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The map label for this gene is moaA [H]

Identifier: 108813002

GI number: 108813002

Start: 3198042

End: 3199067

Strand: Reverse

Name: moaA [H]

Synonym: YPN_2842

Alternate gene names: 108813002

Gene position: 3199067-3198042 (Counterclockwise)

Preceding gene: 108813004

Following gene: 108813001

Centisome position: 70.55

GC content: 49.12

Gene sequence:

>1026_bases
GTGCAAGGTAGAAATGCCTGCATCTCCCGTATTTGGAAAGGTGTTATGGTACAACTCACTGACGCATTTGCGCGTAAATT
CTACTATTTGCGCCTATCGATCACTGATGTGTGCAATTTCCGTTGCACATATTGCTTGCCAGAGGGCTACCGCCCAGATG
GTGTCAAAAGTTTTTTGAGCCTTGACGAAATCAATCGCGTCAGCCGCGCCTTTGCCTTGTTGGGAACGGAAAAAATCCGC
CTGACGGGGGGCGAGCCTTCGATGCGGCGCGACTTCACTGATATTATTGCCACTATCCGGCAAAATCCCGCTATCCGTAC
CTTGGCCGTTACAACTAATGGTTATCGTTTAGTTCGTGATGTGGCGCAATGGCGTGATGCGGGCCTGACGGCAATTAATG
TCAGCGTCGATAGCCTGGATCCGCGACAATTTCATGCCATCACCGGGCAGGATAAATTTTATCAAGTTATGCAGGGCATT
GATGCCGCATTTGATGCCGGTTTTGACAAAGTCAAAGTCAACGCTGTTTTGATGCGCGATGTTAATGATCGCCAACTGAG
TGCATTCCTTGACTGGATCAAACCTCGGCCCATTCAACTGCGTTTTATCGAGCTGATGGAAACCGGCGAAGGCGGTAACC
TGTTCCGTAAACACCACGTTTCTGGTGGCGTCATCCGCCAACAATTACTCGAACAAGGCTGGCAGCAGCAAGATCGGGCG
CGCAGTGATGGCCCGGCTCAGGTGTTTCACCACTCGGATTACCAAGGTGAAATTGGGCTTATCATGCCGTATGAAAAAGA
CTTTTGCGCCAGTTGTAACCGCCTGCGTGTTTCTGCTCTCGGTAATTTGCATTTGTGCTTATTTGGTGAGCAGGGGATTA
CATTACGTGATCTGCTGGGCAGTGATGATCAACAAGATGAGCTGATAGCGCGGATTCAAAGTGCGTTGCAAACGAAGAAA
CAGACTCATTTTTTGCATCAGGGTAACAGCGGTATAACGCAAAATTTATCCTTTATTGGCGGCTGA

Upstream 100 bases:

>100_bases
ATATAAGTTACAGCTGAACATAAACTCCTAGCCTTAGCGTCTACGTTGTCTTTTTTGTATTGGCAATATGATGTTCTGGC
CGTGGCCTTAAGCCACCAGG

Downstream 100 bases:

>100_bases
TGTGAGCGAATTAGCGCCGATGAGCTTACATCAGTAAGTGATTCGGGCAAGTGAATGCCGCTAACCCCCCTGTAATGTCA
AGAACGAAGGGATTTTATTG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQGRNACISRIWKGVMVQLTDAFARKFYYLRLSITDVCNFRCTYCLPEGYRPDGVKSFLSLDEINRVSRAFALLGTEKIR
LTGGEPSMRRDFTDIIATIRQNPAIRTLAVTTNGYRLVRDVAQWRDAGLTAINVSVDSLDPRQFHAITGQDKFYQVMQGI
DAAFDAGFDKVKVNAVLMRDVNDRQLSAFLDWIKPRPIQLRFIELMETGEGGNLFRKHHVSGGVIRQQLLEQGWQQQDRA
RSDGPAQVFHHSDYQGEIGLIMPYEKDFCASCNRLRVSALGNLHLCLFGEQGITLRDLLGSDDQQDELIARIQSALQTKK
QTHFLHQGNSGITQNLSFIGG

Sequences:

>Translated_341_residues
MQGRNACISRIWKGVMVQLTDAFARKFYYLRLSITDVCNFRCTYCLPEGYRPDGVKSFLSLDEINRVSRAFALLGTEKIR
LTGGEPSMRRDFTDIIATIRQNPAIRTLAVTTNGYRLVRDVAQWRDAGLTAINVSVDSLDPRQFHAITGQDKFYQVMQGI
DAAFDAGFDKVKVNAVLMRDVNDRQLSAFLDWIKPRPIQLRFIELMETGEGGNLFRKHHVSGGVIRQQLLEQGWQQQDRA
RSDGPAQVFHHSDYQGEIGLIMPYEKDFCASCNRLRVSALGNLHLCLFGEQGITLRDLLGSDDQQDELIARIQSALQTKK
QTHFLHQGNSGITQNLSFIGG
>Mature_341_residues
MQGRNACISRIWKGVMVQLTDAFARKFYYLRLSITDVCNFRCTYCLPEGYRPDGVKSFLSLDEINRVSRAFALLGTEKIR
LTGGEPSMRRDFTDIIATIRQNPAIRTLAVTTNGYRLVRDVAQWRDAGLTAINVSVDSLDPRQFHAITGQDKFYQVMQGI
DAAFDAGFDKVKVNAVLMRDVNDRQLSAFLDWIKPRPIQLRFIELMETGEGGNLFRKHHVSGGVIRQQLLEQGWQQQDRA
RSDGPAQVFHHSDYQGEIGLIMPYEKDFCASCNRLRVSALGNLHLCLFGEQGITLRDLLGSDDQQDELIARIQSALQTKK
QTHFLHQGNSGITQNLSFIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=311, Percent_Identity=39.5498392282958, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI22027536, Length=311, Percent_Identity=39.5498392282958, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1786999, Length=326, Percent_Identity=78.2208588957055, Blast_Score=532, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI32566331, Length=307, Percent_Identity=38.4364820846906, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566329, Length=307, Percent_Identity=38.4364820846906, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=37.785016286645, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI28574488, Length=310, Percent_Identity=37.0967741935484, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI28574490, Length=310, Percent_Identity=37.0967741935484, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38548; Mature: 38548

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGRNACISRIWKGVMVQLTDAFARKFYYLRLSITDVCNFRCTYCLPEGYRPDGVKSFLS
CCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEHHHCCCEEEEECCCCCCCHHHHHHHH
LDEINRVSRAFALLGTEKIRLTGGEPSMRRDFTDIIATIRQNPAIRTLAVTTNGYRLVRD
HHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
VAQWRDAGLTAINVSVDSLDPRQFHAITGQDKFYQVMQGIDAAFDAGFDKVKVNAVLMRD
HHHHHHCCCEEEEEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
VNDRQLSAFLDWIKPRPIQLRFIELMETGEGGNLFRKHHVSGGVIRQQLLEQGWQQQDRA
CCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHC
RSDGPAQVFHHSDYQGEIGLIMPYEKDFCASCNRLRVSALGNLHLCLFGEQGITLRDLLG
CCCCCCEEEECCCCCCCEEEEECCCCHHHCCCCCEEEEECCCEEEEEECCCCCCHHHHHC
SDDQQDELIARIQSALQTKKQTHFLHQGNSGITQNLSFIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCC
>Mature Secondary Structure
MQGRNACISRIWKGVMVQLTDAFARKFYYLRLSITDVCNFRCTYCLPEGYRPDGVKSFLS
CCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEHHHCCCEEEEECCCCCCCHHHHHHHH
LDEINRVSRAFALLGTEKIRLTGGEPSMRRDFTDIIATIRQNPAIRTLAVTTNGYRLVRD
HHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHH
VAQWRDAGLTAINVSVDSLDPRQFHAITGQDKFYQVMQGIDAAFDAGFDKVKVNAVLMRD
HHHHHHCCCEEEEEEECCCCCHHEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
VNDRQLSAFLDWIKPRPIQLRFIELMETGEGGNLFRKHHVSGGVIRQQLLEQGWQQQDRA
CCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHC
RSDGPAQVFHHSDYQGEIGLIMPYEKDFCASCNRLRVSALGNLHLCLFGEQGITLRDLLG
CCCCCCEEEECCCCCCCEEEEECCCCHHHCCCCCEEEEECCCEEEEEECCCCCCHHHHHC
SDDQQDELIARIQSALQTKKQTHFLHQGNSGITQNLSFIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]