGCCGGGTGAAACGTTTTGCTAAGTTGGCTGGGGAGATGGTATCACTG
GAGAGCGTTGAACAATTGGCAATAAGCCTTTCACCGGAAGGGCAACATGCAGCAGCGGCTAAAACTGACAGTGCGAAAGG
TGAAGCATTGGTGCTGTTTACCACTGACAGTGAGATAACCCGTGAACGGTTAATCAAAGTGGCACGGGAAAATGGTGTGC
CTGAACTGGCGGTGCCGCGCGATATCCGGGTCGTGAAAGCTCTCCCCTTATTAGGCAGCGGTAAACCTGACTTCGTCACG
TTGGGCAAAATGGCACAAGATCCGGAGATGAGCGTATGA

Upstream 100 bases:

>100_bases
CGCCCAATCACGTCTCTTTCCTCGATGGGGCTTTATTAGCGCTATTTCTACCGATCAAGCCAGTATTTGCTGTCTATACC
AGTATTACTGACACCTGTAT

Downstream 100 bases:

>100_bases
GTCAGGACGTATTAGCAGATAAGCCTTTGTTATCTCGGAGCATGGTCGCGGTACTCTGTGCTCAGTTTTTCTCCGCTTTC
GGGGATAATGCCCTGCTGTT

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFG
RLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIED
VSFKEDSYQTLLKKTLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTI
VTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADGSALILFTSGSEGNPKGVVHS
HASLLANVEQIRTIADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFL
GNYARFAHPYDFARVRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLIN
VPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSL
ESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFTTDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVT
LGKMAQDPEMSV

Sequences:

>Translated_652_residues
MRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFG
RLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIED
VSFKEDSYQTLLKKTLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTI
VTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADGSALILFTSGSEGNPKGVVHS
HASLLANVEQIRTIADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFL
GNYARFAHPYDFARVRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLIN
VPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSL
ESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFTTDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVT
LGKMAQDPEMSV
>Mature_652_residues
MRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFG
RLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIED
VSFKEDSYQTLLKKTLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTI
VTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADGSALILFTSGSEGNPKGVVHS
HASLLANVEQIRTIADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFL
GNYARFAHPYDFARVRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLIN
VPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSL
ESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFTTDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVT
LGKMAQDPEMSV

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=351, Percent_Identity=28.4900284900285, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI187761345, Length=402, Percent_Identity=26.1194029850746, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI187761343, Length=402, Percent_Identity=26.1194029850746, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI57165412, Length=407, Percent_Identity=26.2899262899263, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI57165410, Length=407, Percent_Identity=26.044226044226, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1789201, Length=649, Percent_Identity=72.1109399075501, Blast_Score=989, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=514, Percent_Identity=25.0972762645914, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI145693145, Length=355, Percent_Identity=27.887323943662, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786810, Length=355, Percent_Identity=23.6619718309859, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=344, Percent_Identity=27.6162790697674, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=340, Percent_Identity=28.2352941176471, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71994703, Length=508, Percent_Identity=24.6062992125984, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=508, Percent_Identity=24.6062992125984, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71994694, Length=508, Percent_Identity=24.6062992125984, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17560308, Length=367, Percent_Identity=25.6130790190736, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=313, Percent_Identity=25.8785942492013, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17531443, Length=321, Percent_Identity=23.98753894081, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=389, Percent_Identity=23.6503856041131, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559526, Length=521, Percent_Identity=23.0326295585413, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=329, Percent_Identity=23.7082066869301, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=347, Percent_Identity=25.6484149855908, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320852, Length=349, Percent_Identity=25.5014326647564, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI18859661, Length=281, Percent_Identity=27.7580071174377, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21355181, Length=547, Percent_Identity=24.1316270566728, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24581924, Length=546, Percent_Identity=21.2454212454212, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922652, Length=282, Percent_Identity=24.468085106383, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 71790; Mature: 71790

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAA
CCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEECEEEHHCCEEEEEE
KSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRERRVLAG
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHH
EHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKKTLGVSR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHCHHH
ILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTI
HHHHHCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
VTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADG
HHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHCCHHHCCCCCCCC
SALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFGLTVGLF
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHH
TPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFARVRYVVA
HHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHCHHHHCCCCHHHHHHHEEH
GAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLIN
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEE
VPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGF
CCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEEECCCCC
CAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFTTDSEIT
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHH
RERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAA
CCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEECEEEHHCCEEEEEE
KSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRERRVLAG
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHH
EHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKKTLGVSR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHCHHH
ILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTI
HHHHHCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
VTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADG
HHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHCCHHHCCCCCCCC
SALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFGLTVGLF
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHH
TPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFARVRYVVA
HHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHCHHHHCCCCHHHHHHHEEH
GAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLIN
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEE
VPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGF
CCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEEECCCCC
CAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFTTDSEIT
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHH
RERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA